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Results for "

VDR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	VD/VDR (46) Apoptosis (4) Aryl Hydrocarbon Receptor (1) Cytochrome P450 (1) Drug Metabolite (2) Endogenous Metabolite (11) HDAC (2) Isotope-Labeled Compounds (3) LXR (1) PPAR (1) RAR/RXR (2) Small Interfering RNA (siRNA) (3) Sodium Channel (1)
By Research Areas:	Cancer (18) Endocrinology (3) Infection (1) Inflammation/Immunology (8) Metabolic Disease (23) Neurological Disease (1)
Oligonucleotides:	Pre-designed siRNA Sets (3) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: VD/VDR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-32351S

Calcifediol-d3 25-hydroxy Vitamin D3-d₃	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d₃ is a deuterium labeled Calcifediol. Calcifediol, is an effective *VDR* ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-12407

ZK168281 1 Publications Verification	VD/VDR	Metabolic Disease
ZK168281 is a 25-carboxylic ester 1α,25(OH)₂D₃ analog and a pure *VDR* antagonist with a K_d value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor .

HY-149899

VDR agonist 2	VD/VDR	Others
VDR agonist 2 (compound 16i) is a *VDR* (vitamin D receptor) agonist that can effectively inhibit TGF-β1-induced activation of hepatic stellate cells (HSC). VDR agonist 2 has significant anti-hepatic fibrosis effects both in vitro and in vivo .

HY-114310

VDR agonist 1	VD/VDR Apoptosis	Cancer
VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC₅₀ of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2 .

HY-RS15632

VDR Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VDR Human Pre-designed siRNA Set A contains three designed siRNAs for VDR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VDR Human Pre-designed siRNA Set A VDR Human Pre-designed siRNA Set A

HY-RS15633

Vdr Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vdr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Vdr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vdr Mouse Pre-designed siRNA Set A Vdr Mouse Pre-designed siRNA Set A

HY-RS15634

Vdr Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Vdr Rat Pre-designed siRNA Set A contains three designed siRNAs for Vdr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Vdr Rat Pre-designed siRNA Set A Vdr Rat Pre-designed siRNA Set A

HY-107218

11-Hydroxysugiol	RAR/RXR VD/VDR	Infection
11-Hydroxysugiol regulates the SUMOylation of intracellular receptors by modulating RARα and vitamin D₃ receptor (VDR) .

HY-163947

UG-480	VD/VDR	Cancer
UG-480 is a gemini analog that effectively stabilizes the active *VDR* conformation. UG-480 has antiproliferative effects in estrogen receptor-positive MCF-7 breast adenocarcinoma cells. UG-480 can be used in cancer research .

HY-117182

LG190178	Apoptosis VD/VDR RAR/RXR	Metabolic Disease Inflammation/Immunology Cancer
LG190178 is a non-steroidal vitamin D receptor (VDR) ligand that can induce the formation of heterodimer complexes between *VDR* and retinoid X receptor (RXR), stabilizing the agonistic conformation of the *VDR* ligand-binding domain and promoting its interaction with co-activators. LG190178 has functions in regulating calcium homeostasis, bone mineralization, as well as cell proliferation, differentiation, and apoptosis, making it useful for research in psoriasis, osteoporosis, and cancer .

HY-32344

Inecalcitol 1 Publications Verification TX 522	VD/VDR Apoptosis	Cancer
Inecalcitol (TX 522), a unique vitamin D3 analog, is an orally active vitamin D receptor (VDR) agonist with a K_d of 0.53 nM. Inecalcitol can induce cell apoptosis and has potent anticancer activities . Inecalcitol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-76814

Calcitriol-d6	VD/VDR	Metabolic Disease
Calcitriol-d₆ is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR)[1].

HY-15329

Maxacalcitol-d6	VD/VDR	Metabolic Disease
Maxacalcitol-d₆6 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.

HY-147337

MeTC7 1 Publications Verification	VD/VDR	Cancer
MeTC7 is a Vitamin-D receptor (VDR) antagonist. MeTC7 has potent VDR inhibition activity with an IC₅₀ value of 2.9 μM. MeTC7 shows good antitumor effects .

HY-75035

Calcipotriol Impurity C	VD/VDR	Inflammation/Immunology
Calcipotriol Impurity C is the impurity of Calcipotriol, Calcipotriol is a ligand of VDR-like receptors.

HY-15265

Impurity F of Calcipotriol	VD/VDR	Cancer
Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-10002

Calcitriol Maximum Cited Publications 44 Publications Verification 1,25-Dihydroxyvitamin D3	Drug Metabolite VD/VDR Endogenous Metabolite	Cancer
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-15332

Alfacalcidol-d6	VD/VDR	Metabolic Disease
Alfacalcidol-d₆ is the deuterium labeled Alfacalcidol. Alfacalcidol is a non-selective VDR activator.

HY-15264

MC 1046 1 Publications Verification Impurity A of Calcipotriol	VD/VDR	Cancer
MC 1046(Impurity A of Calcipotriol) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-131961

Triciferol	VD/VDR HDAC	Cancer
Triciferol functions as a multiple ligand with combined *VDR* agonist and HDAC antagonist activities. Triciferol binds directly to the VDR (IC₅₀=87 nM), and functions as an agonist with 1,25D-like potency on several 1,25D target genes. Triciferol induces marked tubulin hyperacetylation, and augments histone acetylation. Antiproliferative and cytotoxic activities .

HY-15266

24R-Calcipotriol PRI 2202; Impurity D of Calcipotriol	VD/VDR	Cancer
24R-Calcipotriol(PRI 2202) is an impurity of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors.

HY-13332

Calcifediol-d6 25-hydroxy Vitamin D3-d₆	VD/VDR	Metabolic Disease
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-13294

Impurity C of Alfacalcidol	VD/VDR	Metabolic Disease
Impurity of Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.

HY-75041

Calcitriol Impurities A	VD/VDR	Metabolic Disease
Calcitriol Impurities A is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-10002S

Calcitriol-13C3 1,25-Dihydroxyvitamin D3-¹³C₃	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Calcitriol- ¹³C₃ is the ¹³C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-10002R

Calcitriol (Standard)	Drug Metabolite VD/VDR Endogenous Metabolite	Cancer
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-10003

Alfacalcidol 4 Publications Verification 1-hydroxycholecalciferol; 1.alpha.-Hydroxyvitamin D3	VD/VDR	Metabolic Disease
Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective *VDR* activator medication, and widely be used in the management of osteoporosis .

HY-77274

Calcitriol Impurities D	VD/VDR	Metabolic Disease
Calcitriol Impurities D is the impurity of Calcitriol, Calcitriol is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-103053

PS121912	VD/VDR Apoptosis	Cancer
PS121912 is a selective vitamin D receptor (VDR)-coregulator inhibitor. PS121912 has acceptable metabolic stability in vivo. PS121912 can be used for the research of cancer .

HY-32345

Elocalcitol BXL-628; Ro-26-9228	VD/VDR	Inflammation/Immunology Cancer
Elocalcitol (BXL-628) is a selective, orally active vitamin D receptor (VDR) agonist. Elocalcitol shows anti-inflammatory activity. Elocalcitol inhibits growth of prostate cancer cells .

HY-14863

Lunacalcipol CTA-018	VD/VDR Cytochrome P450	Others Endocrinology
Lunacalcipol (CTA-018), as a vitamin D analogue, has a dual role in the pathogenesis of Chronic Kidney Disease (CKD), as an agonist of vitamin D receptor and an antagonist of cytochrome P450 enzyme 24-hydroxylase. Lunacalcipol binds to *VDR* and regulates transcriptional activity of *VDR* by influencing ligand binding affinity, ligand-dependent coactivator recruitment or inhibitory factor dissociation, efficiency of ligand entry into target cells, tissue specificity and different metabolism of ligand. Lunacalcipol can be used in the study of CKD, especially Secondary Hyperparathyroidism (sHPT) .

HY-10002S1

Calcitriol-d3 1,25-Dihydroxyvitamin D3-d₃	VD/VDR Endogenous Metabolite	Cancer
Calcitriol-d₃ is the deuterium labeled Calcitriol[1]. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist[2][3][4][5].

HY-12398A

TEI-9648 1 Publications Verification	VD/VDR	Metabolic Disease Inflammation/Immunology
TEI-9648, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9648 has the potential for bone metabolism research .

HY-13293

Impurity C of Calcitriol	VD/VDR	Cancer
Impurity C of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-13292

Impurity B of Calcitriol 1β,25-Dihydroxyvitamin-D3; 1-Epicalcitriol	VD/VDR	Cancer
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-32339

Maxacalcitol 4 Publications Verification 22-Oxacalcitriol	VD/VDR	Metabolic Disease Inflammation/Immunology Endocrinology
Maxacalcitol (22-Oxacalcitriol), a vitamin D3 (HY-15398) analog, is an orally active *VDR* agonist. Maxacalcitol has a limited calcemic effect. Maxacalcitol has the potential for psoriasis and hyperparathyroidism research .

HY-10003S

Alfacalcidol-d7 1-hydroxycholecalciferol-d₇; 1.alpha.-Hydroxyvitamin D3-d₇	VD/VDR	Metabolic Disease
Alfacalcidol-d₇ is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis[1][2][3][4].

HY-12398

TEI-9647 1 Publications Verification	VD/VDR	Metabolic Disease Inflammation/Immunology
TEI-9647, a Vitamin D₃ Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9647 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)₂D₃. TEI-9647 inhibits bone resorption and HL-60 cell differentiation induced by of 1α,25(OH)₂D₃. TEI-9647 has the potential for suppressing the excessive bone resorption and osteoclast formation in Paget's disease .

HY-10003R

Alfacalcidol (Standard)	VD/VDR	Metabolic Disease
Alfacalcidol (Standard) is the analytical standard of Alfacalcidol. This product is intended for research and analytical applications. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective *VDR* activator medication, and widely be used in the management of osteoporosis .

HY-32351

Calcifediol 5+ Cited Publications 25-hydroxy Vitamin D3	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol (25-hydroxy Vitamin D3) is an effective *VDR* ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351A

Calcifediol monohydrate 5+ Cited Publications 25-hydroxy Vitamin D3 monohydrate	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective *VDR* ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351AS

Calcifediol-d6 monohydrate 25-hydroxy Vitamin D3-d₆ monohydrate	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol-d₆ monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective *VDR* ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351AR

Calcifediol monohydrate (Standard)	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol monohydrate (Standard) is the analytical standard of Calcifediol (monohydrate). This product is intended for research and analytical applications. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective *VDR* ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351AS1

Calcifediol-13C5 monohydrate 25-Hydroxy Vitamin D3-¹³C₅ monohydrate	Isotope-Labeled Compounds VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol- ¹³C₅ monohydrate is the ¹³C-labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective *VDR* ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-32351R

Calcifediol (Standard)	VD/VDR Endogenous Metabolite	Metabolic Disease
Calcifediol (Standard) is the analytical standard of Calcifediol. This product is intended for research and analytical applications. Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .

HY-B1844

Flucythrinate	Others	Cancer
Flucythrinate is a synthetic pyrethroid with endocrine suppressive properties. Flucythrinate showed good binding affinity to the vitamin D nuclear receptor (VDR) with a score of -11.0 kcal/mol. Flucythrinate has been proposed as a multi-target ligand that may interact with several proteins associated with breast cancer. The screening method for Flucythrinate showed good accuracy in binding site prediction and affinity estimation .

HY-32343

Secalciferol 4 Publications Verification (24R)-24,25-Dihydroxyvitamin D3	Endogenous Metabolite VD/VDR	Metabolic Disease Inflammation/Immunology
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-12397

ZK159222 1 Publications Verification	VD/VDR	Endocrinology
ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .

HY-10002A

(1S)-Calcitriol 1α,25-Dihydroxy-3-epi-vitamin-D3	VD/VDR	Others
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .

HY-77278

25-Hydroxytachysterol3	VD/VDR Aryl Hydrocarbon Receptor LXR PPAR	Others
25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1 .

Cat. No.	Product Name	Category	Target	Chemical Structure