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Lowmolecularweight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. Lowmolecularweight protamine can inhibit tumor growth and is used in cancer research .
NBD-F (4-Fluoro-7-nitrobenzofurazan) is a pro-fluorescent reagent which is developed for amino acid analysis. NBD-F reacts with primary or secondary amines to produce a fluorescent product and used for analysis of amino acids and lowmolecularweight amines .
Melittin is a PLA2 activator, stimulates the activity of the lowmolecularweight PLA2, while it does not the increase activity of the high molecularweight PLA2 .
Melittin TFA is a PLA2 activator, stimulates the activity of the lowmolecularweight PLA2, while it does not the increase activity of the high molecularweight PLA2 .
LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of lowmolecularweight protein tyrosine phosphatase (LMPTP), with an IC50 of 0.8 μM LMPTP-A.
Hexylene glycol is a lowmolecularweight surfactant with antimicrobial properties. Hexylene glycol is widely used in industrial chemicals and cosmetics .
Chitosanase is a glycosyl hydrolase that catalyzes the endo hydrolysis of β-1,4-glycosidic bonds of partially acetylated chitosan to release chitosan oligosaccharides (COS). Chitosanases can convert high molecularweight chitosan into functional chitooligosaccharides with lowmolecularweight .
Heparinase (Heparinase I) degrades heparin to oligosaccharide or unsaturated disaccharide. Heparinase can be used in the preparation of lowmolecularweight heparin (LMWH) .
Tyroservatide (YSV) is an active, low-molecular-weight polypeptide that has been shown to have antitumor effects on hepatocellular carcinoma and lung cancer cell .
Trans-2-Hexenal can be used for the determination of low-molecular-weight carbonyl compounds which are reactive with biological nucleophiles in biological samples .
12-Hydroxystearic acid is a structurally simple and cost-effective lowmolecularweight organogelator, and its metal salts and derivatives find roles in many important applications .
PEG200 (Polyethylene glycol 200), a neutral polymer of molecularweight 200, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
Hexa-arginine, consisting of six arginines, is a polycationic peptide that can penetrate cells efficiently and is mainly used for the intracellular delivery of low-molecular-weight agents, biomolecules, and particles .
PEG300 (Polyethylene glycol 300), a neutral polymer of molecularweight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
ART558 is a nanomolar potent, selective, lowmolecularweight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer .
EILEVPST is a recombinant human fibronectinderived low-molecular-weightpeptide fragment. EILEVPST can promote cell type-specific α4 integrin-mediated adhesion. EILEVPST can be used for the research of thrombogenesis .
Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and lowmolecularweight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH .
Ciraparantag (PER977) acetate is a thrombin and factor Xa inhibitor. Ciraparantag acetate is a broad-spectrum reversal agent for anticoagulants, including lowmolecularweight heparins, unfractionated heparins, and some direct oral anticoagulants, but not VKAs .
Hexylene glycol (Standard) is the analytical standard of Hexylene glycol. This product is intended for research and analytical applications. Hexylene glycol is a lowmolecularweight surfactant that is widely used as an industrial coating solvent without causing adverse health or environmental effects.
IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR; inhibit MVA-induced IFN-α responses by BM-pDCs (IC50=2-8 uM).
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a lowmolecularweight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .
SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research .
Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen–fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS .
BTK-IN-16 is a dual inhibitor of BTK wild type and C481S mutant of Bruton’s tyrosine kinase (BTK) with IC50s of 5.1 and 4.1 μM. BTK-IN-16 can be used for the research of autoimmune diseases and chronic lymphocytic leukemia .
Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .
Bacterial α-Amylase catalyses the hydrolysis of internal α-1,4-glycosidic linkages in starch in lowmolecularweight products, such glucose, maltose and maltotriose units. Bacterial α-Amylase is often used in biochemical studies .
TP-2, a caltrop-like multicationic small molecule, is an antidote that can completely neutralize both unfractionated heparin (UFH) and low-molecular-weight heparins (LMWHs). TP-2 is not only superior to protamine, has higher neutralization activity, but is also biocompatible .
12-Hydroxystearic acid (Standard) is the analytical standard of 12-Hydroxystearic acid. This product is intended for research and analytical applications. 12-Hydroxystearic acid is a structurally simple and cost-effective lowmolecularweight organogelator, and its metal salts and derivatives find roles in many important applications .
Org 43553 is an orally active and lowmolecularweight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine .
Ciraparantag TFA is a thrombin and factor Xa inhibitor. Ciraparantag TFA is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .
2-Hydroxy-Octadecanoic acid-d34 is deuterium labeled 12-Hydroxystearic acid. 12-Hydroxystearic acid is a structurally simple and cost-effective lowmolecularweight organogelator, and its metal salts and derivatives find roles in many important applications .
Chitosan (MW 150000) (Deacetylated chitin (MW 150000)) is a polycationic linear polysaccharide derived from chitin with the molecularweight of 150000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
Chitosan (MW 30000) (Deacetylated chitin (MW 30000)) is a polycationic linear polysaccharide derived from chitin with the molecularweight of 30000. Chitosan is an versatile biomaterial because of its non-toxicity, low allergenicity, biocompatibility and biodegradability. Chitosan also has antitumor, antibacterial, antifungal, and antioxidant activities .
Oxidized low-density lipoprotein (oxLDL) particles contain lowmolecularweight species which are cytotoxic and pro-atherogenic. Many of these substances were isolated and purified from oxLDL and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. PAz-PC (Azelaoyl PC) is one of the predominant oxLDL species and may be one of the important structural determinants of oxLDL.
Surfen is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and lowmolecularweight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
Surfen dihydrochloride is a potent HS (heparan sulfate) antagonist. Surfen binds to glycosaminoglycans. Surfen neutralizes the anticoagulant activity of both unfractionated and lowmolecularweight heparins. Surfen affects sulfation of heparin and inhibits degradation by heparin lyases. Surfen inhibits FGF2 binding and signaling. Surfen inhibits cell attachment, and virus infection .
Dextrins are a group of lowmolecularweight carbohydrates produced by the hydrolysis of starch. Dextrin is commonly used as a thickener, stabilizer or binder in a variety of foods including baked goods, beverages and confectionary. In addition, it is used in the production of adhesives, paper and textiles. Its unique chemical properties make it an important ingredient in a variety of industrial processes, especially in construction and packaging.
UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a Ki of 0.41 μM. UKI-1 is also a lowmolecularweightserine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .
IFN alpha-IFNAR-IN-1 hydrochloride is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. IFN alpha-IFNAR-IN-1 hydrochloride inhibits modified Vaccinia virus ankara (MVA)-induced IFN-α responses in murine bone-marrow-derived, Flt3- L-differentiated pDC cultures (BM-pDCs) (IC50=2-8 μM) .
Sulodexide is an orally active mixture of glycosaminoglycans composed of lowmolecularweight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease .
Ciraparantag-d8 tetrahydrochloride diacetate (PER977-d8 tetrahydrochloride diacetate) is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .
Enoxaparin (PK 10169), a low-molecular-weight heparin (LMWH) derivative. Enoxaparin exerts anticoagulant activity through antithrombin III, an endogenous inhibitor of factor Xa and thrombin IIa. Enoxaparin protect the rat hippocampus against TBI (traumatic brain injury) via antioxidant and anti-inflammatory properties. Enoxaparin can be used for the research of deep vein thrombosis (DVT), pulmonary embolism, TBI and COVID-19 .
β-1,3-1,4-Glucanase catalyzes the hydrolysis ofβ-glucan into lowmolecularweight glucose polymers, thus reducing the hydrophilicity and viscosity of chyme and eliminating the anti-nutritional negative effect. β-1,3-1,4-glucanase can improve feed intake, enhance animal production, regulate cecal microbiota and increase feed conversion ratio .
(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), lowmolecularweightprotein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC50s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively .
Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) (HY-P1363) with a citrullination at the Arg5 site. Compared to the unmodified β-Amyloid (1-42), its formation of soluble low-molecular-weight oligomers is enhanced, the rate of fibril formation is reduced, and like unmodified Aβ42, it forms protofibrils comprised of parallel β-sheets .
β-N-Acetylhexosaminidase, Porcine kidney is a glycosidase with transglycosylation activity, used to generate health-beneficial human milk oligosaccharides, and it effectively interacts with lowmolecularweight sugar alcohols (such as glycerol, erythritol, and xylitol). The enzyme exhibits optimal activity at pH 5 and 40 °C, and shows high thermal stability (up to 55°C) when bound to the cell wall. β-N-Acetylhexosaminidase holds promise for applications in the biotransformation of Chitin (HY-126389) and research in the food health sector .
Oxidized low-density lipoprotein (oxLDL) particles contain lowmolecularweight species that are cytotoxic and proatherogenic. Many of these species were recently isolated and purified from oxLDL and identified as phosphatidylcholine species containing fragmented oxidized short-chain fatty acid residues at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine or KOdiA-PC is one of the most potent CD36 ligands of the oxLDL species. KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle and may be one of the more important structural determinants of oxLDL.
Albenatide (CJC 1134PC) is a modified Exendin-4 (HY-13443) analogue conjugated to human recombinant albumin (HRA) in vitro to form a long-acting DPP-4-resistant GLP-1R agonist. Albenatide covalently binds through a low-molecular chemical linker (cys-C13H19O6N3-lys) to the cysteine residue in position 34 of HRA. Albenatide increases cyclic AMP (cAMP) production in vitro. Albenatide reduces glucose excursions, food intake, gastric emptying in wild-type mice and improves glucose tolerance and reduces body weight in high-fat diet mice .
Fragment-based drug development (FBDD) is a strategy for drug discovery that can be applied both academically and commercially to enhance the identification of some non-drug targets. Fragment-based drug development has identified lowmolecularweight molecules (<300 Da) capable of binding to related macromolecules. These fragments can cover a wide chemical space and are easy to optimize later. Currently, several fragment-based drugs have entered clinical trials, of which two drugs, Vemurafenib and Venetoclax, have been approved for marketing.
Based on Tanimoto coefficient, MCE uses similarity algorithm to carefully select 2,305 high-structurally diverse 'RO3' compliant fragment molecules from large-scale fragment molecules, which can be applied to fragment based drug development.
NBD-F (4-Fluoro-7-nitrobenzofurazan) is a pro-fluorescent reagent which is developed for amino acid analysis. NBD-F reacts with primary or secondary amines to produce a fluorescent product and used for analysis of amino acids and lowmolecularweight amines .
PEG200 (Polyethylene glycol 200), a neutral polymer of molecularweight 200, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
PEG300 (Polyethylene glycol 300), a neutral polymer of molecularweight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
Dextrins are a group of lowmolecularweight carbohydrates produced by the hydrolysis of starch. Dextrin is commonly used as a thickener, stabilizer or binder in a variety of foods including baked goods, beverages and confectionary. In addition, it is used in the production of adhesives, paper and textiles. Its unique chemical properties make it an important ingredient in a variety of industrial processes, especially in construction and packaging.
Oxidized low-density lipoprotein (oxLDL) particles contain lowmolecularweight species that are cytotoxic and proatherogenic. Many of these species were recently isolated and purified from oxLDL and identified as phosphatidylcholine species containing fragmented oxidized short-chain fatty acid residues at the sn-2 position. 1-(Palmitoyl)-2-(5-keto-6-octene-dioyl)phosphatidylcholine or KOdiA-PC is one of the most potent CD36 ligands of the oxLDL species. KOdiA-PC confers CD36 scavenger receptor binding affinity to LDL at a frequency of only 2 to 3 KOdiA-PC molecules/LDL particle and may be one of the more important structural determinants of oxLDL.
Lowmolecularweight protamine is a cell-penetrating peptide with vascular endothelial growth factor (VEGF) inhibitory activity. Lowmolecularweight protamine can inhibit tumor growth and is used in cancer research .
Melittin is a PLA2 activator, stimulates the activity of the lowmolecularweight PLA2, while it does not the increase activity of the high molecularweight PLA2 .
Melittin TFA is a PLA2 activator, stimulates the activity of the lowmolecularweight PLA2, while it does not the increase activity of the high molecularweight PLA2 .
EILEVPST is a recombinant human fibronectinderived low-molecular-weightpeptide fragment. EILEVPST can promote cell type-specific α4 integrin-mediated adhesion. EILEVPST can be used for the research of thrombogenesis .
Citrullinated amyloid-β (1-42) peptide (human) (Citrullinated Aβ (1-42)) is a modified form of β-Amyloid (1-42) (HY-P1363) with a citrullination at the Arg5 site. Compared to the unmodified β-Amyloid (1-42), its formation of soluble low-molecular-weight oligomers is enhanced, the rate of fibril formation is reduced, and like unmodified Aβ42, it forms protofibrils comprised of parallel β-sheets .
Hexa-arginine, consisting of six arginines, is a polycationic peptide that can penetrate cells efficiently and is mainly used for the intracellular delivery of low-molecular-weight agents, biomolecules, and particles .
Delparantag (PMX-60056) is a salicylamide derivative and an effective unfractionated heparin (UFH) and lowmolecularweight heparin (LMWH) reversing agent. Delparantag shows ability to neutralize the anticoagulation and bleeding effects of UFH and LMWH .
Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a lowmolecularweight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus .
Trans-2-Hexenal can be used for the determination of low-molecular-weight carbonyl compounds which are reactive with biological nucleophiles in biological samples .
12-Hydroxystearic acid is a structurally simple and cost-effective lowmolecularweight organogelator, and its metal salts and derivatives find roles in many important applications .
12-Hydroxystearic acid (Standard) is the analytical standard of 12-Hydroxystearic acid. This product is intended for research and analytical applications. 12-Hydroxystearic acid is a structurally simple and cost-effective lowmolecularweight organogelator, and its metal salts and derivatives find roles in many important applications .
LMW-PTP/ACP1, a phosphatase, acts on tyrosine phosphorylated proteins, low-molecular-weight aryl phosphates, and natural and synthetic acyl phosphates. Notably, there are substrate specificity differences between isoform 1 and isoform 2, with isoform 2 lacking phosphatase activity. LMW-PTP/ACP1 Protein, Human (C-His) is the recombinant human-derived LMW-PTP/ACP1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of LMW-PTP/ACP1 Protein, Human (C-His) is 157 a.a., with molecular weight of ~18.0 kDa.
LMW-PTP/ACP1, a phosphatase, acts on tyrosine phosphorylated proteins, low-molecular-weight aryl phosphates, and natural and synthetic acyl phosphates. Notably, there are substrate specificity differences between isoform 1 and isoform 2, with isoform 2 lacking phosphatase activity. LMW-PTP/ACP1 Protein, Human (GST) is the recombinant human-derived LMW-PTP/ACP1 protein, expressed by E. coli , with N-GST labeled tag. The total length of LMW-PTP/ACP1 Protein, Human (GST) is 158 a.a., with molecular weight of ~40 kDa.
2-Hydroxy-Octadecanoic acid-d34 is deuterium labeled 12-Hydroxystearic acid. 12-Hydroxystearic acid is a structurally simple and cost-effective lowmolecularweight organogelator, and its metal salts and derivatives find roles in many important applications .
Ciraparantag-d8 tetrahydrochloride diacetate (PER977-d8 tetrahydrochloride diacetate) is the deuterium labeled Ciraparantag (HY-18660). Ciraparantag is a thrombin and factor Xa inhibitor. Ciraparantag is a broad-spectrum reversal agent for anticoagulants, including low-molecular-weight heparin, unfractionated heparin, and certain direct oral anticoagulants. It is reported to antagonize the effects of all coagulants except VKAs and agratroban .
PEG300 (Polyethylene glycol 300), a neutral polymer of molecularweight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol .
T18.3 aptamer sodium is an anticoagulant RNA aptamer targeting FV/Va and eliminates the interaction of FV/FVa with phospholipid membranes. T18.3 aptamer sodium exhibits clinically relevant anticoagulant activity in plasma and whole blood and acts synergistically with lowmolecularweight heparin. The anticoagulant activity of T18.3 aptamer sodium is effectively and rapidly reversed by protamine sulfate .
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