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dicarboxylic

" in MedChemExpress (MCE) Product Catalog:

49

Inhibitors & Agonists

1

Fluorescent Dye

6

Biochemical Assay Reagents

1

Peptides

17

Natural
Products

11

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-121964
    cis-Piperidine-2,3-dicarboxylic acid

    		iGluR Neurological Disease
    Cis-piperidine-2,3-dicarboxylic acid is a non-specific antagonist of NMDA, AMPA and kainate ionotropic receptors and a partial agonist for NMDA receptors. Cis-piperidine-2,3-dicarboxylic acid can be used in blocking general excitatory synaptic transmissions .
    cis-Piperidine-2,3-dicarboxylic acid
  • HY-Y1024
    Pyridine-2,6-dicarboxylic acid

    2,6-Pyridinedicarboxylic acid

    		 Biochemical Assay Reagents Others
    Pyridine-2,6-dicarboxylic acid is a dicarboxylic acid containing a pyridine ring with unique chemical properties that make it an important ingredient in a variety of industrial processes. Pyridine-2,6-dicarboxylic acid is commonly used as a ligand for metal ions, a building block in the synthesis of pharmaceuticals and organic compounds, and a precursor in the production of pigments and dyes.
    Pyridine-2,6-dicarboxylic acid
  • HY-128426
    Trans-​2-​butene-​1,​4-​dicarboxylic acid

    		Endogenous Metabolite Metabolic Disease
    Trans-​2-​butene-​1,​4-​dicarboxylic acid is an endogenous metabolite.
    Trans-​2-​butene-​1,​4-​dicarboxylic acid
  • HY-131272
    Febuxostat dicarboxylic acid impurity

    		Drug Metabolite Others
    Febuxostat dicarboxylic acid impurity is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM .
    Febuxostat dicarboxylic acid impurity
  • HY-W005178
    Octadecanedioic acid

    		Endogenous Metabolite Others
    Octadecanedioic acid, an endogenous metabolite, is a long-chain dicarboxylic acid that has been found in serum free fatty acid profile in Reye syndrome .
    Octadecanedioic acid
  • HY-W002094S
    Cyclopropane-1,1-dicarboxylic acid-d4

    		Isotope-Labeled Compounds Others
    Cyclopropane-1,1-dicarboxylic acid-d4 is the deuterium labeled Cyclopropane-1,1-dicarboxylic acid[1].
    Cyclopropane-1,1-dicarboxylic acid-d4
  • HY-W002000
    Pyridine-3,5-dicarboxylic acid

    		Biochemical Assay Reagents Others
    Pyridine-3,5-dicarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Pyridine-3,5-dicarboxylic acid
  • HY-W017105
    Pyrazine-2,3-dicarboxylic acid

    2,3-Dicarboxypyrazine

    		 Biochemical Assay Reagents Others
    Pyrazine-2,3-dicarboxylic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Pyrazine-2,3-dicarboxylic acid
  • HY-100616A
    trans-ACBD

    trans-1-Aminocyclobutane-1,3-dicarboxylic acid

    		 iGluR Neurological Disease
    trans-ACBD (trans-1-Aminocyclobutane-1,3-dicarboxylic acid) is a very potent and selective NMDA receptor agonist that modulates glutamatergic neurotransmission .
    trans-ACBD
  • HY-W056964S
    Naphthalene-2,6-dicarboxylic acid-d6

    Naphthalene-2,6-dicarboxylate-d6

    		 Isotope-Labeled Compounds Others
    Naphthalene-2,6-dicarboxylic acid-d6 is the deuterium labeled Naphthalene-2,6-dicarboxylic acid[1].
    Naphthalene-2,6-dicarboxylic acid-d6
  • HY-D1864
    Sulfo-Cy7.5 dicarboxylic acid

    		Fluorescent Dye Others
    Sulfo-Cy7.5 dicarboxylic acid is a dye derivative of Cyanine 7.5 (Cy7.5) (HY-D0926) with carboxylic acid and sulfonate functional groups. The sulfonate ion increases the water solubility of the compound, making it suitable for use in aqueous solutions. Cy7.5 is a near-infrared fluorescent dye commonly used in biomedical research areas such as biomarkers and cell imaging. Sulfo-Cy7.5 dicarboxylic acid can be covalently bound to some biomolecules (especially antibodies, proteins, etc.) to track their location and dynamic changes in biological samples.
    Sulfo-Cy7.5 dicarboxylic acid
  • HY-102091A
    (2R,4R)-APDC hydrate

    (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate

    		 mGluR Neurological Disease
    (2R,4R)-APDC hydrate ((2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid hydrate) is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC hydrate affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC hydrate can be used in the study of epilepsy and other neurological diseases .
    (2R,4R)-APDC hydrate
  • HY-100841
    (Rac)-3-Hydroxyphenylglycine

    3HPG

    		 Others Metabolic Disease
    (Rac)-3-Hydroxyphenylglycine is an phosphoinositide hydrolysis agonist . ACPD: I-aminocyclopcntane-1,3-dicarboxylic acid.
    (Rac)-3-Hydroxyphenylglycine
  • HY-139711
    Anticancer agent 13

    		Others Cancer
    Anticancer agent 13 is an anticancer agent from dicarboxylic acids and amines.
    Anticancer agent 13
  • HY-W012241
    Dodecanedioic acid

    		Endogenous Metabolite Others
    Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates.
    Dodecanedioic acid
  • HY-133681
    (±)-2,3-Dibromosuccinic acid

    		Others Others
    (±)-2,3-Dibromosuccinic acid is the key intermediate in the synthesis of dicarboxylic acid derivatives .
    (±)-2,3-Dibromosuccinic acid
  • HY-W007752
    3-Oxopentanedioic acid

    		Endogenous Metabolite Others
    3-Oxopentanedioic acid is a simple dicarboxylic acid, which is well-known to be used in the tropinone synthesis.
    3-Oxopentanedioic acid
  • HY-W053507
    m-Tolylacetic acid

    3-Methylbenzeneacetic acid

    		 Drug Metabolite Others
    m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid .
    m-Tolylacetic acid
  • HY-W016454
    5-Aminoisophthalic acid

    5-Aminobenzene-1,3-dicarboxylic acid

    		 Biochemical Assay Reagents Others
    5-Aminoisophthalic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    5-Aminoisophthalic acid
  • HY-Y1311
    Malic acid
    1 Publications Verification

    Hydroxybutanedioic acid; E 296

    		 Endogenous Metabolite Others
    Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
    Malic acid
  • HY-Y0262
    Oxalic acid, 99%

    Ethanedioic acid

    		 Endogenous Metabolite Metabolic Disease
    Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic acid, 99%
  • HY-Y0262A
    Oxalic acid diammonium monohydrate

    Ethanedioic acid diammonium monohydrate

    		 Endogenous Metabolite Metabolic Disease
    Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic acid diammonium monohydrate
  • HY-W007894
    Dimethylmalonic acid

    		Endogenous Metabolite Others
    Dimethylmalonic acid is a short-chain dicarboxylic acid in human serum. Dimethylmalonic acid is also a volatile organic compound detected in alveolar breath .
    Dimethylmalonic acid
  • HY-100616
    cis-ACBD

    cis-1-Aminocyclobutane-1,3-dicarboxylic acid

    		 Others Neurological Disease
    cis-ACBD is a potent and selective inhibitor of the high-affinity, Na +-dependent plasma membrane glutamate transporter. cis-ACBD is a glutamate reuptake inhibitor. cis-ACBD also acts as linear competitive inhibitor of the uptake of D-[3H]aspartate .
    cis-ACBD
  • HY-118350
    FR 75513

    		Others Neurological Disease
    FR 75513 is a 1,1'-biphenyl-2,6-dicarboxylic acid diester series compound that can inhibit the contraction of the detrusor muscle of guinea pig bladder (IC50=3.3 μg/mL). After intravenous injection of FR 75513 into anesthetized rats, it also showed strong inhibitory activity on the detrusor contraction (ID50=0.04 mg/kg).
    FR 75513
  • HY-114634
    Mesoxalate

    Ketomalonic acid; Mesoxalic acid; Oxomalonic acid

    		 HIV Infection
    Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM .
    Mesoxalate
  • HY-Y1069
    (S)-Malic acid
    1 Publications Verification

    (S)-Hydroxybutanedioic acid; (S)-E 296; L-Malic acid

    		 Endogenous Metabolite Metabolic Disease
    (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive.
    (S)-Malic acid
  • HY-Y0262S
    Oxalic Acid-d2

    		Endogenous Metabolite Metabolic Disease
    Oxalic Acid-d2 is the deuterium labeled Oxalic Acid. Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic Acid-d2
  • HY-W012241S
    Dodecanedioic acid-d20

    		Endogenous Metabolite Others
    Dodecanedioic acid-d20 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
    Dodecanedioic acid-d20
  • HY-W012241S1
    Dodecanedioic acid-d4

    		Endogenous Metabolite Others
    Dodecanedioic acid-d4 is the deuterium labeled Dodecanedioic acid[1]. Dodecanedioic acid (C12) is a dicarboxylic acid with a metabolic pathway intermediate to those of lipids and carbohydrates[2].
    Dodecanedioic acid-d4
  • HY-W008820
    Glutaric acid

    		Endogenous Metabolite Metabolic Disease
    Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I .
    Glutaric acid
  • HY-Y1311R
    Malic acid (Standard)

    		Endogenous Metabolite Others
    Malic acid (Standard) is the analytical standard of Malic acid. This product is intended for research and analytical applications. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods.
    Malic acid (Standard)
  • HY-Y1311S
    Malic acid-d3

    Hydroxybutanedioic acid-d3; E 296-d3

    		 Endogenous Metabolite Others
    Malic acid-d3 is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods[1][2].
    Malic acid-d3
  • HY-133681A
    2,3-Dibromosuccinic acid

    		Others Others
    2,3-Dibromosuccinic acid is the isomer of (±)-2,3-Dibromosuccinic acid (HY-133681), and can be used as an experimental control. (±)-2,3-Dibromosuccinic acid is the key intermediate in the synthesis of dicarboxylic acid derivatives .
    2,3-Dibromosuccinic acid
  • HY-Y0262R
    Oxalic acid, 99% (Standard)

    		Endogenous Metabolite Metabolic Disease
    Oxalic acid, 99% (Standard) is the analytical standard of Oxalic acid, 99%. This product is intended for research and analytical applications. Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent.
    Oxalic acid, 99% (Standard)
  • HY-Y0262S1
    Oxalic acid-13C2

    		Isotope-Labeled Compounds Others
    Oxalic acid- 13C2is the deuterium labeledOxalic acid, 99%(HY-Y0262) . Oxalic Acid is a strong dicarboxylic acid occurring in many plants and vegetables and can be used as an analytical reagent and general reducing agent .
    Oxalic acid-13C2
  • HY-B0704
    Azelaic acid
    1 Publications Verification

    Nonanedioic acid

    		 Antibiotic Endogenous Metabolite Inflammation/Immunology
    Azelaic acid is a nine-carbon dicarboxylic acid. Azelaic acid has antimicrobial activity against Propionibacterium acnes and Staphylococcus epidermidis through inhibition of microbial cellular prorein synthesis. Azelaic acid has hypopigmentation action resulting from its ability to scavenge free radicals .
    Azelaic acid
  • HY-Y1069S
    (S)-Malic acid-d3

    (S)-Hydroxybutanedioic acid-d3; (S)-E 296-d3; L-Malic acid-d3

    		 Endogenous Metabolite Metabolic Disease
    (S)-Malic acid-d3 is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive[1][2].
    (S)-Malic acid-d3
  • HY-W008820S1
    Glutaric acid-d4

    		Endogenous Metabolite Metabolic Disease
    Glutaric acid-d4 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
    Glutaric acid-d4
  • HY-W008820S2
    Glutaric acid-d2

    		Endogenous Metabolite Metabolic Disease
    Glutaric acid-d2 is the deuterium labeled Glutaric acid. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I[1][2][3].
    Glutaric acid-d2
  • HY-W017132
    2,4-PDCA

    		Histone Demethylase Cancer
    2,4-PDCA (2,4 pyridine dicarboxylic acid) is a broad-spectrum inhibitor of 2OG oxygenase, including JmjC domain-containing family of histone demethylases (JHDMs). 2,4-PDCA is a target chemical in the field of bio-based plastics .
    2,4-PDCA
  • HY-102091
    (2R,4R)-APDC

    (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylic acid

    		 mGluR Neurological Disease
    (2R,4R)-APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R)-APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R)-APDC can be used in the study of epilepsy and other neurological diseases .
    (2R,4R)-APDC
  • HY-113410
    3-Methylglutaric acid

    		Endogenous Metabolite Metabolic Disease
    3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH) .
    3-Methylglutaric acid
  • HY-W127787
    Tartaric acid sodium hydrate

    L-(+)-Tartaric acid sodium hydrate

    		 Endogenous Metabolite Others
    L-Tartaric acid (L-(+)-Tartaric acid) sodium hydrate is the enantiomer of D-tartaric acid. L-Tartaric acid (HY-Y0293) is a white crystalline dicarboxylic acid found in many plants, such as grapes, and is one of the main organic acids in wine. L-Tartaric acid sodium hydrate which acts as a flour bulking agent and as a food additive can interact with sodium bicarbonate to produce carbon dioxide .
    Tartaric acid sodium hydrate
  • HY-113410S
    3-Methylglutaric acid-d4

    		Endogenous Metabolite Metabolic Disease
    3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
    3-Methylglutaric acid-d4
  • HY-W102981
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione

    7-Oxanorborna-2-ene-5,6-dicarboxylic anhydride

    		 Nucleoside Antimetabolite/Analog Cancer
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
    4,10-Dioxatri cyclo[5.2. 1.02.6]dec-8-ene-3,5-dione
  • HY-Y1069R
    (S)-Malic acid (Standard)

    		Endogenous Metabolite Metabolic Disease
    (S)-Malic acid (Standard) is the analytical standard of (S)-Malic acid. This product is intended for research and analytical applications. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive. In Vitro: It is showed that ME is essential for (S)-2-Hydroxysuccinic acid (L-malic acid) utilization in L. casei. Furthermore, deletion of either the gene encoding the histidine kinase or the response regulator of the TC system resulted in the loss of the ability to grow on (S)-2-Hydroxysuccinic acid, thus indicating that the cognate TC system regulates and is essential for the expression of ME. Transcriptional analyses shows that expression of maeE is induced in the presence of (S)-2-Hydroxysuccinic acid and repressed by glucose, whereas TC system expression is induced by (S)-2-Hydroxysuccinic acid and is not repressed by glucose .
    (S)-Malic acid (Standard)
  • HY-W008820R
    Glutaric acid (Standard)

    		Endogenous Metabolite Metabolic Disease
    Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I . In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM .
    Glutaric acid (Standard)
  • HY-P10563
    Noraramtide

    BHV-1100

    		 CD38 Cancer
    Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .
    Noraramtide

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