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Results for "

TNF-α-IN-1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TNF Receptor (29) Adrenergic Receptor (5) Akt (2) AMPK (2) Apoptosis (5) Autophagy (2) Bacterial (2) Bcl-2 Family (2) Cannabinoid Receptor (1) Caspase (4) Cathepsin (1) COX (2) EGFR (3) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Formyl Peptide Receptor (FPR) (1) Glutathione Peroxidase (1) GSK-3 (1) HDAC (1) Histone Demethylase (1) HSV (1) Hydroxycarboxylic Acid Receptor (HCAR) (1) IKK (1) Interleukin Related (28) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) MMP (3) mTOR (2) MyD88 (1) NF-κB (2) NO Synthase (4) NOD-like Receptor (NLR) (1) p38 MAPK (3) Parasite (2) PARP (2) Phosphatase (1) Phosphodiesterase (PDE) (1) PI3K (1) PKA (2) PKC (2) Reactive Oxygen Species (3) RIP kinase (1) ROS Kinase (1) Toll-like Receptor (TLR) (3) Tyrosinase (3) VEGFR (5)
By Research Areas:	Cancer (17) Cardiovascular Disease (7) Infection (4) Inflammation/Immunology (51) Metabolic Disease (1) Neurological Disease (3)

By Targets:

TNF Receptor (29)

Adrenergic Receptor (5)

Akt (2)

AMPK (2)

Apoptosis (5)

Autophagy (2)

Bacterial (2)

Bcl-2 Family (2)

Cannabinoid Receptor (1)

Caspase (4)

Cathepsin (1)

COX (2)

EGFR (3)

Endogenous Metabolite (1)

Epigenetic Reader Domain (1)

Formyl Peptide Receptor (FPR) (1)

Glutathione Peroxidase (1)

GSK-3 (1)

HDAC (1)

Histone Demethylase (1)

HSV (1)

Hydroxycarboxylic Acid Receptor (HCAR) (1)

IKK (1)

Interleukin Related (28)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

MMP (3)

mTOR (2)

MyD88 (1)

NF-κB (2)

NO Synthase (4)

NOD-like Receptor (NLR) (1)

p38 MAPK (3)

Parasite (2)

PARP (2)

Phosphatase (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

PKA (2)

PKC (2)

Reactive Oxygen Species (3)

RIP kinase (1)

ROS Kinase (1)

Toll-like Receptor (TLR) (3)

Tyrosinase (3)

VEGFR (5)

By Research Areas:

Cancer (17)

Cardiovascular Disease (7)

Infection (4)

Inflammation/Immunology (51)

Metabolic Disease (1)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: TNF Receptor Dan family AIM2 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112275

*TNF-α-IN-1* 2 Publications Verification	TNF Receptor	Inflammation/Immunology Cancer
TNF-α-IN-1 is a TNF-α inhibitor extracted from patent US20030096841A1, compound example I-7.

HY-101041

(E)-AG 556 (E)-TyrphostIN AG 556	EGFR	Inflammation/Immunology
(E)-AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production .

HY-N0358

1,4-Dicaffeoylquinic acid 1 Publications Verification 1,4-DCQA	TNF Receptor Interleukin Related	Inflammation/Immunology
1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-N9315

Episappanol	TNF Receptor Interleukin Related	Inflammation/Immunology
Episappanol is a natural compound isolated from Caesalpinia sappan heartwood with anti-inflammatory activity. Episappanol significantly inhibits the IL-6 and *TNF-α* secretion .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-114573

TNF-α-IN-19	IKK Interleukin Related TNF Receptor RIP kinase	Others
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and *RIP1, the EC₅₀* values for *TNFα, IL-1β*, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by *IL-1β* ^[1].

HY-160027

*TNF-alpha-IN-1*	TNF Receptor	Inflammation/Immunology
TNF-alpha-IN-1 (compound 202) is an orally active inhibitor of *TNF-alpha*. TNF-alpha-IN-1 has anti-inflammatory activity which can used in study rheumatoid arthritis, psoriasis, and asthma ^[1].

HY-163642

*TNF-α agonistic 1*	Others	Cancer
TNF-α agonistic 1 (compound 22a) can repolarize tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) from the M2 phenotype to the M1 anti-tumor phenotype ^[1].

HY-167877

PS-166276	p38 MAPK	Inflammation/Immunology
PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC₅₀ of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay .

HY-126414

Methylenedihydrotanshinquinone	Others	Inflammation/Immunology
Methylenedihydrotanshinquinone is a natural product that can be isolated from the dried root of S. miltiorrhiza. Methylenedihydrotanshinquinone has anti-inflammatory effect by inhibiting expression of TNF-α, IL-1β, and IL-8 ^[1].

HY-N3552

Catalposide	NF-κB	Inflammation/Immunology
Catalposide, an iridoid glycoside that could be isolated from Catalpa ovate G. Don (Bignoniaceae), inhibits TNF-α, IL-1β, and IL-6 productions and NF-κB (p65) activation in lipopolysaccharide-activated RAW 264.7 macrophages ^[1].

HY-N0358R

1,4-Dicaffeoylquinic acid (Standard)	TNF Receptor Interleukin Related	Inflammation/Immunology
1,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-W342604R

N-Acetylputrescine (Standard)	Endogenous Metabolite	Neurological Disease Cancer
1,4-Dicaffeoylquinic acid (Standard) is the analytical standard of 1,4-Dicaffeoylquinic acid. This product is intended for research and analytical applications. 1,4-Dicaffeoylquinic acid (1,4-DCQA) is a phenylpropanoid from Xanthii fructus, inhibits LPS-stimulated TNF-α production .

HY-134950

(E)-C-HDMAPP ammonium	TNF Receptor	Inflammation/Immunology
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC₅₀=0.91 nM for TNF-α release) .

HY-N0569

Madecassic acid 1 Publications Verification	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, *TNF-alpha, IL-1beta*, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells ^[1].

HY-156060

NCI126224	Toll-like Receptor (TLR)	Inflammation/Immunology
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases ^[1].

HY-107338

Denotivir VratizolIN; WratizolIN	HSV Interleukin Related	Infection Inflammation/Immunology Cancer
Denotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy ^[1].

HY-N6927

Isoforskolin Coleonol B	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely *TNF-α, IL-1β*, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis ^[1].

HY-168130

TNF-α/IL-1β-IN-1	TNF Receptor Interleukin Related	Cardiovascular Disease
TNF-α/IL-1β-IN-1 (compund 11a) is an anti-inflammatory agent that reduces the expression of TNF-α and IL-1β, inhibits oxidative stress and cardiomyocyte apoptosis, has good activity against septic myocardial injury, and improves myocardial blood supply in vivo ^[1].

HY-N12042

Taxamairin B	TNF Receptor PI3K Reactive Oxygen Species Interleukin Related	Inflammation/Immunology
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice ^[1] .

HY-151188

DHU-Se1	NO Synthase TNF Receptor	Inflammation/Immunology
DHU-Se1 is a potent anti-inflammatory agent. DHU-Se1 can stimulate macrophages to release the reactive selenium compound and reduce the expression of cellular inflammatory factors (eg: iNOS and *TNF-α*). DHU-Se1 alleviate the process of inflammation by blocking the polarization of macrophages from M0 to M1 ^[1].

HY-15507

VGX-1027 1 Publications Verification GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events ^[1] .

HY-B0446

Naphazoline hydrochloride 1 Publications Verification NaphthazolINe hydrochloride	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research ^[1] .

HY-147697

LSD1-IN-21	Histone Demethylase TNF Receptor	Inflammation/Immunology Cancer
LSD1-IN-21 (compound 5a) is a potent and BBB-penetrated *LSD1* (Lysine specific demethylase-1) inhibitor, with an IC₅₀ of 0.956 µM. LSD1-IN-21 significantly reduces the pro-inflammatory cytokine *TNF-α*. LSD1-IN-21 shows good anticancer and anti-inflammatory activity ^[1].

HY-15509

Semapimod CNI-1493 free base; CPSI-2364	Interleukin Related TNF Receptor p38 MAPK	Inflammation/Immunology Cancer
Semapimod, an inhibitor of proinflammatory cytokine production, can inhibit *TNF-α, IL-1β*, and IL-6. Semapimod inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod has potential in a variety of inflammatory and autoimmune disorders ^[1] .

HY-146765

AMS-17	NOD-like Receptor (NLR)	Neurological Disease Inflammation/Immunology
AMS-17 is a potent NLRP3 inhibitor, inhibiting microglia activation in vitro and in vivo. AMS-17 also inhibits cytokines such as caspase-1, TNF-α, IL-1β and inducible nitric oxide synthase (iNOS) in N9 cells. AMS-17 can be used for researching inflammation-associated neurological disorders ^[1].

HY-163998

TLR4-IN-1	Toll-like Receptor (TLR)	Inflammation/Immunology
TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC₅₀ of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models ^[1].

HY-111326

Naphazoline 1 Publications Verification NaphthazolINe	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) is a potent α-adrenergic receptor agonist. Naphazoline reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline can be used for non-bacterial conjunctivitis research ^[1] .

HY-152213

BET-IN-13	Epigenetic Reader Domain	Inflammation/Immunology
BET-IN-13 is a potent BET inhibitor with an IC₅₀ value of 1.6 nM. BET-IN-13 reduces LPS-induced TNF-α, IL-1β, IL-6, and NOS2 mRNA expression levels. BET-IN-13 shows anti-inflammatory activity. BET-IN-13 has the potential for the research of acute liver injury ^[1].

HY-N0569R

Madecassic acid (Standard)	NO Synthase COX TNF Receptor Interleukin Related	Inflammation/Immunology
Madecassic acid (Standard) is the analytical standard of Madecassic acid. This product is intended for research and analytical applications. Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, *TNF-alpha, IL-1beta*, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells ^[1].

HY-168734

CB2 receptor agonist 9	Cannabinoid Receptor	Inflammation/Immunology
CB2 receptor agonist 9 (Compound 33) is an orally active agonist for cannabinoid receptor 2 (CB2 receptor) with an EC₅₀ of 16.2 nM. CB2 receptor agonist 9 inhibits the expression of TNF-α, IL-1β and IL-6, exhibits anti-inflammatory efficacy in DDS (HY-116282)-induced mouse acute colitis model ^[1].

HY-N6927R

Isoforskolin (Standard)	TNF Receptor Interleukin Related	Inflammation/Immunology
Isoforskolin (Standard) is the analytical standard of Isoforskolin. This product is intended for research and analytical applications. Isoforskolin is the principle active component of C. forskohlii native to China. Isoforskolin reduces the secretion of lipopolysaccharide (LPS)-induced cytokines, namely TNF-α, IL-1β, IL-6 and IL-8, in human mononuclear leukocytes. Isoforskolin acts as an anti-inflammatory agent for the treatment of Lyme arthritis ^[1].

HY-111326A

Naphazoline nitrate 1 Publications Verification NaphthazolINe nitrate	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology Cancer
Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research ^[1] .

HY-W505984

TPNA10168 KM05073	Keap1-Nrf2	Inflammation/Immunology
TPNA10168 is an Nrf-2 activator that activates the *Keap1-Nrf2-ARE* pathway. TPNA10168 is neuroprotective against oxidative stress-induced damage. TPNA10168 significantly reduces the transcription of inflammatory genes, including TNF-α, IL-1β, IL-6, and iNOS. TPNA10168 can be used in research on anti-inflammatory and neurological diseases ^[1].

HY-W015879S

2-Heptanol-d5	Bacterial Isotope-Labeled Compounds	Inflammation/Immunology
2-Heptanol-d₅ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is a monoterpene Pelargonium graveolens. Citronellol ((±)-Citronellol) induces necroptosis of cancer cell via up-regulating TNF-α, RIP1/RIP3 activities, down-regulating caspase-3/caspase-8 activities and increasing ROS (reactive oxygen species) accumulation ^[1].

HY-110246

Quin C1	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Quin C1 is a highly specific and potent agonist for formyl peptide receptor 2 (FPR2/ALX). Quin-C1 significantly reduces the neutrophil and lymphocyte counts in BALF, diminishes expression of TNF-α, IL-1β, KC, and TGF-β1, and decreases collagen deposition in lung tissue. Quin C1 has the potential for the research of lung injury ^[1].

HY-15509A

Semapimod tetrahydrochloride 4 Publications Verification CNI-1493; CPSI-2364 tetrahydrochloride	TNF Receptor Interleukin Related p38 MAPK	Inflammation/Immunology Cancer
Semapimod tetrahydrochloride (CNI-1493), an inhibitor of proinflammatory cytokine production, can inhibit *TNF-α, IL-1β*, and IL-6. Semapimod tetrahydrochloride inhibits TLR4 signaling (IC₅₀≈0.3 μM). Semapimod tetrahydrochloride inhibits p38 MAPK and nitric oxide production in macrophages. Semapimod tetrahydrochloride has potential in a variety of inflammatory and autoimmune disorders ^[1] .

HY-N0619

Mulberroside A 3 Publications Verification	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of *TNF-α, IL-1β*, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-B0446R

Naphazoline (hydrochloride) (Standard)	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (hydrochloride) (Standard) is the analytical standard of Naphazoline (hydrochloride). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) hydrochloride is a potent α-adrenergic receptor agonist. Naphazoline hydrochloride reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline hydrochloride reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF。Naphazoline hydrochloride can be used for non-bacterial conjunctivitis research ^[1] .

HY-111326AR

Naphazoline (nitrate) (Standard)	Adrenergic Receptor TNF Receptor Interleukin Related VEGFR	Cardiovascular Disease Inflammation/Immunology
Naphazoline (nitrate) (Standard) is the analytical standard of Naphazoline (nitrate). This product is intended for research and analytical applications. Naphazoline (Naphthazoline) nitrate is an α-adrenergic receptor agonist. Naphazoline nitrate reduces vascular hyperpermeability and promotes vasoconstriction. Naphazoline nitrate reduces the levels of inflammatory factors (TNF-α, IL-1β and IL-6), cytokines (IFN-γ and IL-4), IgE, GMCSF, and NGF. Naphazoline nitrate can be used for non-bacterial conjunctivitis research ^[1] .

HY-170495

HDAC6 degrader-5	HDAC Apoptosis Interleukin Related	Inflammation/Immunology
HDAC6 degrader-5 (Compound 6) exhibits inhibitory and degradation activity against HDAC6, with an IC₅₀ of 4.95 nM and a DC₅₀ of 0.96 nM. HDAC6 degrader-5 inhibits the release of TNF-α, IL-1β and IL-6, blocks the hepatocyte apoptosis. HDAC6 degrader-5 exhibits anti-inflammatory activity in mouse APAP (HY-66005)-induced liver injury models ^[1].

HY-N0619A

cis-Mulberroside A Mulberroside D	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
cis-Mulberroside A (Mulberroside D) is the cis-isomer of Mulberroside A. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of *TNF-α, IL-1β*, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory and anti-apoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-N0619R

Mulberroside A (Standard)	TNF Receptor Interleukin Related Tyrosinase	Inflammation/Immunology
Mulberroside A (Standard) is the analytical standard of Mulberroside A. This product is intended for research and analytical applications. Mulberroside A is one of the main bioactive constituent in mulberry (Morus alba L.) ^[1]. Mulberroside A decreases the expressions of TNF-α, IL-1β, and IL-6 and inhibits the activation of NALP3, caspase-1, and NF-κB and the phosphorylation of ERK, JNK, and p38, exhibiting anti-inflammatory antiapoptotic effects . Mulberroside A shows inhibitory activity against mushroom tyrosinase with an IC₅₀ of 53.6 μM .

HY-156025

HCAR2 agonist 1	Hydroxycarboxylic Acid Receptor (HCAR)	Inflammation/Immunology
HCAR2 agonist 1 (Compound 9n) is a G_i protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the G_i protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis ^[1].

HY-110133

JTE-607 3 Publications Verification	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including *TNF-α, IL-1β*, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively ^[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

HY-N1940

β-Anhydroicaritin 1 Publications Verification CycloicaritIN	Interleukin Related TNF Receptor MMP	Inflammation/Immunology Cancer
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties ^[1]. β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-163670

TLR7 agonist 21	Toll-like Receptor (TLR)	Infection
TLR7 agonist 21 (Compound 27B) is a selective agonist for Toll-like receptor 7(TLR7), with an EC₅₀ of 17.53 nM (for human TLR7) and 41.7 nM (for mouse TLR7). TLR7 agonist 21 stimulates the secretion of pro-inflammatory cytokines, such as IL-6, TNF-α, IFN-α1, and IL-4. TLR7 agonist 21 acts as a vaccine adjuvant, increases levels of IgG and IgA, and protects the mouse from influenza virus infections ^[1].

HY-147924

Keap1-Nrf2-IN-11	Keap1-Nrf2 NO Synthase ROS Kinase	Inflammation/Immunology
Keap1-Nrf2-IN-11 (compound 6k) is a *Keap1-Nrf2* inhibitor with K_D2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research ^[1].

HY-N4288

4-Methylesculetin 1 Publications Verification	Glutathione Peroxidase Cathepsin Phosphatase	Inflammation/Immunology Cancer
4-Methylesculetin is an orally active coumarin derivative, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity. 4-Methylesculetin protects bone resorption by reducing the elevated levels of bone-joint exoglycosidases, cathepsin-D and tartrate resistant acid phosphatases. 4-Methylesculetin ameliorats the upregulated non-enzymatic inflammatory markers like TNF-α, IL-1β, IL-6, COX-2 and PGE2, which is promising for research of inflammatory diseases ^[1] .

HY-110133A

JTE-607 free base	Interleukin Related	Inflammation/Immunology
JTE-607 free base, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 free base inhibits inflammatory cytokine production, including *TNF-α, IL-1β*, IL-6, IL-8 and IL-10, from LPS-stimulated human PBMCs, with IC₅₀s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively ^[1]. Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 free base .

Cat. No.	Product Name	Target	Research Area