2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection
  3. GABA Receptor HIV
  4. L-Cycloserine

L-Cycloserine  (Synonyms: (S)-Cycloserine; (S)-4-Amino-3-isoxazolidone)

Cat. No.: HY-B1122 Purity: 99.44%
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L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains.

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L-Cycloserine Chemical Structure

L-Cycloserine Chemical Structure

CAS No. : 339-72-0

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Based on 1 publication(s) in Google Scholar

L-Cycloserine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE L-Cycloserine

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

L-Cycloserine ((S)-4-Amino-3-isoxazolidone) is an oral inhibitor of the enzyme gamma-aminobutyric acid (GABA) transaminase (GABA-t) and branched-chain transaminases in Mycobacterium tuberculosis. L-Cycloserine has anticonvulsant properties and inhibits the synthesis of neurotensin in mouse brains[1][2][3][4].

In Vitro

L-Cycloserine inhibits the growth of M. tuberculosis, with an MIC of 0.3 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-Cycloserine Related Antibodies
In Vivo

L-Cycloserine (25-50 mg/kg, intraperitoneal injection, single dose) has anticonvulsant effects in mice[2].
L-Cycloserine (30-100 mg/kg, orally or via intraperitoneal injection, twice daily for 5 days) enhances the inhibitory effect on GABA-T activity in mice and boosts its anticonvulsant effects[3].
L-Cycloserine (100-150 mg/kg, subcutaneous or intraperitoneal injection, once daily for 1 week) can reduce the brain content of gangliosides by 28% when injected subcutaneously, with no effect on the content of neurogangliosides; intraperitoneal injection leads to decreased levels of gangliosides and cerebrosides[4].
L-Cycloserine (100 mg/kg, subcutaneous or intraperitoneal injection, single dose) affects the level of inhibition of 3-keto-dihydrosphingosine synthase depending on the method of injection[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Close-crossed epileptic mice (DBA/2J), normal CBNCa mice[2]
Dosage: 25, 50 mg/kg; single dose
Administration: Intraperitoneal injection (i.p.)
Result: Protected mice from seizures three hours later, and the effects gradually weakened thereafter, with lower concentrations of glutamate and aspartate in the hypothalamus decreasing and γ-aminobutyric acid increasing.
Animal Model: DAB/2mice induced by 3-MPA[3]
Dosage: 100 mg/kg; twice a day; 5 days
30 mg/kg; single dose
Administration: Oral; Intraperitoneal injection (i.p.)
Result: Enhanced inhibition of GABA-T activity protected mice from 3-mercaptopropionic acid (3-MPA)-induced tonic seizures, and motor performance deficits decreased over time.
Animal Model: Male Swiss mice[4]
Dosage: 100 mg/kg; single dose
Administration: Subcutaneous injection (s.c.); Intraperitoneal injection (i.p.)
Result: Showed that 2 hours after intraperitoneal injection, the synthase activity was found to be inhibited by 80%, and subcutaneous injection of L-cycloserine had no significant inhibitory effect on the synthase within 2-48 hours.
Molecular Weight

102.09

Formula

C3H6N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1NOC[C@@H]1N
Structure Classification
Initial Source

Erwinia uredovora.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 13.33 mg/mL (130.57 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (122.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.7950 mL 48.9750 mL 97.9499 mL
5 mM 1.9590 mL 9.7950 mL 19.5900 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (12.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (12.24 mM); Clear solution

    This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (979.50 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.44%

SDS (393 KB)

COA (252 KB) HNMR (220 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 9.7950 mL 48.9750 mL 97.9499 mL 244.8748 mL
5 mM 1.9590 mL 9.7950 mL 19.5900 mL 48.9750 mL
10 mM 0.9795 mL 4.8975 mL 9.7950 mL 24.4875 mL
15 mM 0.6530 mL 3.2650 mL 6.5300 mL 16.3250 mL
20 mM 0.4897 mL 2.4487 mL 4.8975 mL 12.2437 mL
25 mM 0.3918 mL 1.9590 mL 3.9180 mL 9.7950 mL
30 mM 0.3265 mL 1.6325 mL 3.2650 mL 8.1625 mL
40 mM 0.2449 mL 1.2244 mL 2.4487 mL 6.1219 mL
50 mM 0.1959 mL 0.9795 mL 1.9590 mL 4.8975 mL
60 mM 0.1632 mL 0.8162 mL 1.6325 mL 4.0812 mL
80 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0609 mL
100 mM 0.0979 mL 0.4897 mL 0.9795 mL 2.4487 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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L-Cycloserine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Cycloserine339-72-0(S)-Cycloserine (S)-4-Amino-3-isoxazolidoneGABA ReceptorHIVGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorHuman immunodeficiency virusBrain cerebroside synthesisanticonvulsantMycobacterium tuberculosis branched-chain aminotransferasegamma-aminobutyric acid (GABA)-aminotransferaseInhibitorinhibitorinhibit

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