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Results for "

WRN

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) DNA/RNA Synthesis (32) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (31)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-160859

WRN inhibitor 8	DNA/RNA Synthesis	Cancer
WRN inhibitor 8 (Example 224) is a WRN helicase inhibitor with IC₅₀ value of 48 nM. WRN inhibitor 8 can be used in cancer research .

HY-153692

WRN inhibitor 1	DNA/RNA Synthesis	Cancer
WRN inhibitor 1 (example 7) is a Wemer Syndrome ATP dependent helicase enzyme (WRN) inhibitor that inhibits *WRN* helicase domain activity. WRN inhibitor 1 has the potential to study cancer .

HY-168592

WRN inhibitor 12	DNA/RNA Synthesis	Cancer
WRN inhibitor 12 (compound 5) is an inhibitor of WRN helicase .

HY-164852

WRN inhibitor 13	DNA/RNA Synthesis	Others
WRN inhibitor 13 is a WRN helicase inhibitor with a pIC₅₀ of 6-7 .

HY-169423

WRN inhibitor 17	DNA/RNA Synthesis	Cancer
WRN inhibitor 17 (Compound 250) is an orally active Werner Syndrome ATP dependent helicase enzyme (WRN) inhibitor, in particular inhibit *WRN* helicase domain activity. WRN inhibitor 17 is promising for research of cancers .

HY-169414

WRN inhibitor 15	DNA/RNA Synthesis	Cancer
WRN inhibitor 15 (Compound 9) is a *WRN* inhibitor with anti-tumor activity that can be used in prostate cancer research, the IC₅₀ values are 37.9, 40.2 and 46.6 μM in PC3, LNCaP, and HeLa .

HY-161386

WRN inhibitor 7	DNA/RNA Synthesis	Cancer
WRN inhibitor 7 (Compound h6) is a *WRN* inhibitor. WRN inhibitor 7 effectively inhibits WRN's helicase and ATPase activity (IC₅₀: 9.8 μM and 15.8 μM respectively). WRN inhibitor 7 can be used for research of microsatellite instable (MSI) cancers .

HY-157954

WRN inhibitor 6	DNA/RNA Synthesis Apoptosis	Cancer
WRN inhibitor 6 (compound 3ci) is a potent *WRN* inhibitor. WRN inhibitor 6 induces apoptosis. WRN inhibitor 6 increases the expression of p-p53, P-Chk2, γH2AX expression .

HY-169422

WRN inhibitor 16	DNA/RNA Synthesis	Cancer
WRN inhibitor 16 (Example 83) is an orally available WRN inhibitor. WRN inhibitor 16 did not induce tumor regression in the SW48 xenograft mouse tumor model.

HY-163797

WRN inhibitor 10	DNA/RNA Synthesis	Cancer
WRN inhibitor 10 (Compound P24) is an inhibitor for the Werner helicase *WRN* with an IC₅₀ of 1.1 nM. WRN inhibitor 10 inhibits the proliferation of cancer cell SW48 with IC₅₀ of 39 nM. WRN inhibitor 10 exhibits good liver microsomal stability and film permeability. WRN inhibitor 10 exhibits good pharmacokinetic characteristics in CD-1 mice .

HY-156579

WRN inhibitor 3	DNA/RNA Synthesis	Cancer
WRN inhibitor 3 (example 110), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 3 can be used for the research of cancer .

HY-156580

WRN inhibitor 4	DNA/RNA Synthesis	Cancer
WRN inhibitor 4 (example 107), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 4 can be used for the research of cancer .

HY-156581

WRN inhibitor 5	DNA/RNA Synthesis	Cancer
WRN inhibitor 5 (example 157), a cyclic vinyl sulfone compound, is a Wemer Syndrome ATP dependent helicase enzyme *(WRN)* inhibitor. WRN inhibitor 5 can be used for the research of cancer .

HY-168583

WRN inhibitor 11	DNA/RNA Synthesis	Cancer
WRN inhibitor 11 (Example 17) is an orally active inhibitor of WRN helicase, with the IC₅₀ of 63 nM .

HY-169424

WRN inhibitor 18	DNA/RNA Synthesis	Cancer
WRN inhibitor 18 (compound 306) is an orally available inhibitor of WRN with in vivo anticancer activity .

HY-169928

WRN inhibitor 14	DNA/RNA Synthesis	Cancer
WRN inhibitor 14 (compound S35) is an orally active *WRN* inhibitor with anticancer activity. WRN inhibitor 14 results in tumor growth inhibition in the SW48 xenograft model in BALB/c nude mice .

HY-153973

WRN inhibitor 2	DNA/RNA Synthesis	Cancer
WRN inhibitor 2 (example 118) is a *WRN* (Werner Syndrome ATP dependent helicase enzyme) inhibitor, with pIC₅₀ ≥ 7.0 .

HY-RS15847

WRN Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
WRN Human Pre-designed siRNA Set A contains three designed siRNAs for WRN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

WRN Human Pre-designed siRNA Set A WRN Human Pre-designed siRNA Set A

HY-162471

GSK_WRN3	DNA/RNA Synthesis	Cancer
GSK_WRN3 is a selective inhibitor of *WRN* protease (pIC₅₀ = 8.6). GSK_WRN3 displays a high degree of selectivity by forming a covalent binding to the Cys727 residue of the WRN protein. GSK_WRN3 reduces growth support for MSI tumor cells by inhibiting WRN protease activity, resulting in increased DNA double-strand breaks and cell growth inhibition .

HY-163942

GSK_WRN4	DNA/RNA Synthesis	Cancer
GSK_WRN4 is a WRN helicase inhibitor (pIC₅₀=7.6) with anticancer activity. GSK_WRN4 selectively inhibits the growth of MSI tumor cells in vitro and in vivo by inducing DNA double-strand breaks, particularly at expanded TA repeats and DNA damage regions .

HY-163941

GSK_WRN2	DNA/RNA Synthesis	Cancer
GSK_WRN2 is a potent and selective covalent WRN helicase inhibitor that suppresses replication stress caused by DNA (TA)_n dinucleotide repeat expansions. GSK_WRN2 can be used to study microsatellite instability (MSI) cancers .

HY-153692A

*(R)-WRN* inhibitor 1**	Biochemical Assay Reagents	Others
(R)-WRN inhibitor 1 is the R-isomer of WRN inhibitor 1 (example 7). WRN inhibitor 1 is a *WRN* inhibitor with anticancer activity .

HY-148700

Werner syndrome RecQ helicase-IN-2	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-2 (example 57) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-128712

NCGC00029283	DNA/RNA Synthesis	Cancer
NCGC00029283 is a *werner syndrome helicase-nuclease (WRN) helicase* inhibitor with IC₅₀s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively .

HY-148699

HRO761 2 Publications Verification Werner syndrome RecQ helicase-IN-1	DNA/RNA Synthesis	Cancer
HRO761 (Werner syndrome RecQ helicase-IN-1) (example 42) is a potent Werner syndrome RecQ DNA helicase enzyme (WRN) inhibitor and can be used in cancer research .

HY-158025

Anticancer agent 198	DNA/RNA Synthesis	Cancer
Anticancer agent 198 (compound 18b) is a potent anticancer agent and potential *WRN* protein inhibitor. Anticancer agent 198 was significantly toxic to K562 cells and WRN-overexpressing PC3 cells .

HY-110185

NSC 617145 2 Publications Verification	DNA/RNA Synthesis	Cancer
NSC 617145 is a selective *werner syndrome helicase (WRN) helicase* inhibitor with an IC₅₀ value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .

HY-168933

KWR095	DNA/RNA Synthesis	Cancer
KWR095 is an orally active *WRN* inhibitor with an IC₅₀ of 0.032 μM for WRN ATPase. KWR095 can impede the duplex unwinding activity of *WRN* and inhibit the proliferation of tumor cells. KWR095 has anti-tumor activity .

HY-149887

H3B-968 1 Publications Verification	DNA/RNA Synthesis	Cancer
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) (IC₅₀=~10 nM)，which acts function as helicase，ATPase，and exonuclease. WRN exhibits synthetic lethal activity in cancer research. However，H3B-968 inhibits WRN helicase activity，competitively with ATP .

HY-158116

VVD-214 RO7589831; VVD-133214	DNA/RNA Synthesis	Cancer
VVD-214 is a synthetic lethal allosteric inhibitor of *WRN* helicase with an IC₅₀ of 0.1316 µM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers .

HY-148740

Werner syndrome RecQ helicase-IN-3	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-3 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-3 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-3 shows anticancer activity .

HY-148741

Werner syndrome RecQ helicase-IN-4	DNA/RNA Synthesis	Cancer
Werner syndrome RecQ helicase-IN-4 is a potent and orally active werner syndrome recQ helicase (WRN) inhibitor with an IC₅₀ value of 0.06 µM. Werner syndrome RecQ helicase-IN-4 shows antiproliferative activity. Werner syndrome RecQ helicase-IN-4 shows anticancer activity .

HY-168934

KWR137	DNA/RNA Synthesis	Cancer
KWR137 is a *WRN* degrader, with an IC₅₀ of 8 nM. KWR137 exhibits good anti-proliferative activity against MSI-H cells, with a GI₅₀ of 509 nM in SW48 cells and a GI₅₀ of 824 μM in HCT116 cells. It also demonstrates anti-tumor growth effects in xenograft mouse models. KWR137 can be used for cancer research .

HY-12342

ML216 Maximum Cited Publications 6 Publications Verification CID-49852229	DNA/RNA Synthesis	Cancer
ML216 (CID-49852229) is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC₅₀s of 2.98 μM and 0.97 μM for BLM ^full-length and BLM ^636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a K_i of 1.76 µM. Antitumor avtivity .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82276

	WRN Antibody (YA2021) Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN	WB	Human
	WRN Antibody (YA2021) is a non-conjugated IgG antibody, targeting WRN, with a predicted molecular weight of 162 kDa (observed band size: 200 kDa). WRN Antibody (YA2021) can be used for WB experiment in human background.

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WRN Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
WRN Human Pre-designed siRNA Set A contains three designed siRNAs for WRN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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