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Isoforms Recommended:	Adenosine A₃ receptor (A₃R)

Results for "

adenosine A3 receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (57) Apoptosis (14) Autophagy (13) Calcium Channel (1) Endogenous Metabolite (14) Isotope-Labeled Compounds (4) Nucleoside Antimetabolite/Analog (13) PI3K (1)
By Research Areas:	Cancer (26) Cardiovascular Disease (8) Inflammation/Immunology (28) Metabolic Disease (13) Neurological Disease (13)

Inhibitors & Agonists

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Isotope-Labeled Compounds

Targets Recommended: Adenosine Kinase Adenosine Receptor Adenosine Deaminase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-19365

AB-MECA 1 Publications Verification	Adenosine Receptor	Neurological Disease
AB-MECA is a high affinity A₃ adenosine receptor agonist with a binding K_i of 430.5 nM for human A₃ receptors in CHO cells. AB-MECA can enhance plasma histamine level .

HY-103187

HEMADO	Adenosine Receptor	Inflammation/Immunology Cancer
HEMADO is a potent and selective **adenosine A₃ receptor agonist with a K_i** of 1.1 nM at the human A₃ subtype . HEMADO is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-103190

MRS1220	Adenosine Receptor	Neurological Disease Cancer
MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a K_i of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system . MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo .

HY-103174

MRS1334	Adenosine Receptor	Cardiovascular Disease
MRS1334 is a potent and selective human **adenosine A₃ receptor antagonist with K_i**s of 2.69 nM, >100 nM, >100 nM for hA₃, rA₁, rA_2A, respectively. MRS1334 blocks the protective effect of Cl-IB-MECA leading to significant bradycardia and elevated ST segment . MRS1334 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100274

Adenosine antagonist-1	Adenosine Receptor	Neurological Disease
Adenosine antagonist-1 is an **adenosine A3 receptor (AA3R**) antagonist.

HY-119191

KF26777 free base	Adenosine Receptor	Neurological Disease
KF26777 (free base) is a potent and selective **adenosine A3 receptor antagonist with an K_i** value of 0.2 nM and possesses 9000-, 2350- and 3100-fold selectivity against adenosine A1, A2A and A2B receptors, respectively. KF26777 (free base) potently inhibits the [125I]AB-MECA binding to **adenosine A3 receptors**. KF26777 (free base) is promising for research of brain ischemia and inflammatory disease including asthma .

HY-118086

MRS1067	Adenosine Receptor	Inflammation/Immunology Cancer
MRS 1067 is a competitive antagonist of the **adenosine A3 receptor that inhibits the suppression of adenylate cyclase** by adenosine A3 receptor agonists and affects the activation of G proteins. MRS 1067 can be used in research related to inflammation and cancer .

HY-120487

VUF8507	Adenosine Receptor	Others
VUF8507 is an allosteric modulator for **adenosine A3 receptor with a K_i** of 204 nM .

HY-118232

VUF8504	Adenosine Receptor	Cardiovascular Disease
VUF-8504 is a potent and selective **adenosine A3 receptor antagonist with K_i** value of 0.017, 14 nM for human A3, A1, respectively .

HY-162851

Adenosine receptor agonist 1	Adenosine Receptor	Others
Adenosine receptor agonist 1 (compound 6m) is an A3 adenosine receptor (AR) partial agonist with K_i value of 6.7 nM .

HY-110037

MRS-3777 hemioxalate	Adenosine Receptor	Neurological Disease
MRS-3777 hemioxalate is a selective **adenosine A3 receptor** antagonist .

HY-115765

N6-Benzyl-5'-ethylcarboxamido adenosine	Adenosine Receptor	Neurological Disease
N6-Benzyl-5'-ethylcarboxamido adenosine is a selective A3 adenosine receptor agonist .

HY-18687

APNEA N6-[2-(4-Aminophenyl)ethyl]adenosine	Adenosine Receptor	Neurological Disease
APNEA (N6-[2-(4-Aminophenyl)ethyl]adenosine) is a potent, non-selective A3 adenosine receptor agonist.

HY-146478

A1/A3 AR antagonist 1	Adenosine Receptor	Neurological Disease Inflammation/Immunology
A1/A3 AR antagonist 1 (compound 10) is a potent adenosine 1 (A1) and **adenosine 3 (A3)** receptor dual antagonist with K_is of 36.7 nM, 25.4 nM and 1.47 nM for human A1, human A3 and rat A1, respectively. A1/A3 AR antagonist 1 can be used for researching kidney failure, inflammatory pulmonary diseases, and Alzheimer’s disease .

HY-118678

MRS1186	Adenosine Receptor	Inflammation/Immunology
MRS1186 is a potent and selective human Adenosine A3 receptor (hA₃AR) antagonist, with a K_i of 7.66 nM.

HY-120090

MRS1177	Adenosine Receptor	Inflammation/Immunology
MRS1177 is a potent and selective human Adenosine A3 receptor (hA₃AR) antagonist, with a K_i of 0.3 nM.

HY-146479

A1/A3 AR antagonist 2	Adenosine Receptor	Inflammation/Immunology
The compound is an a1/a3 adenosine receptor antagonist, which helps to research (neurological) inflammatory diseases.

HY-103183

CV1808 2-Phenylaminoadenosine	Adenosine Receptor Endogenous Metabolite	Inflammation/Immunology
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-146457

A3AR antagonist 1	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 1 (compound 17) is a potent and selective *human A₃ adenosine* receptor (AR) antagonist, with an K_i** of 4.63 nM. A3AR antagonist 1 shows no affinity for the rat A₃ AR even at high concentrations .

HY-139694

hA3AR agonist 1	Adenosine Receptor	Others
hA3AR agonist 1 is a potent human A₃ adenosine receptor (hA₃AR) agonist with a K_i value of 2.40 nM.

HY-103176

PSB11 hydrochloride	Adenosine Receptor	Others
PSB11 hydrochloride is an antagonist with reverse excitatory activity for human A3 **Adenosine Receptor** with high affinity (K_i=2.3 nM) .

HY-12099

A3AR antagonist 2	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 2 (compound 18) is a potent Human A3 adenosine receptor antagonist with an K_i value of 4.54 nM .

HY-13236

LUF6000 1 Publications Verification	Adenosine Receptor	Cardiovascular Disease
LUF6000 is an orally active allosteric modulator of the A3 adenosine receptor. LUF6000 has potent anti-inflammatory effect .

HY-14121

MRS 1754 3 Publications Verification	Adenosine Receptor	Metabolic Disease Inflammation/Immunology
MRS 1754 is a selective antagonist radioligand for A_2B adenosine receptor with very low affinity for A₁ and A₃ receptors of both humans and rats .

HY-161810

MRS8247	Adenosine Receptor	Others
MRS8247 is a positive allosteric modulator (PAM) of the A3 adenosine receptor (A3AR) that can also slow the dissociation rate of agonists .

HY-123203

CP-608039	Adenosine Receptor	Cardiovascular Disease
CP-608039 is a potent and selective **adenosine A3 receptor** agonist. CP-608039 can be used for ischemic myocardial injury research .

HY-164621

A3AR antagonist 5	Adenosine Receptor	Others
A3AR antagonist 5 (Compound 16) is a selective antagonist for human adenosine A3 receptor with an affinity pC of 4.542 μM .

HY-147541

A2A/A3 AR antagonist-1	Adenosine Receptor	Inflammation/Immunology
A2A/A3 AR antagonist-1 (compound 23) is a dual A_2A/A₃ adenosine receptor (AR) fluorescent ligand, with K_is of 90 nM and 31.8 nM for hA_2A AR and hA₃ AR, respectively .

HY-B0228S6

Adenosine-d2 Adenine riboside-d₂; D-adenosine-d₂	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-d₂ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio

HY-B0228S7

Adenosine-d1-1 Adenine riboside-d₁-1; D-adenosine-d-1	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S8

Adenosine-d1-2 Adenine riboside-d₁-2; D-adenosine-d-2	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-124543

MRS-1191 2 Publications Verification	Adenosine Receptor	Neurological Disease
MRS-1191 is a potent and selective A₃ adenosine receptor antagonist with a K_B value of 92 nM, a K_i value of 31.4 nM for human A₃ receptor and an IC₅₀ of 120 nM for CHO cells . MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100678

CGS 15943	Adenosine Receptor PI3K	Inflammation/Immunology Cancer
CGS 15943 is an orally bioavailable non-xanthine **Adenosine Receptor antagonist. Its K_i** for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively. .

HY-10915

LUF6096	Adenosine Receptor	Cardiovascular Disease
LUF6096, a potent allosteric enhancer of the **adenosine A3 receptor*, is able to allosterically enhance agonist binding. LUF6096 shows low orthosteric affinity for any of the adenosine* receptors. LUF6096 shows protective effects in myocardial ischemia/reperfusion injury .

HY-B0228S4

Adenosine-1′-13C Adenine riboside-1′-¹³C; D-adenosine-1′-¹³C	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-1′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S2

Adenosine-2′-13C Adenine riboside-2′-¹³C; D-adenosine-2′-¹³C	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-2′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S3

Adenosine-3′-13C Adenine riboside-3′-¹³C; D-adenosine-3′-¹³C	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine-3′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S14

Adenosine-d9 Adenine riboside-d₉; D-adenosine-d₉	Isotope-Labeled Compounds	Others
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio .

HY-B0228S5

Adenosine-13C Adenine riboside-¹³C; D-adenosine-¹³C	Apoptosis Autophagy Endogenous Metabolite Nucleoside Antimetabolite/Analog	Metabolic Disease Cancer
Adenosine- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,

HY-120652

A3AR antagonist 3	Adenosine Receptor	Inflammation/Immunology
A3AR antagonist 3 (compound 21) is a selective *A3 adenosine* receptor (A3AR) antagonist with a K_i** of 37 nM. A3AR antagonist 3 shows >60-fold selectivity in comparison to A1 and A2A adenosine receptors .

HY-103181

N6-Cyclopentyladenosine CPA; UK-80882	Adenosine Receptor	Neurological Disease
N6-Cyclopentyladenosine (CPA) is a selective **Adenosine A₁ receptor agonist, with K_i** values of 2.3 nM, 790 nM and 43 nM for human A₁, A_2A and A₃ receptors, respectively .

HY-161718

MRS8028	Adenosine Receptor	Inflammation/Immunology
MRS8028 is an agonist for A3 adenosine receptor (A3AR), which binds hA3AR with K_i of 2.44 nM. MRS8028 is potential for ameliorating ischemia and inflammatory diseases .

HY-121119

MRS 1523 2 Publications Verification	Adenosine Receptor Calcium Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
MRS 1523 is a potent and selective **adenosine A₃ receptor antagonist with K_i values of 18.9 nM and 113 nM for human** and rat A₃ receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A₁ and A_2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons .

HY-111767

BAY-545	Adenosine Receptor	Inflammation/Immunology
BAY-545 is a potent and selective A_2B adenosine receptor antagonist, with an IC₅₀ of 59 nM. BAY-545 also exhibits IC₅₀s of 66, 400, 280 nM for human, mouse, rat A_2B adenosine receptor in cells, respectively, and a K_i of 97 nM for human A_2B adenosine receptor, with more selectivity over A₁, A_2A, and A₃ adenosine receptor .

HY-148088

M1069	Adenosine Receptor	Cancer
M1069 is a selective and orall active, dual A_2A/A_2B adenosine receptor antagonist with a selectivity of >100 fold against the A₁ and A₃ receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity .

HY-151899

A3AR modulator 1	Adenosine Receptor	Inflammation/Immunology
A3AR modulator 1 (MRS8054) is an orally active *A3 adenosine* receptor (A3AR)** (Adenosine Receptor) positive allosteric modulator (PAM). A3AR modulator 1 greatly enhances Cl-IB-MECA-stimulated [ ³⁵S]GTPγS binding E_max .

HY-148076

A2A receptor antagonist 3	Adenosine Receptor	Cancer
A2A receptor antagonist 3 (Example 92) is an **adenosine A2a receptor antagonist with a K_i** of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K_is of 37, 107 and 1467 nM, respectively .

HY-W777125

2-Chloro-3-deazaadenosine	Adenosine Receptor	Inflammation/Immunology
2-Chloro-3-deazaadenosine is agonists for **adenosine receptor, with K_i*s of 0.3, 0.08, 25.5 and 1.9 μM, for A1, A2A, A2B, and A3 receptors*, respectively .

HY-12365

Namodenoson 1 Publications Verification CF-102; 2-Cl-IB-MECA	Adenosine Receptor	Cancer
Namodenoson (CF-102) is a selective A3 adenosine receptor (A3AR) agonist (K_i=0.33 nM). Namodenoson displays 2500- and 1400-fold selectivity over A1 and A2A receptors respectively .

HY-103166

PSB-603 2 Publications Verification	Adenosine Receptor	Inflammation/Immunology
PSB-603 is a potent and highly selective A_2B adenosine receptor antagonist exhibiting a K_i value of 0.553 nM and virtually no affinity for the human and rat A₁ and A_2A and the human A₃ receptors up to a concentration of 10 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-103183

CV1808 2-Phenylaminoadenosine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	Adenosine Receptor Endogenous Metabolite
CV1808 (2-Phenylaminoadenosine) is a non-selective A2 adenosine receptor (A2 AR) agonist with K_is of 76 and 1450 nM for A2A and A3 adenosine receptor subtypes, respectively .

HY-B0228

Adenosine 5+ Cited Publications Adenine riboside; D-adenosine	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite
Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

HY-B0228R

Adenosine (Standard)	Structural Classification Natural Products Microorganisms Source classification Endogenous metabolite	Nucleoside Antimetabolite/Analog Autophagy Apoptosis Endogenous Metabolite
Adenosine (Standard) is the analytical standard of Adenosine. This product is intended for research and analytical applications. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

Cat. No.	Product Name	Chemical Structure

HY-B0228S6

Adenosine-d2
Adenosine-d₂ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio

HY-B0228S8

Adenosine-d1-2
Adenosine-d-2 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S4

Adenosine-1′-13C
Adenosine-1′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S5

Adenosine-13C
Adenosine- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology,

HY-B0228S

Adenosine-d1
Adenosine-d is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1][2].

HY-B0228S1

Adenosine-13C5
Adenosine- ¹³C₅ is the ¹³C labeled Adenosine[1]. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[2][3].

HY-B0228S7

Adenosine-d1-1
Adenosine-d-1 is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular phys

HY-B0228S2

Adenosine-2′-13C
Adenosine-2′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S3

Adenosine-3′-13C
Adenosine-3′- ¹³C is the ¹³C labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiolo

HY-B0228S14

Adenosine-d9
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio .

HY-B0228S12

Adenosine-d13

Adenosine-d₁₃ (Adenine riboside-d₁₃; D-Adenosine-d₁₃) is deuterium labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0228S13

Adenosine-13C10

Adenosine- ¹³C₁₀ (Adenine riboside- ¹³C₁₀; D-Adenosine- ¹³C₁₀) is ¹³C-labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.

HY-B0228S11

Adenosine-15N5

Adenosine- ¹⁵N₅ (Adenine riboside- ¹⁵N₅; D-Adenosine- ¹⁵N₅) is the ¹⁵N labled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation .

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