2. Cell Cycle/DNA Damage Cytoskeleton Apoptosis
  3. Microtubule/Tubulin Apoptosis
  4. Tubulin polymerization-IN-24

Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly.

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Tubulin polymerization-IN-24 Chemical Structure

Tubulin polymerization-IN-24 Chemical Structure

CAS No. : 564468-51-5

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Tubulin polymerization-IN-24 Related Antibodies

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Description

Tubulin polymerization-IN-24 (compound HMBA) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-24 inhibits MCF-7 cells proliferation. Tubulin polymerization-IN-24 induces apoptosis and cell cycle arrest at G2/M phase. Tubulin polymerization-IN-24 increase the GTP hydrolysis rate and inhibits microtubule assembly[1].

In Vitro

Tubulin polymerization-IN-24 (compound HMBA) inhibits the assembly of purified tubulin (MAPs-free) in a concentration dependent manner[1].
Tubulin polymerization-IN-24 (0-100 nM) inhibits MCF-7 proliferation in a concentration dependent fashion with an IC50 value of 47 nM[1].
Tubulin polymerization-IN-24 competitively inhibits colchicine binding to tubulin with a Ki value of 3.6 μM[1].
Tubulin polymerization-IN-24 inhibits the progression of MCF-7 cells in mitosis and induces apoptotic cell death involving p53 pathway[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin polymerization-IN-24 Related Antibodies
Molecular Weight

328.36

Formula

C22H16O3
CAS No.
SMILES

O=C1C2=C(C=CC=C2)/C(C3=CC=CC=C13)=C\C4=CC=C(OC)C(O)=C4
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Purity & Documentation
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Tubulin polymerization-IN-24 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin polymerization-IN-24564468-51-5Microtubule/TubulinApoptosisanticanceranti-proliferationMCF-7 cellsG2/M phaseapoptosisGTP hydrolysismicrotubule assemblyp53Inhibitorinhibitorinhibit

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