Search Result

Results for "

cholesterol lowering

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (8) Antibiotic (1) Apical Sodium-Dependent Bile Acid Transporter (3) Apoptosis (2) ATP Citrate Lyase (3) Autophagy (14) Bacterial (7) Biochemical Assay Reagents (4) Cytochrome P450 (1) Drug Metabolite (1) Endogenous Metabolite (16) Estrogen Receptor/ERR (2) Farnesyl Transferase (3) Ferroptosis (7) HCV (2) HMG-CoA Reductase (HMGCR) (23) Integrin (2) Interleukin Related (1) Isotope-Labeled Compounds (7) JAK (2) Keap1-Nrf2 (2) LDLR (2) Microsomal Triglyceride Transfer Protein (MTP) (2) MMP (2) PCSK9 (7) Potassium Channel (7) PPAR (1) Reactive Oxygen Species (2) SOD (1) Thyroid Hormone Receptor (4) TNF Receptor (1) Virus Protease (4) β-catenin (2)
By Research Areas:	Cancer (24) Cardiovascular Disease (31) Endocrinology (4) Infection (3) Inflammation/Immunology (12) Metabolic Disease (56) Neurological Disease (6)
Oligonucleotides:	Fillers (1) Cholesterol (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Acyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-123672

Lovastatin hydroxy acid sodium Mevinolinic acid sodium	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a K_i of 0.6 nM .

HY-N1459

Campesterol 2 Publications Verification	Endogenous Metabolite	Cancer
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-109567

Gemcabene PD-72953	Others	Metabolic Disease Inflammation/Immunology
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity .

HY-109567A

Gemcabene calcium PD-72953 calcium	Others	Metabolic Disease Inflammation/Immunology
Gemcabene calcium (PD-72953 calcium), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity .

HY-N0504

Lovastatin 20+ Cited Publications Mevinolin	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-161941

MeIm	LDLR PCSK9	Cardiovascular Disease
MeIm (compound 7) is a high-affinity PCSK9 targeting peptide mimetic with cholesterol-lowering activity. MeIm increases cellular uptake of LDL (EC₅₀=6.04 μM) by inhibiting the binding of PCSK9 to LDLR (IC₅₀=11.2 μM). MeIm can be used in the study of cardiovascular diseases .

HY-123672R

Lovastatin hydroxy acid (sodium) (Standard)	HMG-CoA Reductase (HMGCR)	Metabolic Disease
Lovastatin hydroxy acid (sodium) (Standard) is the analytical standard of Lovastatin hydroxy acid (sodium). This product is intended for research and analytical applications. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM .

HY-115914

Lipid-lowering agent-1	Others	Others
Lipid-lowering agent-1 is a potent lipid-lowering agent. Lipid-lowering agent-1 has significant pharmacological effects on the inhibition of low-density lipoprotein cholesterol (LDLC) and promotion of high-density lipoprotein cholesterol (HDLC) production. Lipid-lowering agent-1 shows potent hypolipidemic effect in high-fat diet rats .

HY-100253

TA-7552	Others	Cardiovascular Disease
TA-7552 is a potent cholesterol-lowering agent.

HY-16166

Dalvastatin RG-12561	HMG-CoA Reductase (HMGCR)	Inflammation/Immunology
Dalvastatin (RG-12561) inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis .

HY-100288

RP 73163 Racemate	Acyltransferase	Metabolic Disease
RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent ACAT inhibitor, with cholesterol lowering activity.

HY-B0893

3-Pyridinemethanol Nicotinyl alcohol; Pyridine-3-carbinol	Others	Metabolic Disease
3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent .

HY-W134326

Polydextrose	Biochemical Assay Reagents	Metabolic Disease Cancer
Polydextrose has the effect of lowering cholesterol and plasma lipids, and can effectively reduce low-density lipoprotein cholesterol. Polydextrose significantly reduced plasma and liver cholesterol in gerbils fed with enlarged endogenous cholesterol reservoirs .

HY-B0388

Probucol 1 Publications Verification DH-581	Virus Protease	Metabolic Disease
Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-116241

L-157012	HMG-CoA Reductase (HMGCR)	Metabolic Disease
L-157012 is a HMG-CoA reductase (HMGCR) inhibitor. L-157012 is also a cholesterol-lowering agent .

HY-N0504S1

Lovastatin-d9	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d₉ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-117760

Spirolaxine	Bacterial Endogenous Metabolite	Infection
Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .

HY-N0504S2

Lovastatin-d3 Mevinolin-d₃	Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0131

Stigmasterol 5 Publications Verification	MMP Endogenous Metabolite	Inflammation/Immunology
Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

HY-16109

BMS-188494	Others	Metabolic Disease
BMS-188494 is a cholesterol-lowering agent that degrades into a monoester form, BMS-188494, and a free acid form, BMS-187745 .

HY-U00340

PPAR agonist 1	PPAR	Metabolic Disease
PPAR agonist 1 is an agonist of PPAR α and PPAR γ, used for reducing blood glucose, lipid levels, lowering cholesterol and reducing body weight.

HY-N0504R

Lovastatin (Standard) 20+ Cited Publications Mevinolin (Standard)	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis	Cardiovascular Disease Cancer
Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-113288

Campestanol	Others	Metabolic Disease
Campestanol is a phytosterol that can be found in plant food. Campestanol lowers serum cholesterol and low-density lipoprotein. Campestanol can be used for the research of metabolic disorders .

HY-161942

PCSK9-IN-31	PCSK9	Metabolic Disease
PCSK9-IN-31 (Compound WX002) is an orally active PCSK9 inhibitor. PCSK9-IN-31 can lower low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in high cholesterol fed model rats .

HY-B0388S1

Probucol-d6 DH-581-d₆	Isotope-Labeled Compounds Virus Protease	Metabolic Disease
Probucol-d₆ is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-106938

Eldacimibe WAY-ACA 147	Acyltransferase	Cardiovascular Disease Metabolic Disease
Eldacimibe is an ACAT2 inhibitor. Eldacimibe can lower plasma cholesterol levels by blocking cholesterol absorption and can prevent macrophages from turning into foam cells. Eldacimibe can be used in the study of cardiovascular diseases (atherosclerosis), endocrine and metabolic diseases (hypercholesterolemia) .

HY-B1189S

Meglutol-d3 Dicrotalic acid-d₃; 3-Hydroxy-3-methylglutaric acid-d₃	Autophagy HMG-CoA Reductase (HMGCR) Endogenous Metabolite	Cardiovascular Disease
Meglutol-d₃ is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.

HY-14925

Lapaquistat 1 Publications Verification T-91485	Endogenous Metabolite Drug Metabolite	Metabolic Disease
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy .

HY-13556A

Arzoxifene hydrochloride 1 Publications Verification LY353381 hydrochloride; SERM III hydrochloride	Estrogen Receptor/ERR	Cancer
Arzoxifene (LY353381) hydrocloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

HY-B0388S

Probucol-13C3	Isotope-Labeled Compounds Virus Protease	Metabolic Disease
Probucol- ¹³C₃ is the ¹³C-labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-19264

264W94	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
264W94 is a potent ileal bile acid transporter (IBAT) inhibitor and a new cholesterol lowering agent. 264W94 has CYP7A1 induction, and antilipemic action .

HY-153451

PCSK9-IN-15	PCSK9	Metabolic Disease
PCSK9-IN-15 (compound 5) is a potent inhibitor of proprotein convertase subtilisin/kexin 9 (PCSK9, K_D <200 nM). PCSK9 is involved in cholesterol metabolism and regulates levels of low-density lipoprotein cholesterol (LDL-C) in the blood. PCSK9- in -15 can be used to study cholesterol-lowering and dyslipidemia .

HY-B0388R

Probucol (Standard) 1 Publications Verification DH-581 (Standard)	Virus Protease	Metabolic Disease
Probucol (Standard) is the analytical standard of Probucol. This product is intended for research and analytical applications. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-115434

3,5-Diiodothyroacetic acid	Others	Metabolic Disease
3,5-Diiodothyroacetic acid is a thyroid hormone analog. 3,5-Diiodothyroacetic acid lowers blood cholesterol concentrations. 3,5-Diiodothyroacetic acid can be used for hypothyroidism diseases research .

HY-16274

Lapaquistat acetate TAK-475	Others	Metabolic Disease
Lapaquistat acetate (TAK-475) is a squalene synthase inhibitor, blocking the conversion of farnesyl diphosphate (FPP) to squalene in the cholesterol biosynthesis pathway . Lapaquistat acetate is effective at lowering low-density lipoprotein cholesterol, but it might cause liver damage. Lapaquistat acetate is used for hypercholesterolemia and mevalonate kinase deficiency (MKD) research .

HY-N0131S1

Stigmasterol-d5-1 Stigmasterin-d₅-1	Isotope-Labeled Compounds MMP Endogenous Metabolite	Inflammation/Immunology
Stigmasterol-d₅-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases[1].

HY-114866

Eritadenine Lentinacin; D-Eritadenine; Lentysine	Biochemical Assay Reagents	Cardiovascular Disease
Eritadenine (Lentinacin) is a S-adenosyl-L-homocysteine hydrolase (SAHH) inhibitor. Eritadenine can be found in secondary metabolites of shiitake mushrooms. Eritadenine lowers blood cholesterol levels and can be used in cardiovascular disease research .

HY-129459

α-Tocotrienol	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Cancer
α-Tocotrienol is an isoform of vitamin E and found in vegetables, fruits, seeds, nuts, grains, and oils. Vitamin E plays a role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.

HY-113955

CP-346086	Microsomal Triglyceride Transfer Protein (MTP)	Metabolic Disease
CP-346086 is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC₅₀ of 2.0 nM for human and rodent MTP. CP-346086 can lower plasma cholesterol and triglycerides in vivo .

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Cytochrome P450 Bacterial Antibiotic	Infection Metabolic Disease
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-N1459S

(24Rac)-Campesterol-d7 (24Rac)-5-Ergosten-3β-ol-d7	Endogenous Metabolite	Cancer
Campesterol-d₇ ((24R)-5-Ergosten-3β-ol-d₇) is the deuterium labeled Campesterol. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-111288

MB-07811 VK-2809	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist . MB-07811 has cholesterol and triglycerides lowering activity .

HY-B0589H

Atorvastatin strontium	HMG-CoA Reductase (HMGCR) Autophagy	Cardiovascular Disease
Strontium atorvastatin is a cholesterol-lowering drug with activity in ameliorating cardiovascular disease-related events. Strontium atorvastatin exerts its biological activity by inhibiting HMG-CoA reductase in liver tissue. Strontium atorvastatin is also used to suppress dyslipidemia .

HY-B1189

Meglutol Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite	Cardiovascular Disease Metabolic Disease
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-W012946

2-Furoic acid Pyromucic acid	ATP Citrate Lyase Acyltransferase Endogenous Metabolite	Metabolic Disease
2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-122778

δ-Tocotrienol 1 Publications Verification	Others	Cardiovascular Disease Neurological Disease Cancer
δ-Tocotrienol is a Vitamin E in vegetables, fruits, seeds, nuts, grains and oils. Vitamin E has become well known for its role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.

HY-113955A

CP-346086 dihydrate	Microsomal Triglyceride Transfer Protein (MTP)	Metabolic Disease
CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC₅₀ of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo .

HY-N8425

Octacosanoic acid Montanic acid	Endogenous Metabolite	Metabolic Disease
Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models .

HY-124064

TMP-153	Acyltransferase	Metabolic Disease
TMP-153 is an orally active inhibitor of ACAT with an IC₅₀ value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .

HY-19513

MB-07344	Thyroid Hormone Receptor	Metabolic Disease Endocrinology
MB-07344 is a potent thyroid hormone receptor (TR)-β agonist with a K_i of 2.17 nM. MB-07344 has additive cholesterol lowering activity in combination with Atorvastatin (HY-B0589) in rabbits, dogs and monkeys .

Cat. No.	Product Name	Type

HY-W134326

Polydextrose	Biochemical Assay Reagents
Polydextrose has the effect of lowering cholesterol and plasma lipids, and can effectively reduce low-density lipoprotein cholesterol. Polydextrose significantly reduced plasma and liver cholesterol in gerbils fed with enlarged endogenous cholesterol reservoirs .

HY-NP026

Spirulina C-phycocyanin C-phycocyaninfromporphyratenera	Native Proteins
Spirulina C-phycocyanin, a component of the light-harvesting phycobilisome complex in photosystem II, is a highly dominant chromoprotein in Spirulina. Spirulina C-phycocyanin can be detected by Raman spectral measurement. Spirulina C-phycocyanin has antioxidant, anti-inflammatory, antiplatelet, liver-protective and cholesterol-lowering effects .

HY-W250146

Locust bean gum, from Ceratonia siliqua seeds

Locust bean gum, Polysaccharide>75%, 5000-6500 mPa·S

Biochemical Assay Reagents

Locust bean gum is a natural polysaccharide derived from the seeds of the carob tree. It is commonly used as a thickening, stabilizing and gelling agent in a variety of foods, including dairy, baked goods and meat products. Locust bean gum has several properties suitable for these applications, including high water retention capacity, ability to form stable gels at low temperatures, and resistance to acidic conditions. Additionally, it can be used as a dietary fiber supplement due to its potential health benefits, including improving digestion and lowering cholesterol levels.

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Drug Delivery

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1459

Campesterol 2 Publications Verification	Structural Classification Microorganisms other families Classification of Application Fields Source classification Plants Endogenous metabolite Disease Research Fields Steroids Cancer	Endogenous Metabolite
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-N0504

Lovastatin Maximum Cited Publications 22 Publications Verification Mevinolin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0131

Stigmasterol 5 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Source classification Amaranthaceae Plants Endogenous metabolite Achyranthes bidentata Inflammation/Immunology Disease Research Fields Steroids	MMP Endogenous Metabolite
Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

HY-N0504R

Lovastatin (Standard) Maximum Cited Publications 22 Publications Verification Mevinolin (Standard)	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields Cancer	HMG-CoA Reductase (HMGCR) Autophagy Ferroptosis
Lovastatin (Standard) is the analytical standard of Lovastatin. This product is intended for research and analytical applications. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-14925

Lapaquistat 1 Publications Verification T-91485	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Metabolite
Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of Lapaquistat acetate (HY-16274). Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy .

HY-129459

α-Tocotrienol	Cardiovascular Disease Structural Classification Monophenols Neurological Disease Classification of Application Fields Source classification Phenols Endogenous metabolite Disease Research Fields	Endogenous Metabolite
α-Tocotrienol is an isoform of vitamin E and found in vegetables, fruits, seeds, nuts, grains, and oils. Vitamin E plays a role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.

HY-W008226

Phloracetophenone 2,4,6-trihydroxyacetophenone; 1-(2,4,6-Trihydroxyphenyl)ethanone	Structural Classification Classification of Application Fields Source classification Metabolic Disease Plants Curcuma comosa Roxb. Infection other families Ketones, Aldehydes, Acids Phenols Polyphenols Disease Research Fields Zingiberaceae	Cytochrome P450 Bacterial Antibiotic
Phloracetophenone (2,4,6-trihydroxyacetophenone) is the aglycone part of acetophenone glycoside obtained from Curcuma comosa Roxb, with cholesterol-lowering activity. Phloracetophenone enhances cholesterol 7α-hydroxylase (CYP7A1) activity . Phloracetophenone stimulats bile secretion mediated through Mrp2 .

HY-B1189

Meglutol Dicrotalic acid; 3-Hydroxy-3-methylglutaric acid	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	HMG-CoA Reductase (HMGCR) Autophagy Endogenous Metabolite
Meglutol is a lipid-lowering agent. Meglutol can reduces cholesterol, triglycerides, serum β-lipoprotein, and phospholipids, and inhibits the activity of HMG-CoA reductase (a rate-limiting enzyme in cholesterol biosynthesis). Meglutol can induce significant lipid oxidative damage in brain tissue. It is promising for research in the field of cardiovascular diseases and metabolic diseases .

HY-W012946

2-Furoic acid Pyromucic acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-117760

Spirolaxine	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Phenols Disease Research Fields	Bacterial Endogenous Metabolite
Spirolaxine is a plant growth inhibitor and possess significant anti-Helicobacter pylori activity. Spirolaxine exhibits cholesterol-lowering activity .

HY-N8425

Octacosanoic acid Montanic acid	Structural Classification Croton caudatus Geisel. Croton. Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Euphorbiaceae Plants Disease Research Fields	Endogenous Metabolite
Octacosanoic acid is a very long-chain saturated fatty acid. It is the major component of D-003, a mixture of very long-chain aliphatic acids purified from sugar cane wax that has antiplatelet and cholesterol-lowering activities in animal models .

HY-129459R

α-Tocotrienol (Standard)	Structural Classification Monophenols Source classification Phenols Endogenous metabolite	Endogenous Metabolite
α-Tocotrienol (Standard) is the analytical standard of α-Tocotrienol. This product is intended for research and analytical applications. α-Tocotrienol is an isoform of vitamin E and found in vegetables, fruits, seeds, nuts, grains, and oils. Vitamin E plays a role as an antioxidant, in lowering cholesterol and other lipids, as a neuroprotective and anticancer agent, and in cardiovascular disease protection.

HY-42680

D-Tagatose D-(-)-Tagatose	Structural Classification Microorganisms Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Food Research	Endogenous Metabolite
D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .

HY-W012946R

2-Furoic acid (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Endogenous metabolite	ATP Citrate Lyase Acyltransferase Endogenous Metabolite
2-Furoic acid (Standard) is the analytical standard of 2-Furoic acid. This product is intended for research and analytical applications. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation . 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats .

HY-N0527

Pentagalloylglucose 5+ Cited Publications Penta-O-galloyl-β-D-glucose; 1,2,3,4,6-Pentagalloyl glucose	Infection Structural Classification other families Classification of Application Fields Anti-aging Source classification Phenols Polyphenols Plants Disease Research Fields	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

HY-100313

YM-53601 free base	Structural Classification Alkaloids Carbazole Alkaloids	Farnesyl Transferase HCV
YM-53601 free base, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo . YM-53601 free base inhibits squalene synthase derived from human hepatoma cells with an IC₅₀ of 79 nM. Lipid-lowering agent . YM-53601 free base is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation .

HY-42680R

D-Tagatose (Standard)	Structural Classification Microorganisms Source classification Endogenous metabolite Saccharides Monosaccharides	Endogenous Metabolite
D-Tagatose (Standard) is the analytical standard of D-Tagatose. This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a rare monosaccharide found in nature with prebiotic characteristics. D-Tagatose is as a substitute for sucrose and a low-calorie sweetener in foodstuffs such as gum, fruit juice, and beverages. D-Tagatose is also a potential antidiabetic agent for the research of type II diabetes and a prebiotic to help elevate beneficial bacteria in the colon, prevent colon cancer, and lower cholesterol .

HY-N0527R

Pentagalloylglucose (Standard)	Structural Classification other families Source classification Phenols Polyphenols Plants	JAK Keap1-Nrf2 Apoptosis β-catenin Reactive Oxygen Species
Pentagalloylglucose (Standard) is the analytical standard of Pentagalloylglucose. This product is intended for research and analytical applications. Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) is an orally active gallic tannin compound and an inducer of apoptosis and autophagy. Pentagalloglucose induces cell apoptosis and autophagy through the GSK3β/β-catenin pathway. Pentagalloglucose has antioxidant, anti mutagenic, anti-inflammatory, anticonvulsant, cardioprotective, anti allergic, cholesterol lowering, and anti-tumor activities .

Cat. No.	Product Name	Chemical Structure

HY-B1189S

Meglutol-d3
Meglutol-d₃ is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.

HY-N0504S1

Lovastatin-d9
Lovastatin-d₉ is the deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-N0504S2

Lovastatin-d3
Lovastatin-d₃ is deuterium labeled Lovastatin. Lovastatin is a cell-permeable HMG-CoA reductase inhibitor used to lower cholesterol.

HY-B0388S1

Probucol-d6
Probucol-d₆ is deuterium labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-B0388S

Probucol-13C3
Probucol- ¹³C₃ is the ¹³C-labeled Probucol. Probucol (DH-581) is an anti-hyperlipidemic agent by lowering the level of cholesterol in the bloodstream by increasing the rate of LDL catabolism.

HY-N0131S1

Stigmasterol-d5-1
Stigmasterol-d₅-1 is deuterium labeled Stigmasterol. Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases[1].

HY-N1459S

(24Rac)-Campesterol-d7
Campesterol-d₇ ((24R)-5-Ergosten-3β-ol-d₇) is the deuterium labeled Campesterol. Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-B0723S

Ospemifene D4
Ospemifene-d₄ is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active estrogen receptor modulator for the prevention of osteoporosis with IC50 values of 827 nM and 1633 nM for estrogen receptor α (ERα) and ERβ, respectively. Ospemifene has bone-sparing, antitumor, and cholesterol-lowering effects[1][2].

HY-W012946S

2-Furoic acid-d3
2-Furoic acid-d₃ is the deuterium labeled 2-Furoic acid[1]. 2-Furoic acid (Furan-2-carboxylic acid) is an organic compound produced through furfural oxidation[2]. 2-Furoic acid exhibits hypolipidemic effet, lowers both serum cholesterol and serum triglyceride levels in rats[3].

HY-109523S

Cerivastatin-d3 sodium

Cerivastatin-d₃ sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect .

HY-17504BS2

Rosuvastatin-13C,d3 sodium

Rosuvastatin- ¹³C,d₃ sodium is ¹³C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC₅₀ of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC₅₀ of 195 nM . Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels .

Cat. No.	Product Name		Classification

HY-N1459

Campesterol 2 Publications Verification		Cholesterol
Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

HY-W134326

Polydextrose		Fillers
Polydextrose has the effect of lowering cholesterol and plasma lipids, and can effectively reduce low-density lipoprotein cholesterol. Polydextrose significantly reduced plasma and liver cholesterol in gerbils fed with enlarged endogenous cholesterol reservoirs .

HY-N0131

Stigmasterol 5 Publications Verification		Cholesterol
Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases.

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