2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. β-Nicotinamide mononucleotide-d4

β-Nicotinamide mononucleotide-d4  (Synonyms: β-NM-d4; NMN-d4)

Cat. No.: HY-F0004S Purity: 99.55%
COA Handling Instructions

Molarity Calculator

β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

For research use only. We do not sell to patients.

β-Nicotinamide mononucleotide-d<sub>4</sub> Chemical Structure

β-Nicotinamide mononucleotide-d4 Chemical Structure

Size Price Stock Quantity
500 μg USD 680 In-stock
1 mg USD 1150 In-stock
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of β-Nicotinamide mononucleotide-d4:

β-Nicotinamide mononucleotide-d4 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Nicotinamide mononucleotide-d4 is the deuterium labeled β-Nicotinamide mononucleotide. β-nicotinamide mononucleotide (β-NM) is a product of the nicotinamide phosphoribosyltransferase (NAMPT) reaction and a key NAD+ intermediate. The pharmacological activities of β-nicotinamide mononucleotide include its role in cellular biochemical functions, cardioprotection, diabetes, Alzheimer's disease, and complications associated with obesity[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

β-Nicotinamide mononucleotide-d4 Related Antibodies
Molecular Weight

338.24

Formula

C11H11D4N2O8P
Unlabeled CAS

1094-61-7
Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H]([N+]2=C([2H])C([2H])=C([2H])C(C(N)=O)=C2[2H])O[C@@H]1COP(O)([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (246.36 mM; Need ultrasonic and warming)

PBS (pH 7.2) : ≥ 10 mg/mL (29.56 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9565 mL 14.7824 mL 29.5648 mL
5 mM 0.5913 mL 2.9565 mL 5.9130 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.55%

COA (258 KB) HNMR (160 KB) RP-HPLC (183 KB) LCMS (100 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
PBS (pH 7.2) / H2O 1 mM 2.9565 mL 14.7824 mL 29.5648 mL 73.9120 mL
5 mM 0.5913 mL 2.9565 mL 5.9130 mL 14.7824 mL
10 mM 0.2956 mL 1.4782 mL 2.9565 mL 7.3912 mL
15 mM 0.1971 mL 0.9855 mL 1.9710 mL 4.9275 mL
20 mM 0.1478 mL 0.7391 mL 1.4782 mL 3.6956 mL
25 mM 0.1183 mL 0.5913 mL 1.1826 mL 2.9565 mL
H2O 30 mM 0.0985 mL 0.4927 mL 0.9855 mL 2.4637 mL
40 mM 0.0739 mL 0.3696 mL 0.7391 mL 1.8478 mL
50 mM 0.0591 mL 0.2956 mL 0.5913 mL 1.4782 mL
60 mM 0.0493 mL 0.2464 mL 0.4927 mL 1.2319 mL
80 mM 0.0370 mL 0.1848 mL 0.3696 mL 0.9239 mL
100 mM 0.0296 mL 0.1478 mL 0.2956 mL 0.7391 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

β-Nicotinamide mononucleotide-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

β-Nicotinamide mononucleotide-d4β-NM-d4NMN-d4Endogenous MetaboliteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
β-Nicotinamide mononucleotide-d4
Cat. No.:
HY-F0004S
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.