Xanthoangelol

Name: Xanthoangelol
Brand: MedChemExpress
SKU: HY-111588
Rating: 4.5 (1 reviews)

Cat. No.: HY-111588 Purity: 99.65%: FAQs
Data Sheet SDS COA Handling Instructions

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Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells.

For research use only. We do not sell to patients.

Xanthoangelol Chemical Structure

CAS No. : 62949-76-2

Size	Price	Stock	Quantity
1 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 370	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

1 Publications Citing Use of MCE Xanthoangelol

•Reprod Biomed Online. 2023 Apr 12.

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MAO-A MAO-B

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

View All Caspase Isoform Specific Products:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	CC₅₀	11.8 μM Compound: 30	Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay Cytotoxicity against hamster BHK-21 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay	[PMID: 36940609]
HEK293	IC₅₀	21.5 μM Compound: Xanthoangelol	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
HeLa	IC₅₀	1.03 μM Compound: 11	Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay Inhibition of TNF-alpha-induced NF-kappaB activation in human HeLa cells by SEAP reporter gene assay	[PMID: 18841906]
HepG2	IC₅₀	13.7 μM Compound: Xanthoangelol	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
HUVEC	IC₅₀	> 100 μM Compound: 1b	Toxicity against HUVEC incubated for 48 hrs by MTT assay Toxicity against HUVEC incubated for 48 hrs by MTT assay	[PMID: 25590864]
K562	IC₅₀	3.98 μM Compound: 1b	Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay Antitumor activity against human K562 cells incubated for 48 hrs by MTT assay	[PMID: 25590864]
MRC5	IC₅₀	21.7 μM Compound: Xanthoangelol	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
MRC5	IC₅₀	25 μM Compound: 23	Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis Cytotoxicity against human MRC5 cells after 48 hrs by resazurin dye-based fluorescence analysis	[PMID: 28075580]
RAW264.7	IC₅₀	1.83 μM Compound: 11	Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay Inhibition of LPS-induced NF-kappaB activation in mouse RAW264.7 cells by SEAP reporter gene assay	[PMID: 18841906]
THP-1	IC₅₀	23.6 μM Compound: Xanthoangelol	Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by resazurin reagent based assay	[PMID: 31648878]
THP-1	IC₅₀	25 μM Compound: 23	Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis Cytotoxicity against human THP1 cells after 48 hrs by resazurin dye-based fluorescence analysis	[PMID: 28075580]

In Vitro

Xanthoangelol (1 and 5 μM, 24 h) combined with 4-HD suppresses proinflammatory factors, such as NO, TNF-a, and MCP-1 through inhibition of the JNK pathway in the co-culture system of fully differentiated 3T3-L1 adipocytes and RAW264.7 macrophages^[1].
Xanthoangelol (1-100 μM, 48 h) reduces the neuroblastoma and leukemia cells survival with cytotoxicity^[4].
Xanthoangelol (1-10 μM, 4 h) induces concentration-dependent early apoptosis followed by secondary cell death through activation of caspase-3 in Jurkat cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:	LPS-stimulated RAW264.7 macrophages
Concentration:	1 and 5 μM
Incubation Time:	24 h
Result:	Decreased NO release, TNF-a and MCP-1 secretion, as well as the mRNA expression in LPS-stimulated RAW264.7 macrophages.

Western Blot Analysis^[1]

Cell Line:	LPS-stimulated RAW264.7 macrophages
Concentration:	5 μM
Incubation Time:	1 h
Result:	Alleviated JNK phosphorylation (by 38% and 49%, respectively), but had no effect on IjB degradation and p38 phosphorylation in LPS-stimulated RAW264.7 macrophages.

Cell Viability Assay^[4]

Cell Line:	IMR-32 and Jurkat cells
Concentration:	1-100 μM
Incubation Time:	48 h
Result:	Markedly reduced IMR-32 and Jurkat cells viability in a concentration-dependent manner.

Apoptosis Analysis^[4]

Cell Line:	Jurkat cells
Concentration:	1-10 μM
Incubation Time:	4 h
Result:	Significantly increased the ratio of apoptotic IMR-32 cells.

In Vivo

Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	High-fat diet-induced obese (DIO) mice^[1]
Dosage:	0.1% or 0.15% w/w
Administration:	mixed in a high-fat diet, daily for 14 weeks
Result:	Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice.

Molecular Weight

392.49

Formula

C₂₅H₂₈O₄

CAS No.

62949-76-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(/C=C/C1=CC=C(O)C=C1)C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)/C)=C2O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (254.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5478 mL	12.7392 mL	25.4784 mL
5 mM	0.5096 mL	2.5478 mL	5.0957 mL
10 mM	0.2548 mL	1.2739 mL	2.5478 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (277 KB) SDS (251 KB)

COA (247 KB) HNMR (260 KB) LCMS (266 KB)

Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Xanthoangelol and 4-hydroxyderrcin suppress obesity-induced inflammatory responses. Obesity (Silver Spring). 2016 Nov;24(11):2351-2360. [Content Brief]

[2]. Inamori Y, et al. Antibacterial activity of two chalcones, xanthoangelol and 4-hydroxyderricin, isolated from the root of Angelica keiskei KOIDZUMI. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1604-5. [Content Brief]

[3]. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. [Content Brief]

[4]. Keiichi TABATA, et al. Xanthoangelol, a Major Chalcone Constituent of Angelica keiskei, Induces Apoptosis in Neuroblastoma and Leukemia Cells. Biol. Pharm. Bull. 28(8) 1404-1407 (2005).

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5478 mL	12.7392 mL	25.4784 mL	63.6959 mL
	5 mM	0.5096 mL	2.5478 mL	5.0957 mL	12.7392 mL
	10 mM	0.2548 mL	1.2739 mL	2.5478 mL	6.3696 mL
	15 mM	0.1699 mL	0.8493 mL	1.6986 mL	4.2464 mL
	20 mM	0.1274 mL	0.6370 mL	1.2739 mL	3.1848 mL
	25 mM	0.1019 mL	0.5096 mL	1.0191 mL	2.5478 mL
	30 mM	0.0849 mL	0.4246 mL	0.8493 mL	2.1232 mL
	40 mM	0.0637 mL	0.3185 mL	0.6370 mL	1.5924 mL
	50 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2739 mL
	60 mM	0.0425 mL	0.2123 mL	0.4246 mL	1.0616 mL
	80 mM	0.0318 mL	0.1592 mL	0.3185 mL	0.7962 mL
	100 mM	0.0255 mL	0.1274 mL	0.2548 mL	0.6370 mL

Xanthoangelol Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthoangelol62949-76-2ApoptosisMonoamine OxidaseBacterialAMPKCaspaseMAOAMP-activated protein kinaseInhibitorinhibitorinhibit

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Xanthoangelol

Customer Review

Xanthoangelol Related Antibodies

1 Publications Citing Use of MCE Xanthoangelol

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Monoamine Oxidase Isoform Specific Products:

View All AMPK Isoform Specific Products:

View All Caspase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Xanthoangelol Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Xanthoangelol Related Classifications

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