2. Anti-infection
  3. Bacterial Fungal Antibiotic
  4. Bafilomycin B1

Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli.

For research use only. We do not sell to patients.

Bafilomycin B1 Chemical Structure

Bafilomycin B1 Chemical Structure

CAS No. : 88899-56-3

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1 mg USD 305 In-stock
5 mg USD 920 In-stock
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Based on 1 publication(s) in Google Scholar

Bafilomycin B1 Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

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Description

Bafilomycin B1 is a macrolide antibiotic isolated from Streptomyces sp, inhibits Gram-positive bacteria and fungi, and acts as an inhibitor of K+-dependent ATPase of E. coli[1].

IC50 & Target

Macrolide

 

Molecular Weight

815.99

Formula

C44H65NO13
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C(O[C@@H]1C[C@@]([C@@H](C)[C@H](O)[C@@H]([C@H]([C@@H](OC)/C=C/C=C(C)/C[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C=C2\OC)OC2=O)C)(O)O[C@H](C(C)C)[C@H]1C)/C=C/C(NC3=C(O)CCC3=O)=O
Structure Classification
Initial Source

Streptomyces halstedii K122
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (122.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2255 mL 6.1275 mL 12.2551 mL
5 mM 0.2451 mL 1.2255 mL 2.4510 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.22%

COA (250 KB) RP-HPLC (1188 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2255 mL 6.1275 mL 12.2551 mL 30.6376 mL
5 mM 0.2451 mL 1.2255 mL 2.4510 mL 6.1275 mL
10 mM 0.1226 mL 0.6128 mL 1.2255 mL 3.0638 mL
15 mM 0.0817 mL 0.4085 mL 0.8170 mL 2.0425 mL
20 mM 0.0613 mL 0.3064 mL 0.6128 mL 1.5319 mL
25 mM 0.0490 mL 0.2451 mL 0.4902 mL 1.2255 mL
30 mM 0.0409 mL 0.2043 mL 0.4085 mL 1.0213 mL
40 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7659 mL
50 mM 0.0245 mL 0.1226 mL 0.2451 mL 0.6128 mL
60 mM 0.0204 mL 0.1021 mL 0.2043 mL 0.5106 mL
80 mM 0.0153 mL 0.0766 mL 0.1532 mL 0.3830 mL
100 mM 0.0123 mL 0.0613 mL 0.1226 mL 0.3064 mL
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Bafilomycin B1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bafilomycin B188899-56-3Bafilomycin B 1Bafilomycin B-1BacterialFungalAntibioticInhibitorinhibitorinhibit

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