Coenzyme A

Name: Coenzyme A
Brand: MedChemExpress
SKU: HY-128851
Rating: 4.5 (1 reviews)

Cat. No.: HY-128851 Purity: 96.38%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Coenzyme A (CoASH) is a ubiquitous and essential cofactor, which is an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. Coenzyme A plays a central role in the oxidation of pyruvate in the citric acid cycle and the metabolism of carboxylic acids, including short- and long-chain fatty acids.

For research use only. We do not sell to patients.

Coenzyme A Chemical Structure

CAS No. : 85-61-0

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 51	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 51	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Coenzyme A:

Coenzyme A trilithium Get quote
Coenzyme A sodium Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Clinical Trial

Molecular Weight

767.53

Formula

C₂₁H₃₆N₇O₁₆P₃S

CAS No.

85-61-0

Appearance

Solid

Color

White to light yellow

SMILES

CC([C@H](C(NCCC(NCCS)=O)=O)O)(C)COP(OP(OC[C@H]1O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@H](O)[C@@H]1OP(O)(O)=O)(O)=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (130.29 mM; ultrasonic and warming and heat to 60°C)

DMSO : 100 mg/mL (130.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3029 mL	6.5144 mL	13.0288 mL
5 mM	0.2606 mL	1.3029 mL	2.6058 mL
10 mM	0.1303 mL	0.6514 mL	1.3029 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.63 mg/mL (2.12 mM); Clear solution

This protocol yields a clear solution of ≥ 1.63 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.3 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.63 mg/mL (2.12 mM); Clear solution

This protocol yields a clear solution of ≥ 1.63 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.3 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 1.63 mg/mL (2.12 mM); Clear solution

This protocol yields a clear solution of ≥ 1.63 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (16.3 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 25 mg/mL (32.57 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (270 KB) SDS (393 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Roberta Leonardi, et al. Coenzyme A: back in action. Prog Lipid Res. 2005 Mar-May;44(2-3):125-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.3029 mL	6.5144 mL	13.0288 mL	32.5720 mL
	5 mM	0.2606 mL	1.3029 mL	2.6058 mL	6.5144 mL
	10 mM	0.1303 mL	0.6514 mL	1.3029 mL	3.2572 mL
	15 mM	0.0869 mL	0.4343 mL	0.8686 mL	2.1715 mL
	20 mM	0.0651 mL	0.3257 mL	0.6514 mL	1.6286 mL
	25 mM	0.0521 mL	0.2606 mL	0.5212 mL	1.3029 mL
	30 mM	0.0434 mL	0.2171 mL	0.4343 mL	1.0857 mL
	40 mM	0.0326 mL	0.1629 mL	0.3257 mL	0.8143 mL
	50 mM	0.0261 mL	0.1303 mL	0.2606 mL	0.6514 mL
	60 mM	0.0217 mL	0.1086 mL	0.2171 mL	0.5429 mL
	80 mM	0.0163 mL	0.0814 mL	0.1629 mL	0.4072 mL
	100 mM	0.0130 mL	0.0651 mL	0.1303 mL	0.3257 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Coenzyme A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coenzyme A85-61-0Fatty Acid Synthase (FASN)Endogenous Metaboliteubiquitous essential cofactoracyl group carriercitric acid cyclefatty acid metabolismmetabolismInhibitorinhibitorinhibit

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Coenzyme A

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Other Forms of Coenzyme A:

Coenzyme A Related Antibodies

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Molarity Calculator

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Complete Stock Solution Preparation Table

Coenzyme A Related Classifications

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