9-cis-Retinoic acid-d₅

Name: 9-cis-Retinoic acid-d 5
Brand: MedChemExpress
SKU: HY-132334S
Rating: 4.5 (1 reviews)

Cat. No.: HY-132334S Purity: 98.64%: FAQs
Data Sheet SDS COA Handling Instructions

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9-cis-Retinoic acid-d₅ is the deuterium labeled 9-cis-Retinoic acid. 9-cis-Retinoic acid (ALRT1057), a vitamin A derivative, is a potent RAR/RXR agonist. 9-cis-Retinoic acid induces apoptosis, regulates cell cycle and has anticancer, anti-inflammatory and neuroprotection activities[1][2][3][4][5][6].

For research use only. We do not sell to patients.

9-cis-Retinoic acid-d<sub>5</sub> Chemical Structure

9-cis-Retinoic acid-d₅ Chemical Structure

Size	Price	Stock	Quantity
100 μg	USD 105	In-stock	Estimated Time of Arrival: December 31
1 mg	USD 420	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 1260	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 2020	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 9-cis-Retinoic acid-d₅:

9-cis-Retinoic acid Get quote

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•Related Small Molecules:

•Related Proteins:

View All RAR/RXR Isoform Specific Products:

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RXRα RXRβ RXRγ

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

305.47

Formula

C₂₀H₂₃D₅O₂

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC(/C=C/C(C(C)(CCC1([2H])[2H])C)=C1C([2H])([2H])[2H])=C/C=C/C(C)=C/C(O)=O

Shipping

Shipping with dry ice.

Storage

-80°C, protect from light, stored under nitrogen

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (327.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 25 mg/mL (81.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2736 mL	16.3682 mL	32.7364 mL
5 mM	0.6547 mL	3.2736 mL	6.5473 mL
10 mM	0.3274 mL	1.6368 mL	3.2736 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.64%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (249 KB) HNMR (118 KB) RP-HPLC (141 KB) LCMS (392 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Raul Rosas, et al. Retinoids Augment Thiazolidinedione PPARγ Activation in Oral Cancer Cells. Anticancer Res. 2020 Jun;40(6):3071-3080. [Content Brief]

[3]. Hua Yang, et al. Effects of 9-cis-retinoic Acid on the Proliferation and Apoptosis of Cutaneous T-cell Lymphoma Cells. Anticancer Drugs. 2019 Jan;30(1):56-64. [Content Brief]

[4]. Zhiqing Yuan, et al. 9-cis-retinoic Acid Elevates MRP3 Expression by Inhibiting Sumoylation of RXRα to Alleviate Cholestatic Liver Injury. Biochem Biophys Res Commun. 2018 Sep 3;503(1):188-194. [Content Brief]

[5]. V M Manzano, et al. Human Renal Mesangial Cells Are a Target for the Anti-Inflammatory Action of 9-cis Retinoic Acid. Br J Pharmacol. 2000 Dec;131(8):1673-83. [Content Brief]

[6]. Gro H Mathisen, et al. Delayed Translocation of NGFI-B/RXR in Glutamate Stimulated Neurons Allows Late Protection by 9-cis Retinoic Acid. Biochem Biophys Res Commun. 2011 Oct 14;414(1):90-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / DMSO	1 mM	3.2736 mL	16.3682 mL	32.7364 mL	81.8411 mL
	5 mM	0.6547 mL	3.2736 mL	6.5473 mL	16.3682 mL
	10 mM	0.3274 mL	1.6368 mL	3.2736 mL	8.1841 mL
	15 mM	0.2182 mL	1.0912 mL	2.1824 mL	5.4561 mL
	20 mM	0.1637 mL	0.8184 mL	1.6368 mL	4.0921 mL
	25 mM	0.1309 mL	0.6547 mL	1.3095 mL	3.2736 mL
	30 mM	0.1091 mL	0.5456 mL	1.0912 mL	2.7280 mL
	40 mM	0.0818 mL	0.4092 mL	0.8184 mL	2.0460 mL
	50 mM	0.0655 mL	0.3274 mL	0.6547 mL	1.6368 mL
	60 mM	0.0546 mL	0.2728 mL	0.5456 mL	1.3640 mL
	80 mM	0.0409 mL	0.2046 mL	0.4092 mL	1.0230 mL
DMSO	100 mM	0.0327 mL	0.1637 mL	0.3274 mL	0.8184 mL