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By Targets:	Adenosine Receptor (1) Adrenergic Receptor (4) Angiotensin-converting Enzyme (ACE) (2) Apoptosis (4) Biochemical Assay Reagents (1) Calcium Channel (1) CCR (1) DGK (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) Endogenous Metabolite (2) ERK (1) Mitochondrial Metabolism (1) MMP (2) Myosin (1) Neprilysin (1) NF-κB (1) Phosphodiesterase (PDE) (1) Platelet-activating Factor Receptor (PAFR) (1) Potassium Channel (6) Prostaglandin Receptor (2) Sodium Channel (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (28) Endocrinology (4) Inflammation/Immunology (4) Neurological Disease (9)

By Targets:

Adenosine Receptor (1)

Adrenergic Receptor (4)

Angiotensin-converting Enzyme (ACE) (2)

Apoptosis (4)

Biochemical Assay Reagents (1)

Calcium Channel (1)

CCR (1)

DGK (1)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (2)

Endogenous Metabolite (2)

ERK (1)

Mitochondrial Metabolism (1)

MMP (2)

Myosin (1)

Neprilysin (1)

NF-κB (1)

Phosphodiesterase (PDE) (1)

Platelet-activating Factor Receptor (PAFR) (1)

Potassium Channel (6)

Prostaglandin Receptor (2)

Sodium Channel (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (28)

Endocrinology (4)

Inflammation/Immunology (4)

Neurological Disease (9)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0259

Indapamide	Potassium Channel	Cardiovascular Disease
Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

HY-101415

Coenzyme Q9 Ubiquinone Q9; CoQ9; Ubiquinone 9	Apoptosis Endogenous Metabolite	Cardiovascular Disease
Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .

HY-106961

ONO 1301 ONO-AP 500-02	Prostaglandin Receptor	Cardiovascular Disease
ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .

HY-106961A

(Z)-ONO 1301 (Z)-ONO-AP 500-02	Prostaglandin Receptor	Cardiovascular Disease
(Z)-ONO 1301 is the isomer of ONO 1301 (HY-106961), and can be used as an experimental control. ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig .

HY-107428

PD-166793	MMP	Cardiovascular Disease
PD-166793 is a potent, selective, orally active and wide‐broad spectrum inhibitor of MMP, exhibiting nanomolar potency against MMP-2, MMP-3 and MMP-13 (IC₅₀=4, 7, and 8 nM, respectively) and micromolar potency vs MMP-1, -7 and -9 (IC₅₀=6.0, 7.2, and 7.9 μM, respectively). PD-166793 can attenuate left ventricular remodeling and dysfunction in a rat model of progressive heart failure .

HY-B0259A

Indapamide hemihydrate	Potassium Channel	Cardiovascular Disease
Indapamide hemihydrate is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide hemihydrate is also can reduce left ventricular hypertrophy .

HY-100961

NPC 200 1,3-Dipropyl-8-phenylxanthine	Adenosine Receptor	Inflammation/Immunology
NPC 200 is a potent and selective antagonist of Adenosine A1 Receptor. NPC 200 reverses NECA-induced left and right atrial depression with EC₅₀s of 1.08 and 2.03 μM .

HY-120355

AP14145	Potassium Channel	Cardiovascular Disease
AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits K_Ca2.2 channel and K_Ca channel with IC₅₀ of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect .

HY-101415R

Coenzyme Q9 (Standard)	Apoptosis Endogenous Metabolite	Cardiovascular Disease
Coenzyme Q9 (Standard) is the analytical standard of Coenzyme Q9. This product is intended for research and analytical applications. Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .

HY-106049

Acrihellin	Others	Cardiovascular Disease
Acrihellin is a type of cardiac-active steroid. Acrihellin can increase the contractility of the left atrium in guinea pigs .

HY-106369

HMR 1556 1 Publications Verification	Potassium Channel	Cardiovascular Disease
HMR 1556, a chromanol derivative, is a potent I_Ks blocker with IC₅₀s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively .

HY-121460

Spiraprilat	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Spiraprilat is a potent angiotensin-converting enzyme (ACE) inhibitor. Spiraprilat has ability to improve left ventricular (LV) function and metabolism in anesthetized open-chest dogs with acute ventricular failure (ALVF) .

HY-19121

TCV-309	Platelet-activating Factor Receptor (PAFR)	Cardiovascular Disease
TCV-309 is an antagonist for platelet activating factor (PAF). TCV-309 improves the left ventricular function during ischemia-reperfusion (77.6% recover at 1 μM), protects the cardiac function .

HY-116119

BDF 9148	Sodium Channel	Cardiovascular Disease
BDF 9148 is a sodium-channel activator with antiarrhythmic properties that produces a significant CAMP-independent positive inotropic effect in left ventricular myocardium from failing hearts. BDF 9148 is promising for research of myocardial failure .

HY-116478

L-3373	Others	Others
L-3373 is a voltage-dependent potassium channel inhibitor with activity that reduces the effective refractory period and the dispersion of monophasic action potential duration, while significantly reducing susceptibility to ventricular fibrillation in a cat model of left ventricular hypertrophy.

HY-120298

LY-510929	Others	Others
LY-510929 is a compound that induces left ventricular hypertrophy (LVH). Related studies have identified the relevant conditions in which LY-510929 may induce LVH by measuring multiple markers and using multiple techniques.

HY-129782

SC-55858	Others	Cardiovascular Disease
SC-55858 is an effective superoxide dismutase simulator. SC-55858 increased heart rate and decreased mean arterial pressure and left ventricular systolic and end-diastolic pressures in conscious, chronically instrumented dogs .

HY-114683

KS370G	Others	Cardiovascular Disease
KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .

HY-119817

Flosequinan BTS 49465; Flosequinon	Others	Cardiovascular Disease
Flosequinan is a balanced vasodilator. Flosequinan not only significantly reduces systemic vascular resistance, but also significantly reduces the beating component of left ventricular afterload, characteristic impedance and arterial wave reflection, which can be used in the research of acute heart failure .

HY-12788A

(S)-PF-04449613	Phosphodiesterase (PDE)	Neurological Disease
(S)-PF-04449613 is the left-handed isomer of PF-04449613 (HY-12788). PF-04449613 is a selective PDE9A inhibitor with an IC₅₀ of 22 nM. PF-04449613 improves motor learning ability in a mouse model .

HY-153343A

(S)-BAY 2965501	DGK ERK	Cancer
(S)-BAY 2965501 is the left-handed isomer of BAY 2965501 (HY-153343). BAY 2965501 is a potent and selective diacylglycerol kinase zeta (DGKζ) inhibitor. BAY 2965501 induces pERK activation. BAY 2965501 can be used for the research of cancer .

HY-17498B

Atenolol hydrochloride (RS)-Atenolol hydrochloride; Tenormin hydrochloride; ICI 66082 hydrochloride	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol hydrochloride is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol hydrochloride can be used for the research of hypertension and angina pectoris .

HY-106509

Velaresol BW 12C; 12C79; BW 12C79	Others	Others
Velaresol (BW 12C) is a potent left-shifting anti-sickling compound in vitro . Sickle cell disease is an inherited disorder of the hemoglobin molecule. When hemoglobin molecules are exposed to a variety of environments, the red blood cell hemoglobin polymerizes, twists, and morphs into a sickle shape.

HY-110116

SD-2590 hydrochloride	MMP	Cardiovascular Disease Inflammation/Immunology Cancer
SD-2590 hydrochloride is a potent MMP inhibitor with IC₅₀ values of ﹤0.1, ﹤0.1, 0.18, and 1.7 nM for MMP2, MMP13, MMP9, and MMP8, respectively. SD-2590 hydrochloride inhibits dilation of the left ventricle in rats .

HY-112792A

(1S)-CCR2 antagonist 1	CCR	Endocrinology
(1S)-CCR2 antagonist 1 is a left-handed chiral body of CCR2 antagonist 1 (HY-112792). CCR2 antagonist 1 is a high-affinity and long-residence-time CCR2 antagonist, with a K_i of 2.4 nM .

HY-17498

Atenolol Maximum Cited Publications 13 Publications Verification (RS)-Atenolol	Adrenergic Receptor	Cardiovascular Disease Neurological Disease Endocrinology Cancer
Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM at β1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-141552

FC9402	Mitochondrial Metabolism Others	Cardiovascular Disease
FC9402 is a potent and selective sulfide quinone oxidoreductase (SQOR) inhibitor extracted from patent WO 2020/146636 A1. FC9402 attenuates TAC-induced cardiomyocyte hypertrophy and left ventricle (LV) fibrosis. FC9402 can be used for cardiovascular regulation .

HY-B0259R

Indapamide (Standard)	Potassium Channel	Cardiovascular Disease
Indapamide (Standard) is the analytical standard of Indapamide. This product is intended for research and analytical applications. Indapamide is an orally active sulphonamide diuretic agent, that can reduce blood pressure by decreasing vascular reactivity and peripheral vascular resistance. Indapamide is also can reduce left ventricular hypertrophy .

HY-U00049A

Mioflazine (di(hydrochloride) hydrate)	Calcium Channel	Cardiovascular Disease Neurological Disease
Mioflazine dihydrochloride hydrate is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride hydrate helps maintain the mechanical function of the left ventricle and significantly improves the heart's recovery ability after global ischemia at new temperatures. Mioflazine dihydrochloride hydrate reduces the mitochondrial calcium content in guinea-pig .

HY-12550

GW542573X	Potassium Channel	Neurological Disease
GW542573X is a potent and selective Ca ²⁺-activated K ⁺ 2 (SK2) channels activator. GW542573X induces the Ca ²⁺-response curve of hSK1 that left-shifted from an EC₅₀ (Ca ²⁺) value of 410 nM to 240 nM .

HY-106024A

Alagebrium bromide ALT711 bromide	DNA Alkylator/Crosslinker	Cardiovascular Disease
Alagebrium bromide is an analog of Alagebrium Chloride (HY-106024B), a glucose cross-link blocker. Alagebrium Chloride disrupts glucose cross-links and may improve ventricular and arterial compliance. Alagebrium Chloride improves left ventricular diastolic filling and has the potential to inhibit diastolic heart failure (DHF) .

HY-W722221

Colterol acetate	Adrenergic Receptor	Cardiovascular Disease
Colterol acetate is a selective inhibitor of β-adrenergic receptors. Colterol acetate can relax tracheal smooth muscle (primarily acting on β2 receptors), reduce subspastic contractions of tricholoma (acting on β2), and increase contractility of left ventricular papillary muscles (acting on β1) .

HY-17498R

Atenolol (Standard) Maximum Cited Publications 13 Publications Verification (RS)-Atenolol (Standard)	Adrenergic Receptor	Neurological Disease Endocrinology Cancer
Atenolol (Standard) is the analytical standard of Atenolol. This product is intended for research and analytical applications. Atenolol ((RS)-Atenolol) is a cardioselective β1-adrenergic receptor blocker, with a K_i of 697 nM atβ1-adrenoceptor in guine pig left ventricle membrane. Atenolol can be used for the research of hypertension and angina pectoris .

HY-129706

LY127210 free base	Others	Cardiovascular Disease
LY127210 (free base) is a potent vasodilator with antihypertensive effects that reduces pressure in chloralose-anesthetized spontaneously hypertensive rats primarily by direct arteriolar dilation and to a lesser extent by decreasing cardiac output. LY127210 (free base) reduces blood pressure, heart rate and left ventricular end-diastolic pressure in hypertensive rats by reducing vascular resistance .

HY-Y0958

Methoxyamine hydrochloride O-Methylhydroxylamine hydrochloride	DNA/RNA Synthesis Apoptosis	Cancer
Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .

HY-W145695

Chitoheptaose	Biochemical Assay Reagents	Inflammation/Immunology
Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

HY-121239

Lemnalol	NF-κB	Neurological Disease Inflammation/Immunology Cancer
Lemnalol is a potent agent for neuropathic pain. Lemnalol possesses potent anti-inflammatory, analgesic and anti-tumor activities. Lemnalol has the capacity to attenuate hyperalgesia and allodynia by modulation of neuroinflammatory processes in neuropathy. Lemnalol modulates LPS-induced alterations of left atrial (LA) calcium homeostasis and blocks the NF-κB pathways, which may contribute to the attenuation of lipopolysaccharide (LPS)-induced arrhythmogenesis and neuropathic pain. Lemnalolis a ylangene-type sesquiterpenoid compound, isolated from Lemnalia cervicorni .

HY-Y0958R

Methoxyamine hydrochloride (Standard)	DNA/RNA Synthesis Apoptosis	Cancer
Methoxyamine (hydrochloride) (Standard) is the analytical standard of Methoxyamine (hydrochloride). This product is intended for research and analytical applications. Methoxyamine (O-Methylhydroxylamine) hydrochloride is an orally active and potent base excision repair (BER) inhibitor. Methoxyamine hydrochloride binds to 3’ hydroxyl groups that are left behind by 3-methylpurine-DNA glycosylase (MPG) following excision of the damaged base and thus inhibits BER activity. Methoxyamine hydrochloride binds directly to the apyrimidinic (AP) sites. Methoxyamine hydrochloride synergistically enhances the therapeutic efficacy of DNA-damaging agents .

HY-163120

Myosin-IN-1	Myosin	Cardiovascular Disease
Myosin-IN-1 (compound F10) is a Myosin inhibitor that specifically targets cardiac myosin. Myosin-IN-1 stabilizes the biochemical and structural closed state of the cardiac myosin motor domain and reduces myocardial force production and calcium sensitivity in vitro. Myosin-IN-1 acts as a negative inotropic agent in isolated Langendroff-perfused rat hearts, reducing stress in isolated myofilaments and left ventricular pressure development. Myosin-IN-1 can be used in heart failure research .

HY-118264

MDL-100240	Angiotensin-converting Enzyme (ACE) Neprilysin	Cardiovascular Disease
MDL-100240 is a dual-acting angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) inhibitor. MDL-100240 can significantly lower blood pressure, reverse left ventricular hypertrophy, and effectively prevent hypertrophy and dilatation of the aorta and resistance arteries, with an effect comparable to that of ramipril (HY-B0279). In addition, MDL-100240 can also reduce aldosterone levels, but has no significant effect on atrial natriuretic peptide and cGMP. In 3-month-old transgenic rats, MDL-100240 can reduce adrenomedullin concentrations, prevent and reverse severe hypertension and cardiovascular damage, and enhance bradykinin effects.

HY-106844A

(+)-EMD 57033	Others	Cardiovascular Disease
(+)-EMD 57033 is a cardiac troponin C (cTnC) activator, is a dominant Ca ²⁺ sensitizer. (+)-EMD 57033 binds the cardiac/slow skeletal troponin C isoform and exerts myocardial contractile promotion function .

Cat. No.	Product Name	Type

HY-W145695

Chitoheptaose	Biochemical Assay Reagents
Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

Chitoheptaose

Biochemical Assay Reagents

Chitoheptaose is a chitosan oligosaccharide. Chitoheptaose is capable of extracting exoskeletons from crustaceans, such as the shells of crabs, shrimp and lobsters. Chitoheptaose has antioxidant, anti-inflammatory and anti-apoptotic activities and can be used in the study of myocarditis. Chitoheptaose has cardioprotective effects and improves cardiac parameters (left ventricular internal size, end-systolic and end-diastolic, ejection fraction and shortening fraction), inflammatory cytokines (IL-1β) in vanishing models .

Cat. No.	Product Name	Target	Research Area

HY-P3776

a-Bag Cell Peptide (1-8)	Peptides	Neurological Disease
a-Bag Cell Peptide (1-8) is a NH2-terminal fragment α-bag cell peptide. α-bag cell peptide can inhibit the left upper quadrant (LUQ) neurons and the depolarization of the bag cells .

HY-P3775

a-Bag Cell Peptide (1-7)	Peptides	Neurological Disease
a-Bag Cell Peptide (1-7) is a NH2-terminal fragment α-bag cell peptide. α-bag cell peptide can inhibit the left upper quadrant (LUQ) neurons and the depolarization of the bag cells . α-Bag Cell Peptide Fragment

HY-P2601A

Tyr-α-CGRP (human) (TFA)	Peptides	Others
Tyr-α-CGRP (human) TFA is an N-terminally extended human α-CGRP analog. Tyr-α-CGRP (human) TFA can bind to membrane preparations from rat brain and spleen with IC₅₀ values of 0.2 nM and 0.5 nM, respectively, and induce positive chronotropic and inotropic effects in isolated guinea pig right and left atria with EC₅₀ values of 282 nM and 74 nM, respectively. Tyr-α-CGRP (human) TFA also inhibits contractile responses in rat vas deferens with an EC₅₀ value of 1.9 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-101415

Coenzyme Q9 Ubiquinone Q9; CoQ9; Ubiquinone 9	Cardiovascular Disease Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Benzene Quinones Endogenous metabolite Disease Research Fields	Apoptosis Endogenous Metabolite
Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .

HY-101415R

Coenzyme Q9 (Standard)	Quinones Structural Classification Microorganisms Source classification Benzene Quinones Endogenous metabolite	Apoptosis Endogenous Metabolite
Coenzyme Q9 (Standard) is the analytical standard of Coenzyme Q9. This product is intended for research and analytical applications. Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .

HY-121239

Lemnalol	Structural Classification Natural Products Animals Source classification	NF-κB
Lemnalol is a potent agent for neuropathic pain. Lemnalol possesses potent anti-inflammatory, analgesic and anti-tumor activities. Lemnalol has the capacity to attenuate hyperalgesia and allodynia by modulation of neuroinflammatory processes in neuropathy. Lemnalol modulates LPS-induced alterations of left atrial (LA) calcium homeostasis and blocks the NF-κB pathways, which may contribute to the attenuation of lipopolysaccharide (LPS)-induced arrhythmogenesis and neuropathic pain. Lemnalolis a ylangene-type sesquiterpenoid compound, isolated from Lemnalia cervicorni .

Cat. No.	Compare	Product Name	Species	Source

HY-P70191

	Lefty-A/TGF-beta 4 Protein, Human (HEK293, His) rHuleft-right determination factor 2, His; left-right determination factor 2; Endometrial bleeding-associated factor; left-right determination factor A; Protein lefty-2; Protein lefty-A; Transforming growth factor beta-4; TGF-beta-4; leftY2; EBAF; leftA; leftYA; TGFB4	Human	HEK293
	Lefty-A, or TGF-beta 4, plays a crucial role in determining left-right (L-R) asymmetry in mammalian organ systems. Its implication in endometrial bleeding suggests a potential role in reproductive processes, highlighting its significance beyond embryonic development. Lefty-A/TGF-beta 4 Protein, Human (HEK293, His) is the recombinant human-derived Lefty-A/TGF-beta 4 protein, expressed by HEK293 , with N-6*His labeled tag.

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