Search Result

Results for "

anti-platelet aggregation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Platelet-activating Factor Receptor (PAFR) (3) 5-HT Receptor (1) Adrenergic Receptor (1) Apoptosis (5) Autophagy (2) Calcium Channel (2) Caspase (2) Cytochrome P450 (3) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (1) Endogenous Metabolite (2) Factor Xa (1) HSP (2) Integrin (3) Isotope-Labeled Compounds (1) JAK (2) NADPH Oxidase (1) NF-κB (4) NO Synthase (2) NOD-like Receptor (NLR) (1) P2Y Receptor (13) p38 MAPK (1) Parasite (2) Phosphodiesterase (PDE) (1) PI3K (3) Prostaglandin Receptor (4) Protease Activated Receptor (PAR) (7) Src (1) Syk (1) Thrombin (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (18) Cardiovascular Disease (48) Endocrinology (1) Infection (5) Inflammation/Immunology (15) Metabolic Disease (2) Neurological Disease (3)

By Targets:

Platelet-activating Factor Receptor (PAFR) (3)

5-HT Receptor (1)

Adrenergic Receptor (1)

Apoptosis (5)

Autophagy (2)

Calcium Channel (2)

Caspase (2)

Cytochrome P450 (3)

Drug Derivative (1)

Drug Intermediate (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Factor Xa (1)

HSP (2)

Integrin (3)

Isotope-Labeled Compounds (1)

JAK (2)

NADPH Oxidase (1)

NF-κB (4)

NO Synthase (2)

NOD-like Receptor (NLR) (1)

P2Y Receptor (13)

p38 MAPK (1)

Parasite (2)

Phosphodiesterase (PDE) (1)

PI3K (3)

Prostaglandin Receptor (4)

Protease Activated Receptor (PAR) (7)

Src (1)

Syk (1)

Thrombin (2)

Wnt (1)

β-catenin (1)

By Research Areas:

Cancer (18)

Cardiovascular Disease (48)

Endocrinology (1)

Infection (5)

Inflammation/Immunology (15)

Metabolic Disease (2)

Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Platelet-activating Factor Receptor (PAFR) PDGFR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2375

L-Quebrachitol	Wnt β-catenin p38 MAPK	Metabolic Disease
L-Quebrachitol is a methoxy analog of inositol isolated from plants, which has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

HY-N0120

(E/Z)-Polydatin (E/Z)-Piceid	Others	Inflammation/Immunology
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .

HY-163504

PAR4 antagonist 5	Protease Activated Receptor (PAR)	Cardiovascular Disease
PAR4 antagonist 5 (compound 1) is a PAR4 antagonist with an IC₅₀ less than 20 μM and potent anti-platelet aggregation activity. PAR4 antagonist 5 can be used for research of thrombosis disease .

HY-N3047

Piperolactam C O-Methylpiperolactam B; Piperolactam B methyl ether	Others	Cardiovascular Disease
Piperolactam C (O-Methylpiperolactam B) is a natural alkaloid with anti-platelet aggregation effects .

HY-N12067

Columbianetin β-D-glucopyranoside	Others	Inflammation/Immunology
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity .

HY-N3049

Piperlotine C	Others	Cardiovascular Disease
Piperlotine C is an alkaloid isolated from Piper lolot, with anti-platelet aggregation induced by arachidonic acid, and the IC₅₀ is 26.6 µg/mL .

HY-167743

Platelet aggregation-IN-2	Endogenous Metabolite	Cardiovascular Disease
Platelet aggregation-IN-2 is an anti-platelet aggregation agent with significant anticoagulant activity. Platelet aggregation-IN-2 can inhibit platelet aggregation reaction and reduce the risk of thrombosis. The application of Platelet aggregation-IN-2 can potentially be used for the prevention and suppression of cardiovascular diseases .

HY-N12647

cis-Hinkiresinol	Others	Infection Inflammation/Immunology
cis-Hinkiresinol is a bioactive constituent of Rhizoma anemarrhenae. Rhizoma anemarrhenae is reprted to have anti-pathogenic microorganism, hypoglycemic effects, anti-inflammatory, antipyretic effects and anti-platelet aggregation .

HY-U00367

(4E)-SUN9221	Adrenergic Receptor 5-HT Receptor	Cardiovascular Disease Endocrinology
(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

HY-N3048

Piperlotine D	Others	Cardiovascular Disease
Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC₅₀ of 43.4 μg/mL .

HY-146498

Antiplatelet agent 1	P2Y Receptor	Cardiovascular Disease Cancer
Antiplatelet agent 1 (compound 7q) is a Ticagrelor analoguehas, possessing antiplatelet activity. Antiplatelet agent 1 can be used for researching platelet aggregation .

HY-146499

Antiplatelet agent 2	P2Y Receptor	Cardiovascular Disease Cancer
Antiplatelet agent 2 (compound 7p) is a Ticagrelor analoguehas, possessing antiplatelet activity. Antiplatelet agent 2 can be used for researching platelet aggregation .

HY-N7991

Rubiayannone A	Others	Cardiovascular Disease
Rubiayannone A is an anthraquinone glycoside with an antiplatelet aggregation activity .

HY-119145

MRS2496	P2Y Receptor	Cardiovascular Disease
MRS2496 is a selective P2Y1 receptor antagonist with an IC₅₀ value of 1.5 μM, exhibiting antiplatelet aggregation activity. MRS2496 can be used in the research of antiplatelet aggregation and blood-related diseases .

HY-N15271

Oxopurpureine	Thrombin Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
Oxopurpureine is an oxoaporphine with **antiplatelet aggregation** activity. Oxopurpureine inhibits collagen, thrombin and arachidonic acid-induced platelet aggregation and can be utilized in relevant research .

HY-33351

Eugenin	Others	Cardiovascular Disease
Eugenin is a chromone isolated from Peucedanum japonicum, with potent antiplatelet aggregation activity .

HY-N3051

Piperlotine A	Others	Cardiovascular Disease
Piperlotine A is an alkaloid isolated from Piper lolot, with potent antiplatelet aggregation activity .

HY-N1861

3-O-Methylquercetin tetraacetate Quercetin 3-O-methyl ether peracetate	P2Y Receptor	Cardiovascular Disease Cancer
3-O-Methylquercetin tetraacetate is an antiplatelet agent. 3-O-Methylquercetin tetraacetate has potent antiplatelet effect on arachidonic acid, collagen-induced and PAF-induced platelet aggregation .

HY-N3668

Cyclomorusin Cyclomorusin A; Cyclomulberrochromene	Others	Cardiovascular Disease
Cyclomorusin (Cyclomorusin A; Cyclomulberrochromene) is a prenylflavonoid with antiplatelet activity. Cyclomorusin also inhibits markedly collagen-induced platelet aggregation .

HY-124365

Rhamnetin tetraacetate	Others	Infection Cancer
Rhamnetin tetraacetate (compound 4) is a xanthone compound with antiplatelet activity. Rhamnetin tetraacetate inhibited platelet aggregation induced by arachidonic acid .

HY-171241

Imolamine	Drug Derivative	Cardiovascular Disease
Imolamine is a potent antiplatelet aggregation agent, is a phenyl aminoxidiazole derivative. Imolamine has the potential for the research of coronary heart disease .

HY-111755

Oral antiplatelet agent 1	P2Y Receptor	Cardiovascular Disease
Oral antiplatelet agent 1 is a potent P2Y₁₂ receptor antagonist. Oral antiplatelet agent 1 exhibits excellent antiplatelet aggregation potency with an IC₅₀ value of 2.94 μM as well as antithrombotic efficacy in a rat ferric chloride model. Oral antiplatelet agent 1 shows a superior safety profile than Clopidogrel (HY-15283) in a rat tail-bleeding model. Oral antiplatelet agent 1 can be used to research thromboembolic disorders .

HY-N12995

α-Bulnesene	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-125123

Euchrestaflavanone A	Integrin	Cardiovascular Disease
Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis .

HY-123112

Hoe 892 S792892A	Prostaglandin Receptor	Cardiovascular Disease
Hoe 892 (S792892A) is an orally active prostacyclin derivative with antiplatelet aggregation and vasodilatory activity. Hoe 892 can be used in the study of cardiovascular diseases such as thrombosis .

HY-151146

(1R,3S)-THCCA-Asn	Thrombin	Cardiovascular Disease
(1R,3S)-THCCA-Asn (4j) is a selective thrombin inhibitor with the IC₅₀ value in the range of 0.07 to 0.14 μM. ((1R,3S)-THCCA-Asn has antithrombotic activity .

HY-N2081

Skimmianine 2 Publications Verification	Others	Inflammation/Immunology Cancer
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-162375

AF299	Drug Intermediate	Cardiovascular Disease
AF299 can reduce collagen-related peptide-induced platelet Ca ²⁺ rises and collagen-induced platelet aggregation. AF299 can be used for research of antiplatelet research .

HY-169788

Graveolinine	Others	Cardiovascular Disease
Graveolinine is a quinoline alkaloid, that can be isolated from Ruta chalepensis. Graveolinine exhibits antiplatelet activity, that reduces Arachidonic Acid (HY-109590)- and Collagen-induced aggregation of washed rabbit platelets .

HY-B0428A

Ozagrel sodium 1 Publications Verification OKY-046 sodium	Prostaglandin Receptor	Cardiovascular Disease
Ozagrel sodium (OKY-046 sodium) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel sodium is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC₅₀ of 53.12 μM .

HY-P1956

Human serum albumin 2 Publications Verification HSA	NF-κB NO Synthase	Cardiovascular Disease Inflammation/Immunology Cancer
Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-167848

DMP-728 free base XL-118	Others	Cardiovascular Disease
DMP-728 free base (XL-118) is a highly potent and selective GPIIb/IIIa antagonist with antiplatelet and antithrombotic activities. DMP-728 free base can inhibit ADP-induced human platelet aggregation in vitro, with an IC₅₀ of 46 nmol/L, and can significantly reduce the interaction between fibrinogen and human platelets or Binding of purified human GPIIb/IIIa receptors. DMP-728 free base exhibits dose-dependent antiplatelet effects in anesthetized mongrel dogs, effectively inhibiting ADP-induced platelet aggregation and prolonging template bleeding time .

HY-162558

NCGC00351170	Factor Xa	Cardiovascular Disease
NCGC00351170 is an antiplatelet agent that disrupts the calcium and integrin-binding protein 1 (CIB1)-α_IIbβ₃ interaction. NCGC00351170 inhibits thrombin-induced human platelet aggregation .

HY-B0428

Ozagrel 1 Publications Verification OKY-046	Prostaglandin Receptor	Cardiovascular Disease
Ozagrel (OKY-046)is an anti-asthmatic agent and a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC₅₀ of 53.12 μM .

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-N11920

Kadsurenin B	Platelet-activating Factor Receptor (PAFR)	Infection Neurological Disease Inflammation/Immunology
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-120080

UR-2922	Integrin	Others
UR-2922 is a platelet GPIIb/IIIa antagonist with antiplatelet aggregation and cardiovascular disease inhibition activities. UR-2922 has high affinity for human platelet receptors and has good pharmacokinetic properties, and can be used to inhibit cardiovascular diseases.

HY-Y0152

Cinchonine 3 Publications Verification (8R,9S)-Cinchonine; LA40221	Apoptosis Parasite Autophagy Caspase Calcium Channel	Others Inflammation/Immunology Cancer
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-15799

AZD1283	P2Y Receptor	Cardiovascular Disease
AZD1283 is a potent P2Y₁₂ receptor antagonist with a binding IC₅₀ of 11 nM and a GTPγS IC₅₀ of 25 nM. AZD1283 has excellent antiplatelet aggregation potency. AZD1283 can be used to research thromboembolic disorders .

HY-N2081R

Skimmianine (Standard)	Others	Inflammation/Immunology Cancer
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-W699533

4-Hydroxy valsartan Valeryl-4-hydroxyvalsartan; CGP 71580	Drug Metabolite	Cardiovascular Disease
4-Hydroxy valsartan is a metabolite of Valsartan (HY-18204). 4-Hydroxy valsartan regulates the expression of platelet surface receptors and inhibits conventional plasma or whole blood collagen induced platelet aggregation. 4-Hydroxy valsartan has antiplatelet activity .

HY-124371

Amentoflavone hexaacetate	Phosphodiesterase (PDE)	Cardiovascular Disease
Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects .

HY-19638A

Cangrelor tetrasodium 2 Publications Verification AR-C69931MX tetrasodium	P2Y Receptor	Cardiovascular Disease Inflammation/Immunology
Cangrelor tetrasodium, an adenosine triphosphate analogue, is a reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor tetrasodium directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor tetrasodium is also a nonspecific GPR17 antagonist .

HY-10119

Vorapaxar 5+ Cited Publications SCH 530348	Protease Activated Receptor (PAR)	Cardiovascular Disease
Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-B0428D

(E/Z)-Ozagrel sodium (E/Z)-OKY-046 sodium	Prostaglandin Receptor	Cardiovascular Disease
(E/Z)-Ozagrel (sodium) [(E/Z)-OKY-046 (sodium)] is an EZ configuration mixture of Ozagrel (sodium) (HY-B0428A). Ozagrel (sodium) is a thromboxane A2 (TXA2) synthase inhibitor. Ozagrel (sodium) is an antiplatelet agent, which selectively inhibits human platelet aggregation with an IC₅₀ of 53.12 μM .

HY-N0293

Paeoniflorin Maximum Cited Publications 22 Publications Verification Peoniflorin	HSP	Infection Neurological Disease Cancer
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-10119A

Vorapaxar sulfate 5+ Cited Publications SCH 530348 sulfate	Protease Activated Receptor (PAR)	Cardiovascular Disease
Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) HSA (Cell culture grade, Endotoxin<0.125 EU/mg)	NF-κB NO Synthase	Cardiovascular Disease Inflammation/Immunology
Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-19638

Cangrelor AR-C69931MX	P2Y Receptor	Cardiovascular Disease Inflammation/Immunology
Cangrelor (AR-C69931MX), an adenosine triphosphate analogue, is an intravenous, reversible and selective platelet P2Y12 antagonist, with prompt and potent antiplatelet effects. Cangrelor directly blocks adenosine diphosphate (ADP)-induced activation and aggregation of platelets. Cangrelor is also a nonspecific GPR17 antagonist .

HY-123669A

trans-R-138727	P2Y Receptor	Cardiovascular Disease
Trans-R-138727 is the trans isomer of R-138727 (HY-123669). R-138727 is the active metabolite of the antiplatelet agent Prasugrel (HY-15284). R-138727 is an irreversible inhibitor for the platelet receptor P2Y12, and inhibits ADP-induced platelet activation and aggregation .

Cat. No.	Product Name	Type

HY-P1956

Human serum albumin

2 Publications Verification

HSA

Native Proteins

Human serum albumin (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, NF-κB, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

HY-P1956A

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg)

HSA (Cell culture grade, Endotoxin<0.125 EU/mg)

Native Proteins

Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) (HSA) is the most abundant protein in plasma and is a major determinant of plasma oncotic pressure. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) exhibits antioxidant, anticoagulant, anti-inflammatory, anti-platelet aggregation activities as well as colloid osmotic action. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) can block the inhibitory effect of GML on human T cells, providing protective function for T cells. Human serum albumin (Cell culture grade, Endotoxin<0.125 EU/mg) is also associated with cardiovascular diseases and can partially prevent the LPS (HY-D1056) induced oxidative stress, as well as the upregulation of NF-κB, iNOS, and peroxynitrite (ONOO ⁻) in the vascular wall, contributing to the reduction of blood pressure .

Cat. No.	Product Name	Target	Research Area

HY-P3082

SKF 106760	Peptides	Cardiovascular Disease
SKF 106760 is a potent platelet fibrin receptor (glycoprotein IIb/IIIa) antagonist with significant antiplatelet and antithrombotic activities. SKF 106760 inhibits platelet aggregation in dogs in vitro and prevents thrombus formation in stenotic carotid arteries. SKF 106760 has also shown elimination effects against aspirin-resistant thrombi that develop in the setting of high-grade stenosis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2375

L-Quebrachitol	Structural Classification Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Wnt β-catenin p38 MAPK
L-Quebrachitol is a methoxy analog of inositol isolated from plants, which has free-radical scavenging, gastroprotection, anti-platelet aggregation and anti-diabetic activity. L-Quebrachitol promotes osteoblastogenesis by uppregulation of BMP-2, runt-related transcription factor-2 (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathway .

HY-N0120

(E/Z)-Polydatin (E/Z)-Piceid	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Others
(E/Z)-Polydatin ((E/Z)-Piceid) is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .

HY-33351

Eugenin	Cardiovascular Disease Structural Classification Monophenols Classification of Application Fields Source classification Phenols Decachaeta ovatifolia (DC.) R.M.King & H.Rob. Umbelliferae Plants Disease Research Fields	Others
Eugenin is a chromone isolated from Peucedanum japonicum, with potent antiplatelet aggregation activity .

HY-N3047

Piperolactam C O-Methylpiperolactam B; Piperolactam B methyl ether	Structural Classification Alkaloids Piper taiwanense Lin & Lu Other Alkaloids Source classification Piperaceae Plants	Others
Piperolactam C (O-Methylpiperolactam B) is a natural alkaloid with anti-platelet aggregation effects .

HY-N12067

Columbianetin β-D-glucopyranoside	Structural Classification Source classification Plants Umbelliferae Seriphidium transiliense Saccharides Monosaccharides	Others
Columbianetin β-D-glucopyranoside can be isolated from Angelicae pubescentis radix and has antiplatelet aggregation, anti-inflammatory and analgesic activities. Columbianetin β-D-glucopyranoside exerts significant protective effects against glutamate-induced toxicity .

HY-N3049

Piperlotine C	Cardiovascular Disease Alkaloids Pyrrole Alkaloids Classification of Application Fields Source classification Piperaceae Plants Disease Research Fields Piper nigrum Linn.	Others
Piperlotine C is an alkaloid isolated from Piper lolot, with anti-platelet aggregation induced by arachidonic acid, and the IC₅₀ is 26.6 µg/mL .

HY-N12647

cis-Hinkiresinol	Structural Classification Liliaceae Source classification Phenols Polyphenols Anemarrhena asphodeloides Bunge Plants	Others
cis-Hinkiresinol is a bioactive constituent of Rhizoma anemarrhenae. Rhizoma anemarrhenae is reprted to have anti-pathogenic microorganism, hypoglycemic effects, anti-inflammatory, antipyretic effects and anti-platelet aggregation .

HY-N3048

Piperlotine D	Structural Classification Alkaloids Pyrrole Alkaloids Piper sarmentosum Roxb. Source classification Piperaceae Plants	Others
Piperlotine D is an antiplatelet aggregation agent. Piperlotine D can be extracted from Piper lolot with antiplatelet aggregation activity. Piperlotine D inhibits arachidonic acid-induced platelet aggregation with an IC₅₀ of 43.4 μg/mL .

HY-N7991

Rubiayannone A	Cardiovascular Disease Quinones Classification of Application Fields Anthraquinones Source classification Rubiaceae Phenols Polyphenols Rubia yunnanensis Diels Plants Disease Research Fields	Others
Rubiayannone A is an anthraquinone glycoside with an antiplatelet aggregation activity .

HY-N15271

Oxopurpureine	Structural Classification Alkaloids Source classification Plants Annonaceae Annona purpurea Moc. & Sessé ex Dunal Isoquinoline Alkaloids	Thrombin Platelet-activating Factor Receptor (PAFR)
Oxopurpureine is an oxoaporphine with **antiplatelet aggregation** activity. Oxopurpureine inhibits collagen, thrombin and arachidonic acid-induced platelet aggregation and can be utilized in relevant research .

HY-N3051

Piperlotine A	Cardiovascular Disease Alkaloids other families Pyrrole Alkaloids Classification of Application Fields Source classification Plants Disease Research Fields	Others
Piperlotine A is an alkaloid isolated from Piper lolot, with potent antiplatelet aggregation activity .

HY-N1861

3-O-Methylquercetin tetraacetate Quercetin 3-O-methyl ether peracetate	Rhamnus nakaharai (Hayata) Hayata Structural Classification Flavonoids Flavones Source classification Plants Rhamnaceae	P2Y Receptor
3-O-Methylquercetin tetraacetate is an antiplatelet agent. 3-O-Methylquercetin tetraacetate has potent antiplatelet effect on arachidonic acid, collagen-induced and PAF-induced platelet aggregation .

HY-N3668

Cyclomorusin Cyclomorusin A; Cyclomulberrochromene	Flavonoids Source classification Plants Moraceae Other Flavonoids Morus alba Linn.	Others
Cyclomorusin (Cyclomorusin A; Cyclomulberrochromene) is a prenylflavonoid with antiplatelet activity. Cyclomorusin also inhibits markedly collagen-induced platelet aggregation .

HY-N12995

α-Bulnesene	Structural Classification Entada phaseoloides (L.) Merr. Terpenoids Labiatae Sesquiterpenes Source classification Plants	Platelet-activating Factor Receptor (PAFR)
α-Bulnesene is a novel PAF receptor antagonist with the IC₅₀ of 17.62 μM. α-Bulnesene can be isolated from Pogostemon cablin. α-Bulnesene shows inhibitory effect on platelet-activating factor and arachidonic acid induced rabbit platelet aggregation .

HY-125123

Euchrestaflavanone A	Structural Classification Flavonoids Flavones Leguminosae Source classification Sophora alopecuroides L Plants	Integrin
Euchrestaflavanone A is a flavonoid found in the root bark of Cudrania tricuspidate. Euchrestaflavanone A inhibits platelet aggregation and has some antiplatelet and antithrombotic properties, making it a potential compound for thromboprophylaxis .

HY-N2081

Skimmianine 2 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Inflammation/Immunology Disease Research Fields	Others
Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-169788

Graveolinine	Structural Classification Alkaloids Source classification Ruta chalepensis var. latifolia Quinoline Alkaloids Plants Asparagaceae Juss.	Others
Graveolinine is a quinoline alkaloid, that can be isolated from Ruta chalepensis. Graveolinine exhibits antiplatelet activity, that reduces Arachidonic Acid (HY-109590)- and Collagen-induced aggregation of washed rabbit platelets .

HY-N11920

Kadsurenin B	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi	Platelet-activating Factor Receptor (PAFR)
Kadsurenin B is a PAF (platelet-activating factor) antagonist with neuroprotective activity. Kadsurenin B has a wide range of pharmacological research potential, such as antibacterial, anti-inflammatory, neuroprotective, antioxidant, antiplatelet aggregation, cytotoxic, antiparasitic, etc .

HY-Y0152

Cinchonine 3 Publications Verification (8R,9S)-Cinchonine; LA40221	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants Disease Research Fields Cancer	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-N2081R

Skimmianine (Standard)	Alkaloids Structural Classification Source classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort.	Others
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is a furoquinoline alkaloid present mainly in the Rutaceae family, with antispastic, anti-inflammatory activities and antiplatelet aggregation effect. Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity .

HY-124371

Amentoflavone hexaacetate	Structural Classification Flavonoids Viburnaceae Source classification Plants Biflavones Viburnum lantana L.	Phosphodiesterase (PDE)
Amentoflavone hexaacetate is a 3,5-cyclic nucleotide phosphodiesterase inhibitor with antiplatelet aggregation activity. Amentoflavone hexaacetate can inhibit the aggregation of eluted human platelets induced by ADP or collagen. Amentoflavone hexaacetate can also inhibit the cAMP phosphodiesterase activity in human platelets. Amentoflavone hexaacetate can significantly increase the cAMP level of platelets in the presence of prostaglandin E1. Amentoflavone hexaacetate has anti-angiogenic and anti-metastatic effects .

HY-N0293

Paeoniflorin Maximum Cited Publications 22 Publications Verification Peoniflorin	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	HSP
Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-N11905

Kadsurenin A	Structural Classification Source classification Lignans Piperaceae Phenylpropanoids Plants Piper kadsura (Choisy) Ohwi	Others
Kadsurenin A is a bioactive Lignan from the genus Piper L.

HY-Y0152R

Cinchonine (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Source classification Rubiaceae Cinchona calisaya Wedd. Quinoline Alkaloids Plants	Apoptosis Parasite Autophagy Caspase Calcium Channel
Cinchonine (Standard) is the analytical standard of Cinchonine. This product is intended for research and analytical applications. Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells .

HY-N0293R

Paeoniflorin (Standard)	Structural Classification Other Monoterpenes Paeonia lactiflora Pall. Terpenoids Source classification Plants Paeoniaceae	HSP
Paeoniflorin (Standard) is the analytical standard of Paeoniflorin. This product is intended for research and analytical applications. Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity .

HY-W017158R

Melilotic acid (Standard)	Structural Classification Monophenols Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Endogenous Metabolite
Vorapaxar (sulfate) (Standard) is the analytical standard of Vorapaxar (sulfate). This product is intended for research and analytical applications. Vorapaxar sulfate (SCH 530348 sulfate), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (Ki=8.1 nM). Vorapaxar sulfate inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-N2515

Ginsenoside Rk1 5+ Cited Publications	Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Inflammation/Immunology Disease Research Fields Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

HY-N2515R

Ginsenoside Rk1 (Standard)	Panax ginseng C. A. Meyer Triterpenes Structural Classification Terpenoids Source classification Plants Araliaceae	NF-κB PI3K JAK Apoptosis
Ginsenoside Rk1 (Standard) is the analytical standard of Ginsenoside Rk1. This product is intended for research and analytical applications. Ginsenoside Rk1 is a unique component created by processing the ginseng plant (mainly Sung Ginseng, SG) at high temperatures . Ginsenoside Rk1 has anti-inflammatory effect, suppresses the activation of Jak2/Stat3 signaling pathway and NF-κB . Ginsenoside Rk1 has anti-tumor effect, antiplatelet aggregation activities, anti-insulin resistance, nephroprotective effect, antimicrobial effect, cognitive function enhancement, lipid accumulation reduction and prevents osteoporosis . Ginsenoside Rk1 induces cell apoptosis by triggering intracellular reactive oxygen species (ROS) generation and blocking PI3K/Akt pathway .

Cat. No.	Product Name	Chemical Structure

HY-10119S

Vorapaxar-d5
Vorapaxar-d₅ is deuterated labeled Vorapaxar (HY-10119). Vorapaxar (SCH 530348), an antiplatelet agent, is a selective, orally active, and competitive thrombin receptor protease-activated receptor (PAR-1) antagonist (K_i=8.1 nM). Vorapaxar (SCH 530348) inhibits thrombin receptor-activating peptide (TRAP)-induced platelet aggregation in a dose-dependent manner .

HY-17459S

Clopidogrel-d3 hydrogen sulfate

Clopidogrel-d₃ (hydrogen sulfate) is the deuterium labeled Clopidogrel hydrogen sulfate[1]. Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[2][3][4][5][6].

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