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Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocytegrowthfactor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research .
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocytegrowthfactor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocytegrowthfactor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion .
(Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocytegrowthfactor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .
Val-Cit-amide-Ph-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocytegrowthfactor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
Pamufetinib (TAS-115) is a potent VEGFR and hepatocytegrowthfactor receptor (c-Met/HGFR)-targeted kinase inhibitor with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
Pamufetinib (TAS-115) mesylate is a potent VEGFRand hepatocytegrowthfactor receptor (c-Met/HGFR)-targeted kinase inhibitor, with IC50s of 30 and 32 nM for rVEGFR2 and rMET, respectively.
Val-Cit-amide-Cbz-N(Me)-Maytansine is an antibody and bispecific antigen-binding mol. that bind hepatocytegrowthfactor receptor c-Met (MET) or antibody-drug conjugates (ADCs) .
Norleual, an angiotensin (Ang) IV analog, is a hepatocytegrowthfactor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocytegrowthfactor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .
Vabametkib is a potent inhibitor of hepatocytegrowthfactor receptor (HGFR). Vabametkib inhibits Hs746T cells proliferation and inhibits c-Met with an IC50 value of 7 nM. Vabametkib can be used as an antineoplastic agent .
Fosgonimeton (ATH-1017) is a hepatocytegrowthfactor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models .
Foretinib phosphate is an orally bioavailable small molecule with potential anti-tumor activity. Foretinib phosphate can selectively inhibit hepatocytegrowthfactor (HGF) receptor c-MET and vascular endothelial growthfactor receptor 2 (VEGFR2), thereby potentially inhibiting tumor angiogenesis, tumor cell proliferation and metastasis. Foretinib phosphate shows different anti-cancer activity from cabozantinib in lung cancer cells and has stronger inhibitory effects on targets such as MEK1/2, FER and AURKB .
Dextran sulfate sodium salt (MW 450000-550000) is a polymer of anhydroglucose with a molecular weight range of 450000-550000. Dextran sulfate sodium salt (MW 450000-550000) can effectively enrich precipitated cells and can be used to isolate neutrophils from human and rat blood. Dextran sulfate sodium salt (average MW 500000) can effectively enhance the conversion activity of coagulation factor XIIa (FXIIa) to induce hepatocytegrowthfactor (HGF) and increase the specific activity of FXIIa.
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocytegrowthfactor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocytegrowthfactor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocytegrowthfactor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer .
Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocytegrowthfactor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease .
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocytegrowthfactor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
Norleual TFA, an angiotensin (Ang) IV analog, is a hepatocytegrowthfactor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual TFA is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .
NFF-3 TFA, the peptide, is a selective MMP substrate. NFF-3 TFA selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 TFA is also cleaved by trypsin, hepatocytegrowthfactor activator, and factor Xa. Label NFF-3 TFA with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
Norleual, an angiotensin (Ang) IV analog, is a hepatocytegrowthfactor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities .
NFF-3, the peptide, is a selective MMP substrate. NFF-3 selectively binds to MMP-3 and MMP-10 to be hydrolyzed. NFF-3 is also cleaved by trypsin, hepatocytegrowthfactor activator, and factor Xa. Label NFF-3 with a CyDye pair, Cy3/Cy5Q, can produce fluorescence in cell assays to detect cell activity .
Telisotuzumab (ABT-700) is a human recombinant bivalent antibody, a therapeutic antibody against the hepatocytegrowthfactor receptor (MET) that binds c-Met with high affinity and inhibits c-Met signaling. Telisotuzumab has antitumor activity .
Rilotumumab (AMG 102) is an anti-HGF (anti-hepatocytegrowthfactor) monoclonal antibody, inhibits HGF/MET-driven signaling. Rilotumumab shows anti-tumor activity, and can be used in castration-resistant prostate cancer (CRPC) and solid tumor research .
Ficlatuzumab is a monoclonal antibody (McAb) targeting human hepatocytegrowthfactor (HGF). Ficlatuzumab blocks the activation of the HGF/c-Met signaling pathway, and inhibits c-Met receptor-mediated cancer cell proliferation, migration, and invasion .
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth, acting as a hepatotrophic factor for various tissues.It activates MAPK signaling through TMPRSS13 cleavage and activates MET receptor tyrosine kinase by promoting its dimerization.Structurally, HGF comprises alpha and beta chains connected by a disulfide bond.Interaction with SRPX2 enhances its mitogenic activity.HGF Protein, Rat (GST) is the recombinant rat-derived HGF protein, expressed by E.coli , with N-GST labeled tag.
HGF Protein is a hepatocyte growth factor involved in signaling pathways including MET and MAPK. The HGF Protein consists of 728 amino acids, with an alpha chain containing an n-terminal domain four kringle domains, and a β serine protease domain. HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293 , with C-His labeled tag. The total length of HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-37 & 52-70 & 80-100 kDa, respectively.
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (HEK293, His) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with C-6*His labeled tag.
HGF Protein is a hepatocyte growth factor involved in signaling pathways including MET and MAPK.The HGF Protein consists of an alpha chain containing an n-terminal domain four kringle domains, and a β serine protease domain.HGF Protein, Human (HEK293) is the recombinant Virus-derived HGF protein, expressed by HEK293 , with tag free.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Canine (HEK293, His) is the recombinant canine-derived HGFR protein, expressed by HEK293 , with N-His labeled tag. The total length of HGFR Protein, Canine (HEK293, His) is 911 a.a., with molecular weight of ~35-43 kDa & 80-100 kDa, respectively.
HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Mouse (HEK293, His) is the recombinant mouse-derived HGFR protein, expressed by HEK293, with C-His labeled tag. The total length of HGFR Protein, Mouse (HEK293, His) is 905 a.a., with molecular weight of ~34-42 kDa & 79-90 kDa, respectively.
HGFR Protein is a receptor tyrosine kinase that acts as a signal transducer of the extracellular matrix by binding to hepatocyte growth factor /HGF ligands. HGFR Protein participate in the activation of RAS-ERK, PI3 kinase-AKT, and PLCgamma-PKC signaling pathways. HGFR Protein is essential for embryonic development, organogenesis, and wound healing. HGFR Protein, Rat (HEK293, Fc) is the recombinant rat-derived HGFR protein, expressed by HEK293, with C-hFc labeled tag. The total length of HGFR Protein, Rat (HEK293, Fc) is 908 a.a., with molecular weight of ~97 & 39 kDa, respectively.
HGFR Protein, a receptor tyrosine kinase, transduces signals by binding hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. Upon ligand binding, HGFR undergoes autophosphorylation, creating docking sites for downstream molecules like PI3K, PLCG1, SRC, GRB2, STAT3, or GAB1, activating RAS-ERK, PI3K-AKT, and PLCgamma-PKC cascades. HGFR Protein, Cynomolgus/Rhesus Macaque (HEK293) is the recombinant Rhesus Macaque, cynomolgus-derived HGFR protein, expressed by HEK293 , with tag free.
HGF Protein is a hepatocyte growth factor involved in signaling pathways including MET and MAPK. The HGF Protein consists of 728 amino acids, with an alpha chain containing an n-terminal domain four kringle domains, and a β serine protease domain. GMP HGF Protein, Human (HEK293, His) is the recombinant human-derived HGF protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP HGF Protein, Human (HEK293, His) is 697 a.a., with molecular weight of 32-38 & 50-65 kDa, respectively.
The HGFR protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix by binding to hepatocyte growth factor/HGF ligand. This interaction regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (sf9, His-GST) is the recombinant human-derived HGFR protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.
The HGF gene encodes hepatocyte growth factor (HGF), a protein involved in organ regeneration, angiogenesis, and myelination. It is located in the extracellular space and serves as a biomarker for cholangiocarcinoma. Implicated in various diseases, HGF plays a crucial role in physiological and pathological conditions. It shows biased expression in the liver (RPKM 137.5), lung (RPKM 132.1), and other tissues. HGF Protein, Rat (HEK293) is the recombinant rat-derived HGF protein, expressed by HEK293 , with tag free.
HGF Protein, a potent mitogen, stimulates mature hepatocyte cell growth and acts as a hepatotrophic factor for various tissues. As an activating ligand for MET receptor tyrosine kinase, HGF binds and promotes dimerization, activating MAPK signaling through TMPRSS13 cleavage. Structurally, HGF comprises alpha and beta chains connected by a disulfide bond. Interaction with SRPX2 enhances its mitogenic activity. HGF Protein, Mouse (HEK293) is the recombinant mouse-derived HGF protein, expressed by HEK293 , with tag free.
HGF protein is a potent hepatocyte mitogen that stimulates mature hepatocyte proliferation and exhibits multiple growth factor properties in different tissues. As a ligand of MET receptor tyrosine kinase, HGF initiates downstream signaling cascades upon binding, activating MAPK signaling after TMPRSS13 cleavage. HGF Protein, Canine (HEK293) is the recombinant canine-derived HGF protein, expressed by HEK293 , with tag free.
HGF Protein, a potent mitogen, stimulates mature hepatocyte growth and exhibits hepatotrophic properties for various tissues. It acts as an activating ligand for the receptor tyrosine kinase MET, promoting dimerization upon binding. Structurally, HGF Protein comprises alpha and beta chains linked by a disulfide bond. Additionally, it interacts with SRPX2, enhancing HGF's mitogenic activity. HGF Protein, Cynomolgus (HEK293) is the recombinant cynomolgus-derived HGF protein, expressed by HEK293 , with tag free.
HGFA/HGF-activating proteins play a crucial role by catalyzing the activation of hepatocyte growth factor (HGF) and converting it into biologically active heterodimers. The process involves the formation of heterodimers with short and long chains linked by disulfide bonds. HGFA/HGF Activator Protein, Human (HEK293, His) is the recombinant human-derived HGFA/HGF Activator protein, expressed by HEK293 , with C-His labeled tag.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (495a.a, HEK293, His) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-6*His labeled tag.
HABP2 is a protein that cleaves the alpha chain of fibrinogen as well as the beta chain between "Lys-53" and "Lys-54" at multiple sites, preventing direct formation of a fibrin clot. It activates coagulation factor VII and converts prourokinase into its active form. HABP2 Protein, Human (HEK293, His) is the recombinant human-derived HABP2 protein, expressed by HEK293 , with C-6*His labeled tag.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.
The MSP/MST1 protein, encoded by this gene, is predicted to have receptor tyrosine kinase binding activity. It is involved in various processes, including embryo implantation, mammary duct growth, and regulation of mammary gland cell proliferation. The protein is mainly found in the vacuole and expressed in tissues like the esophagus, liver, pharynx, and stomach. Notably, the gene shows liver-biased expression in both adult and embryonic stages. MSP/MST1 Protein, Mouse (C677A, HEK293) is the recombinant mouse-derived MSP/MST1 protein, expressed by HEK293 , with tag free. and C677A, , , , mutation.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, His) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-6*His labeled tag.
The HGFR protein is a receptor tyrosine kinase that transduces signals by binding to hepatocyte growth factor/HGF ligand. It regulates proliferation, scattering, morphogenesis, and cell survival. HGFR Protein, Human (HEK293, Fc) is the recombinant human-derived HGFR protein, expressed by HEK293 , with C-hFc labeled tag.
HAI-2 protein is a multifunctional inhibitor that regulates multiple cellular processes by potently inhibiting HGFAC and reducing serine protease activity, specifically TMPRSS13 and ST14/matriptase. HAI-2 is good at inhibiting plasmin, plasma and tissue kallikrein, with broad-spectrum inhibitory capabilities. HAI-2 Protein, Human (HEK293, His) is the recombinant human-derived HAI-2 protein, expressed by HEK293 , with C-6*His labeled tag.
MET; hepatocytegrowthfactor receptor; HGF receptor; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met
WB, IP
Human
Phospho-c-Met (Tyr1349) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 156 kDa, targeting to Phospho-c-Met (Tyr1349). It can be used for WB,IP assays with tag free, in the background of Human.
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