2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis NF-κB Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK Immunology/Inflammation
  3. RAR/RXR Bcl-2 Family NF-κB PPAR VEGFR Interleukin Related
  4. BMS-195614

BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis.

For research use only. We do not sell to patients.

BMS-195614 Chemical Structure

BMS-195614 Chemical Structure

CAS No. : 182135-66-6

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Based on 1 publication(s) in Google Scholar

BMS-195614 Related Antibodies

Top Publications Citing Use of Products

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RXRα RXRβ RXRγ

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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PPARα PPARβ/δ PPARγ PPAR PPARδ

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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  • Purity & Documentation

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Description

BMS-195614 (BMS 614) is an orally active neutral RARα-selective antagonist with a Ki of 2.5 nM. BMS-195614 restores the expression of Bcl2. BMS-195614 inhibits the transactivation of NF-κB, AP-1 and PPAR. BMS-195614 downregulates the expression of IL-6 and VEGF. BMS-195614 reduces blue light-induced phototoxicity and inhibits cell migration. BMS-195614 modulates inflammation and angiogenesis[1][2][3][4][5].

IC50 & Target[1][2][3][4][5]

BCL2

 

IL-6

 

In Vitro

BMS-195614 (10-20 μM) reduces blue light-induced phototoxicity and modulates inflammation and angiogenesis in the presence of A2E in RPE cells[2].
BMS-195614 (6 μM, 24 h) reverses the anti-inflammatory effect of Vitamin A (HY-B1342) and RA on the release of IL-6 by LPS-activated BV-2 cells[3].
BMS-195614 (1 μM, 24 h) inhibits Retinoic acid (HY-14649)­induced migration of MC3T3­E1 osteoblast­like cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-195614 Related Antibodies

Real Time qPCR[2]

Cell Line: RPE cells
Concentration: 10 µM
Incubation Time:
Result: Inhibited NF-κB transactivation, the transactivation of AP-1, the expression of IL-6 and VEGF mRNA.
In Vivo

BMS-195614 (2-10 mg/kg, p.o., 7 days) results in minimal or no inhibition of overall spermatogenesis in mice[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

448.51

Formula

C29H24N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(NC(C2=CC=C3C(C)(C)CC=C(C4=CC5=CC=CC=C5N=C4)C3=C2)=O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (66.89 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2296 mL 11.1480 mL 22.2960 mL
5 mM 0.4459 mL 2.2296 mL 4.4592 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.5%

SDS (251 KB)

COA (252 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2296 mL 11.1480 mL 22.2960 mL 55.7401 mL
5 mM 0.4459 mL 2.2296 mL 4.4592 mL 11.1480 mL
10 mM 0.2230 mL 1.1148 mL 2.2296 mL 5.5740 mL
15 mM 0.1486 mL 0.7432 mL 1.4864 mL 3.7160 mL
20 mM 0.1115 mL 0.5574 mL 1.1148 mL 2.7870 mL
25 mM 0.0892 mL 0.4459 mL 0.8918 mL 2.2296 mL
30 mM 0.0743 mL 0.3716 mL 0.7432 mL 1.8580 mL
40 mM 0.0557 mL 0.2787 mL 0.5574 mL 1.3935 mL
50 mM 0.0446 mL 0.2230 mL 0.4459 mL 1.1148 mL
60 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9290 mL
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BMS-195614 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-195614182135-66-6BMS 614BMS195614BMS 195614BMS614BMS-614RAR/RXRBcl-2 FamilyNF-κBPPARVEGFRInterleukin RelatedRetinoic acid receptorsRetinoid X receptorsNuclear factor-κBNuclear factor-kappaBPeroxisome proliferator-activated receptorsVascular endothelial growth factor receptorILInhibitorinhibitorinhibit

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