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blue light

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By Targets:	Apoptosis (2) Autophagy (2) Bacterial (1) Biochemical Assay Reagents (2) Cryptochrome (1) DNA Stain (1) Epigenetic Reader Domain (1) Fluorescent Dye (5) Isotope-Labeled Compounds (1) PROTACs (1) Reactive Oxygen Species (2) Sodium Channel (1) Wnt (1)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dye	Others
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 . Storage: protect from light.

HY-D1416

HMBR	Fluorescent Dye	Others
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-D1571

CellTracker Blue CMF2HC Dye	DNA Stain	Others
CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .

HY-D0025

7-Amino-4-methylcoumarin-3-acetic acid	Fluorescent Dye	Others
7-Amino-4-methylcoumarin-3-acetic acid is a fluorescent protein labelling agent. 7-Amino-4-methylcoumarin-3-acetic acid emits in the blue region (440-460 nm) on activation with UV light (350 nm) .

HY-108468

KL001	Cryptochrome	Metabolic Disease
KL001 is a first-in-class cryptochrome (CRY, a flavoproteins that are sensitive to blue light, and is involved in the circadian rhythms of plants and animals) stabilizer which specifically interacts with CRY1 and CRY2. KL001 prevents ubiquitin-dependent degradation of CRY, resulting in lengthening of the circadian period. KL001 has the potential to control fasting hormone-induced gluconeogenesis .

HY-125667

PA1 Photoamiloride-1	Sodium Channel	Metabolic Disease
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC₅₀ values of 4.3nM, 90 nM, and 390 nM, respectively .

HY-W087913

alpha-Naphtholphthalein	Biochemical Assay Reagents	Others
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .

HY-162825

Antitumor photosensitizer-7	Others	Cancer
Antitumor photosensitizer-7 (compound 15) is a photosensitizer with anti-cancer activity. Antitumor photosensitizer-7 exhibits significant cytotoxicity against the G361 melanoma cell line under 414 nm blue light irradiation .

HY-109116

Hydromethylthionine Leukomethylene blue	Biochemical Assay Reagents	Others
Hydromethylthionine (Leukomethylene blue) has a very active photochemically active reagent, especially in its interaction with dissolved oxygen. The photochemical activity of Hydromethylthionine is mainly regulated by the reaction of its triplet state with dissolved oxygen, which reacts with dissolved oxygen to form Methylene Blue (HY-14536) and hydronium ions under ultraviolet light. Hydromethylthionine can be used for the photodegradation of model pollutants in semiconductor photocatalysis and for the study of indicators in chemical analysis .

HY-N7171

4,4'-Di-O-methylellagic acid 4,4'-DiOMEA; Nasutin C	Wnt	Cancer
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light . 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway .

HY-118462A

Coelenteramine 400a hydrochloride Coelenterazine 400a hydrochloride; Bisdeoxycoelenterazine hydrochloride	Others	Others
Coelenteramine (Coelenterazine) 400a hydrochloride, a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a hydrochloride, RLuc can emit blue light at 395 nm . Coelenteramine 400a hydrochloride will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenteramine 400a hydrochloride provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-118462

Coelenteramine 400a Coelenterazine 400a; Bisdeoxycoelenterazine	Fluorescent Dye	Others
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-N11499

Myricetin 3-O-α-L-arabinopyranoside	Bacterial	Infection Inflammation/Immunology
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA A2E-d₄ TFA	Isotope-Labeled Compounds	Cancer
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species .

HY-134928

Pyridinium bisretinoid A2E A2E	Apoptosis Autophagy Reactive Oxygen Species	Cancer
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .

HY-D0150

Thiazole Orange 1 Publications Verification	Fluorescent Dye	Others
Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λ_ex = 510 nm (488 nm and 470 nm also show strong excitation) and λ_em = 527 nm, respectively .

HY-134928A

Pyridinium bisretinoid A2E TFA A2E TFA	Apoptosis Autophagy Reactive Oxygen Species	Cancer
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .

HY-161650

PROTAC BRD4 Degrader-26	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-26 (PROTAC-2) is a photo-regulated PROTAC, which degrades 80% BRD4 at 1 μM by using photocleavable linker. PROTAC BRD4 Degrader-26 will be deactivated by UV light. (Pink: ligand for target protein BRD4 ligand 6 (HY-161651); Black: linker (HY-161653); Blue: E3 ligase ligand Thalidomide 4-fluoride (HY-41547))

Cat. No.	Product Name	Type

HY-D0219

Thymol blue Thymolsulphonephthalein	Fluorescent Dyes/Probes
Thymol Blue sodium is an acid-base indicator used to indicate changes in pH. Thymol Blue sodium fades from red to yellow at pH 1.2 to 2.8 and from yellow to blue at pH 8.0 to 9.6 . Storage: protect from light.

HY-D1416

HMBR	Fluorescent Dyes/Probes
HMBR, an analog bearing an additional methyl group on the aromatic ring, is nonfluorescent by itself, but it fluoresces yellow light upon blue-light excitation when bound to Y-FAST. HMBR is nontoxic for zebrafish embryos. cell-permeant .

HY-D1571

CellTracker Blue CMF2HC Dye	Fluorescent Dyes/Probes
CellTracker Blue CMF2HC Dye is a blue dye, can be used in two-channel nuclei acid sequencing, with blue and purple excitation light (450-460 nm/400-405nm or 415-450 nm/480-525nm). CellTracker Blue CMF2HC Dye can be used to rapid determination of antibiotic sensitivity of microorganisms .

HY-D0025

7-Amino-4-methylcoumarin-3-acetic acid	Fluorescent Dyes/Probes
7-Amino-4-methylcoumarin-3-acetic acid is a fluorescent protein labelling agent. 7-Amino-4-methylcoumarin-3-acetic acid emits in the blue region (440-460 nm) on activation with UV light (350 nm) .

HY-118462

Coelenteramine 400a Coelenterazine 400a; Bisdeoxycoelenterazine	Dyes
Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

Coelenteramine 400a

Coelenterazine 400a; Bisdeoxycoelenterazine

Dyes

Coelenteramine 400a (Coelenterazine 400a), a derivative of Coelenterazine, is a Renilla luciferase (RLuc) substrate. In the presence of Coelenteramine 400a, RLuc can emit blue light at 395 nm . Coelenterazine 400a will causes color change in the bioluminescence reaction of Rluc by replacing the sulfur and oxygen heteroatoms of the methylene bridge. Coelenterazine 400a provides higher signal resolution and can be used in the research of bioluminescence resonance energy transfer (BRET) .

HY-D0150

Thiazole Orange 1 Publications Verification	Fluorescent Dyes/Probes
Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λ_ex = 510 nm (488 nm and 470 nm also show strong excitation) and λ_em = 527 nm, respectively .

Thiazole Orange

1 Publications Verification

Fluorescent Dyes/Probes

Thiazole Orange is an asymmetric anthocyanin dye that can be coupled with oligonucleotides (ONs) to prepare fluorescent hybridization probes. Thiazole Orange has been widely used in biomolecular detection and staining of DNA/ RNA in gels and can be used for reticulocyte analysis. Thiazole orange generates a significant fluorescence enhancement and high quantum yield when it binds with nucleic acids, especially RNA. Thiazole orange can permeate living cell membranes. Thiazole orange can use UV light for detection, but can also be detected with blue light. The excitation and emission of Thiazole orange are λ_ex = 510 nm (488 nm and 470 nm also show strong excitation) and λ_em = 527 nm, respectively .

HY-D0012A

Bromothymol Blue sodium	Fluorescent Dyes/Probes
Bromothymol Blue sodium salt is a pH indicator. Storage: protect from light.

HY-109116

Hydromethylthionine Leukomethylene blue	Fluorescent Dyes/Probes
Hydromethylthionine (Leukomethylene blue) has a very active photochemically active reagent, especially in its interaction with dissolved oxygen. The photochemical activity of Hydromethylthionine is mainly regulated by the reaction of its triplet state with dissolved oxygen, which reacts with dissolved oxygen to form Methylene Blue (HY-14536) and hydronium ions under ultraviolet light. Hydromethylthionine can be used for the photodegradation of model pollutants in semiconductor photocatalysis and for the study of indicators in chemical analysis .

Hydromethylthionine

Leukomethylene blue

Fluorescent Dyes/Probes

Hydromethylthionine (Leukomethylene blue) has a very active photochemically active reagent, especially in its interaction with dissolved oxygen. The photochemical activity of Hydromethylthionine is mainly regulated by the reaction of its triplet state with dissolved oxygen, which reacts with dissolved oxygen to form Methylene Blue (HY-14536) and hydronium ions under ultraviolet light. Hydromethylthionine can be used for the photodegradation of model pollutants in semiconductor photocatalysis and for the study of indicators in chemical analysis .

Cat. No.	Product Name	Type

HY-W087913

alpha-Naphtholphthalein	Biochemical Assay Reagents
alpha-Naphtholphthalein is an indicator that is light yellow at pH 6 and gradually shows a clear color change with increasing pH to light green-green-blue. alpha-Naphtholphthalein can be impregnated into cotton-blend fabrics and used to develop medical supplies for wound pH monitoring, such as medical gauze, hospital gowns and compression bandages .

4,4'-Di-O-methylellagic acid 4,4'-DiOMEA; Nasutin C	Structural Classification Animals Source classification Phenols Polyphenols	Wnt
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light . 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway .

Myricetin 3-O-α-L-arabinopyranoside	Structural Classification Flavonoids Flavones Source classification Plants Sapotaceae Pouteria torta (Mart.) Radlk.	Bacterial
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

Cat. No.	Product Name	Chemical Structure

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species .

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blue light

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Natural
Products