Search Result
Results for "
aspergillus
" in MedChemExpress (MCE) Product Catalog:
4
Biochemical Assay Reagents
5
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-P2973
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aspergillus acid protease
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Others
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Others
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Aspergillopepsin I (Aspergillus acid protease) is an aspartic endopeptidase that catalyses the hydrolysis of peptide bonds in proteins, with broad specificity .
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- HY-B2228
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- HY-B2192A
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- HY-116909
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Others
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Others
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O-Methylsterigmatocystin is a metabolite in Aspergillus flavus and Aspergillus parasiticus .
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- HY-135849
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Reactive Oxygen Species
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Cancer
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Catalase, Aspergillus niger is a key enzyme in the metabolism of H2O2 and reactive oxygen species (ROS), and its expression and localization is markedly altered in tumors . Free oxygen radical scavenger.
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- HY-P2773
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DNA/RNA Synthesis
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Others
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Nuclease S1, Aspergillus oryzae is a specific endonuclease that degrades single stranded DNA (ssDNA) and RNA. Nuclease S1 can also remove protruding single-strand ends from double-stranded DNA .
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- HY-E70222
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Others
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Others
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Phytase, from Aspergillus niger degrades phytic acid into inositol and phosphate. Phytase, from Aspergillus niger phytase treatment can minimize the anti-nutritional effect of phytic acid .
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- HY-P2762
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Amylases
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Others
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α-Amylase from Aspergillus oryzae is an amylase. α-Amylase from Aspergillus oryzae can be used for various biochemical studies .
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- HY-E70326
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Endogenous Metabolite
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Others
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Acid Protease, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-E70332
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Endogenous Metabolite
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Others
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Lipase, Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-164620
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Fungal
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Infection
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Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candida albicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively .
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- HY-E70350
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Endogenous Metabolite
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Others
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Ribonuclease T2, Aspergillus oryzae is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-123006
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- HY-N8258
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- HY-N10235
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- HY-126657
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Fungal
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Infection
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Fumigaclavine A, a clavine alkaloid, is a Mycotoxin produced by Aspergillus fumigatus. A. fumigatus can be isolated from contaminating moldy silage .
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- HY-N12183
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Others
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Others
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Brevianamide Q (Compound 3) is an alkaloid derived from Aspergillus versicolor .
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- HY-122336
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Others
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Others
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Asperlicin D is a asperlicin productionfrom Aspergillus alliaceus strain (ATCC 20656) .
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- HY-N8846
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Fungal
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Infection
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dl-Aloesol is a natural product that can be isolated from fungus Aspergillus sp. Aspergillus sp metabolites has cytotoxic, antibacterial, free radical scavenging, anti-parasitic, antiviral and antiproliferative activities, etc .
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- HY-N12903
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Others
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Others
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Carnemycin B is an aryl C-glycoside and can be isolated from Aspergillus carneus .
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- HY-125723
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- HY-N3300
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- HY-N8267
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Others
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Others
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Territrem A is a shock-causing mycotoxin isolated from Aspergillus terreus .
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- HY-N12916
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Others
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Others
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Dihydrogeodin is a substrate of dihydrodixin oxidase and can be isolated from Aspergillus terreus .
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- HY-N8571
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Others
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Others
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6-Methoxyflavonol (Compound 15) is a natural flavone isolated from the marine-derived fungus Aspergillus candidus .
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- HY-N8552
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- HY-105713
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Bacterial
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Infection
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Sulochrin is a metabolite produced by Aspergillus terreus var. aureus. I. Sulochrin has antimicrobial activities .
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- HY-E70333
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AR2000
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Endogenous Metabolite
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Others
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Rapidase Revelation Aroma (AR2000), Aspergillus niger is a biocatalyst and a key enzyme in new biocatalyst technology. Enzyme engineering focuses on enhancing enzyme reaction kinetics, substrate selectivity, and activity under harsh conditions such as low or high pH. By introducing stimulus responsiveness to these enzyme modifications, dynamic control of activity is also possible .
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- HY-P0229
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Rnase T1
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DNA/RNA Synthesis
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Others
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Ribonulease T1, Aspergillus oryzae (Rnase T1), is commonly used in biochemical research. Ribonuclease T1 is an endonuclease that can specifically degrade single stranded RNA. Ribonuclease T1 can form nucleoside 2 ', 3 '-cyclic phosphoric acid intermediates to cut the phosphodiester bond between 3' -guanosine residues and adjacent nucleoside 5 '-OH groups to produce 3' -GMP terminal oligonucleotides .
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- HY-N10311
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Fungal
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Infection
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Neosartoricin B is the secondary metabolite, which can be produced by Aspergillus nidulans. Neosartoricin B may regulate immunomodulatory effects with the host during infection and colonization by pathogenic fungi .
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- HY-19404
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CS-758; R-120758
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Fungal
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Infection
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Embeconazole (CS-758; R-120758) is an antifungal agent against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively .
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- HY-108416
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Others
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Others
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5,7-Dihydroxy-4-methylphthalide is a key intermediate in the synthesis of Mycophenolic acid and a secondary metabolite of Aspergillus flavus .
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- HY-W077257
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- HY-P2857
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Amyloglucosidase; 1,4-α-D-Glucan glucohydrolase; Exo-1,4-α-glucosidase
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Others
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Metabolic Disease
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Amyloglucosidase, Aspergillus niger is an enzyme derived from many sources including plants, animals and microorganisms, can be use for industrial production. Amyloglucosidase can be widely used for starch saccharification, brewing and distilling industry .
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- HY-121133
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Endogenous Metabolite
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Others
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(-)-Cyclopenol is a fungal metabolite isolated from an Australian marine-derived isolate of Aspergillus versicolor (MST-MF495) .
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- HY-P0068
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HMR 3270; IP960; NXL201
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Fungal
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Infection
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Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .
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- HY-127157
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Others
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Others
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Aspterric acid is a carotane compound, which is initially isolated from Aspergillus terreus. Aspterric acid is an inhibitor for pollen development in Arabidopsis thaliana .
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- HY-N8520
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Bacterial
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Infection
Cancer
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Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .
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- HY-N7780
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Others
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Neurological Disease
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Aflatrem is a mycotoxin that can be isolated from Aspergillus flavus. Aflatrem has acute neurotoxic effects and can be ued in neurological disease .
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- HY-N12056
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Fungal
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Infection
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Cyclo(L-leucyl-L-valyl) inhibits Aflatoxin production by Aspergillus parasiticus.Cyclo(L-leucyl-L-valyl) inhibits transcription of the Aflatoxin-related genes aflR, hexB, pksL1, and dmtA. .
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- HY-E70396
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Others
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Others
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Pectolyase Y-23, A. japonicus is an enzyme derived from Aspergillus japonicas. Pectolyase Y-23, A. japonicus can be used in combination with cellulase to isolate bioactive protoplasts .
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- HY-P2871
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EC 3.2.1.22
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Endogenous Metabolite
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Others
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α-Galactosidase, Aspergillus niger (EC 3.2.1.22), that is, α-galactosidase, is a glycoside hydrolase that widely exists in animals, plants and microorganisms, and is often used in biochemical research. α-Galactosidase catalyzes the hydrolysis of α-1,6-linked terminal galactose residues, including galactooligosaccharides, galactomannans, and galactolipids. Catalyzes many catabolic processes including cleavage of glycoproteins, glycolipids and polysaccharides .
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- HY-125538
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- HY-N7312
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(-)-Ditryptophenaline
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Neurokinin Receptor
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Inflammation/Immunology
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Ditryptophenaline ((-)-Ditryptophenaline) is the metabolites of Aspergillus flavus. Ditryptophenaline inhibits substance P receptor and has anti-inflammatory activity .
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- HY-135154
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GABA Receptor
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Neurological Disease
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epi-Aszonalenin A is a benzodiazepine fungal metabolite originally isolated from Aspergillus novofumigatus. epi-Aszonalenin A can be used as a psychoactive agent .
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- HY-126795
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Fungal
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Infection
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Aspergillin PZ is a novel isoindole-alkaloid from Aspergillus awamori. Aspergillin PZ induces conidia of P. oryzae to deform moderately .
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- HY-123519
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Others
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Infection
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14α-Hydroxy Paspalinine is a paspalinine derivative with antiinsectan activity from the sclerotia of Aspergillus nomius .
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- HY-122367
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Bacterial
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Neurological Disease
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Neoxaline is an alkaloid produced by Aspergillus japonicus. Neoxaline does not possess antimicrobial activities, but weakly stimulates the central nervous system .
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- HY-N11989
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Others
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Cancer
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Nanangenine B is a sesquiterpenoid, which can be isolated from Aspergillus nanangensis. Nanangenine B exhibits cytotixicity in cancer cell NS-1 with an IC50 of 38 μg/mL .
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- HY-N3687
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Others
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Cancer
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Dasycarpol (compound 2) is a product of microbial transformation of fraxinellone by Aspergillus niger (AS 3.421). Dasycarpol shows moderate cytotoxicity against A549 cells ,with the IC50 of 20 ug/mL .
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- HY-121463
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Bacterial
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Infection
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Rubrosulphin is a fungal metabolite, which can be isolated from Aspergillus sp.. Rubrosulphin exhibits slight anti-tuberculosis activity, inhibits Mycobacterium bovis and M. smegmatis with MIC >200 µg/mL .
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- HY-N12179
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Bacterial
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Others
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Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .
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- HY-113542
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(+)-Blasticidin A
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Bacterial
Antibiotic
Parasite
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Infection
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Blasticidin A ((+)-Blasticidin A) is an inhibitor of Aflatoxin production by Aspergillus parasiticus. Blasticidin A almost completely inhibits Aflatoxin production at 0.5 μM . Blasticidin A is a potent antibiotic produced by Streptomyces, inhibits Aflatoxin production without strong growth inhibition toward Aflatoxin-producing fungi .
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- HY-123161
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Others
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Others
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JBIR-15 is a new aspochracin derivative. JBIR-15 is isolated from a sponge-derived fungus, Aspergillus sclerotiorum Huber Sp080903f04 .
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- HY-N8908
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Others
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Infection
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2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus .
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- HY-117934
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Drug Metabolite
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Infection
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Isokotanin B is a metabolite of bicoumarin isolated from the sclerotia of Aspergillus alliaceus. Isokotanin B shows activity against the corn earworm Helicoverpa zea and the dried fruit bettle Carpophilus hemipterus .
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- HY-124874
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(rel)-Aspergillimide; (rel)-VM55598
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nAChR
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Neurological Disease
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(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms .
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- HY-N8512
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Fungal
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Infection
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Asperfuran is an antifungal dihydrobenzofuran derivative produced by a strain of Aspergillus oryzae. Asperfuran weakly inhibits chitin synthase from Coprinus cinereus. Asperfuran shows weak cytotoxicity In HeLa S3 and L1210 cells with an IC50 of 25 μg/ml .
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- HY-101399
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γ-Glutamylphenylalanine
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Endogenous Metabolite
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Others
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γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
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- HY-N6181
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Others
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Endocrinology
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Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .
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- HY-W099579
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Kojic dipalmitate
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-101399A
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γ-Glutamylphenylalanine TFA
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Endogenous Metabolite
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Others
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γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
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- HY-169119
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Cytochrome P450
Fungal
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Infection
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Antifungal agent 114 (Compound 19g) is an inhibitor for Cytochrome P450, that inhibits CYP1A2, CYP2C9, CYP2C19 CYP2D6 and CYP3A4 at 10 μM. Antifungal agent 114 exhibits antifungal activity against Cryptococcus neoformans, Candida and Aspergillus, with MIC <0.0625 μg/mL. Antifungal agent 114 exhibits good metabolic stability in human liver microsomes with a half-time of 107 minutes .
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- HY-114664
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HSP
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Infection
Cancer
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KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research .
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- HY-122467
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Bacterial
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Infection
Cancer
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Kumbicin C is a bis-indolyl benzenoid compound from an Australian soil fungus, Aspergillus kumbius. Kumbicin C inhibits the growth of mouse myeloma cells and the Gram-positive bacterium Bacillus subtilis .
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- HY-N12614
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Phosphatase
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Metabolic Disease
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Diorcinol is a potent SHP1 inhibitor with an IC50 value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research .
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- HY-W099579R
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Tyrosinase
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Endocrinology
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Kojic acid dipalmitate (Standard) is the analytical standard of Kojic acid dipalmitate. This product is intended for research and analytical applications. Kojic acid dipalmitate (Kojic dipalmitate) is a derivative of Kojic acid (HY-W050154), a fungal metabolite that can be produced by species of Aspergillus, Acetobacter and Penicillium. Kojic acid dipalmitate is a slow and reversible competitive inhibitor of tyrosinase. Kojic acid dipalmitate can be used for skin‐lightening agent research .
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- HY-114220
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Fungal
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Infection
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T-2307, an arylamidine, has antifungal activities in vitro and in vivo. T-2307 exhibits broad-spectrum activity against clinically significant pathogens, including Candida species (MIC range, 0.00025 to 0.0078 μg/ml), Cryptococcus neoformans (MIC range, 0.0039 to 0.0625 μg/ml), and Aspergillus species (MIC range, 0.0156 to 4 μg/mL) .
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- HY-146024
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Fungal
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Infection
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Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .
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- HY-W320276
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Endogenous Metabolite
Bacterial
Parasite
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Infection
Others
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Dill apiole is an aromatic ether, which is an important aroma component in herbs and spices such as dill (Anethum graveolens), parsley (Petroselinum crispum) and basil (Perilla frutescens). Dill apiole exhibits antimicrobial activity against Aspergillus parasiticus and Aedes aegypti .
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- HY-N10268
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NSC 299113
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Apoptosis
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Cancer
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3-Hydroxyterphenyllin is a metabolite of Aspergillus candidus.3-Hydroxyterphenyllin suppresses proliferation and causes cytotoxicity against A2780/CP70 and OVCAR-3 cells. 3-Hydroxyterphenyllin induces S phase arrest and apoptosis. 3-Hydroxyterphenyllin has the potential for the research of ovarian cancer .
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- HY-146464
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Fungal
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Infection
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Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .
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- HY-N12264
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Antibiotic
Bacterial
Fungal
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Infection
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Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
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- HY-P2124
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Antibiotic
Bacterial
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Infection
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Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
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- HY-109706
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Bacterial
Fungal
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Infection
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(Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans .
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- HY-116132
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- HY-126386
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EC 3.2.1.15
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Others
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Others
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Pectinase (EC 3.2.1.15) is a mixed enzymes that hydrolyze pectic substances, it mostly presents in microorganisms and higher plants. Pectinase is involved in the metabolism of the cell wall as well as in the growth of the cell, senescence, ripening of fruits, pathogenesis and abscission process .
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- HY-W068682
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Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin
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Amylases
Bacterial
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Infection
Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
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- HY-N10080
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- HY-N10193
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- HY-N10257
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- HY-111238
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- HY-N9713
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Others
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Others
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Dihydroxyaflavinine (Compound Ⅲ) is an indole metabolite extracted from Aspergillus flavus .
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- HY-N12197
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Others
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Others
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Terretonin A is a meroterpenoid that can be isolated from the endophytic fungus Aspergillus terreus .
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- HY-133196
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Others
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Others
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Ustusolate A is a Sesquiterpenoids product that can be isolated from From Aspergillus ustus .
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- HY-N7609
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Bacterial
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Infection
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Kipukasin D is an natural nucleoside derived from Aspergillus versicolor with antibacterial activity .
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- HY-N12181
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Others
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Others
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Brevianamide R (compound 4) is an alkaloid isolated from Aspergillus versicolor on fermented rice .
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- HY-133709
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Others
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Others
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β-Aflatrem is a Diterpenoids product that can be isolated from From Aspergillus flavus .
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- HY-N11541
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Didemethylasperxanthone
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Others
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Others
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Norrubrofusarin (Didemethylasperxanthone) is a natural product that can be obtained by demethylation of the metabolite (Compound III) of Aspergillus nige .
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- HY-137141
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SB202327
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Parasite
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Infection
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16-Keto Aspergillimide (SB202327) is an anthelmintic agent isolated from Aspergillus strain IMI 337664 .
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- HY-E70105
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AxlA
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Others
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Others
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α-Xylosidase (AxlA) belongs to the GH31 family of glycoside hydrolases and catalyzes the hydrolysis of an α1,6-linked xyloside. α-Xylosidase can effectively release terminal xylose from xyloglucan, a major plant hemicellulose .
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- HY-U00249
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R66905
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Fungal
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Infection
|
|
Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
|
-
- HY-116671
-
|
|
Phospholipase
|
Others
|
|
Folipastatin is a potent inhibitor of phospholipase A2 with an IC50 of 39 μM. Folipastatin is a new depsidone compound from Aspergillus unguis .
|
-
- HY-N12389
-
|
|
Fungal
|
Infection
|
|
Quellenin is an anti-saprolegnia compound. Quellenin can be isolated from deep-sea fungus Aspergillus sp. YK-76
|
-
- HY-N1734
-
|
|
Others
|
Others
|
|
2-Hydroxydiplopterol is a Triterpenoids product that can be isolated from the metabolites of the fungal strain Aspergillus variecolor B-17. .
|
-
- HY-N7078
-
|
|
Biochemical Assay Reagents
|
Others
|
|
Spiculisporic acid is a γ-butenolide isolated from the cultue of Aspergillus sp . Spiculisporic acid is a microbial biosurfactant and has anti-oxidative stress actions .
|
-
- HY-126765
-
-
- HY-111357
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL.
|
-
- HY-P5569
-
|
|
Fungal
|
Infection
|
|
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
|
-
- HY-N12727
-
|
|
Bacterial
|
Infection
|
|
Okaramine I is an Escherichia coli glycosyltransferase (MurG) inhibitor. Okaramine I can be used as an antibacterial agent. Okaramine I can be found in Aspergillus aculeatus .
|
-
- HY-119821
-
|
|
Glucosidase
|
Infection
|
|
Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has significant α-glucosidase inhibitory activity .
|
-
- HY-126603
-
|
|
Others
|
Infection
|
|
Asperlactone has anti-inflammatory activity. Asperlactone inhibits superoxide anion generation. Asperlactone is a fungal metabolite that can be isolated from isolated from Aspergillus ochraceus .
|
-
- HY-W357146
-
|
Phenethyl β-D-galactoside
|
Others
|
Others
|
|
2-Phenylethyl β-D-galactopyranoside (Phenethyl β-D-galactoside) can be synthesized catalyzed by Aspergillus oryzae β-galactosidase .
|
-
- HY-N8894
-
|
(-)-Isolariciresinol 3α-O-β-D-glucopyranoside
|
Others
|
Others
|
|
(-)-Isolariciresinol 9'-O-glucoside ((-)-Isolariciresinol 3α-O-β-D-glucopyranoside) is a Diterpenoids product that can be isolated from From Aspergillus flavus .
|
-
- HY-125694
-
|
|
Fungal
|
Infection
|
|
MFB-1041 is an orally active antifungal agent, but exhibits poor oral absorption. MFB-1041 induces the binding of drug to serum albumin .
|
-
- HY-108009
-
|
Biafungin; CD101; SP-3025
|
Fungal
|
Infection
|
|
Rezafungin (Biafungin) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
|
-
- HY-108009A
-
|
Biafungin acetate; CD101 acetate; SP-3025 acetate
|
Fungal
|
Infection
|
|
Rezafungin acetate (Biafungin acetate) is a next-generation, broad-spectrum, and long-lasting echinocandin. Rezafungin acetate shows potent antifungal activity against Candida spp., Aspergillus spp., and Pneumocystis spp. .
|
-
- HY-P10588
-
|
|
Neurokinin Receptor
|
Others
|
|
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and NK2 receptors .
|
-
- HY-N7585
-
|
|
Others
|
Others
|
|
Ustusolate C is a drimane sesquiterpene that can be isolated from Aspergillus ustus 094102
. Ustusolate C exhibits moderate cytotoxicity against A549 cells with an IC50 of 10.5 μM .
|
-
- HY-107126B
-
|
MK 3118 phosphate; SCY-078 phosphate
|
Fungal
|
Infection
|
|
Ibrexafungerp phosphate is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp phosphate can be used for research of Candida and Aspergillus infections .
|
-
- HY-N6783
-
|
|
Fungal
Antibiotic
|
Infection
|
|
Oligomycin C is a macrolide antibiotic produced by Streptomyces strains. Oligomycin C exhibits a strong activity against Aspergillus niger, Alternaria alternata, Botrytis cinerea and Phytophthora capsici but no activity toward bacteria .
|
-
- HY-133101
-
|
|
Others
|
Cancer
|
|
14-Norpseurotin is a compound isolated from the culture of Aspergillus fumigatus. 14-Norpseurotin significantly induces neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration .
|
-
- HY-107126
-
|
MK 3118; SCY-078
|
Fungal
|
Infection
|
|
Ibrexafungerp (MK 3118) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp can be used for research of Candida and Aspergillus infections .
|
-
- HY-113614
-
|
|
Bacterial
|
Infection
|
|
Tetrahydrobostrycin is a secondary metabolite from Aspergillus sp., which exhibits a weak inhibitory activity against Staphylococcus aureus and Escherichia coli (100 mg/disc with the inhibition zones of 15 and 9.2 mm in diameter) .
|
-
- HY-N6786
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
|
-
- HY-125916
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Pseurotin A, a secondary metabolite of Aspergillus and other fungi, is a competitive inhibitor of chitin synthase and a neuritogenic agent. Pseurotin A inhibits IgE production (IC50=3.6 μM). Antitumor activity .
|
-
- HY-N7569
-
|
|
Apoptosis
Caspase
PPAR
|
Cancer
|
|
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .
|
-
- HY-104029
-
|
F901318
|
Fungal
|
Infection
|
|
Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp. .
|
-
- HY-N12877
-
|
|
Bacterial
|
Infection
|
|
Ophiobolin H is a fungal metabolite that can be isolated from Aspergillus ustus. Ophiobolin H inhibits growth of Bacillus subtilis cultures. Ophiobolin H induces hyperacusia in day-old chicks at rates up to 375 mg/kg .
|
-
- HY-122785
-
|
|
Others
|
Infection
|
|
Fusapyrone is a broad-spectrum antifungal metabolite first isolated from Fusarium species. It has been investigated for use in the control of postharvest crop diseases such as inhibiting the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes.
|
-
- HY-N8406
-
|
|
Bacterial
Antibiotic
|
Infection
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
|
-
- HY-107126A
-
|
MK 3118 citrate; SCY-078 citrate
|
Fungal
|
Infection
|
|
Ibrexafungerp citrate (MK 3118 citrate) is an orally active β-1,3-glucan synthesis inhibitor, with potential antifungal activity. Ibrexafungerp citrate is an investigational agent for the treatment of Candida and Aspergillus infections .
|
-
- HY-N6772
-
|
|
Autophagy
|
Cancer
|
|
Cytochalasin E, an epoxide containing Aspergillus-derived fungal metabolite, inhibits angiogenesis and tumor growth. Cytochalasin E is a potent actin depolymerization agent, and it binds and caps the barbed end of actin filaments to prevent actin elongation .
|
-
- HY-P2996
-
|
|
Others
|
Others
|
|
NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
|
-
- HY-W010476S1
-
-
- HY-123888
-
|
|
Others
|
Cancer
|
|
Viomellein is an anticancer compound produced by the fungus Aspergillus ochraceus isolated from the Mediterranean sponge Agelas oroides. Viomellein exhibits cytotoxicity against A2780 human ovarian cancer cells with an IC50 value of 5.0 μM .
|
-
- HY-B0751
-
|
Amebacilin; NSC9168
|
Parasite
HIV
Antibiotic
|
Infection
|
|
Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
|
-
- HY-N6688
-
|
|
Potassium Channel
Bacterial
Antibiotic
|
Infection
|
|
Verruculogen is a toxin produced mainly by Penicillium and Aspergillus spp. and causes severe tremors in affected animals. Verruculogen inhibits Ca 2+-activated K + channels. Verruculogen is an M phase inhibitor of the mammalian cell cycle .
|
-
- HY-N6777
-
|
|
Caspase
Bacterial
Apoptosis
Antibiotic
|
Infection
Cancer
|
|
Penicillic acid is a polyketide mycotoxin produced by several species of Aspergillus and Penicillium. Penicillic acid exhibits cytotoxicity in rat alveolar macrophages (AM) in vitro. Penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 .
|
-
- HY-N10272
-
|
|
Fungal
Bacterial
|
Infection
|
|
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .
|
-
- HY-N12534
-
|
|
Apoptosis
|
Cancer
|
|
Monaspin B is a natural product produced by the co-culture of Monascus purpureus and Aspergillus oryzae. Monaspin B exerts anti-proliferation activity by inducing apoptosis of HL-60 cells, IC50 160 nM. Monaspin B has antitumor activity .
|
-
- HY-N6779
-
Patulin
3 Publications Verification
Terinin
|
Bacterial
Apoptosis
Autophagy
Antibiotic
|
Infection
|
|
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
|
-
- HY-N6725
-
-
- HY-129578
-
-
- HY-159809
-
|
|
Others
|
Infection
Inflammation/Immunology
|
|
Antibacterial agent 249 demonstrates broad-spectrum antimicrobial properties, effectively inhibiting the growth of Aspergillus niger, Bacillus subtilis, Pseudomonas albicans, Escherichia coli, and Staphylococcus aureus, while also exhibiting anti-inflammatory activity in vitro, making it a potential candidate for treating bacterial infections.
|
-
- HY-N1063
-
|
Xanthoxyline
|
Fungal
|
Infection
Metabolic Disease
|
|
Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .
|
-
- HY-137990
-
|
|
Bacterial
|
Infection
|
|
Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 µg/mL, 62.5 µg/mL, 62.5 µg/mL, and 125 µg/mL .
|
-
- HY-W013973
-
|
|
Fungal
|
Cancer
|
|
p-Terphenyl is a p-terphenyl that can be isolated from Aspergillus of the genus Thelephora. p-Terphenyl showed significant anti-tumor and anti-metastatic effects in xenograft models of gastric and pancreatic cancer. Derivatives of p-Terphenyl also have anti-inflammatory or anti-proliferative effects .
|
-
- HY-N8285
-
|
|
Parasite
|
Infection
|
|
Sporogen AO-1 is a fungal metabolite originally isolated from the fungusAspergillus oryzae. Sporogen AO-1 has significant antimalarial activity againstplasmodium falciparum, with an IC50 value of 1.53 μM, and also has certain cytotoxicity .
|
-
- HY-E70107
-
|
Cbh1
|
Others
|
Others
|
|
Cellobiohydrolase I (Cbh1) belongs to glycoside hydrolase family 7 (GH7) that catalyzes the processive hydrolysis of cellulose into cellobiose .
|
-
- HY-119728
-
|
|
Influenza Virus
|
Infection
|
|
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC50 of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .
|
-
- HY-P2274
-
|
|
Parasite
|
Infection
|
|
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .
|
-
- HY-N10281
-
|
|
Bacterial
|
Infection
|
|
Asperglaucin B is an alkylated salicylaldehyde derivative from the fungus Aspergillus chevalieri SQ-8, with antibacterial activities. Asperglaucin B displays potent antibacterial activities against two plant pathogens Pseudomonas syringae pv actinidae (Psa) and Bacillus cereus, with an MIC value of 6.25 μM .
|
-
- HY-P2569
-
|
|
Apoptosis
|
Cancer
|
|
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .
|
-
- HY-N12196
-
|
|
Others
|
Infection
|
|
Terretonin is a fungal terpenoid isolated from Aspergillus terreus. The complete biosynthetic pathway of terretonin includes: cytochrome P450 Trt6 catalyzes the oxidation of terrenoid to obtain an unstable intermediate; then it is catalyzed by isomerase Trt14 and processed by non-heme iron-dependent dioxygenase Trt7 to complete the biosynthesis of terretonin .
|
-
- HY-N6786R
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Ochratoxin B (Standard) is the analytical standard of Ochratoxin B. This product is intended for research and analytical applications. Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
|
-
- HY-B0751R
-
|
|
Parasite
HIV
Antibiotic
|
Infection
|
|
Fumagillin (Standard) is the analytical standard of Fumagillin. This product is intended for research and analytical applications. Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
|
-
- HY-P2996A
-
|
|
Others
|
Others
|
|
Nitrate Reductase, Arabidopsis thaliana is the isomer of NAD(P)H-Nitrate reductase (HY-P2996). NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants，the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .
|
-
- HY-135422
-
|
Methylustin
|
Bacterial
Fungal
|
Infection
|
|
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
|
-
- HY-N6786S
-
|
|
Isotope-Labeled Compounds
|
Cancer
|
|
Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
|
-
- HY-N6725R
-
|
|
DNA/RNA Synthesis
Bacterial
Apoptosis
Antibiotic
Endogenous Metabolite
|
Infection
Cancer
|
|
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
|
-
- HY-N1952S
-
|
iso-Eugenol-d3
|
Bacterial
Isotope-Labeled Compounds
|
Infection
|
|
Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
|
-
- HY-N6779R
-
|
|
Bacterial
Apoptosis
Autophagy
Antibiotic
|
Infection
|
|
Patulin (Standard) is the analytical standard of Patulin. This product is intended for research and analytical applications. Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
|
-
- HY-147804
-
|
|
SARS-CoV
Bacterial
Fungal
|
Infection
|
|
SARS-CoV-2 3CLpro-IN-3 (Compound 3d) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities .
|
-
- HY-109125A
-
|
SPA-S-753; SPA-S-752 L-aspartate
|
Antibiotic
Fungal
|
Infection
|
|
Amcipatricin diaspartate (SPA-S-753) is a semi-synthetic polyene antibiotic, with potent broad-spectrum antifungal activity .
|
-
- HY-P2902
-
|
|
Endogenous Metabolite
|
Cancer
|
|
Glucose oxidase is used in the food and beverage industry as a preservative and stabilizer and is commonly derived from the fungus Aspergillus niger. Glucose oxidase can react with intracellular glucose and oxygen (O2) to produce hydrogen peroxide (H2O2) and gluconic acid, which can cut off the nutrition source of cancer cells and consequently inhibit their proliferation .
|
-
- HY-121003
-
|
|
Fungal
Parasite
|
Infection
|
|
Aspyrone is a polyketide fungal metabolite that has been found in Aspergillus and has diverse biological activities. It is active against a panel of 13 fungi when used at a concentration of 20 μg/mL and a panel of 21 bacteria in a disc assay when used at a concentration of 100 μg per disc.1 Aspyrone (10-1,000 mg/L) is nematocidal against P. penetrans.
|
-
- HY-136153
-
|
|
Fungal
|
Infection
|
|
Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively .
|
-
- HY-N11576
-
|
|
Apoptosis
GSK-3
c-Myc
β-catenin
|
Cancer
|
|
Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis .
|
-
- HY-W013973R
-
|
|
Fungal
|
Cancer
|
|
p-Terphenyl (Standard) is the analytical standard of p-Terphenyl. This product is intended for research and analytical applications. p-Terphenyl is a p-terphenyl that can be isolated from Aspergillus of the genus Thelephora. p-Terphenyl showed significant anti-tumor and anti-metastatic effects in xenograft models of gastric and pancreatic cancer. Derivatives of p-Terphenyl also have anti-inflammatory or anti-proliferative effects .
|
-
- HY-N6779S
-
|
Terinin-13C7
|
Isotope-Labeled Compounds
|
Infection
|
|
Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
|
-
- HY-135445
-
|
21-Norrapamycin
|
Fungal
|
Infection
|
|
Prolylrapamycin (21-Norrapamycin) is the derivative of Rapamycin (HY-10219). Prolylrapamycin exhibits antifungal activity, that inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum with MIC of 0.125-2 μg/mL .
|
-
- HY-103027
-
|
5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido-1,5-dideoxy-1-(3,4-dihydro-5-hydroxymethyl-2,4-dioxo-1(2H)-pyrimidinyl)-β-D-allofuranuronic acid
|
Fungal
|
Infection
Inflammation/Immunology
|
|
Polyoxin B is a potent chitin synthase inhibitor (IC50=0.08 mM) and an effective antifungal agent .
|
-
- HY-117766
-
|
|
Fungal
Cytochrome P450
|
Infection
|
|
PC945, a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. PC945 is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively .
|
-
- HY-119387
-
|
|
Bacterial
|
Infection
|
|
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.
|
-
- HY-B0856
-
|
|
Fungal
Tyrosinase
Antibiotic
|
Infection
|
|
Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM .
|
-
- HY-101399S
-
|
γ-Glutamylphenylalanine-13C9,15N
|
Isotope-Labeled Compounds
|
Others
|
|
γ-Glu-(Phe- 13C9, 15N) is the 13C and 15N labeled isotope of γ-Glu-Phe(HY-101399).γ-Glu-Phe or the postenzymatic reaction mixture enhanced the umami intensity of commercial soy sauce and model chicken soup.
|
-
- HY-B0856R
-
|
|
Fungal
Tyrosinase
Antibiotic
|
Infection
|
|
Validamycin A (Standard) is the analytical standard of Validamycin A. This product is intended for research and analytical applications. Validamycin A, a fungicidal, is an agricultural antibiotic. Validamycin A is originally isolated from Streptomyces hygroscopicus var. limoneus. Validamycin A inhibits the growth of A. flavus, with a MIC of 1 μg/mL . Validamycin A shows potent inhibitory activity against trehalase of Rhizoctonia solani, with an IC50 of 72 μM . Validamycin A is a reversible tyrosinase inhibitor, with a Ki of 5.893 mM .
|
-
- HY-B1324A
-
|
Ro 13-8996 free base
|
Fungal
Cytochrome P450
Antibiotic
|
Infection
Cancer
|
|
Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
|
-
- HY-P10329
-
|
|
Fungal
|
Infection
|
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
-
- HY-N7236
-
|
|
Parasite
Fungal
|
Infection
|
|
Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases .
|
-
- HY-B1324
-
|
Ro 13-8996
|
Fungal
Cytochrome P450
Antibiotic
|
Infection
Cancer
|
|
Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
|
-
- HY-Y0337A
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) .
|
-
- HY-147814
-
|
|
Bacterial
Fungal
|
Infection
|
|
KFU-127 (Compound 6b) is a broad spectrum topical antimicrobial capable of one-shot targeting of bacterial and fungal-bacterial biofilms. KFU-127 is considerably toxic for eukaryotic cells . KFU-127 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-146023
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .
|
-
- HY-158402
-
|
|
Bacterial
Fungal
|
Infection
Inflammation/Immunology
|
|
Anti-inflammatory agent 84 (Compound 4D) is a derivative of Coumarin (HY-N0709) with antimicrobial and anti-inflammatory activities. Anti-inflammatory agent 84 inhibits E. coli, Candida albicans, Staphylococcus aureus and methicillin-resistant S. aureus (MRSA), with MIC of 312, 156, 19 and 316 μg/mL, respectively. Anti-inflammatory agent 84 inhibits biofilm formation of S. aureus, E. coli and MRSA, with IC50 of 185, 321 and 99 μM, respectively. Anti-inflammatory agent 84 inhibits nitric oxide production in Lipopolysaccharide (HY-D1056)-stimulated RAW264.7 macrophage cell .
|
-
- HY-N2544
-
-
- HY-W050154
-
|
|
Parasite
Tyrosinase
NF-κB
CDK
|
Infection
Inflammation/Immunology
Cancer
|
|
Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity .
|
-
- HY-W162983
-
|
|
Others
|
Neurological Disease
Inflammation/Immunology
|
|
3,4-Diphenyl-5H-furan-2-one is a natural compound isolated from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. 3,4-Diphenyl-5H-furan-2-one is a derivative of 2,3-diphenyltetrahydrofuran (DPTF), which is a COX-2 inhibitor. 3,4-Diphenyl-5H-furan-2-one can be used as a lead compound for inflammation and pain .
|
-
- HY-B1324R
-
|
|
Fungal
Cytochrome P450
Antibiotic
|
Infection
Cancer
|
|
Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest .
|
-
- HY-Y0337AR
-
|
|
Endogenous Metabolite
|
Metabolic Disease
Cancer
|
|
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].
|
-
- HY-147805
-
|
|
SARS-CoV
Bacterial
Fungal
|
Infection
|
|
SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities .
|
-
- HY-124902
-
|
|
Antibiotic
Fungal
Bacterial
|
Infection
|
|
Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans.
|
-
- HY-W050154R
-
|
|
Parasite
Tyrosinase
NF-κB
CDK
|
Infection
Inflammation/Immunology
Cancer
|
|
Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .
|
-
- HY-P0263A
-
|
|
Bacterial
Fungal
|
Infection
|
|
Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .
|
-
- HY-138050
-
|
(-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol
|
NO Synthase
Bacterial
Fungal
Parasite
Leukotriene Receptor
|
Infection
Inflammation/Immunology
|
|
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
|
-
- HY-Y0790R
-
|
|
Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
α-synuclein
Lipoxygenase
Opioid Receptor
Interleukin Related
TNF Receptor
|
Infection
Neurological Disease
Inflammation/Immunology
Cancer
|
|
Cuminaldehyde (Standard) is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL) and α-glucosidase (IC50=0.5 mg/mL). Cuminaldehyde can modulate α-synuclein fibrils. Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
|
-
- HY-W104752
-
-
- HY-153624
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-B2228
-
-
- HY-W013973
-
|
|
Biochemical Assay Reagents
|
|
p-Terphenyl is a p-terphenyl that can be isolated from Aspergillus of the genus Thelephora. p-Terphenyl showed significant anti-tumor and anti-metastatic effects in xenograft models of gastric and pancreatic cancer. Derivatives of p-Terphenyl also have anti-inflammatory or anti-proliferative effects .
|
-
- HY-N10272
-
|
|
Microbial Culture
|
|
Avenaciolide is an antifungal bis-γ-lactone found in Aspergillus avenaceus. Avenaciolide has also antibacterial action. Avenaciolide is a specific inhibitor of glutamate transport in rat liver mitochondria. Avenaciolide interferes with the ability of ADP to stimulate the rate of glutamate oxidation .
|
-
- HY-W013973R
-
|
|
Biochemical Assay Reagents
|
|
p-Terphenyl (Standard) is the analytical standard of p-Terphenyl. This product is intended for research and analytical applications. p-Terphenyl is a p-terphenyl that can be isolated from Aspergillus of the genus Thelephora. p-Terphenyl showed significant anti-tumor and anti-metastatic effects in xenograft models of gastric and pancreatic cancer. Derivatives of p-Terphenyl also have anti-inflammatory or anti-proliferative effects .
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-101399
-
|
γ-Glutamylphenylalanine
|
Endogenous Metabolite
|
Others
|
|
γ-Glu-Phe (γ-Glutamylphenylalanine) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
|
-
- HY-101399A
-
|
γ-Glutamylphenylalanine TFA
|
Endogenous Metabolite
|
Others
|
|
γ-Glu-Phe TFA (γ-Glutamylphenylalanine TFA) is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .
|
-
- HY-P2124
-
|
|
Antibiotic
Bacterial
|
Infection
|
|
Cyclo(L-Trp-L-Trp) is an antibiotic, and shows antimicrobial activity. Cyclo(L-Trp-L-Trp) can inhibit A. baumannii, as well as Candida albicans, Bacillus subtilis, Micrococcus luteus, Saccharomyces cerevisiae, Aspergillus niger, Staphylococcus aureus. Cyclo(L-Trp-L-Trp) can be used in microbial infection research .
|
-
- HY-P2274
-
|
|
Parasite
|
Infection
|
|
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .
|
-
- HY-P0068
-
|
HMR 3270; IP960; NXL201
|
Fungal
|
Infection
|
|
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .
|
-
- HY-P5640
-
|
|
Peptides
|
Infection
|
|
Tritrpticin is an antimicrobial peptide derived from pig bone marrow. Tritrpticin shows activity against Aspergillus fumigatus and Candida albicans (MIC=250 and 1000 μg/ml, respectively) .
|
-
- HY-P5569
-
|
|
Fungal
|
Infection
|
|
SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
|
-
- HY-P10588
-
|
|
Neurokinin Receptor
|
Others
|
|
WIN 66306 is a cyclic heptapeptide that can be isolated from an Aspergillus species. WIN 66306 is a neurokinin antagonist with antagonistic effects on both NK1 and NK2 receptors .
|
-
- HY-P2005
-
|
|
Peptides
|
Others
|
|
Malformin C is an algicidal peptide can be isolated from Aspergillus and exhibits dose-dependent algicidal activity. Malformin C induces a significant increase in ROS levels in algal cells, resulting in impaired SOD activity and high production of MDA content .
|
-
- HY-P2569
-
|
|
Apoptosis
|
Cancer
|
|
Malformin A1, a cyclic pentapeptide isolated from Aspergillus niger, possess a range of bioactive properties including antibacterial activity. Malformin A1 shows potent cytotoxic activities on human colorectal cancer cells. Malformin A1 induces apoptosis by activating PARP, caspase 3, -7, and -9 .
|
-
- HY-P10329
-
|
|
Fungal
|
Infection
|
|
KK14(R) is an analog of the de novo synthetic peptide KK14, which exhibits antifungal activity against Fusarium culmorum, Penicillium expansum and Aspergillus niger , with MICs of 6.25, 12.5 and 12.5 μg/mL, respecitvely. KK14(R) exhibits good heat- and pH-stability. KK14(R) exhibits cytotoxicity against cells Caco-2 and RAW264.7 .
|
-
- HY-P0263A
-
|
|
Bacterial
Fungal
|
Infection
|
|
Dermaseptin TFA, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-116909
-
-
-
- HY-123006
-
-
-
- HY-N8258
-
-
-
- HY-N10235
-
-
-
- HY-126657
-
-
-
- HY-N12183
-
-
-
- HY-N8846
-
-
-
- HY-N12903
-
-
-
- HY-125723
-
-
-
- HY-N3300
-
-
-
- HY-N8267
-
-
-
- HY-N12916
-
-
-
- HY-N8571
-
-
-
- HY-N8552
-
-
-
- HY-105713
-
-
-
- HY-N10311
-
-
-
- HY-W077257
-
-
-
- HY-P2857
-
-
-
- HY-121133
-
-
-
- HY-127157
-
-
-
- HY-N8520
-
-
-
- HY-N7780
-
-
-
- HY-N12056
-
-
-
- HY-125538
-
-
-
- HY-N7312
-
-
-
- HY-135154
-
-
-
- HY-126795
-
-
-
- HY-123519
-
-
-
- HY-122367
-
-
-
- HY-N11989
-
-
-
- HY-N3687
-
-
-
- HY-121463
-
-
-
- HY-N12179
-
-
-
- HY-123161
-
-
-
- HY-N8908
-
-
-
- HY-117934
-
-
-
- HY-124874
-
|
(rel)-Aspergillimide; (rel)-VM55598
|
Alkaloids
Microorganisms
Pyrrole Alkaloids
Source classification
|
nAChR
|
|
(rel)-Asperparaline A ((rel)-Aspergillimide), an anthelmintic metabolite, is isolated from okara that has been fermented with Aspergillus japonicas JV-23. (rel)-Asperparaline A is also a potent and selective antagonist of nAChR. (rel)-Asperparaline A exhibits paralytic activity in silk worms .
|
-
-
- HY-N8512
-
-
-
- HY-101399
-
-
-
- HY-N6181
-
-
-
- HY-101399A
-
-
-
- HY-122467
-
-
-
- HY-N12614
-
-
-
- HY-N10268
-
-
-
- HY-N12264
-
|
|
Structural Classification
Microorganisms
Antibiotics
Source classification
|
Antibiotic
Bacterial
Fungal
|
|
Burnettramic acid A is an antibiotic, which can be isolated from Aspergillus burnettii. Burnettramic acid A exhibits antibacterial and antifungal activities, with IC50 of 0.2, 0.5, 2.3 and 5.9 μg/mL, for Saccharomyces cerevisiae, Candida albicans, Bacillus subtilis and Staphylococcus aureus, respectively. Burnettramic acid A exhibits cytotoxicity in cancer cell NS-1 with IC50 of 13.8 μg/mL .
|
-
-
- HY-116132
-
-
-
- HY-N10080
-
-
-
- HY-N10193
-
-
-
- HY-N10257
-
-
-
- HY-111238
-
-
- HY-N9713
-
-
- HY-N12197
-
-
- HY-133196
-
-
- HY-N7609
-
-
- HY-N12181
-
-
- HY-133709
-
-
- HY-N11541
-
-
- HY-137141
-
-
- HY-116671
-
-
- HY-N12389
-
-
- HY-N1734
-
-
- HY-N7078
-
-
- HY-N12727
-
-
- HY-119821
-
-
- HY-N8894
-
-
- HY-N7585
-
-
- HY-N6783
-
-
- HY-113614
-
-
- HY-N6786
-
-
- HY-125916
-
-
- HY-N7569
-
-
- HY-N12877
-
-
- HY-N8406
-
|
|
Microorganisms
Source classification
Phenols
|
Bacterial
Antibiotic
|
|
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
|
-
- HY-N6772
-
-
- HY-123888
-
-
- HY-B0751
-
-
- HY-N6688
-
-
- HY-N10272
-
-
- HY-P2005
-
-
- HY-N12534
-
-
- HY-N6779
-
-
- HY-N6725
-
-
- HY-129578
-
-
- HY-N1063
-
-
- HY-137990
-
-
- HY-N8285
-
-
- HY-119728
-
-
- HY-P2274
-
-
- HY-N10281
-
-
- HY-P2569
-
-
- HY-N12196
-
-
- HY-N6786R
-
-
- HY-B0751R
-
-
- HY-135422
-
|
Methylustin
|
Structural Classification
Natural Products
Microorganisms
Source classification
|
Bacterial
Fungal
|
|
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .
|
-
- HY-N6725R
-
-
- HY-N6779R
-
-
- HY-N11576
-
-
- HY-135445
-
-
- HY-103027
-
-
- HY-119387
-
|
|
Other Terpenoids
Structural Classification
Microorganisms
Terpenoids
Source classification
|
Bacterial
|
|
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.
|
-
- HY-B0856
-
-
- HY-B0856R
-
-
- HY-N7236
-
|
|
Triterpenes
Structural Classification
Animals
Terpenoids
Source classification
|
Parasite
Fungal
|
|
Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases .
|
-
- HY-Y0337A
-
-
- HY-N2544
-
-
- HY-W050154
-
-
- HY-W162983
-
-
- HY-Y0337AR
-
|
|
Structural Classification
Source classification
Amino acids
Endogenous metabolite
|
Endogenous Metabolite
|
|
L-Cysteine (hydrochloride) (Standard) is the analytical standard of L-Cysteine (hydrochloride). This product is intended for research and analytical applications. L-Cysteine hydrochloride is an orally active conditionally essential amino acid, which acts as a precursor for biologically active molecules such as hydrogen sulphide (H2S), glutathione and taurine. L-Cysteine hydrochloride suppresses ghrelin and reduces appetite in rodents. L-Cysteine hydrochloride inhibits Aspergillus flavus growth and AFB synthesis by disrupting cell structure and antioxidant system balance. L-Cysteine hydrochloride enhances relaxant responses of rat aortic rings to NO and reduces responses to endothelium-derived relaxing factor (EDRF) [4].
|
-
- HY-124902
-
|
|
Structural Classification
Microorganisms
Antibiotics
Source classification
|
Antibiotic
Fungal
Bacterial
|
|
Valclavam is an antibiotic, which exhibits antibacterial and antifungal activities. Valclavam inhibits homoserine-O-succinyltransferase (EC 2.3.1.46), blocks the methionine synthesis, and thus inhibits Escherichia coli. Valclavam inhibits Saccharomyces cerevisiae through inhibition of RNA formation. Valclavam inhibits the movement and reproduction of nematode Caenorhabditis elegans.
|
-
- HY-W050154R
-
|
|
Structural Classification
Human Gut Microbiota Metabolites
Microorganisms
Ketones, Aldehydes, Acids
Source classification
Endogenous metabolite
|
Parasite
Tyrosinase
NF-κB
CDK
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Kojic acid (Standard) is the analytical standard of Kojic acid. This product is intended for research and analytical applications. Kojic acid is a substance produced by Aspergillus oryzae, with various biological activities including antitumor, insecticidal, antibacterial, antioxidant, and radioprotective effects. Kojic acid exhibits tyrosinase inhibition activity by capturing copper ions that bind to the active site of tyrosinase, preventing its activation. Tyrosinase is a key enzyme in the biosynthesis of melanin, so kojic acid can block melanin production. Additionally, kojic acid shows potential inhibition of NF-κB activity in human keratinocytes, which may also be related to the anti-melanogenic effect induced by kojic acid. Kojic acid is effective when administered orally and can also be absorbed transdermally. Nano-carrier systems prepared with kojic acid demonstrate effective delivery of anticancer drugs. Kojic acid holds promise for research in cancer, infectious diseases, and skin whitening among other fields .
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- HY-138050
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- HY-Y0790R
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Structural Classification
Ketones, Aldehydes, Acids
Rudbeckia laciniata L.
Source classification
Umbelliferae
Plants
Endogenous metabolite
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Endogenous Metabolite
Apoptosis
DNA/RNA Synthesis
α-synuclein
Lipoxygenase
Opioid Receptor
Interleukin Related
TNF Receptor
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Cuminaldehyde (Standard) is the analytical standard of Cuminaldehyde. This product is intended for research and analytical applications. Cuminaldehyde is the main component of Cuminum cyminum and has multiple biological activities, including anti-inflammatory, anti-cancer, anti-diabetic, anti-injury, anti-neuropathy and antibacterial effects. Cuminaldehyde is an inhibitor of aldose reductase (IC50= 0.00085 mg/mL) and α-glucosidase (IC50=0.5 mg/mL). Cuminaldehyde can modulate α-synuclein fibrils. Cuminaldehyde can induce apoptosis in colon adenocarcinoma cells by targeting topoisomerase I and II. In addition, Cuminaldehyde also exerts anti-inflammatory activity by inhibiting lipoxygenase. Cuminaldehyde has a strong inhibitory effect on the growth of Aspergillus flavus and the biosynthesis of aflatoxin B1 (AFB1). Cuminaldehyde can exert anti-injury and anti-neuropathy effects by participating in opioid receptors, L-arginine/NO/cGMP pathways and anti-inflammatory effects. Cuminaldehyde has potential application value in the research of neurodegenerative diseases, cancer, diabetes and neuropathic pain diseases .
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Chemical Structure |
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- HY-W010476S1
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2,3,5-Trimethylpyrazine-d3 is deuterated labeled Kojic acid (HY-W050154). Kojic acid is a natural substance produced by Aspergillus oryzae, also used as an anti-oxidant and radio-protective agent .
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- HY-N6786S
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Ochratoxin B- 13C20 is 13C-labeled Ochratoxin B (HY-N6786). Ochratoxin B, a secondary metabolite of Aspergillus ochraceus, is the nonchlorinated analogue of the mycotoxin Ochratoxin A. Ochratoxin B has been shown to reduce the toxic effects of Ochratoxin A, and it is one of the most potent renal carcinogens in rodents .
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- HY-N1952S
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Isoeugenol-d3 is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .
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- HY-N6779S
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Patulin- 13C7 (Terinin- 13C7) is the 13C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .
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- HY-101399S
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γ-Glu-(Phe- 13C9, 15N) is the 13C and 15N labeled isotope of γ-Glu-Phe(HY-101399).γ-Glu-Phe or the postenzymatic reaction mixture enhanced the umami intensity of commercial soy sauce and model chicken soup.
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