2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Catechol O-methyltransferase, porcine liver

Catechol O-methyltransferase, porcine liver  (Synonyms: COMT)

Cat. No.: HY-E70007
Data Sheet
SDS
COA
Handling Instructions Technical Support

Catechol O-methyltransferase, porcine liver (COMT), the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain.

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Catechol O-methyltransferase, porcine liver Chemical Structure

Catechol O-methyltransferase, porcine liver Chemical Structure

CAS No. : 9012-25-3

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Based on 1 publication(s) in Google Scholar

Catechol O-methyltransferase, porcine liver Related Antibodies

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Description

Catechol O-methyltransferase, porcine liver (COMT), the magnesium-dependent transfer of methyl groups from S-adenosyl methionine to a hydroxyl group on dopamine, converting it to 3-methoxytyramine. Catechol O-methyltransferase has two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). Catechol O-methyltransferase is to regulate epinephrine, norepinephrine, and dopamine levels in the brain[1].

In Vitro

Instructions
Water-soluble enzymes can be used and 1% BSA can be added when dissolving. The solution should be freshly prepared.
Or dissolve according to the specific experimental reference.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Catechol O-methyltransferase, porcine liver Related Antibodies
Clinical Trial
NCT NumberSponsorConditionStart DatePhase
NCT01570699Assistance Publique - Hôpitaux de Paris
Opioid-related Disorders|Opiate Dependence|Opiate Addiction|Opiate Abuse
December 2012
NCT03364075Mark Ware|McGill University Health Centre+Research Institute of the McGill University Health Centre
Low Back Pain
September 1, 2017Phase 2
NCT00664274Manhattan Psychiatric Center|National Institute of Mental Health (NIMH)|Albert Einstein College of Medicine
Chronic Schizophrenia
April 2007Not Applicable
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Catechol O-methyltransferase]
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Data Sheet (263 KB) SDS (251 KB)

COA (293 KB)

Handling Instructions (2659 KB)
References
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Catechol O-methyltransferase, porcine liver Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Catechol O-methyltransferase, porcine liver9012-25-3COMTEndogenous MetabolitemagnesiumS-adenosyl methionine3-methoxytyramineS-COMTMB-COMTInhibitorinhibitorinhibit

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