2. Apoptosis Neuronal Signaling Anti-infection PI3K/Akt/mTOR Epigenetics
  3. Apoptosis Monoamine Oxidase Bacterial AMPK Caspase
  4. Xanthoangelol

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells.

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Xanthoangelol Chemical Structure

Xanthoangelol Chemical Structure

CAS No. : 62949-76-2

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Based on 1 publication(s) in Google Scholar

Xanthoangelol Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Xanthoangelol

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MAO-A MAO-B

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NUAK1 NUAK2 AMPK AMPK α1β1γ1 AMPK α2β1γ1 AMPK α1β2γ1 AMPK α2β2γ1

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • Biological Activity

  • Purity & Documentation

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Description

Xanthoangelol, extracted from Angelica keiskei, suppresses obesity-induced inflammatory responses. Xanthoangelol possesses antibacterial activity. Xanthoangelol inhibits monoamine oxidases. Xanthoangelol induces apoptosis in neuroblastoma and leukemia cells[1][2][3][4].

In Vitro

Xanthoangelol (1 and 5 μM, 24 h) combined with 4-HD suppresses proinflammatory factors, such as NO, TNF-a, and MCP-1 through inhibition of the JNK pathway in the co-culture system of fully differentiated 3T3-L1 adipocytes and RAW264.7 macrophages[1].
Xanthoangelol (1-100 μM, 48 h) reduces the neuroblastoma and leukemia cells survival with cytotoxicity[4].
Xanthoangelol (1-10 μM, 4 h) induces concentration-dependent early apoptosis followed by secondary cell death through activation of caspase-3 in Jurkat cells[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Xanthoangelol Related Antibodies

Real Time qPCR[1]

Cell Line: LPS-stimulated RAW264.7 macrophages
Concentration: 1 and 5 μM
Incubation Time: 24 h
Result: Decreased NO release, TNF-a and MCP-1 secretion, as well as the mRNA expression in LPS-stimulated RAW264.7 macrophages.

Western Blot Analysis[1]

Cell Line: LPS-stimulated RAW264.7 macrophages
Concentration: 5 μM
Incubation Time: 1 h
Result: Alleviated JNK phosphorylation (by 38% and 49%, respectively), but had no effect on IjB degradation and p38 phosphorylation in LPS-stimulated RAW264.7 macrophages.

Cell Viability Assay[4]

Cell Line: IMR-32 and Jurkat cells
Concentration: 1-100 μM
Incubation Time: 48 h
Result: Markedly reduced IMR-32 and Jurkat cells viability in a concentration-dependent manner.

Apoptosis Analysis[4]

Cell Line: Jurkat cells
Concentration: 1-10 μM
Incubation Time: 4 h
Result: Significantly increased the ratio of apoptotic IMR-32 cells.
In Vivo

Xanthoangelol (0.1% or 0.15% w/w, mixed in a high-fat diet, daily for 14 weeks) suppresses inflammatory mediators in WAT of diet-induced obese mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet-induced obese (DIO) mice[1]
Dosage: 0.1% or 0.15% w/w
Administration: mixed in a high-fat diet, daily for 14 weeks
Result: Showed fewer positively stained macrophages, suppressed the gene expression of inflammatory marker MCP-1 and TNF-a, increased oxygen consumption in DIO mice.
Molecular Weight

392.49

Formula

C25H28O4
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(/C=C/C1=CC=C(O)C=C1)C2=CC=C(O)C(C/C=C(C)/CC/C=C(C)/C)=C2O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5478 mL 12.7392 mL 25.4784 mL
5 mM 0.5096 mL 2.5478 mL 5.0957 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

COA (247 KB) HNMR (260 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5478 mL 12.7392 mL 25.4784 mL 63.6959 mL
5 mM 0.5096 mL 2.5478 mL 5.0957 mL 12.7392 mL
10 mM 0.2548 mL 1.2739 mL 2.5478 mL 6.3696 mL
15 mM 0.1699 mL 0.8493 mL 1.6986 mL 4.2464 mL
20 mM 0.1274 mL 0.6370 mL 1.2739 mL 3.1848 mL
25 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.5478 mL
30 mM 0.0849 mL 0.4246 mL 0.8493 mL 2.1232 mL
40 mM 0.0637 mL 0.3185 mL 0.6370 mL 1.5924 mL
50 mM 0.0510 mL 0.2548 mL 0.5096 mL 1.2739 mL
60 mM 0.0425 mL 0.2123 mL 0.4246 mL 1.0616 mL
80 mM 0.0318 mL 0.1592 mL 0.3185 mL 0.7962 mL
100 mM 0.0255 mL 0.1274 mL 0.2548 mL 0.6370 mL
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Xanthoangelol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Xanthoangelol62949-76-2ApoptosisMonoamine OxidaseBacterialAMPKCaspaseMAOAMP-activated protein kinaseInhibitorinhibitorinhibit

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