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reproductive toxicity

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29

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1

Biochemical Assay Reagents

2

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6

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1

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B1945
    DEHP
    2 Publications Verification

    Bis(2-ethylhexyl) phthalate; Ergoplast FDO; ESBO-D 82

    		 Endogenous Metabolite Metabolic Disease
    DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .
    DEHP
  • HY-N6771
    Cyclopiazonic acid
    3 Publications Verification

    		 Calcium Channel 5-HT Receptor MDM-2/p53 Apoptosis RSV Infection
    Cyclopiazonic acid is an endoplasmic reticulum calcium ATPase (ECAs) inhibitor and human respiratory syncytial virus (RSV) inhibitor (EC50 value of 4.13 μ M), which can reduce the antagonistic effect of 5-HT receptors in rat thoracic aorta, induce p53 dependent cell apoptosis and reproductive toxicity in mouse testes, and inhibit the biological activation of aflatoxin B [1][4][5].
    Cyclopiazonic acid
  • HY-B1866
    Linuron

    		Androgen Receptor Endocrinology
    Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron
  • HY-148163
    Polystyrene
    1 Publications Verification

    		 Others Others
    Polystyrene can form Polystyrene microplastics (PS-MPs), a hazardous material with potential toxicity. Polystyrene microplastics is harm to zebrafish heart and induces male reproductive toxicity in mice . MCE provides Polystyrene products in solution packaging.
    Polystyrene
  • HY-B0847
    Propiconazole
    1 Publications Verification

    		 Fungal Reactive Oxygen Species Infection
    Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
    Propiconazole
  • HY-B1945R
    DEHP (Standard)

    		Endogenous Metabolite Metabolic Disease
    DEHP (Standard) is the analytical standard of DEHP. This product is intended for research and analytical applications. DEHP (Bis(2-ethylhexyl) phthalate) is a widely used plasticizer, which has orally active. DEHP can produce a wide spectrum of toxic effects on organisms including neurotoxicity, liver toxicity, immunotoxicity, and reproductive toxicity .
    DEHP (Standard)
  • HY-B1866R
    Linuron (Standard)

    		Androgen Receptor Endocrinology
    Linuron (Standard) is the analytical standard of Linuron. This product is intended for research and analytical applications. Linuron is a phenylurea herbicide that is widely used to control the growth of grass and weeds in various agriculture crops and in orchards. Linuron is a photosystem II inhibitor. Linuron is also a competitive androgen receptor (AR) antagonist with a Ki of 100 μM. Linuron shows reproductive toxicity in animals that acts as an endocrine disruptor .
    Linuron (Standard)
  • HY-W102684
    N,N-Dicyclohexyl-2-benzothiazolesulfenamide

    		Others Others
    N,N-Dicyclohexyl-2-benzothiazolesulfenamide is a compound with reproductive and developmental toxicity that can affect body weight gain, reproductive organ weight, and multiple reproductive and developmental indicators in rats.
    N,N-Dicyclohexyl-2-benzothiazolesulfenamide
  • HY-114558
    Resmethrin

    Benzofuroline; Isathrine; Resmethrin(mixture of isomers)

    		 Others Others
    Resmethrin (Benzofuroline) is a reproductively toxic compound that inhibits spermatogenesis and induces apoptosis of germ cells in mouse testis culture in vitro, but has no significant toxicity to supporting cells and interstitial cells.
    Resmethrin
  • HY-W088190
    Dicyclohexyl ketone

    Cyclohexyl ketone

    		 Others Others
    Dicyclohexyl ketone (Cyclohexyl ketone) is a toxic compound that causes toxic effects in rats at high doses, including death, decreased activity, staining of the fur on the lower body, reddening of the tears, and reproductive and developmental effects.
    Dicyclohexyl ketone
  • HY-B0847R
    Propiconazole (Standard)

    		Fungal Reactive Oxygen Species Infection
    Propiconazole (Standard) is the analytical standard of Propiconazole. This product is intended for research and analytical applications. Propiconazole is an orally active N-substituted triazole used as a fungicide. Propiconazole is a mouse liver hepatotoxicant and a hepatocarcinogen that has adverse reproductive and developmental toxicities in experimental animals .
    Propiconazole (Standard)
  • HY-P1197
    Kisspeptin-10 (mouse, rat)

    		Kisspeptin Receptor Cardiovascular Disease Inflammation/Immunology
    Kisspeptin-10 (mouse, rat) is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
    Kisspeptin-10 (mouse, rat)
  • HY-B1066
    Butylhydroxyanisole
    5 Publications Verification

    Butylated hydroxyanisole; BHA; E320

    		 Reactive Oxygen Species Ferroptosis Neurological Disease Inflammation/Immunology
    Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .
    Butylhydroxyanisole
  • HY-Y0284
    Diethyl phthalate

    		Others Endocrinology
    Diethyl phthalate is an endocrine disruptor that has the activity of affecting the apoptosis system of PC12 cells. Diethyl phthalate is widely used in a variety of plastics and personal care products. Diethyl phthalate has shown the potential to induce male reproductive toxicity unrelated to androgens in animal experiments .
    Diethyl phthalate
  • HY-B0806
    Proguanil
    1 Publications Verification

    		 Parasite Antifolate Infection
    Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil
  • HY-B0806A
    Proguanil hydrochloride
    1 Publications Verification

    		 Parasite Antifolate Infection
    Proguanil hydrochloride, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil hydrochloride is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil hydrochloride
  • HY-B0806R
    Proguanil (Standard)

    		Parasite Antifolate Infection
    Proguanil (Standard) is the analytical standard of Proguanil. This product is intended for research and analytical applications. Proguanil, an antimalarial proagent, is metabolized to the active metabolite Cycloguanil (HY-12784). Proguanil is a dihydrofolate reductase (DHFR) inhibitor .
    Proguanil (Standard)
  • HY-N6678
    Zearalanone
    1 Publications Verification

    		 Estrogen Receptor/ERR Endocrinology
    Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    Zearalanone
  • HY-P1197A
    Kisspeptin-10 (mouse, rat) (TFA)

    		Kisspeptin Receptor Cardiovascular Disease Inflammation/Immunology
    Kisspeptin-10 (mouse, rat) TFA is a potent vasoconstrictor and inhibitor of angiogenesis. Kisspeptin-10 (mouse, rat) TFA is a ligand for the rodent kisspeptin receptor (KISS1, GPR54). Kisspeptin-10 (mouse, rat) TFA reduces Methotrexate-induced reproductive toxicity as a potential antioxidant compound .
    Kisspeptin-10 (mouse, rat) (TFA)
  • HY-76547
    p-Toluic acid
    1 Publications Verification

    4-Methylbenzoic acid

    		 Endogenous Metabolite Metabolic Disease
    p-Toluic acid (4-Methylbenzoic acid), coumarin, is a substituted benzoic acid. p-Toluic acidis synthetic p-aminomethylbenzoic acid (PAMBA), intermediates such as p-toluonitrile. p-Toluic acidMay have potential reproductive toxicity, press 1g/kgRepeated administration of doses can produce a variety of adverse effects on the epididymis .
    p-Toluic acid
  • HY-B1066R
    Butylhydroxyanisole (Standard)

    Butylated hydroxyanisole (Standard); BHA (Standard); E320 (Standard)

    		 Reactive Oxygen Species Ferroptosis Neurological Disease Inflammation/Immunology
    Butylhydroxyanisole (Standard) is the analytical standard of Butylhydroxyanisole. This product is intended for research and analytical applications. Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development . Butylhydroxyanisole is a ferroptosis inducer .
    Butylhydroxyanisole (Standard)
  • HY-N6678S
    (Rac)-Zearalanone-d6

    		Isotope-Labeled Compounds Estrogen Receptor/ERR Endocrinology
    (Rac)-Zearalanone-d6 is the racemate of Zearalanone. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system[1][2].
    (Rac)-Zearalanone-d6
  • HY-N6678R
    Zearalanone (Standard)

    		Estrogen Receptor/ERR Endocrinology
    Zearalanone (Standard) is the analytical standard of Zearalanone. This product is intended for research and analytical applications. Zearalenone is a nonsteroidal estrogenic mycotoxin produced by Fusarium species, which colonizes several grains. Zearalenone has low acute toxicity and carcinogenicity. Due to its agonistic effect on the estrogen receptor, Zearalenone exhibits distinct estrogenic and anabolic properties in several animal species, resulting in severe effects on the reproductive system .
    Zearalanone (Standard)
  • HY-W042337
    3-Methyl-4-nitrophenol

    		Apoptosis Others
    3-Methyl-4-nitrophenol, an environmental contaminant, is a well-known constituent of diesel exhaust particles and degradation products of insecticide fenitrothion. 3-Methyl-4-nitrophenol can induce nasal epithelial cell apoptosis and increase the permeability of the nasal epithelial barrier. 3-Methyl-4-nitrophenol is also toxic to the female reproductive system.
    3-Methyl-4-nitrophenol
  • HY-B0854
    Mancozeb

    		Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450 Infection Metabolic Disease Cancer
    Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells .
    Mancozeb
  • HY-B0854R
    Mancozeb (Standard)

    		Fungal Keap1-Nrf2 Apoptosis Lactate Dehydrogenase Cytochrome P450 Infection Metabolic Disease Cancer
    Mancozeb (Standard) is the analytical standard of Mancozeb. This product is intended for research and analytical applications. Mancozeb is a widely used fungicide that is effective against fungal diseases in most cereals, vegetables, fruits and ornamental plants. In addition, Mancozeb can cause liver damage in mice by activating the Keap1/Nrf2 signaling pathway. Mancozeb upregulates lactate dehydrogenase and cytochrome c to alter cell metabolism and induce cell death. Mancozeb has reproductive toxicity and can induce apoptosis in ovarian cells.
    Mancozeb (Standard)
  • HY-131384
    8,11,14-Eicosatriynoic acid

    8,11,14-Icosatriynoic acid

    		 COX Others
    8,11,14-Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid-induced platelet aggregation, blocks human 12-lipoxygenase (12-LO), cyclooxygenase (COX)and 5-lipoxygenase (5-LO) with IC50 values of 0.46 μM, 14 μMand 25 μM, respectively. In addition, 8,11,14-Eicosatriynoic Acid inhibits the action of slow-reacting substances of allergic reactions, with IC50 value of 10 μM. Lipoxygenase is widely found in fungi, plants and animals. 12-LO involves in many important disease states and may play a role in oxidative glutamate toxicity. COX enzymes play complex roles in human physiology and pathology involving the neuronal, immune, renal, cardiovascular, gastrointestinal and reproductive systems. COX enzymes are blocked by aspirin and a variety of other NSAIDs, which makes them clinically important. 5-LO involves in cancer pathology. It is expressed by a variety of cancer cells, including colon, lung, breast, and prostate cancers, and promotes cancer cell growth and neovascularization . 8,11,14-Eicosatriynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    8,11,14-Eicosatriynoic acid
  • HY-B1978
    Iprodione

    		Fungal Reactive Oxygen Species Androgen Receptor Infection
    Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .
    Iprodione
  • HY-B1978R
    Iprodione (Standard)

    		Fungal Reactive Oxygen Species Androgen Receptor Infection
    Iprodione (Standard) is the analytical standard of Iprodione. This product is intended for research and analytical applications. Iprodione is an orally active diformimide fungicide. Iprodione can specifically cause oxidative damage by producing free radicals (ROS). Iprodione is also an antiandrogen agent that delays adolescent development in rats and reduces sexual behavior and reproductive ability in rats .
    Iprodione (Standard)

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