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reproductive toxicity

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41

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3

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8

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1945
    DEHP
    2 Publications Verification

    Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82

    		 Endogenous Metabolite Metabolic Disease
    DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .
    DEHP
  • HY-W013058
    Decabromodiphenyl ethane

    DBDPE; 1,2-Bis(perbromophenyl)ethane

    		 Biochemical Assay Reagents Neurological Disease Metabolic Disease
    Decabromodiphenyl ethane (DBDPE; 1,2-Bis(perbromophenyl)ethane) is a brominated flame retardant. Decabromodiphenyl ethane can exhibit neurotoxicity, thyroid toxicity, reproductive developmental toxicity, hepatotoxicity, and oxidative stress in living organisms .
    Decabromodiphenyl ethane
  • HY-B1945R
    DEHP (Standard)

    Bis(2-ethylhexyl) phthalate (Standard); Ergoplast FDO (Standard); ESBO-D 82 (Standard)

    		 Reference Standards Endogenous Metabolite Metabolic Disease
    DEHP (Standard) is the analytical standard of DEHP. This product is intended for research and analytical applications. DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .
    DEHP (Standard)
  • HY-N6771
    Cyclopiazonic acid
    4 Publications Verification

    		 Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV Infection
    Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B [1][4][5].
    Cyclopiazonic acid
  • HY-B1866
    Linuron

    		Androgen Receptor Endocrinology
    Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron
  • HY-W102684
    N,N-Dicyclohexyl-2-benzothiazolesulfenamide

    		Biochemical Assay Reagents Others
    N,N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain, reproductive organ weight, and multiple reproductive and developmental indicators in rats.
    N,N-Dicyclohexyl-2-benzothiazolesulfenamide
  • HY-114558
    Resmethrin

    Benzofuroline; Isathrine; Resmethrin(mixture of isomers)

    		 Insecticide Others
    Resmethrin (Benzofuroline) is a reproductively toxic compound that inhibits spermatogenesis and induces apoptosis of germ cells in mouse testis culture in vitro, but has no significant toxicity to supporting cells and interstitial cells.
    Resmethrin
  • HY-148163
    Polystyrene sulfonic acid (30% in water)
    1 Publications Verification

    		 Biochemical Assay Reagents Others
    Polystyrene sulfonic acid (30% in water) is a potentially toxic hazardous substance. Polystyrene-derived microplastics (PS-MPs) are harmful to zebrafish hearts and induce male reproductive toxicity in mice. MCE offers Polystyrene products in solution packaging .
    Polystyrene sulfonic acid (30% in water)
  • HY-B1866R
    Linuron (Standard)

    		Reference Standards Androgen Receptor Endocrinology
    Linuron (Standard) is the analytical standard of Linuron. This product is intended for research and analytical applications. Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron (Standard)
  • HY-W088190
    Dicyclohexyl ketone

    Cyclohexyl ketone

    		 Drug Intermediate Biochemical Assay Reagents Others
    Dicyclohexyl ketone (Cyclohexyl ketone) is a toxic compound that causes toxic effects in rats at high doses, including death, decreased activity, staining of the fur on the lower body, reddening of the tears, and reproductive and developmental effects.
    Dicyclohexyl ketone
  • HY-B0847
    Propiconazole
    1 Publications Verification

    		 Fungal Reactive Oxygen Species (ROS) Infection
    Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
    Propiconazole
  • HY-N6771R
    Cyclopiazonic acid (Standard)

    		Reference Standards Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV Infection
    Ancitabine (hydrochloride) (Standard) is the analytical standard of Ancitabine (hydrochloride). This product is intended for research and analytical applications. 0
    Cyclopiazonic acid (Standard)
  • HY-W011787
    DPPD

    N,N′-Diphenyl-p-phenylenediamine

    		 Reactive Oxygen Species (ROS) Metabolic Disease
    DPPD (N,N′-Diphenyl-p-phenylenediamine) is an orally active polymerization inhibitor and antioxidant with antioxidative activity. DPPD causes reproductive/developmental toxicity in rats. DPPD is widely used in rubber, oils, and feedstuffs, especially for tires in the rubber industry .
    DPPD
  • HY-B0847R
    Propiconazole (Standard)

    		Reference Standards Fungal Reactive Oxygen Species (ROS) Infection
    Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
    Propiconazole (Standard)
  • HY-P1197
    Kisspeptin-10 (mouse, rat)

    		Kisspeptin Receptor Cardiovascular Disease Inflammation/Immunology
    Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
    Kisspeptin-10 (mouse, rat)
  • HY-B1024
    DL-Panthenol

    DL-Pantothenol; DL-Pantothenyl alcohol

    		 Biochemical Assay Reagents Inflammation/Immunology
    DL-Panthenol (DL-Pantothenol) is a precursor of pantothenic acid. DL-Panthenol easily penetrates the skin and has effects of deep moisturizing, promoting wound healing and anti-inflammation. DL-Panthenol can also be used as a hair conditioner in cosmetics. DL-Panthenol has low acute toxicity, non-sensitizing property, and no significant genotoxicity or reproductive and developmental toxicity. DL-Panthenol can be applied to the research of cosmetics .
    DL-Panthenol
  • HY-Y0284
    Diethyl phthalate

    		Apoptosis Endocrinology
    Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
    Diethyl phthalate
  • HY-B1066
    Butylhydroxyanisole
    5 Publications Verification

    Butylated hydroxyanisole; E320

    		 Reactive Oxygen Species (ROS) Ferroptosis Neurological Disease Inflammation/Immunology
    Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .
    Butylhydroxyanisole
  • HY-115584
    Lufenuron

    		Parasite Infection
    Lufenuron is an orally active lipophilic benzoylurea insecticide and a chitin synthesis inhibitor that can used for flea and fish lice control. Lufenuron inhibits moulting of arthropods. Lufenuron induces reproductive toxicity, genotoxic effects and oxidative stresses in pregnant albino rats and their fetuses .
    Lufenuron
  • HY-B0806R
    Proguanil (Standard)

    		Reference Standards Parasite Antifolate Infection
    Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil (Standard)
  • HY-B0806
    Proguanil
    3 Publications Verification

    		 Parasite Antifolate Infection
    Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil
  • HY-B0806AR
    Proguanil hydrochloride (Standard)

    		Reference Standards Parasite Antifolate Infection
    Proguanil (hydrochloride) (Standard) is the analytical standard of Proguanil (hydrochloride). This product is intended for research and analytical applications. Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil hydrochloride (Standard)
  • HY-B0806A
    Proguanil hydrochloride
    3 Publications Verification

    		 Parasite Antifolate Infection
    Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil hydrochloride
  • HY-N6678
    Zearalanone
    2 Publications Verification

    		 Estrogen Receptor/ERR Endocrinology
    Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    Zearalanone
  • HY-P1197A
    Kisspeptin-10 (mouse, rat) (TFA)
    1 Publications Verification

    		 Kisspeptin Receptor Cardiovascular Disease Inflammation/Immunology
    Kisspeptin-10 (mouse, rat) TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) TFA is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 (mouse, rat) TFA reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
    Kisspeptin-10 (mouse, rat) (TFA)
  • HY-76547
    p-Toluic acid
    1 Publications Verification

    4-Methylbenzoic acid

    		 Endogenous Metabolite Metabolic Disease
    p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis .
    p-Toluic acid
  • HY-B1066R
    Butylhydroxyanisole (Standard)

    Butylated hydroxyanisole (Standard); E320 (Standard)

    		 Reference Standards Reactive Oxygen Species (ROS) Ferroptosis Neurological Disease Inflammation/Immunology
    Butylhydroxyanisole (Standard) is the analytical standard of Butylhydroxyanisole. This product is intended for research and analytical applications. Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .
    Butylhydroxyanisole (Standard)
  • HY-N6678S
    (Rac)-Zearalanone-d6

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology
    (Rac)-Zearalanone-d6 is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    (Rac)-Zearalanone-d6
  • HY-Y0284R
    Diethyl phthalate (Standard)

    		Apoptosis Reference Standards Endocrinology
    Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
    Diethyl phthalate (Standard)
  • HY-109521A
    Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)

    Manganese(Ⅱ) chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)

    		 Biochemical Assay Reagents Histone Acetyltransferase HDAC Neurological Disease
    Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research.
    Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT)
  • HY-G0008AR
    O-Desmethyl Mebeverine alcohol hydrochloride (Standard)

    Mebeverine metabolite O-desmethyl Mebeverine alcohol hydrochloride (Standard)

    		 Reference Standards Adrenergic Receptor Drug Metabolite Metabolic Disease
    Diethyl phthalate (Standard) is the analytical standard of Diethyl phthalate. This product is intended for research and analytical applications. Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
    O-Desmethyl Mebeverine alcohol hydrochloride (Standard)
  • HY-W042337
    3-Methyl-4-nitrophenol

    		Apoptosis Others
    3-Methyl-4-nitrophenol, an environmental contaminant, is a well-known constituent of diesel exhaust particles and degradation products of insecticide fenitrothion. 3-Methyl-4-nitrophenol can induce nasal epithelial cell apoptosis and increase the permeability of the nasal epithelial barrier. 3-Methyl-4-nitrophenol is also toxic to the female reproductive system.
    3-Methyl-4-nitrophenol
  • HY-B1866S
    Linuron-d6

    		Androgen Receptor Isotope-Labeled Compounds Others
    Linuron-d6 is the deuterium labeled Linuron (HY-B1866). Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron-d6
  • HY-N6678R
    Zearalanone (Standard)

    		Reference Standards Estrogen Receptor/ERR Endocrinology
    Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    Zearalanone (Standard)
  • HY-B0854
    Mancozeb

    		Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450 Infection Metabolic Disease Cancer
    Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells .
    Mancozeb
  • HY-B0854R
    Mancozeb (Standard)

    		Reference Standards Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450 Infection Metabolic Disease Cancer
    Mancozeb (Standard) is the analytical standard of Mancozeb. This product is intended for research and analytical applications. Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.
    Mancozeb (Standard)
  • HY-Y1117
    Melamine
    1 Publications Verification

    		 Apoptosis TGF-β Receptor NF-κB COX NADPH Oxidase ROS Kinase Neurological Disease Inflammation/Immunology
    Melamine is an orally active inducer of Apoptosis. Melamine induces animal disease models. Melamine affects the activity of Sertoli cell and can be used for research on male reproductive function. Melamine also has neurotoxicity and nephrotoxicity. Melamine induces cognitive impairment and acute kidney injury models. Melamine can also be used to induce bladder cancer and urinary stone models .
    Melamine
  • HY-Y1316
    Sodium benzoate

    		Biochemical Assay Reagents NF-κB Apoptosis Inflammation/Immunology Cancer
    Sodium benzoate is an orally active pharmaceutical excipient, such as an antibacterial agent, preservative, lubricant, etc. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.Sodium benzoate activates NF-κB and induces Apoptosis. Sodium benzoate induces immune suppression and produces reproductively toxic. Sodium benzoate can be used for colon cancer and immune disease research .
    Sodium benzoate
  • HY-131384
    8,11,14-Eicosatriynoic acid

    8,11,14-Icosatriynoic acid

    		 COX Others
    8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    8,11,14-Eicosatriynoic acid
  • HY-B1978R
    Iprodione (Standard)

    		Reference Standards Fungal Reactive Oxygen Species (ROS) Androgen Receptor Infection
    Iprodione (Standard) is the analytical standard of Iprodione. This product is intended for research and analytical applications. Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .
    Iprodione (Standard)
  • HY-B1978
    Iprodione

    		Fungal Reactive Oxygen Species (ROS) Androgen Receptor Infection
    Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .
    Iprodione

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