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RAD51

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAD51 (25) Apoptosis (6) Autophagy (2) c-Kit (2) c-Met/HGFR (2) CRISPR/Cas9 (1) DNA/RNA Synthesis (5) Epigenetic Reader Domain (1) FLT3 (2) MicroRNA (1) PARP (2) PDGFR (2) Proteasome (1) Reactive Oxygen Species (1) RET (2) Small Interfering RNA (siRNA) (7) VDAC (2)
By Research Areas:	Cancer (35) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (2)
Oligonucleotides:	Pre-designed siRNA Sets (7) siRNAs (7)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: RAD51

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101462

RAD51 Inhibitor B02 5+ Cited Publications B02	RAD51 Apoptosis	Cancer
RAD51 Inhibitor B02 (B02) is an inhibitor of human *RAD51* with an IC₅₀ of 27.4 μM.

HY-143736

RAD51-IN-5	RAD51	Cancer
RAD51-IN-5 is a potent inhibitor of *RAD51. RAD51* is a eukaryote gene. RAD51-IN-5 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2021164746A1, compound 3) .

HY-RS11603

RAD51 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAD51 Human Pre-designed siRNA Set A contains three designed siRNAs for RAD51 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAD51 Human Pre-designed siRNA Set A RAD51 Human Pre-designed siRNA Set A

HY-RS11604

Rad51 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rad51 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Rad51 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rad51 Mouse Pre-designed siRNA Set A Rad51 Mouse Pre-designed siRNA Set A

HY-RS11605

Rad51 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Rad51 Rat Pre-designed siRNA Set A contains three designed siRNAs for Rad51 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Rad51 Rat Pre-designed siRNA Set A Rad51 Rat Pre-designed siRNA Set A

HY-R04608

RAD51 SSDNA-1	MicroRNA	Cancer
RAD51 SSDNA-1 is a chemically synthesized miRNA mimic that mimics endogenous miRNAs and upregulates miRNA activity for gain-of-function studies .

RAD51 SSDNA-1 RAD51 SSDNA-1

HY-143737

RAD51-IN-6	RAD51	Cancer
RAD51-IN-6 is a potent inhibitor of *RAD51. RAD51* is a eukaryote gene. RAD51-IN-6 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2021164746A1, compound 23) .

HY-143741

RAD51-IN-7	RAD51	Cancer
RAD51-IN-7 is a potent inhibitor of *RAD51. RAD51* is a eukaryote gene. RAD51-IN-7 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2021164746A1, compound 71) .

HY-143735

RAD51-IN-4	RAD51	Cancer
RAD51-IN-4 is a potent inhibitor of *RAD51. RAD51* is a eukaryote gene. RAD51-IN-4 has the potential for the research of conditions involving mitochondrial defects (extracted from patent WO2019014315A1, compound R12) .

HY-150958

RAD51-IN-8	RAD51	Cancer
RAD51-IN-8, a new RAD51 binder, is a *RAD51-BRCA2* inhibitor that inhibits the RAD51 BRCA2 protein protein interaction. RAD51-IN-8 also is a protein−protein interaction (PPI) inhibitor. RAD51-IN-8 has inhibitory activity for H4A4 with an EC₅₀ value of 19 μM .

HY-122705

RAD51-IN-1	RAD51	Cancer
RAD51-IN-1, a derivative of B02, is a potent inhibitor of *RAD51. RAD51*-IN-1 can be used for cancer research .

HY-136604

RAD51-IN-3	RAD51	Cancer
RAD51-IN-3 is a *Rad51* inhibitor extracted from patent WO2019051465A1, compound Example 66A .

HY-111887

Emzadirib CYT-0851; RAD51-IN-2	RAD51	Cancer
Emzadirib (RAD51-IN-2) is a *RAD51* inhibitor extracted from patent WO2019/051465A1 .

HY-RS11607

RAD51B Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAD51B Human Pre-designed siRNA Set A contains three designed siRNAs for RAD51B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAD51B Human Pre-designed siRNA Set A RAD51B Human Pre-designed siRNA Set A

HY-RS11608

RAD51C Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAD51C Human Pre-designed siRNA Set A contains three designed siRNAs for RAD51C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAD51C Human Pre-designed siRNA Set A RAD51C Human Pre-designed siRNA Set A

HY-RS11609

RAD51D Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAD51D Human Pre-designed siRNA Set A contains three designed siRNAs for RAD51D gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAD51D Human Pre-designed siRNA Set A RAD51D Human Pre-designed siRNA Set A

HY-RS11606

RAD51AP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RAD51AP1 Human Pre-designed siRNA Set A contains three designed siRNAs for RAD51AP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RAD51AP1 Human Pre-designed siRNA Set A RAD51AP1 Human Pre-designed siRNA Set A

HY-162104

*BRCA2-RAD51-IN-1*	Others	Cancer
BRCA2-RAD51-IN-1 (Compound 46) is a *BRCA2-RAD51* inhibitor with an EC₅₀ value of 28 μM. BRCA2-RAD51-IN-1 has antitumor activity .

HY-15317

RI-1 5 Publications Verification	RAD51	Cancer
RI-1 is a *RAD51* inhibitor, with IC₅₀s ranging from 5 to 30 μM. RI-1 binds covalently to the surface of RAD51 protein at cysteine 319. RI-1 inactivates RAD51 by directly binding to a protein surface that serves as an interface between protein subunits in RAD51 filaments. RI-1 can disrupt homologous recombination in human cells .

HY-103710

IBR2 3 Publications Verification	RAD51 Apoptosis	Cancer
IBR2 is a potent and specific *RAD51* inhibitor and inhibits *RAD51*-mediated DNA double-strand break repair. IBR2 disrupts *RAD51* multimerization, accelerates proteasome-mediated *RAD51* protein degradation, inhibits cancer cell growth and induces apoptosis .

HY-103710A

(R)-IBR2	Others	Cancer
(R)-IBR2 is the isomer of IBR2 (HY-103710). IBR2 is a potent and specific *RAD51* inhibitor and inhibits *RAD51*-mediated DNA double-strand break repair. IBR2 disrupts *RAD51* multimerization, accelerates proteasome-mediated *RAD51* protein degradation, inhibits cancer cell growth and induces apoptosis .

HY-126972A

RI(dl)-2 TFA	RAD51	Cancer
RI(dl)-2 TFA is a potent and selective RAD51-mediated D-loop formation inhibitor with an IC₅₀ of 11.1 μM. RI(dl)-2 TFA does not influence RAD51 binding to ssDNA and inhibits homologous recombination (HR) activity in human cells (IC₅₀ of 3.0 μM) .

HY-P10516

BRC4 peptide	DNA/RNA Synthesis RAD51	Cancer
BRC4 peptide is a specific peptide in BRCA2 protein that interacts with *RAD51* protein to help repair broken DNA chains. BRC4 peptide can be used to study DNA repair mechanisms and cancer occurrence .

HY-121693

DIDS MDL101114ZA free base	VDAC RAD51	Cancer
DIDS is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits *RAD51, inhibiting RAD51*-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-150147

CAM833	RAD51 Apoptosis	Cancer
CAM833 is a potent orthosteric inhibitor of the interaction between BRCA2 and *RAD51* with a K_d of 366 nM against the ChimRAD51 protein. CAM833 also inhibits RAD51 oligomerization. CAM833 increases the progression of G2/M-arrested cells into apoptosis .

HY-D0086

DIDS sodium salt Maximum Cited Publications 13 Publications Verification MDL101114ZA	VDAC RAD51	Cancer
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits *RAD51, inhibiting RAD51*-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

HY-126972

RI(dl)-2	RAD51	Cancer
RI(dl)-2 blocks *RAD51’s D-loop activity in biochemical systems with an IC₅₀* value of 11.1 µM and inhibits homologous recombination (HR) activity with an IC₅₀ value of 3.0 µM. RI(dl)-2 inhibits HR-mediated repair of DNA double strand breaks and sensitizes different cancer cell lines .

HY-19793

RS-1 1 Publications Verification	RAD51 CRISPR/Cas9	Cancer
RS-1 is a *RAD51* activator, and also increases CRISPR/Cas9-mediated knock-in efficiencies.

HY-148183

Homologous recombination-IN-1	RAD51	Cancer
Homologous recombination-IN-1 is a novel RAD51-BRCA2 protein-protein interaction inhibitor (EC₅₀=19 μM). Homologous recombination-IN-1 can interfere with homologous recombination .

HY-16904

RI-2 1 Publications Verification	RAD51	Cancer
RI-2 is a reversible *RAD51* inhibitor, with an IC₅₀ of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.

HY-126020

Bractoppin 2 Publications Verification	DNA/RNA Synthesis RAD51	Cancer
Bractoppin is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC₅₀: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response .

HY-157212

PARP-1/Proteasome-IN-1	Apoptosis PARP Proteasome	Cancer
PARP-1/Proteasome-IN-1 (compound 42i) is a dual PARP-1 and proteasome inhibitor with significant inhibitory effects on breast cancer. PARP-1/Proteasome-IN-1 can downregulate the expression of BRCA1 and RAD51 to inhibit homologous recombination repair function and induce apoptosis .

HY-10206

Amuvatinib 5+ Cited Publications MP470; HPK 56	c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET Apoptosis	Cancer
Amuvatinib (MP470) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib (MP470) is also a DNA repair suppressor through suppression of DNA repair protein *RAD51*, thereby disrupting DNA damage repair . Antineoplastic activity .

HY-10206A

Amuvatinib hydrochloride MP470 hydrochloride; HPK 56 hydrochloride	c-Kit PDGFR RAD51 FLT3 c-Met/HGFR RET	Cancer
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein *RAD51*, thereby disrupting DNA damage repair . Antineoplastic activity .

HY-146194

NHEJ inhibitor-1	Reactive Oxygen Species	Cancer
NHEJ inhibitor-1 (Compound C2) is a trifunctional Pt(II) complex, alleviates the non-homologous end connection (NHEJ)/homologous recombination (HR)-related double strand breaks (DSBs) repairs to evade Cisplatin-resistance in non-small cell lung cancer (NSCLC). NHEJ inhibitor-1 inhibits the damage repair proteins Ku70 and Rad51 to make tumors re-sensitive to Cisplatin。NHEJ inhibitor-1 also induces ROS generation and MMP deduction .

HY-124691

D-I03 2 Publications Verification	DNA/RNA Synthesis	Cancer
D-I03 is a selective *RAD52* inhibitor with a K_d of 25.8 µM. D-I03 specifically inhibits *RAD52*-dependent single-strand annealing (SSA) and D-loop formation with IC₅₀s of 5 µM and 8 µM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced *RAD52* foci, but does not effect on RAD51 foci induced by Cisplatin .

HY-N3980

Guaiol Champacol; Guaiac alcohol	Autophagy RAD51	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of *RAD51* through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[4]

HY-N3980R

Guaiol (Standard)	Autophagy RAD51	Infection Cardiovascular Disease Inflammation/Immunology Cancer
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]

HY-169170

PARP1/BRD4-IN-3	Apoptosis DNA/RNA Synthesis Epigenetic Reader Domain PARP	Cancer
PARP1/BRD4-IN-3 (compound HF4) is a potent BRD4 and PARP1 inhibitor with IC₅₀ values of 1210, 2019 nM for BRD4, PARP1, respectively. PARP1/BRD4-IN-3 shows antiproliferative activities. PARP1/BRD4-IN-3 induces apoptosis and cell cycle arrest at G0/G1 phase. PARP1/BRD4-IN-3 causes DNA damage and reduces the protein expression of Rad51. PARP1/BRD4-IN-3 shows antitumor efficacy .

HY-120264

YPC-22026	Others	Cancer
YPC-22026 is a zinc-finger protein 143 (ZNF143) inhibitor with an IC₅₀ value of 9.0 μM. YPC-22026 is a potent tumor regression inducer. YPC-22026 exhibits anti‐tumor activities .

HY-110185

NSC 617145	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

Cat. No.	Product Name	Type

HY-D0086

DIDS sodium salt 10+ Cited Publications MDL101114ZA	Dyes
DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1. DIDS also inhibits *RAD51, inhibiting RAD51*-mediated homologous pairing and strand exchange reactions. DIDS inhibits anion exchange and binding to red blood cell membranes, inhibits the activation of caspase-3 and -9, and can be used in cancer research .

Cat. No.	Product Name	Target	Research Area

HY-P10516

BRC4 peptide	DNA/RNA Synthesis RAD51	Cancer
BRC4 peptide is a specific peptide in BRCA2 protein that interacts with *RAD51* protein to help repair broken DNA chains. BRC4 peptide can be used to study DNA repair mechanisms and cancer occurrence .

HY-P10434

BRC4wt BRC4 repeat motif	Peptides	Cancer
BRC4wt (BRC4 repeat motif) is part of the BRACA2 tumor suppressor protein, which exhibits inhibitory activity against interaction of the BRACA2 protein with RAD51, and is involved in the repair of DNA damage .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3980

Guaiol Champacol; Guaiac alcohol	Infection Structural Classification Natural Products Classification of Application Fields Source classification Distemonanthus benthamianus Baill. Plants Compositae Disease Research Fields	Autophagy RAD51
Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of *RAD51* through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC₅₀ of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions ^[4]

HY-N3980R

Guaiol (Standard)	Structural Classification Natural Products Source classification Distemonanthus benthamianus Baill. Plants Compositae	Autophagy RAD51
Guaiol (Standard) is the analytical standard of Guaiol. This product is intended for research and analytical applications. Guaiol is a sesquiterpenoid alcohol with oral activity found in various traditional Chinese medicines, exhibiting biological activities such as anti-proliferative, autophagy-promoting, insecticidal, anti-anxiety, anti-inflammatory, diuretic, and blood pressure-lowering effects. Guaiol induces apoptosis in non-small cell lung cancer cells by regulating the stability of RAD51 through autophagy modulation. Guaiol can also act directly on parasites, inhibiting their growth by affecting the kinetoplast, mitochondrial matrix and plasma membrane of the promastigotes. Guaiol kills amastigotes at an IC50 of 0.01 µg/mL. Guaiol can be used in research related to cancer, infections, cardiovascular diseases, and inflammatory conditions [4]

Species:	Human (1)
Tag:	His (1) Tag Free (2)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P702777

	RAD51 Protein, Human (His) DNA repair protein RAD51 homolog 1; HsRAD51; hRAD51; RAD51 homolog A; RAD51A, RECA	Human	E. coli

HY-P703440

	RAD51 Protein, Pyrococcus furiosus DNA repair and recombination protein RADA; RADA; Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); DNA-binding	Others	E. coli
	RAD51 Protein, Pyrococcus furiosus is the recombinant RAD51, expressed by E. coli , with tag Free labeled tag. ,

HY-P703439

	RAD51 Protein, Pyrococcus furiosus(del R288-G301) DNA repair and recombination protein RADA; RADA; Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); DNA-binding	Others	E. coli
	RAD51 Protein, Pyrococcus furiosus(del R288-G301) is the recombinant RAD51, expressed by E. coli , with tag Free labeled tag. ,

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Cat. No.	Compare	Product Name	Application	Reactivity

HY-P80297

	Rad51 Antibody	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse, Rat
	Rad51 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 37 kDa, targeting to Rad51. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82063

	Rad51D Antibody (YA1808) TRAD; R51H3; BROVCA4; RAD51L3	WB, IP	Human, Mouse, Rat
	Rad51D Antibody (YA1808) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1808), targeting Rad51D, with a predicted molecular weight of 35 kDa (observed band size: 35 kDa). Rad51D Antibody (YA1808) can be used for WB, IP experiment in human, mouse, rat background.