2. Anti-infection NF-κB PI3K/Akt/mTOR Epigenetics
  3. Bacterial Antibiotic NF-κB AMPK Fungal
  4. α-Terpineol

α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation.

For research use only. We do not sell to patients.

α-Terpineol Chemical Structure

α-Terpineol Chemical Structure

CAS No. : 98-55-5

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Based on 1 publication(s) in Google Scholar

Other Forms of α-Terpineol:

α-Terpineol Related Antibodies

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  • Biological Activity

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Description

α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation[1][2][3][4][5][6][7].

In Vitro

α-Terpineol (1-10 µM, 20 h) exerts anti-inflammatory effects in LPS-stimulated mouse peritoneal macrophages by inhibiting the NF-κB signaling pathway[4].
α-Terpineol (0.06-0.125% v/v, 48 h) inhibits the growth of G. vaginalis (MIC = 0.06%) and C. albicans (MIC = 0.125%), showing antimicrobial activity comparable to Clotrimazole (HY-10882) ((v/v) represents volume/volume concentration, indicating the proportion of α-Terpineol in the culture medium)[4].
α-Terpineol (1-100 μM, 24 h) inhibits AMPK phosphorylation, activates SREBP-1, and promotes lipid synthesis in HepG2 cells[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Terpineol Related Antibodies

Western Blot Analysis[7]

Cell Line: HepG2 cells (hepatocellular carcinoma)
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Inhibited AMPK phosphorylation, promoted p70S6K phosphorylation, and increased SREBP-1 maturation.

Real Time qPCR[7]

Cell Line: HepG2 cells (hepatocellular carcinoma)
Concentration: 1, 10, 100 μM
Incubation Time: 24 h
Result: Upregulated lipid synthesis-related genes Srebf-1c, Acc, Fasn, Scd-1.
In Vivo

α-Terpineol (6.25-50 mg/kg, p.o., single administration) exhibits antidiarrheal activity by exerting anticholinergic effects, blocking PGE2 and GM1 receptors, and interacting with cholera toxin, thereby reducing castor oil-induced diarrhea in a mouse model of acute diarrhea[5].
\ α-Terpineol (56 mg/kg, i.p., single administration) provides short-term relief of mechanical pain in a mouse model of neuropathic pain induced by chronic constriction injury[6].
α-Terpineol (100 mg/kg and 500 mg/kg, p.o., once daily for 2 weeks) induces fatty liver and promoted hepatic lipid accumulation in C57BL/6 mice[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Castor oil-induced acute diarrhea Swiss mouse model[5]
Dosage: 6.25, 12.5, 25, 50 mg/kg
Administration: Oral gavage (p.o.), single dose
Result: Significantly reduced total stool amount (55%, 48%, 44%, 24%) and diarrhea rate (47%, 66%; 56%, 10%). All doses significantly decreased castor oil-induced enteropooling (46%, 78%, 66%, 41%)
Animal Model: Neuropathic pain C57BL/6 mouse model induced by Chronic Constriction Injury[6]
Dosage: 56 mg/kg
Administration: ntraperitoneal injection (i.p.), single dose
Result: Complete reversal of mechanical allodynia at 30 min, returning to baseline at 2 h, partial reversal at 3 h, no significant effect at 6 h.
Animal Model: C57BL/6 mice[7]
Dosage: 100 mg/kg and 500 mg/kg
Administration: Oral gavage (p.o.), once daily, for 2 weeks
Result: Increased hepatic triglyceride (TG) levels by 2-fold and serum TG levels by 25% (500 mg/kg);
Induced microvesicular steatosis in the liver, and enhanced neutral lipid accumulation as revealed by Oil Red O staining.
Molecular Weight

154.25

Formula

C10H18O
CAS No.
Appearance

<31°C Solid,>35°C Liquid

Color

Colorless to off-white

SMILES

OC(C)(C)C1CC=C(C)CC1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1296.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.4829 mL 32.4143 mL 64.8286 mL
5 mM 1.2966 mL 6.4829 mL 12.9657 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 5 mg/mL (32.41 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.47%

SDS (393 KB)

COA (246 KB) HNMR (245 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.4829 mL 32.4143 mL 64.8286 mL 162.0714 mL
5 mM 1.2966 mL 6.4829 mL 12.9657 mL 32.4143 mL
10 mM 0.6483 mL 3.2414 mL 6.4829 mL 16.2071 mL
15 mM 0.4322 mL 2.1610 mL 4.3219 mL 10.8048 mL
20 mM 0.3241 mL 1.6207 mL 3.2414 mL 8.1036 mL
25 mM 0.2593 mL 1.2966 mL 2.5931 mL 6.4829 mL
30 mM 0.2161 mL 1.0805 mL 2.1610 mL 5.4024 mL
40 mM 0.1621 mL 0.8104 mL 1.6207 mL 4.0518 mL
50 mM 0.1297 mL 0.6483 mL 1.2966 mL 3.2414 mL
60 mM 0.1080 mL 0.5402 mL 1.0805 mL 2.7012 mL
80 mM 0.0810 mL 0.4052 mL 0.8104 mL 2.0259 mL
100 mM 0.0648 mL 0.3241 mL 0.6483 mL 1.6207 mL
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α-Terpineol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Terpineol98-55-5BacterialAntibioticNF-κBAMPKFungalNuclear factor-κBNuclear factor-kappaBAMP-activated protein kinaseacute diarrheaNeuropathic painantineuropathicanti-inflammatoryanti-bacterialHepG2 cellsInhibitorinhibitorinhibit

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