2. PROTAC
  3. Ligands for E3 Ligase
  4. cIAP1 ligand 1

cIAP1 ligand 1  (Synonyms: E3 ligase Ligand 12)

Cat. No.: HY-128808 Purity: 99.07%
COA Handling Instructions

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cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER.

For research use only. We do not sell to patients.

cIAP1 ligand 1 Chemical Structure

cIAP1 ligand 1 Chemical Structure

CAS No. : 2095244-42-9

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Based on 1 publication(s) in Google Scholar

cIAP1 ligand 1 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP

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Description

cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER.

IC50 & Target

cIAP1

 

Molecular Weight

598.75

Formula

C31H42N4O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C(C2=CSC([C@H]3N(CCC3)C([C@@H](NC([C@@H](N(C(OC(C)(C)C)=O)C)C)=O)C4CCCCC4)=O)=N2)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (167.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6701 mL 8.3507 mL 16.7015 mL
5 mM 0.3340 mL 1.6701 mL 3.3403 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.90%

COA (255 KB) HNMR (300 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6701 mL 8.3507 mL 16.7015 mL 41.7537 mL
5 mM 0.3340 mL 1.6701 mL 3.3403 mL 8.3507 mL
10 mM 0.1670 mL 0.8351 mL 1.6701 mL 4.1754 mL
15 mM 0.1113 mL 0.5567 mL 1.1134 mL 2.7836 mL
20 mM 0.0835 mL 0.4175 mL 0.8351 mL 2.0877 mL
25 mM 0.0668 mL 0.3340 mL 0.6681 mL 1.6701 mL
30 mM 0.0557 mL 0.2784 mL 0.5567 mL 1.3918 mL
40 mM 0.0418 mL 0.2088 mL 0.4175 mL 1.0438 mL
50 mM 0.0334 mL 0.1670 mL 0.3340 mL 0.8351 mL
60 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6959 mL
80 mM 0.0209 mL 0.1044 mL 0.2088 mL 0.5219 mL
100 mM 0.0167 mL 0.0835 mL 0.1670 mL 0.4175 mL
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cIAP1 ligand 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cIAP1 ligand 12095244-42-9E3 ligase Ligand 12Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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