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Results for "

retinoic acid receptor (RAR)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	RAR/RXR (46) Apoptosis (5) Autophagy (24) Biochemical Assay Reagents (1) Drug Metabolite (3) Endogenous Metabolite (10) HCV (2) Isotope-Labeled Compounds (13) Organoid (1) PPAR (8) Reference Standards (6) SphK (2)
By Research Areas:	Cancer (40) Endocrinology (1) Infection (2) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (3)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
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Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: RAR/RXR ROR Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Amino Acid Oxidase Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14649

Retinoic acid Maximum Cited Publications 98 Publications Verification Vitamin A acid; all-trans-retinoic acid; ATRA	Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of *RAR* nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-14649R

Retinoic acid (Standard) Maximum Cited Publications 98 Publications Verification Vitamin A acid (Standard); all-trans-retinoic acid (Standard); ATRA (Standard)	Reference Standards RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of *RAR* nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-14799

Palovarotene 10+ Cited Publications R 667; Ro 3300074	RAR/RXR Autophagy	Others
Palovarotene is a nuclear retinoic acid receptor γ (RAR-γ) agonist.

HY-14652

Tamibarotene 5+ Cited Publications Am 80	RAR/RXR Autophagy Apoptosis	Cancer
Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.

HY-100532

CD437 3 Publications Verification AHPN	RAR/RXR Autophagy	Cancer
CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.

HY-14649S4

Retinoic acid-d5 Vitamin A acid-d₅; all-trans-retinoic acid-d₅; ATRA-d₅	Isotope-Labeled Compounds RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of *RAR* nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-15682G

TTNPB Ro 13-7410; Arotinoid acid; AGN191183	RAR/RXR	Cancer
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent **retinoic acid receptor (RAR)** agonist .

HY-14649S5

Retinoic acid-d3 Vitamin A acid-d₃; all-trans-retinoic acid-d₃; ATRA-d₃	Isotope-Labeled Compounds RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid-d₃ is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S6

Retinoic acid-d3-1 Vitamin A acid-d₃-1; all-trans-retinoic acid-d₃-1; ATRA-d₃-1	Isotope-Labeled Compounds RAR/RXR PPAR Endogenous Metabolite Autophagy	Metabolic Disease Cancer
Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S2

11-cis-Retinoic Acid-d5	Isotope-Labeled Compounds RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-114071

BMS270394	RAR/RXR	Cancer
BMS270394 is a nuclear retinoic acid receptor (RAR-γ) agonist with the EC₅₀ values of 30 nM and 400 nM for humanRAR-γ and *RAR-β*, respectively .

HY-14649S3

Retinoic acid-d6 Vitamin A acid-d₆; all-trans-retinoic acid-d₆; ATRA-d₆	Isotope-Labeled Compounds RAR/RXR PPAR Autophagy Endogenous Metabolite	Cancer
Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-107765

LY2955303 3 Publications Verification	RAR/RXR Autophagy	Inflammation/Immunology
LY2955303 is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a K_i of 1.09 nM.

HY-107395

BMS 753	RAR/RXR	Inflammation/Immunology
BMS 753 is an isotype-selective retinoic acid receptor α (RARα) agonist, with a K_i of 2 nM .

HY-118761

5,6-Epoxyretinoic acid 5,6-epoxy atRA; 5,6-epoxy RA	RAR/RXR	Metabolic Disease
all-trans-5,6-epoxy Retinoic acid (5,6-epoxy RA) is an agonist of all isoforms of the retinoic acid receptor (RAR; EC₅₀s=77, 35, and 4 nM for RARα, RARβ, and RARγ, respectively). 5,6-epoxy RA (1 μM) also induces growth arrest of MCF-7 and NB4 cells in vitro. It is a natural metabolite of all-trans retinoic acid, which is a metabolite of vitamin A.

HY-156280

RARα antagonist 1	RAR/RXR	Endocrinology
RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α(RARα) antagonist, with the IC₅₀ of 4.6nM .

HY-U00449A

AGN 193109 sodium	RAR/RXR	Cancer
AGN 193109 sodium is the sodium salt form of AGN 193109 (HY-U00449). AGN 193109 sodium is the pan antagonist for **retinoic acid receptor** (RAR), with K_d of 2, 2 and 3 nM, for RARα, RARβ and RARγ, respectively. AGN 193109 sodium reverses TTNPB-induced morphology changes and all-trans retinoic acid (tRA)/9-cis RA/13-cis RA-induced proliferation suppression in ECE16-1 cell. AGN 193109 sodium is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity .

HY-U00449S

AGN 193109-d7	Isotope-Labeled Compounds RAR/RXR	Cancer
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-118420

BMS-185411	RAR/RXR	Cancer
BMS-185411 is a selective retinoic acid receptor alpha (RARα) antagonist, with an IC₅₀ value of 140 nM .

HY-U00449

AGN 193109 5+ Cited Publications	RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of **retinoic acid receptors (RARs), with K_d*s of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic* acidosis, that ameliorates the skin and mucosal toxicity.

HY-U00449R

AGN 193109 (Standard)	RAR/RXR	Cancer
AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively. AGN 193109 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-14652R

Tamibarotene (Standard)	RAR/RXR Autophagy Apoptosis	Cancer
Tamibarotene (Standard) is the analytical standard of Tamibarotene. This product is intended for research and analytical applications. Tamibarotene is an orally active retinoic acid receptor α (RARα) agonist, showing high selectivity over RARγ.

HY-108528

BMS961	RAR/RXR	Inflammation/Immunology
BMS961 is a selective retinoic acid receptor-γ (RARγ) agonist. BMS961 shows anti-inflammatory activity .

HY-15373

Fenretinide 5+ Cited Publications 4-HPR	RAR/RXR Autophagy	Cancer
Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

HY-14649G

Retinoic acid Vitamin A acid; all-trans-retinoic acid; ATRA	RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of **RAR nuclear receptors** .

HY-107494A

all-trans-4-Oxoretinoic acid all-trans 4-Keto retinoic acid	Endogenous Metabolite	Metabolic Disease
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-108529

BMS493 5+ Cited Publications	RAR/RXR	Metabolic Disease
BMS493 is an inverse pan-retinoic acid receptor (RAR) agonist. BMS493 increases nuclear corepressor interaction with *RARs. BMS493 also could prevent retinoic* acid-induced differentiation . BMS493 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-100532S

CD437-13C6 AHPN-¹³C₆	Isotope-Labeled Compounds RAR/RXR Autophagy	Cancer
CD437- ¹³C₆ is the ¹³C- and deuterium labeled CD437. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.

HY-100532R

CD437 (Standard) AHPN (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
CD437 (Standard) is the analytical standard of CD437. This product is intended for research and analytical applications. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.

HY-116248

Ro 41-5253 2 Publications Verification	RAR/RXR Apoptosis	Cancer
Ro 41-5253 is an orally active selective retinoic acid receptor alpha (RARα) antagonist. Ro 41-5253 can bind RARα without inducing transcription or affecting RAR/RXR heterodimerization and DNA binding. Ro 41-5253 can inhibit cancer cell proliferation and induce apoptosis, has antitumor activity .

HY-101108

Tazarotenic acid 2 Publications Verification AGN 190299	Drug Metabolite	Others
Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-15388S

Tazarotene-d8 AGN 190168-d₈	Isotope-Labeled Compounds RAR/RXR Autophagy	Inflammation/Immunology Cancer
Tazarotene-d₈ is the deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris .

HY-101106

AR7 10+ Cited Publications	RAR/RXR	Neurological Disease Cancer
AR7 is an atypical *RARA/RARα* (retinoic acid receptor, alpha) antagonist. AR7 specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy .

HY-14653

Amsilarotene TAC-101; Am 555S	RAR/RXR Apoptosis	Cancer
Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with K_i of 2.4, 400 nM for RAR-α and RAR-β. Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells. Amsilarotene can be used for the research of cancer .

HY-15373R

Fenretinide (Standard) 4-HPR (Standard)	Reference Standards RAR/RXR Autophagy	Cancer
Fenretinide (Standard) is the analytical standard of Fenretinide. This product is intended for research and analytical applications. Fenretinide (4-HPR) is a synthetic retinoid deriverative, binding to the retinoic acid receptors (RAR) at concentrations necessary to induce cell death.

HY-W587468

all-trans-3,4-Didehydro retinoic acid 3,4-DHRA	Biochemical Assay Reagents
All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is a compound with gene-regulating activity that binds to retinoic acid receptors (RARs) and triggers receptor activation. All-trans-3,4-Didehydro retinoic acid plays an important role in skin development and differentiation and has potential anti-tumor and anti-inflammatory properties. All-trans-3,4-Didehydro retinoic acid is also being studied for the inhibition of a variety of diseases, including skin diseases and certain types of cancer.

HY-107397

Ch55 2 Publications Verification	RAR/RXR	Cancer
Ch55 is a potent synthetic retinoid. Ch55 binds to *RAR-α* and **RAR-β receptors** with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC₅₀ of 200 nM. Ch55 can be used for cancer research .

HY-101108S

Tazarotenic acid-d6 AGN 190299-d₆	Isotope-Labeled Compounds Drug Metabolite	Others
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-106735

Arotinoid Ro 13-6298; Arotinoid ethyl ester	RAR/RXR	Inflammation/Immunology Cancer
Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED₅₀ of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas .

HY-15388

Tazarotene 2 Publications Verification AGN 190168	RAR/RXR Autophagy	Inflammation/Immunology Cancer
Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-124136

WYC-209 1 Publications Verification	RAR/RXR Apoptosis Autophagy	Cancer
WYC-209, a synthetic retinoid, is a **retinoic acid receptor (RAR) agonist. WYC-209 induces apoptosis primarily via the caspase 3 pathway (IC₅₀**=0.19 μM for inmalignant murine melanoma TRCs), and has long-term effects with little toxicity .

HY-107810

Methyl 13-cis-4-oxoretinoate	RAR/RXR	Cancer
Methyl 13-cis-4-oxoretinoate (Compound 4b) is a retinoic acid receptors (RARs) agonist. Methyl 13-cis-4-oxoretinoate is promising for research of dermatological diseases (e.g., disorders related to abnormal differentiation of keratinocytes) and cancers .

HY-107494AR

all-trans-4-Oxoretinoic acid (Standard) all-trans 4-Keto retinoic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-111573

KCL-286 C286	RAR/RXR	Others Neurological Disease Inflammation/Immunology
KCL-286 (C286) is an orally active and brain-penetrant retinoic acid receptor (RAR) β2 agonist (EC₅₀ = 1.9 nM). KCL-286 targets RARβ2 with good selectivity over RAR α (EC₅₀ = 26 nM) and RAR γ (EC₅₀ = 11 nM). KCL-286 activates RARβ2 in the injured neurons. KCL-286 induces axonal regeneration of both spinal and sensory nerves through the inhibitory environment of the CNS, modulates neuroinflammation and extracellular matrix molecules. KCL-286 can modulate the expression of CSPGs by neuronal secretion of decorin which promotes myelination and aids axonal growth. KCL-286 can be studied in research for area such as spinal cord injury and traumatic nerve injury .

HY-106963

ALRT1550 LGD1550	RAR/RXR	Cancer
ALRT1550 (LGD1550) is a selective retinoic acid receptor (RAR) agonist that binds *RARs* with exceptional potency, with K_d values of approximately 1-4 nM. ALRT1550 exhibits anti-proliferative activity, with an IC₅₀ value of 0.22 nM in UMSCC-22B squamous carcinoma cells. In a mouse tumor xenograft model, ALRT1550 inhibited tumor growth in a dose-dependent manner, achieving a maximum inhibition rate of 89%. ALRT1550 is applicable for research in the field of cancer .

HY-15388R

Tazarotene (Standard) AGN 190168 (Standard)	Reference Standards RAR/RXR Autophagy	Inflammation/Immunology Cancer
Tazarotene (Standard) is the analytical standard of Tazarotene. This product is intended for research and analytical applications. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S3

Tazarotene-d6 AGN 190168-d₆	Isotope-Labeled Compounds	Inflammation/Immunology Cancer
Tazarotene-d₆ (AGN 190168-d₆) is deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S2

Tazarotene-13C6 AGN 190168-¹³C₆	Isotope-Labeled Compounds RAR/RXR Autophagy	Inflammation/Immunology Cancer
Tazarotene- ¹³C₆ (AGN 190168- ¹³C₆) is ¹³C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-U00449G

AGN 193109	RAR/RXR	Cancer
AGN 193109 (GMP) is AGN 193109 (HY-U00449) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AGN 193109 is a specific and highly effective retinoic acid receptor (RAR) antagonist . AGN 193109 (GMP) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-125904

4-Hydroxyretinoic acid	RAR/RXR	Neurological Disease Inflammation/Immunology Cancer
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoid derivative with diverse biological effects. 4-Hydroxyretinoic acid is formed from retinol catalyzed by cytochrome P-450 isozyme(s), and is mainly metabolized by the liver in the body. 4-Hydroxyretinoic acid also serves as the substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. 4-Hydroxyretinoic acid regulates gene expression and cell differentiation via binding to nuclear receptor *RAR* (Retinoic Acid Receptor), and activates *RARs and RXR-alpha, to induce cancer cell apoptosis*. In addition, 4-Hydroxyretinoic acid is also involved in various physiological processes such as immune regulation, neuroprotection, and anti-oxidation .

Cat. No.	Product Name	Type

HY-14649G

Retinoic acid (GMP) Vitamin A acid (GMP); all-trans-retinoic acid (GMP); ATRA (GMP)	Fluorescent Dye
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of **RAR nuclear receptors** .

HY-U00449G

AGN 193109 (GMP)

Fluorescent Dye

AGN 193109 (GMP) is AGN 193109 (HY-U00449) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AGN 193109 is a specific and highly effective retinoic acid receptor (RAR) antagonist . AGN 193109 (GMP) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. AGN 193109 is the antidote for retinoic acidosis, that ameliorates the skin and mucosal toxicity.

HY-15682G

TTNPB (GMP) Ro 13-7410 (GMP); Arotinoid acid (GMP); AGN191183 (GMP)	Fluorescent Dye
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent **retinoic acid receptor (RAR)** agonist .

Cat. No.	Product Name	Type

HY-14649G

Retinoic acid (GMP) Vitamin A acid (GMP); all-trans-retinoic acid (GMP); ATRA (GMP)	Biochemical Assay Reagents
Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of **RAR nuclear receptors** .

HY-W587468

all-trans-3,4-Didehydro retinoic acid

3,4-DHRA

Cell Assay Reagents

All-trans-3,4-Didehydro retinoic acid (3,4-DHRA) is a compound with gene-regulating activity that binds to retinoic acid receptors (RARs) and triggers receptor activation. All-trans-3,4-Didehydro retinoic acid plays an important role in skin development and differentiation and has potential anti-tumor and anti-inflammatory properties. All-trans-3,4-Didehydro retinoic acid is also being studied for the inhibition of a variety of diseases, including skin diseases and certain types of cancer.

HY-U00449G

AGN 193109 (GMP)

Biochemical Assay Reagents

HY-15682G

TTNPB (GMP) Ro 13-7410 (GMP); Arotinoid acid (GMP); AGN191183 (GMP)	Biochemical Assay Reagents
TTNPB (Ro 13-7410) (GMP) is TTNPB (HY-15682) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. TTNPB is a highly potent **retinoic acid receptor (RAR)** agonist .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14649

Retinoic acid 95+ Cited Publications Vitamin A acid; all-trans-retinoic acid; ATRA	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Cancer	Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of *RAR* nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-14649R

Retinoic acid (Standard) 95+ Cited Publications Vitamin A acid (Standard); all-trans-retinoic acid (Standard); ATRA (Standard)	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Reference Standards RAR/RXR PPAR Endogenous Metabolite Autophagy
Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of *RAR* nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-107494A

all-trans-4-Oxoretinoic acid all-trans 4-Keto retinoic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-107494AR

all-trans-4-Oxoretinoic acid (Standard) all-trans 4-Keto retinoic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

Cat. No.	Compare	Product Name	Species	Source

HY-P70099

	Chemerin/RARRES2 Protein, Human (HEK293, His) 1 Publications Verification rHuretinoic acid receptor responder protein 2/Chemerin, His; retinoic acid receptor responder protein 2; Chemerin; RAR-responsive protein TIG2; Tazarotene-induced gene 2 protein; RARRES2; TIG2	Human	HEK293
	Chemerin/RARRES2 protein is an adipokine secreted by adipocytes that is activated by CMKLR1 and serves as a CMKLR2 ligand to complexly regulate adipogenesis, metabolism, and inflammation. It actively regulates adipocyte differentiation, affects lipid and glucose metabolism, and plays a role in angiogenesis. Chemerin/RARRES2 Protein, Human (HEK293, His) is the recombinant human-derived Chemerin/RARRES2 protein, expressed by HEK293 , with C-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-14649S5

Retinoic acid-d3

Retinoic acid-d₃ is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S6

Retinoic acid-d3-1

Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-14649S2

11-cis-Retinoic Acid-d5

11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-U00449S

AGN 193109-d7
AGN 193109-d₇ is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

HY-100532S

CD437-13C6
CD437- ¹³C₆ is the ¹³C- and deuterium labeled CD437. CD437 is a selective Retinoic Acid Receptor γ (RARγ) agonist.

HY-15388S

Tazarotene-d8
Tazarotene-d₈ is the deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris .

HY-101108S

Tazarotenic acid-d6
Tazarotenic acid-d₆ is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-15388S3

Tazarotene-d6
Tazarotene-d₆ (AGN 190168-d₆) is deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15388S2

Tazarotene-13C6
Tazarotene- ¹³C₆ (AGN 190168- ¹³C₆) is ¹³C labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101108S1

Tazarotenic acid-13C2,d2
Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .

HY-15388S1

Tazarotene-13C2,d2

Tazarotene-13C2,d2 (AGN 190168-13C2,d2) is the ¹³C and deuterium labeled isotope of Tazarotene (HY-15388). Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris. Tazarotene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81829

	Retinoic Acid Receptor beta Antibody (YA1574) RARB; HAP; NR1B2; retinoic acid receptor beta; RAR-beta; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon	WB, IHC-P, ICC/IF	Human
	Retinoic Acid Receptor beta Antibody (YA1574) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Retinoic Acid Receptor beta.

HY-P83758

	ROR gamma T Antibody (YA3559) IMD42 antibody; MGC129539 antibody; NR1F3 antibody; Nuclear receptor ROR gamma antibody; Nuclear receptor subfamily 1 group F member 3 antibody; RAR related orphan receptor C antibody; retinoic acid binding receptor gamma antibody; Retinoid related orphan receptor gamma antibody; Rorc antibody; RORG antibody; RORG_HUMAN antibody; RZR GAMMA antibody; RZRG antibody; TOR antibody	WB, IHC-P	Human, Rat
	ROR gamma T Antibody (YA3559) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ROR gamma T.

HY-P82115

	Retinoic Acid Receptor gamma Antibody (YA1860) NR1B3; RAR gamma; RARC; Rarg	WB, ICC/IF	Human, Rat
	Retinoic Acid Receptor gamma Antibody (YA1860) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Retinoic Acid Receptor gamma.

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