1. Gene
  2. IFITM3 - interferon induced transmembrane protein 3 Gene

IFITM3 - interferon induced transmembrane protein 3 Gene

Homo sapiens

Also known as 1-8U; IP15; DSPA2b

Gene ID: 10410 | Gene type: protein coding

About IFITM3

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:319,676-320,860 (from NCBI)

This gene has 27 transcripts (splice variants), 243 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 370.9), placenta (RPKM 358.2) and 25 other tissues.

Summary

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced Antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 and belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

IFITM3 Products(1)

mRNA Protein Name
NM_021034.3 NP_066362.2 interferon-induced transmembrane protein 3

IFITM3 Protein Structure

CD225

CD225: Interferon-induced transmembrane protein (42 - 122)

  • 0
  • 100
  • 133 a.a.
Protein Preferred Names Protein Names

interferon-induced transmembrane protein 3

dispanin subfamily A member 2b

IFITM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
IFITM3 Q01628 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
IFITM3 Q01628 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
IFITM3 Q01628 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
IFITM3 Q01628 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra
IFITM3 Q01628 MS4A3 Homo sapiens Q96HJ5
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 MS4A3 Homo sapiens Q96HJ5
Validated Y2H
32296183
Intra
IFITM3 Q01628 MS4A3 Homo sapiens Q96HJ5
Y2H Array
32296183
Intra
IFITM3 Q01628 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
IFITM3 Q01628 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
IFITM3 Q01628 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
IFITM3 Q01628 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra
IFITM3 Q01628 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
IFITM3 Q01628 LYPD5 Homo sapiens Q6UWN5
Validated Y2H
32296183
Intra
IFITM3 Q01628 LYPD5 Homo sapiens Q6UWN5
Y2H Array
32296183
Intra
IFITM3 Q01628 LYPD5 Homo sapiens Q6UWN5
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 ELOVL2 Homo sapiens Q9NXB9
Y2H Array
32296183
Intra
IFITM3 Q01628 ELOVL2 Homo sapiens Q9NXB9
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 ELOVL2 Homo sapiens Q9NXB9
Validated Y2H
32296183
Intra
IFITM3 Q01628 SLC10A2 Homo sapiens Q12908
Validated Y2H
32296183
Intra
IFITM3 Q01628 SLC10A2 Homo sapiens Q12908
Y2H Array
32296183
Intra
IFITM3 Q01628 SLC10A2 Homo sapiens Q12908
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
IFITM3 Q01628 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
IFITM3 Q01628 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
IFITM3 Q01628 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
IFITM3 Q01628 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 NAMPT Homo sapiens P43490
Y2H
18486613
Intra
IFITM3 Q01628 NAMPT Homo sapiens P43490
Anti Bait CoIP
18486613
Intra
IFITM3 Q01628 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
IFITM3 Q01628 BRI3 Homo sapiens O95415
Anti Tag CoIP
30983867
Intra
IFITM3 Q01628 ABHD16A Homo sapiens O95870
Y2H Array
32296183
Intra
IFITM3 Q01628 ABHD16A Homo sapiens O95870
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
IFITM3 Q01628 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
IFITM3 Q01628 SLC16A7 Homo sapiens O60669
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 SLC16A7 Homo sapiens O60669
Y2H Array
32296183
Intra
IFITM3 Q01628 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 SLC10A1 Homo sapiens Q14973
Validated Y2H
32296183
Intra
IFITM3 Q01628 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra
IFITM3 Q01628 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
IFITM3 Q01628 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
IFITM3 Q01628 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
IFITM3 Q01628 REEP4 Homo sapiens Q9H6H4
Anti Tag CoIP
33961781
Intra
IFITM3 Q01628 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
IFITM3 Q01628 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
IFITM3 Q01628 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
IFITM3 Q01628 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
IFITM3 Q01628 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
IFITM3 Q01628 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
IFITM3 Q01628 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFITM3 Proteins

Cat. No. Product Name Accession Purity
HY-P77370 IFITM3/Fragilis Protein, Human (HEK293, Fc) Q01628/NP_066362.2 (M1-H57) ≥95%

Related Diseases

Diseases Alias
Influenza, Severe

Influenza, Severe, Susceptibility To

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Stomatitis
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus

Hepatitis C

Chronic Hepatitis C

Hepatitis C Infection

Hepatitis Nona Nonb

Nanbh

Viral Hepatitis C

Hepatitis C Chronic

Hepatitis C, Chronic

Chronic Type C Viral Hepatitis

Chronic Hcv - [Hepatitis C Virus] Infection

Hepatitis C Nos

Hepatitis C Infection Nos

Hepatitis C-Related Cirrhosis

Type C Viral Hepatitis

Hep C Nos

West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever

Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever

Hepatitis

Chronic Hepatitis

Chronic Persistent Hepatitis

Acute Hepatitis

Hepatitis, Chronic

Acute And Subacute Liver Necrosis

Acute/Subac. Necrosis Of Liver

Animal Hepatitis

Hepatitis Chronic

Hepatitis A

Hepatitis, Animal

Hepatitis Due To Toxoplasmosis

Hepatitis In Toxoplasmosis

Toxoplasmal Hepatitis

Chronic Hepatitis, Unspecified

Chronic Active Hepatitis Nec

Other Specified Chronic Hepatitis

Chronic Persistent Hepatitis Nec

Chronic Lobular Hepatitis Nec

Rift Valley Fever

Rfv - [Rift Valley Fever]

Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem

Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Mouth Disease

Mouth Diseases

Mouth Disorders

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus IFITM3 MGD MGI:1913391
Rattus norvegicus IFITM3 RGD RGD:1595844
Others IFITM3 NCBI