2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Deubiquitinase

Deubiquitinase

Deubiquitinase

DUBs

Deubiquitinase

Related Products

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Deubiquitinases (DUBs) are a family of proteases whose function is to cleave ubiquitin (Ub) or ubiquitin-like proteins from proproteins or ubiquitin(s) conjugated with target substrate. DUBs are divided into two main classes according to their enzymatic cleavage mechanism: cysteine proteases and zinc metalloproteases. These include ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), ovarian tumor proteases (OTUs), Machado-Joseph disease proteases (MJDs), Jab1/Mov34/Mpr1 (JAMM) metalloproteases, and MIU-containing novel DUB family, (MINDY) proteases.

Ubiquitination is an important post-translational modification that plays a key role in many vital cellular events. In this process, ubiquitin is attached to a substrate protein by the concerted action of an enzyme cascade involving E1, E2 and E3 enzymes and it is removed by DUBs. DUBs are therefore important regulators of the Ub system and regulate a plethora of cellular processes, including protein turnover, protein sorting, and trafficking. Altered DUB activity is associated with a multitude of pathologies including cancer. DUBs represent novel candidates for target-directed drug development.

Deubiquitinase Isoform Specific Products:

Deubiquitinase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-162312
    LLK203
    		Inhibitor 98.58%
    LLK203 is a potent USP2/USP8 dual-target inhibitor with IC50s of 0.89 μM and 0.52 μM, respectively. LLK203 leads a degradation of ERα and induces apoptosis of breast cancer MCF-7 cells. LLK203 demonstrates antitumor activities against the 4T1 tumor mice model.
    LLK203
  • HY-120458
    LCAHA
    		Inhibitor 99.91%
    LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a.
    LCAHA
  • HY-124855
    STD1T
    		Inhibitor 99.78%
    STD1T is a deubiquitinase USP2a inhibitor with an IC50 of 3.3 μM in Ub-AMC Assay.
    STD1T
  • HY-159000
    VCPIP1-IN-2
    		Inhibitor ≥98.0%
    VCPIP1-IN-1 (Compound 076) is a VCPIP1 inhibitor.
    VCPIP1-IN-2
  • HY-149902
    USP8-IN-3
    		Inhibitor 99.17%
    USP8-IN-3 (Compd U51) is a deubiquitinase USP8 inhibitor with an IC50 value of 4.0 μM. USP8-IN-3 also inhibits the proliferation of GH3 and H1957 cells with GI50s of 37.03 μM and 6.01 μM, respectively.
    USP8-IN-3
  • HY-158999
    VCPIP1-IN-1
    		99.53%
    VCPIP1-IN-1 (Compound 001) is a VCPIP1 inhibitor, with an IC50 of 0.41 μM.
    VCPIP1-IN-1
  • HY-RS15530
    USP2 Human Pre-designed siRNA Set A
    		Inhibitor

    USP2 Human Pre-designed siRNA Set A contains three designed siRNAs for USP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    USP2 Human Pre-designed siRNA Set A
    USP2 Human Pre-designed siRNA Set A
  • HY-149229
    USP28-IN-3
    		Inhibitor 98.26%
    USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331).
    USP28-IN-3
  • HY-138978
    MF-095
    		Inhibitor 98.7%
    MF-095 is a USP30 inhibitor. MF-095 promotes mitochondrial autophagy. MF-095 can be used in neurological disease-related research.
    MF-095
  • HY-154914
    GK16S
    GK16S is a UCHL1 chemogenomic probe. GK16S can be used as a complement to GK13S. GK16S and GK13S can be used to study UCHL1 function in cells. GK16S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    GK16S
  • HY-P10714
    Ub4ix
    		Inhibitor 99.32%
    Ub4ix is a DUB/26S proteasome inhibitor. Ub4ix can protect K48-linked Ub chains from being chopped up by deubiquitinating enzymes (DUBs) and prevent the proteasomal degradation of Ub-tagged proteins. Ub4ix can reduce the viability of Hela cells and induce apoptosis, with an IC50 value of 1.6 μM.
    Ub4ix
  • HY-148481A
    USP7-IN-10 hydrochloride
    		Inhibitor 99.38%
    USP7-IN-10 hydrochloride (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC50 of 13.39 nM.
    USP7-IN-10 hydrochloride
  • HY-148184
    USP1-IN-3
    		Inhibitor 99.30%
    USP1-IN-3 is a selective USPI inhibitor. USP1-IN-3 inhibits USPI-UAFI with an IC50 value of ＜30 nM. USP1-IN-3 can be used for the research of cancer.
    USP1-IN-3
  • HY-149901
    USP8-IN-2
    		Inhibitor 99.91%
    USP8-IN-2 (Compd U52) is a deubiquitinase USP8 inhibitor with an IC50 value of 6.0 μM. USP8-IN-2 also inhibits the proliferation of H1957 cells with an GI50 value of 24.93 μM, respectively.
    USP8-IN-2
  • HY-147031
    JAMM protein inhibitor 2
    		Inhibitor 98.20%
    JAMM protein inhibitor 2 (compound 180) is a potent JAMM protease inhibitor with IC50s of 10 μM, 46 μM and 89 μM for thrombin, Rpn11 and MMP2, respectively. JAMM protein inhibitor 2 can be used for researching anticancer
    JAMM protein inhibitor 2
  • HY-16709
    USP7-IN-1
    		Inhibitor 98.92%
    USP7-IN-1 is a selective and reversible inhibitor of ubiquitin-specific protease 7 (USP7), with an IC50 of 77 μM, and can be used for the research of cancer.
    USP7-IN-1
  • HY-161446
    USP1-IN-7
    		Inhibitor 99.93%
    USP1-IN-7 (Compound 3) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC50 ≤50 nM. USP1-IN-7 inhibits proliferation of MDA-MB-436 with IC50 ≤50 nM.
    USP1-IN-7
  • HY-161378
    UCHL1-IN-1
    		Inhibitor ≥98.0%
    UCHL1-IN-1 (Compound 46) is an inhibitor for Ubiquitin C-terminal Hydrolase L1 (UCHL1), with an IC50 of 5.1 μM. UCHL1-IN-1 can be used for cancer research.
    UCHL1-IN-1
  • HY-153996
    CT1113
    		Inhibitor
    CT1113 is a potent USP28 and USP25 inhibitor. CT1113 decreases the MYC level in vivo，exhibits anti-tumor activity in mouse pancreatic cancer CDX model.
    CT1113
  • HY-148481
    USP7-IN-10
    		Inhibitor
    USP7-IN-10 (compound 1) is a potent ubiquitin-specific protease 7 (USP7) inhibitor, with an IC50 of 13.39 nM.
    USP7-IN-10
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
Deubiquitinase Isoform Comparison

USP1

USP2

USP7

USP8

USP30

UCHL1

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

Deubiquitinase Degraders & Inhibitors
Product NameUSP1USP2USP7USP8USP30UCHL1Purity    
KSQ-4279
USP1
     99.95%
CMPD-39    
USP30, IC50: 0.02 μM
 99.65%
HBX 41108  
USP7, IC50: 424 nM
   99.61%
USP7-797  
USP7, IC50: 0.5 nM
   
U7D-1  
USP7
   99.65%
GK13S     
UCHL1, IC50: 50 nM
≥98.0%
YCH2823  
USP7, IC50: 49.6 nM
   99.87%
OTUB1/USP8-IN-1 TFA   
USP8, IC50: 0.28 nM
  99.56%
LLK203 
USP2, IC50: 0.89 μM
 
USP8, IC50: 0.52 μM
  98.58%
USP8-IN-3   
USP8, IC50: 4.0 μM
  99.17%
USP2 Human Pre-designed siRNA Set A 
USP2
    
USP8-IN-2   
USP8, IC50: 6.0 μM
  99.91%
UCHL1-IN-1     
UCHL1
≥98.0%
Q14    
USP30, IC50: 57.2 nM
 
USP7-IN-12  
USP7, IC50: 3.67 nM
   
USP1-IN-10
USP1, IC50: 7.6 nM
     
KSQ-4279 (gentisate)
USP1
     
USP7-IN-16  
USP7, IC50: 5.5 nM
USP7, IC50: 2.1 nM
   
YCH3124  
USP7, IC50: 41.9 nM
   
XM-U-14  
USP7
   
USP1-IN-4
USP1, IC50: 2.44 nM
     
USP7-IN-15  
USP7
   
USP7-055  
USP7
   
HBX 28258  
USP7, IC50: 22.6 μM