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genotoxic

" in MedChemExpress (MCE) Product Catalog:

103

Inhibitors & Agonists

6

Fluorescent Dye

4

Biochemical Assay Reagents

22

Natural
Products

14

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-119329
    Glycidamide
    1 Publications Verification

    Oxiranecarboxamide; 2,3-Epoxypropanamide

    		 Drug Metabolite Others
    Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .
    Glycidamide
  • HY-114517
    3-Acetyl-2,5-dimethylfuran

    		Biochemical Assay Reagents Metabolic Disease
    3-Acetyl-2,5-dimethylfuran is a flavoring agent exhibiting genotoxic potential in vitro assays .
    3-Acetyl-2,5-dimethylfuran
  • HY-23498
    Benzo[k]fluoranthene

    		Endogenous Metabolite Others
    Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .
    Benzo[k]fluoranthene
  • HY-W587892
    Decyl methyl ether

    1-Methoxydecane

    		 Biochemical Assay Reagents Others
    Decyl methyl ether is a new type of strong fatty ether. Decyl methyl ether is non-genotoxic and phototoxic/photosensitizing .
    Decyl methyl ether
  • HY-N8022
    Lucidin primeveroside

    Lucidin 3-O-β-primeveroside

    		 Biochemical Assay Reagents Cancer
    Lucidin primeveroside (Lucidin 3-O-β-primeveroside) is an anthraquinone derivative present in madder root, which has been used as a coloring agent and food additive. Lucidin primeveroside can be metabolically converted to genotoxic compound Lucidin, which subsequently forms lucidin-specific DNA adducts .
    Lucidin primeveroside
  • HY-133647
    Dibromoacetaldehyde

    		Others Others
    Dibromoacetaldehyde, a halogenated product, is a byproduct in drinking water and has genotoxicity .
    Dibromoacetaldehyde
  • HY-133649
    Dibromochloroacetaldehyde

    		Drug Derivative Others
    Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity .
    Dibromochloroacetaldehyde
  • HY-121345
    Homobaldrinal

    		Drug Metabolite Neurological Disease Cancer
    Homobaldrinal is a decomposition product of Valepotriate (HY-N0718). Homobaldrinal exhibits genotoxic activity in the Salmonella/microsome test .
    Homobaldrinal
  • HY-400785
    Dapagliflozin impurity A

    		Drug Derivative Cancer
    Dapagliflozin impurity A (Compound A) is a dapagliflozin peroxide, a genotoxic impurity, can cause damage to human genetic material at very low concentrations, leading to genetic mutations and possibly tumorigenesis .
    Dapagliflozin impurity A
  • HY-23498R
    Benzo[k]fluoranthene (Standard)

    		Reference Standards Endogenous Metabolite Others
    Benzo[k]fluoranthene (Standard) is the analytical standard of Benzo[k]fluoranthene. This product is intended for research and analytical applications. Benzo[k]fluoranthene is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic and genotoxic .
    Benzo[k]fluoranthene (Standard)
  • HY-W100026
    Galaxolide

    		Estrogen Receptor/ERR Glutathione S-transferase Metabolic Disease Endocrinology
    Galaxolide can induce estrogenic activity (Estrogen Receptor/ERR), trigger oxidative stress and genotoxicity, and induce EROD and GST (Glutathione S-transferase) enzyme activity .
    Galaxolide
  • HY-151629
    MRV03-069

    		Others Cancer
    MRV03-069 (Compound 3) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-069 can be used in colorectal cancer research .
    MRV03-069
  • HY-151628
    MRV03-068

    		Others Cancer
    MRV03-068 (Compound 2) is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-068 can be used in colorectal cancer research .
    MRV03-068
  • HY-119635
    Albicanol

    		Others Cancer
    Albicanol is a sesquiterpenoid with potent antioxidant and antagonistic activities against heavy metal toxicity. Albicanol shows cytotoxicity. Albicanol suppress Profenofos (HY-B0832) induced genotoxicity in grass carp hepatocytes .
    Albicanol
  • HY-133787
    Levofloxacin N-oxide

    		Drug Metabolite Infection
    Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .
    Levofloxacin N-oxide
  • HY-125098
    Illudin S

    		DNA Alkylator/Crosslinker Apoptosis Infection Cancer
    Illudin S, a cytotoxic Illudin, is a natural sesquiterpene with strong anti-tumour and antiviral activities. Illudin S has genotoxic activities. Illudin S blocks the G1-S phase interface of the cell cycle in human leukemia cells .
    Illudin S
  • HY-171982
    ATII

    		Biochemical Assay Reagents Others
    ATII (Traseolide), a Polycyclic musk fragrance, is a hydrophobic hapten. ATII has no genotoxicity in the human lymphocytes and the human hepatoma cell line Hep G2. ATII can be bound by antibody M02/05/01 (H93 Val) with superior binding capacity. ATII can be conjugated to carrier proteins for antigen design .
    ATII
  • HY-133787R
    Levofloxacin N-oxide (Standard)

    		Reference Standards Drug Metabolite Infection
    Levofloxacin N-oxide (Standard) is the analytical standard of Levofloxacin N-oxide. This product is intended for research and analytical applications. Levofloxacin N-oxide is a minor metabolite of Levofloxacin (HY-B0330). Levofloxacin N-oxide does not exhibit significantly genotoxic risks. Levofloxacin is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria .
    Levofloxacin N-oxide (Standard)
  • HY-N6714
    Alternariol

    		Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis Infection Cancer
    Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .
    Alternariol
  • HY-D0257
    Tartrazine
    1 Publications Verification

    Acid Yellow 23; FD&C Yellow No. 5

    		 Fluorescent Dye Apoptosis Mitochondrial Metabolism Cardiovascular Disease Neurological Disease
    Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity .
    Tartrazine
  • HY-N6714R
    Alternariol (Standard)

    		Reference Standards Topoisomerase Androgen Receptor Estrogen Receptor/ERR Apoptosis Infection Cancer
    Alternariol (Standard) is the analytical standard of Alternariol. This product is intended for research and analytical applications. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects .
    Alternariol (Standard)
  • HY-146121
    Antitubercular agent-26

    		Bacterial Infection
    Antitubercular agent-26 (Compound 32) is an orally active anti-tubercular agent with an extracellular IC50 of 0.50 μM and an intracellular IC50 of 0.51 μM against M. tuberculosis H37Rv. Antitubercular agent-26 shows good metabolic stability, low risk of cardiotoxicity and no genotoxicity .
    Antitubercular agent-26
  • HY-N2081
    Skimmianine
    3 Publications Verification

    		 Cholinesterase (ChE) PI3K Akt NF-κB Neurological Disease Inflammation/Immunology Cancer
    Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
    Skimmianine
  • HY-W014940
    Ethylene glycol dimethacrylate

    		Reactive Oxygen Species (ROS) Apoptosis Glutathione Peroxidase SOD Others
    Ethylene glycol dimethacrylate is a diester formed by the condensation of Ethylene glycol (HY-Y0338) and Methacrylic acid. Ethylene glycol dimethacrylate is a cross-linking agent for polymers. Ethylene glycol dimethacrylate increases Apoptosis, GPx4, SOD2, ROS. Ethylene glycol dimethacrylate is cytotoxic and genotoxic. Ethylene glycol dimethacrylate exhibits cross-linking activity, enhancing the mechanical properties and stability of materials .
    Ethylene glycol dimethacrylate
  • HY-134273A
    8-Br-dGTP sodium

    8-Bromo-dGTP sodium

    		 Nucleoside Antimetabolite/Analog Others
    8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5), an 8-brominated purine nucleotide, is a syn-oriented analog of dGTP. 8-Br-dGTP sodium can be hydrolyzed by the enzyme hMTH1 protein (HY-P74740). 8-Br-dGTP sodium inhibits dGTP-activated ADP reduction with a Ki of 56  μM. 8-Br-dGTP sodium has no significant genotoxicity and mutagenic potentials during DNA synthesis .
    8-Br-dGTP sodium
  • HY-N2081R
    Skimmianine (Standard)

    		Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB Neurological Disease Inflammation/Immunology Cancer
    Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC50 = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca 2+ signaling and protein kinase C signaling .
    Skimmianine (Standard)
  • HY-W795264
    FR900098

    		Parasite Infection
    FR900098 is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 has no effect on bone marrow red blood cells in NMRI mice .
    FR900098
  • HY-122817
    FR900098 sodium

    		Antibiotic Parasite Infection
    FR900098 sodium is an antimalarial agent that inhibits 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase. FR900098 sodium has no significant acute toxicity or genotoxicity, and does not have the ability to cause chromosome breakage or heterogeneity. FR900098 sodium has no effect on bone marrow red blood cells in NMRI mice .
    FR900098 sodium
  • HY-W043437
    Isopropyl benzenesulfonate

    Isopropyl besylate

    		 Drug Intermediate Others
    Isopropyl benzenesulfonate (Isopropyl besylate) is a sulfonate ester and a potential genotoxic impurity .
    Isopropyl benzenesulfonate
  • HY-W776973
    Glycidamide-13C3

    Oxiranecarboxamide-13C3; 2,3-Epoxypropanamide-13C3

    		 Isotope-Labeled Compounds Drug Metabolite Others
    Glycidamide- 13C3 (Oxiranecarboxamide- 13C3) is the 13C-labeled Glycidamide (HY-119329). Glycidamide is the genotoxic metabolite of Acrylamide. Glycidamide can react with proteins, such as hemoglobin, or with DNA, and induces genotoxic effects .
    Glycidamide-13C3
  • HY-W103488
    Chloridazon

    		Herbicide Others
    Chloridazon is a herbicide with an LD50 value of 76.6 ppm at genotoxicity assay .
    Chloridazon
  • HY-121213
    Erysolin

    		Cytochrome P450 Cancer
    Erysolin is a CYP1A inhibitor with antigenic toxicity. Erysolin reduces benzo(a)pyrene-induced genotoxicity .
    Erysolin
  • HY-131102
    Mequindox

    		Bacterial DNA/RNA Synthesis Infection
    Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .
    Mequindox
  • HY-W010553
    2,5-Dimethyl-3(2H)-furanone

    2,5-Dimethyl-2,3-dihydrofuran-3-one

    		 Biochemical Assay Reagents Others
    2,5-Dimethyl-3(2H)-furanone is a flavouring substance without genotoxicity .
    2,5-Dimethyl-3(2H)-furanone
  • HY-136375
    Cyanazine

    		Herbicide Others
    Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .
    Cyanazine
  • HY-N4183
    Licoflavone C

    		Others Cancer
    Licoflavone C is a prenyl-flavone extracted from Genista ephedroides, reduces the genotoxicity of cancer agents in human peripheral lymphocytes .
    Licoflavone C
  • HY-122099
    Riddelline

    		DNA/RNA Synthesis Others
    Riddelline, a pyrrolizidine alkaloid, is a potent genotoxic agent. Riddelline induces significant elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver .
    Riddelline
  • HY-W011817
    6-Acetyl-1,1,2,4,4,7-hexamethyltetraline

    AHTN

    		 Biochemical Assay Reagents Others
    6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN) is a synthetic fragrance ingredient that is not significantly genotoxic in mammalian systems .
    6-Acetyl-1,1,2,4,4,7-hexamethyltetraline
  • HY-118948
    MSN-50

    		Bcl-2 Family Neurological Disease
    MSN-50 is a Bax and Bak oligomerization inhibitor. MSN-50 efficiently inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection .
    MSN-50
  • HY-B1244
    Dimetridazole
    1 Publications Verification

    1,2-Dimethyl-5-nitroimidazole

    		 Parasite Antibiotic Bacterial Infection
    Dimetridazole is a nitroimidazole antibiotic. Dimetridazole inhibits protein synthesis in cultures of Campylobacter jejuni. Dimetridazole is genotoxic. Dimetridazole can be used in the research of protozoal and bacterial infections .
    Dimetridazole
  • HY-D0211
    Phenolphthalein

    		Fluorescent Dye Cancer
    Phenolphthalein is an acid-base indicator that is colorless in an acidic environment and pink in an alkaline environment. Phenolphthalein is genotoxic and potentially carcinogenic to mice. In addition, phenolphthalein is also a blood indicator .
    Phenolphthalein
  • HY-116108
    Musk tibetene

    Musk tibetine

    		 Olfactory Receptor Cancer
    Musk tibetene (Musk tibetine) is a nitro musk compound with carcinogenic activity. Musk tibetine reveals no genotoxicity in the micronucleus test with human lymphocytes and human hepatoma cell line .
    Musk tibetene
  • HY-136375S
    Cyanazine-d5

    		Isotope-Labeled Compounds Others
    Cyanazine-d5 is deuterium labeled Cyanazine. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .
    Cyanazine-d5
  • HY-124489
    2-Hydroxyestradiol
    2 Publications Verification

    		 Endogenous Metabolite Metabolic Disease
    2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity .
    2-Hydroxyestradiol
  • HY-154958
    mTOR inhibitor-12

    		mTOR Neurological Disease
    mTOR inhibitor-12 (Compound 11) is a selective brain penetrant mTOR inhibitor without genotoxicity risk. mTOR inhibitor-12 can be used for the research of CNS diseases .
    mTOR inhibitor-12
  • HY-131102R
    Mequindox (Standard)

    		Reference Standards Bacterial DNA/RNA Synthesis Infection
    Mequindox (Standard) is the analytical standard of Mequindox. This product is intended for research and analytical applications. Mequindox is an antimicrobial agent . Mequindox acts as an inhibitor of DNA synthesis. Mequindox induces genotoxicity and carcinogenicity in mice .
    Mequindox (Standard)
  • HY-136375R
    Cyanazine (Standard)

    		Herbicide Reference Standards Others
    Cyanazine (Standard) is the analytical standard of Cyanazine. This product is intended for research and analytical applications. Cyanazine, a triazine herbicide cyanazine, is used to control a variety of grass weeds and broadleaf weed. Cyanazine is proved non-genotoxic .
    Cyanazine (Standard)
  • HY-176347S
    Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2

    		Isotope-Labeled Compounds Cancer
    Alpha Feto Protein, Arg- 13C36, 15N4, Lys- 13C6, 15N2 is the 13C- and 15N-labeled Alpha Feto Protein.
    Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
  • HY-151626
    MRV03-037

    		Bacterial Infection
    MRV03-037 is a selective colibactin-activated peptidase (ClbP) inhibitor that blocks the genotoxic effect of Colibactin (HY-145930) on eukaryotic cells. MRV03-037 prevents gut bacterial genotoxin production .
    MRV03-037
  • HY-W612269S
    Isonicotinoyl chloride-d4

    		Isotope-Labeled Compounds Others
    Isonicotinoyl chloride-d4 is the deuterated labeled Isonicotinoyl chloride (HY-W612269). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .
    Isonicotinoyl chloride-d4

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