2. Anti-infection
  3. Bacterial
  4. Anti-inflammatory agent 14

Anti-inflammatory agent 14 (compound 28) is an anti-inflammatory agent, with a MIC50 of 2 μM for Mtb H37Rv.

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Anti-inflammatory agent 14 Chemical Structure

Anti-inflammatory agent 14 Chemical Structure

CAS No. : 894496-27-6

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Anti-inflammatory agent 14 Related Antibodies

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Description

Anti-inflammatory agent 14 (compound 28) is an anti-inflammatory agent, with a MIC50 of 2 μM for Mtb H37Rv[1].

Cellular Effect
Cell Line Type Value Description References
RAW264.7 CC50
≥ 200 μM
Compound: 28
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
Cytotoxicity against LPS-stimulated mouse RAW264.7 cells after 24 hrs by MTT assay
[PMID: 34890996]
RAW264.7 IC50
13.7 μM
Compound: 28
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
Inhibition of NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based analysis
[PMID: 34890996]
RAW264.7 IC50
20.7 μM
Compound: 28
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in TNFalpha protein expression level after 24 hrs by ELISA
[PMID: 34890996]
RAW264.7 IC50
33.2 μM
Compound: 28
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
Anti-inflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as reduction in IL1beta protein expression level after 24 hrs by ELISA
[PMID: 34890996]
In Vitro

Anti-inflammatory agent 14 (compound 28) inhibits IL-1β dose-dependently[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-inflammatory agent 14 Related Antibodies
Molecular Weight

300.38

Formula

C16H16N2O2S
CAS No.
SMILES

S=C(NCC1=CC=CC=C1)NC2=CC=C3OCCOC3=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-inflammatory agent 14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 14894496-27-6BacterialinflammationmycobacteriumthioureatuberculosisInhibitorinhibitorinhibit

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Anti-inflammatory agent 14
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