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Pathways Recommended: Stem Cell/Wnt Cell Cycle/DNA Damage
Results for "

cell permeant

" in MedChemExpress (MCE) Product Catalog:

26

Inhibitors & Agonists

9

Fluorescent Dye

1

Biochemical Assay Reagents

3

Peptides

1

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Products

1

Click Chemistry

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-D1078
    5(6)-Carboxy-2',7'-dichlorofluorescein diacetate

    		Reactive Oxygen Species Others
    5(6)-Carboxy-2',7'-dichlorofluorescein diacetate is a cell permeant fluorescent indicator. 5(6)-Carboxy-2',7'-dichlorofluorescein diacetate can be used to assess reactive oxygen species (ROS) generation within human neuronal-glial (HNG) cells in primary co-culture
    5(6)-Carboxy-2',7'-dichlorofluorescein diacetate
  • HY-117359
    UCD38B hydrochloride

    		PAI-1 Apoptosis Cancer
    UCD38B hydrochloride is a cell permeant, competitive enzymatic uPA inhibitor with an IC50 value of 7 μM. UCD38B hydrochloride targets intracellular uPA causing mistrafficking of uPA into perinuclear mitochondria, reducing the mitochondrial membrane potential, and followed by the release of apoptotic inducible factor (AIF). UCD38B hydrochloride induces apoptosis .
    UCD38B hydrochloride
  • HY-110256
    N-Acetylcysteine amide
    Maximum Cited Publications
    11 Publications Verification

    		 Reactive Oxygen Species Neurological Disease Inflammation/Immunology
    N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent, reduces ROS production.
    N-Acetylcysteine amide
  • HY-D1176
    Calcium Green 1AM

    		Fluorescent Dye Others
    Calcium Green 1AM is a cell-permeant fluorescent calcium indicator (Excitation 506 nm; Emission 531 nm). Calcium Green 1AM is converted to the fluorescent calcium indicator by intracellular esterases .
    Calcium Green 1AM
  • HY-103306
    Ryanodine
    5 Publications Verification

    		 Calcium Channel Others Neurological Disease
    Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca 2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.
    Ryanodine
  • HY-D1748
    Rhodamine B hexyl ester perchlorate

    		Fluorescent Dye Others
    Rhodamine B hexyl ester perchlorate is a cell-permeant, orange-fluorescent dye for mitochondria.
    Rhodamine B hexyl ester perchlorate
  • HY-P10167
    11R-CaN-AID

    		Phosphatase Others
    11R-CaN-AID is a potent and cell permeant inhibitor of calcineurin .
    11R-CaN-AID
  • HY-D1759
    Fura-4F AM

    		Fluorescent Dye Others
    Fura-4F AM is a cell-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
    Fura-4F AM
  • HY-D1758
    Fura-5F AM

    		Fluorescent Dye Others
    Fura-5F AM is a membrane-permeant fluorescent calcium indicator. Upon entering the cell, this probe is hydrolyzed by cytosilic esterases and trapped as the active chelator.
    Fura-5F AM
  • HY-121970
    iGP-1

    		Aldehyde Dehydrogenase (ALDH) Metabolic Disease
    iGP-1 is a selective and cell-permeant mitochondrial sn-glycerol 3-phosphate dehydrogenase (mGPDH) inhibitor. iGP-1 inhibits H2O2 production by mGPDH .
    iGP-1
  • HY-129677
    ORC-13661 hydrochloride

    		TRP Channel Others
    ORC-13661 hydrochloride is a hair cell protector. ORC-13661 hydrochloride protects sensory hair cells from aminoglycoside and Cisplatin (HY-17394) ototoxicity. ORC-13661 hydrochloride is a reversibly mechanoelectrical transducer (MET) channel permeant blocker .
    ORC-13661 hydrochloride
  • HY-P1986
    Z-DEVD-AFC

    		Caspase Cancer
    Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity .
    Z-DEVD-AFC
  • HY-D1768
    Fluo-4FF AM

    		Fluorescent Dye Others
    Fluo-4FF AM is a cell-permeant fluorescent calcium indicator. Fluo-4FF is an analog of Fluo-4 with a lower affinity for calcium, which is suitable for investigation of relatively high level of intracellular calcium.
    Fluo-4FF AM
  • HY-114227
    Hexidium iodide

    		DNA Stain Inflammation/Immunology
    Hexidium iodide, a fluorescent nucleic binding acid stain (excitation/emission ~ 518/600 nm), permeants to mammalian cells and selectively stains almost all gram-positive bacteria. Hexidium iodide can bind to the DNA of all bacteria after permeabilization by EDTA .
    Hexidium iodide
  • HY-121764
    MPCI

    		Melanocortin Receptor Metabolic Disease
    MPCI is a cell-permeant MC4R-selective ligand with pharmacological chaperone activity. MPCI is a MC4R antagonist with a Ki value of 0.218 μM on HEK293 cells expressing hMC4R. MPCI can be used for the research of MC4R-deficient obesity .
    MPCI
  • HY-D1643
    5,5'-Dinitro BAPTA AM

    		Biochemical Assay Reagents Others
    5,5'-Dinitro BAPTA AM is a membrane-permeant, high-affinity calcium chelator, it can be used for investigation of the role of cytosolic Ca 2+. 5,5'-Dinitro BAPTA AM can be loaded by incubation into live cells, and is cleaved by cytosolic esterases to liberate the active tetra-carboxylate ligand .
    5,5'-Dinitro BAPTA AM
  • HY-D1746
    EDTA-AM

    EDTA acetoxymethyl ester; Ethylenediaminetetraacetic acid acetoxymethyl ester

    		 Biochemical Assay Reagents Others
    EDTA-AM (ethylenediaminetetraacetic acid, acetoxymethyl ester) is the membrane-permeant form of the metal chelator EDTA (HY-Y0682). Live cells passively load EDTA-AM by incubating with EDTA-AM. Once internalized, cytoplasmic esterase decomposes AM esters, releasing the active ligand EDTA, which isolates metal ions within the cell. EDTA-AM induces an arrest of mitotic progression and chromosome decondensation .
    EDTA-AM
  • HY-D1742
    DRAQ5

    		Fluorescent Dye DNA Stain Others
    DRAQ5 is a novel cell permeant and far red-fluorescing DNA probe. DRAQ5 excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DRAQ5 fluorescence reflects cellular DNA content. DRAQ5 can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .
    DRAQ5
  • HY-141510
    myo-Inositol trispyrophosphate hexasodium

    ITPP hexasodium

    		 HIF/HIF Prolyl-Hydroxylase Cardiovascular Disease Cancer
    myo-Inositol trispyrophosphate (ITPP) hexasodium is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate (ITPP) hexasodium is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate (ITPP) hexasodium enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate (ITPP) hexasodium can be used in the study of cardiovascular disease and cancer .
    myo-Inositol trispyrophosphate hexasodium
  • HY-141510A
    myo-Inositol trispyrophosphate hexa-triethylamine

    ITPP hexa-triethylamine

    		 Biochemical Assay Reagents HIF/HIF Prolyl-Hydroxylase Cardiovascular Disease Cancer
    myo-Inositol trispyrophosphate (ITPP) hexa-triethylamine is a salt form of inositol triphosphate (ITPP). myo-Inositol trispyrophosphate hexa-triethylamine is a membrane-permeant hemoglobin allosteric regulator. myo-Inositol trispyrophosphate hexa-triethylamine enhances the oxygen release capacity of red blood cells by reducing the affinity of hemoglobin to oxygen. myo-Inositol trispyrophosphate hexa-triethylamine can be used in the study of cardiovascular disease and cancer .
    myo-Inositol trispyrophosphate hexa-triethylamine
  • HY-P3412
    MMI-0100

    		MAPKAPK2 (MK2) Inflammation/Immunology
    MMI-0100 is a cell-permeant peptide inhibitor of mitogen activated protein kinase activated protein kinase II (MK2). MMI-0100 reduces intimal hyperplasia ex vivo and in vivo. MMI-0100 suppresses IL-6 expression without effect on IL-8 expression. MMI-0100 suppresses fibrotic processes such as vein graft disease .
    MMI-0100
  • HY-112210
    Shield-1
    5 Publications Verification

    Shld1

    		 FKBP Others
    Shield-1 (Shld1) is a specific, cell-permeant and high-affinity ligand of FK506-binding protein-12 (FKBP), and reverses the instability by binding to mutated FKBP (mtFKBP), allowing conditional expression of mtFKBP-fused proteins. Shield-1 can stabilize proteins tagged with a mutated FKBP12-derived destabilization domain (DD) .
    Shield-1
  • HY-Z0816
    Dehydronitrosonisoldipine
    3 Publications Verification

    		 Calcium Channel Others
    Dehydronitrosonisoldipine, a derivative of Nisoldipine (HY-17402), is an irreversible and cell-permeant sterile alpha and TIR motif-containing 1 (SARM1) inhibitor. Dehydronitrosonisoldipine acts mainly by blocking SARM1 activation but not its enzymatic activities. Dehydronitrosonisoldipine inhibits SARM1 and axon degenration (AxD) by covalently modifying cysteines, also inhibits the Vincristine-activated cADPR production in neurons. Dehydronitrosonisoldipine can be used for researching neurodegenerative disorders .
    Dehydronitrosonisoldipine
  • HY-W008344
    2-Chloroadenosine

    		Nucleoside Antimetabolite/Analog Apoptosis Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
    2-Chloroadenosine is an adenosine analog, a transporter permeabilizer of nucleoside transporters, and a competitive uridine influx inhibitor (apparent Ki=33 μM). 2-Chloroadenosine binds to nitrobenzylthioinosine with high affinity (apparent Ki=0.18 mM). 2-Chloroadenosine promotes Apoptosis and increases cerebral blood flow. 2-Chloroadenosine has anticonvulsant properties. 2-Chloroadenosine is used to study infection, inflammatory diseases, cancer, blood-related diseases, lung injury, epilepsy, and kidney disease .
    2-Chloroadenosine
  • HY-131442
    Alkyne-phenol
    2 Publications Verification

    Alkyne tyramide; Alk-Ph

    		 Biochemical Assay Reagents Others
    Alkyne-phenol (Alk-Ph) is a clickable ascorbate peroxidase 2 (APEX2) probe. Alkyne-phenol substantially improves APEX-labeling efficiency in intact yeast cells, as it is more cell wall-permeant than APEX2 substrate biotin-phenol (BP). Alkyne-phenol also facilitates the identification of APEX-labeling sites, allowing the unambiguous assignment of membrane topology of mitochondrial proteins . Alkyne-phenol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-phenol
  • HY-108611
    AACOCF3
    3 Publications Verification

    Arachidonyl trifluoromethyl ketone

    		 Phospholipase Cardiovascular Disease
    AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
    AACOCF3