2. Apoptosis
  3. Apoptosis
  4. Yakuchinone A

Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities.

For research use only. We do not sell to patients.

Yakuchinone A Chemical Structure

Yakuchinone A Chemical Structure

CAS No. : 78954-23-1

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5 mg USD 180 In-stock
10 mg USD 300 In-stock
25 mg USD 600 In-stock
50 mg USD 950 In-stock
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Based on 1 publication(s) in Google Scholar

Yakuchinone A Related Antibodies

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Description

Yakuchinone A is a natural product isolated from the fruit of Alpinia oxyphylla, which can induce apoptosis and has anticancer and anti-inflammatory activities[1].

Cellular Effect
Cell Line Type Value Description References
A-375 IC50
23.8 μM
Compound: Yakuchinone A
Cytotoxicity against human A375 cells after 72 hrs by MTT assay
Cytotoxicity against human A375 cells after 72 hrs by MTT assay
[PMID: 31336310]
A-431 IC50
13.3 μM
Compound: Yakuchinone A
Cytotoxicity against human A431 cells after 72 hrs by MTT assay
Cytotoxicity against human A431 cells after 72 hrs by MTT assay
[PMID: 31336310]
SCC-25 IC50
18.7 μM
Compound: Yakuchinone A
Cytotoxicity against human SCC25 cells after 72 hrs by MTT assay
Cytotoxicity against human SCC25 cells after 72 hrs by MTT assay
[PMID: 31336310]
In Vitro

Yakuchinone A acts on A375P, B16F1, B16F10, A549, MCF-7 and HT-29 cell lines with the IC50 values of 14.75, 31.73, 21.71, 26.07, 11.50 and 11.96 μM, respectively[1].
Yakuchinone A (0-64 μM, 16 h) can reduce IL-17 production in a dose-dependent manner and the IC50 value is 11.5 μM in EL4 (a mouse lymphoma cell line) cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Yakuchinone A Related Antibodies
In Vivo

Yakuchinone A (50 mg/kg, i.p., daily, 14 days) can reduce the symptoms of EAE in mice in autoimmune encephalomyelitis (EAE) mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice[1]
Dosage: 50 mg/kg
Administration: i.p., daily, 14 days
Result: Showed a significant EAE score reduction from Day 9 to Day 15 after EAE onset.
Molecular Weight

312.40

Formula

C20H24O3
CAS No.
Appearance

Liquid (Density: 1.095±0.06 g/cm3)

Color

Colorless to off-white

SMILES

O=C(CCCCC1=CC=CC=C1)CCC2=CC=C(O)C(OC)=C2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (320.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2010 mL 16.0051 mL 32.0102 mL
5 mM 0.6402 mL 3.2010 mL 6.4020 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (8.00 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2010 mL 16.0051 mL 32.0102 mL 80.0256 mL
5 mM 0.6402 mL 3.2010 mL 6.4020 mL 16.0051 mL
10 mM 0.3201 mL 1.6005 mL 3.2010 mL 8.0026 mL
15 mM 0.2134 mL 1.0670 mL 2.1340 mL 5.3350 mL
20 mM 0.1601 mL 0.8003 mL 1.6005 mL 4.0013 mL
25 mM 0.1280 mL 0.6402 mL 1.2804 mL 3.2010 mL
30 mM 0.1067 mL 0.5335 mL 1.0670 mL 2.6675 mL
40 mM 0.0800 mL 0.4001 mL 0.8003 mL 2.0006 mL
50 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6005 mL
60 mM 0.0534 mL 0.2668 mL 0.5335 mL 1.3338 mL
80 mM 0.0400 mL 0.2001 mL 0.4001 mL 1.0003 mL
100 mM 0.0320 mL 0.1601 mL 0.3201 mL 0.8003 mL
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Yakuchinone A Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yakuchinone A78954-23-1ApoptosisapoptosisAlpinia oxyphyllaanticanceranti-inflammatoryInhibitorinhibitorinhibit

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