TIGIT

By Targets:	CD28 (2) Endogenous Metabolite (1) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (2) Thyroid Hormone Receptor (1) Transmembrane Glycoprotein (7)
By Research Areas:	Cancer (9) Endocrinology (1) Infection (1) Inflammation/Immunology (8)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P9986

Tiragolumab MTIG-7192A; RG-6058	CD28	Inflammation/Immunology Cancer
Tiragolumab is an immune checkpoint inhibitor binding to T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab, alone or in combination with the PD-L1 inhibitor Atezolizumab (HY-P9904), may be effective against multiple solid malignancies-most notably non-small cell lung cancer (NSCLC) .

HY-P990704

Rilvegostomig AZD-2936	PD-1/PD-L1	Inflammation/Immunology
Rilvegostomig is an anti-PDCD1/TIGIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990031

Dargistotug M-6223	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting *TIGIT* (T cell immune receptor with Ig domain and ITIM). *TIGIT* is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

HY-P990032

Belrestotug EOS-448; EOS884448; GSK4428859A	Transmembrane Glycoprotein	Cancer
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity .

HY-P99202

Vibostolimab	Transmembrane Glycoprotein	Cancer
Vibostolimab is an *anti-TIGIT* (T cell immunoglobulin and ITIM domain) monoclonal antibody. Vibostolimab shows antitumor activity, and can be used in non-small cell lung cancer (NSCLC) and melanoma research .

HY-RS14524

TIGIT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TIGIT Human Pre-designed siRNA Set A contains three designed siRNAs for TIGIT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TIGIT Human Pre-designed siRNA Set A TIGIT Human Pre-designed siRNA Set A

HY-RS16565

Tigit Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
Tigit Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tigit gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Tigit Mouse Pre-designed siRNA Set A Tigit Mouse Pre-designed siRNA Set A

HY-P991111

*Anti-Mouse TIGIT* Antibody (10A7)**	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse TIGIT Antibody (10A7) is a mouse IgG2 monoclonal antibody that targets *TIGIT*. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-P990079

Renvistobart	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P990746

Lancastotug	Transmembrane Glycoprotein	Inflammation/Immunology
Lancastotug is an anti-TIGIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990960

Lucorafusp alfa	Transmembrane Glycoprotein	Inflammation/Immunology
HY-P990960 is an *TIGIT*-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990030

Ralzapastotug AB-308	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Ralzapastotug (AB-308) is an anti-TIGIT (T cell immunoreceptor with Ig and ITIM domains) IgG1 monoclonal antibody. Ralzapastotug is a monoclonal antibody targeting amino acids 106-126 of the cellular prion protein PrP ^C .

HY-A0070A

Liothyronine 20+ Cited Publications Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Thyroid Hormone Receptor Endogenous Metabolite	Endocrinology Cancer
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

Cat. No.	Product Name	Target	Research Area

HY-P990155

*Anti-Mouse TIGIT* Antibody (1G9)**	Inhibitory Antibodies	Others
Anti-Mouse TIGIT Antibody (1G9) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse TIGIT.

HY-P99508

Tamgiblimab IBI939	Inhibitory Antibodies	Cancer
Tamgiblimab (IBI939) is a fully human monoclonal antibody targeting T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT). Tamgiblimab has anticancer effects .

HY-P99949

Etigilimab OMP-313M32	Inhibitory Antibodies	Cancer
Etigilimab (OMP-313M32), a humanized IgG1 monoclonal antibody, blocks *TIGIT* interaction with PVR (CD155; poliovirus receptor) and inhibits downstream signalling with target cell killing .

HY-P9986

Tiragolumab MTIG-7192A; RG-6058	CD28	Inflammation/Immunology Cancer
Tiragolumab is an immune checkpoint inhibitor binding to T-cell immunoglobulin and ITIM domain (TIGIT). Tiragolumab, alone or in combination with the PD-L1 inhibitor Atezolizumab (HY-P9904), may be effective against multiple solid malignancies-most notably non-small cell lung cancer (NSCLC) .

HY-P99858

Domvanalimab AB154	Inhibitory Antibodies	Cancer
Domvanalimab (AB154) is an anti-TIGIT humanized monoclonal antibody. Domvanalimab binds human TIGIT9 and blocks the TIGIT-CD155 interaction. Domvanalimab can be used in research of cancer .

HY-P99763

Ociperlimab BGB-A1217	Inhibitory Antibodies	Cancer
Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (K_D = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer .

HY-P990704

Rilvegostomig AZD-2936	PD-1/PD-L1	Inflammation/Immunology
Rilvegostomig is an anti-PDCD1/TIGIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990031

Dargistotug M-6223	Transmembrane Glycoprotein	Inflammation/Immunology Cancer
Dargistotug (M-6223) is a fully human IgG1 monoclonal antibody targeting *TIGIT* (T cell immune receptor with Ig domain and ITIM). *TIGIT* is an inhibitory immune checkpoint that promotes NK cell depletion and reduces the secretion of cytokines by binding to CD155 and other antibodies. It can also directly or indirectly inhibit effector T cells and upregulate Tregs cells, thereby exerting immunosuppression. Function .

HY-P991111

*Anti-Mouse TIGIT* Antibody (10A7)**	Transmembrane Glycoprotein	Inflammation/Immunology
Anti-Mouse TIGIT Antibody (10A7) is a mouse IgG2 monoclonal antibody that targets *TIGIT*. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).

HY-P990079

Renvistobart	CD28	Inflammation/Immunology
Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody .

HY-P990746

Lancastotug	Transmembrane Glycoprotein	Inflammation/Immunology
Lancastotug is an anti-TIGIT human IgG1 κ monoclonal antibody . Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990032

Belrestotug EOS-448; EOS884448; GSK4428859A	Transmembrane Glycoprotein	Cancer
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity .

HY-P99202

Vibostolimab	Transmembrane Glycoprotein	Cancer
Vibostolimab is an *anti-TIGIT* (T cell immunoglobulin and ITIM domain) monoclonal antibody. Vibostolimab shows antitumor activity, and can be used in non-small cell lung cancer (NSCLC) and melanoma research .

HY-P990960

Lucorafusp alfa	Transmembrane Glycoprotein	Inflammation/Immunology
HY-P990960 is an *TIGIT*-targeting IgG4κ type humanized antibody, the recommed isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .

HY-P990030

Ralzapastotug AB-308	Transmembrane Glycoprotein	Infection Inflammation/Immunology
Ralzapastotug (AB-308) is an anti-TIGIT (T cell immunoreceptor with Ig and ITIM domains) IgG1 monoclonal antibody. Ralzapastotug is a monoclonal antibody targeting amino acids 106-126 of the cellular prion protein PrP ^C .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-A0070A

Liothyronine 20+ Cited Publications Triiodothyronine; 3,3',5-Triiodo-L-thyronine; T3	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology	Thyroid Hormone Receptor Endogenous Metabolite
Liothyronine is an active form of thyroid hormone. Liothyronine binds to thyroid hormone receptors TRα and TRβ with K_is of 2.33 and 2.29 nM for hTRα and hTRβ, respectively. Liothyronine also binds to PVR and blocks the interaction of TIGIT/PVR .

Species:	Human (5) Mouse (3) Rat (1) Cynomolgus (3) Rabbit (1)
Tag:	His (5) Avi (2) Fc (8)
Source:	HEK293 (13)

Cat. No.	Compare	Product Name	Species	Source

HY-P77235

	TIGIT Protein, Mouse (HEK293, mFc) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (HEK293, mFc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TIGIT Protein, Mouse (HEK293, mFc) is 125 a.a., with molecular weight of ~39-52 KDa.

HY-P74513

	TIGIT Protein, Rat (HEK293, Fc) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Rat	HEK293
	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the PVR (poliovirus receptor) family of immunoglobin proteins, binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation or T cell dependent B cell responses by promoting the generation of mature immunoregulatory dendritic cells. TIGIT Protein, Rat (HEK293, Fc) is the recombinant rat-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72449

	TIGIT Protein, Mouse (110a.a, HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; TIGIT; V-set and transmembrane domain-containing protein 3; VSTM3	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (110a.a, HEK293, His) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Mouse (110a.a, HEK293, His) is 110 a.a., with molecular weight of 15-22 kDa.

HY-P70624

	TIGIT Protein, Human (HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, His) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70677

	TIGIT Protein, Cynomolgus (HEK293, His) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Cynomolgus	HEK293
	Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TIGIT Protein, Cynomolgus (HEK293, His) is 121 a.a., with molecular weight of 16-30 kDa.

HY-P71363

	TIGIT Protein, Human (HEK293, mFc) T-cell immunoreceptor with Ig and ITIM domains; ; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, mFc) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P71009

	TIGIT Protein, Mouse (118a.a, HEK293, Fc) T-cell immunoreceptor with Ig and ITIM domains; TIGIT	Mouse	HEK293
	TIGIT protein, with signaling receptor binding activity, functions upstream of T cell activation suppression. Active on the cell surface, it shares orthology with human TIGIT. Associated with modulating T cell responses, TIGIT exhibits biased expression, notably in the large intestine, small intestine, and other tissues. This highlights its potential in immune regulation within these contexts. TIGIT Protein, Mouse (118a.a, HEK293, Fc) is the recombinant mouse-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Mouse (118a.a, HEK293, Fc) is 118 a.a., with molecular weight of 50-60 kDa.

HY-P76674

	TIGIT Protein, Cynomolgus (HEK293, Fc) T cell immunoreceptor with Ig and ITIM domains; TIGIT; VSIG9; VSTM3	Cynomolgus	HEK293
	TIGIT is a receptor of the Ig superfamily that plays a key role in restricting adaptive and innate immunity. TIGIT can be used as an immune modulator to inhibit the activity of T cells and NK cells, and also regulates the recognition of cancer cells. TIGIT consists of an extracellular immunoglobulin (Ig) variable domain, a type 1 transmembrane domain, and a cytoplasmic tail with two inhibitory motifs. TIGIT Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P71007

	TIGIT Protein, Cynomolgus (HEK293, C-hFc) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9	Cynomolgus	HEK293
	Ig-like domain-containing protein is a class of proteins that may be involved in protein–protein and protein–ligand interactions, therefore being involved in biological processes such as down-regulation of T cell activation or cardiac and neuronal development. TIGIT Protein, Cynomolgus (HEK293, C-hFc) is the recombinant cynomolgus-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Cynomolgus (HEK293, C-hFc) is 121 a.a., with molecular weight of 45-55 kDa.

HY-P72418

	TIGIT Protein, Human (HEK293, His-Avi) T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (HEK293, His-Avi) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of TIGIT Protein, Human (HEK293, His-Avi) is 120 a.a., with molecular weight of 17-23 kDa.

HY-P78602

	TIGIT Protein, Rabbit (HEK293, Fc) TIGIT; VSIG9; VSTM3	Rabbit	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Rabbit (HEK293, Fc) is the recombinant Rabbit-derived TIGIT protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TIGIT Protein, Rabbit (HEK293, Fc) is 127 a.a., with molecular weight of 45-55 kDa.

HY-P78216

	TIGIT Protein, Human (Biotinylated, HEK293, His-Avi) TIGIT; VSIG9; VSTM3; WUCAM	Human	HEK293
	The TIGIT protein plays a key role in immune regulation and binds with high affinity to the poliovirus receptor (PVR). This interaction induces an immunosuppressive environment by increasing IL10 secretion and decreasing IL12B secretion. TIGIT Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived TIGIT protein, expressed by HEK293 , with C-Avi, C-His labeled tag.

HY-P7414

	TIGIT Protein, Human (HEK293, Fc) rHuTIGIT, Fc Chimera; VSIG9; VSTM3; T Cell Immunoreceptor with Ig and ITIM Domains	Human	HEK293
	TIGIT Protein, Human (HEK293, Fc) produced in HEK293 cells with the C-termimal human IgG1 Fc fragment. T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3). It belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM).

Compare Products

Products

Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample
Size

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81752

	TIGIT Antibody (YA1497) TIGIT; VSIG9; VSTM3	FC, ELISA	Human
	TIGIT Antibody (YA1497) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1497), targeting TIGIT. TIGIT Antibody (YA1497) can be used for FC, ELISA experiment in human background.

Compare Products

Products

Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample
Size

Cat. No.	Product Name		Classification

HY-RS14524

TIGIT Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
TIGIT Human Pre-designed siRNA Set A contains three designed siRNAs for TIGIT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS16565

Tigit Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Tigit Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tigit gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Oligonucleotides

TIGIT

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Antibodies

Oligonucleotides

Natural
Products