CEBPG - CCAAT enhancer binding protein gamma Gene

Homo sapiens

Also known as GPE1BP; IG/EBP-1

Gene ID: 1054 | Gene type: protein coding

About CEBPG

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,373,709-33,382,686 (from NCBI)

This gene has 3 transcripts (splice variants), 129 orthologues and 4 paralogues. Ubiquitous expression in thyroid (RPKM 20.4), colon (RPKM 19.6) and 25 other tissues.

Summary

The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each Other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]

CEBPG Products(2)

mRNA	Protein	Name
NM_001252296.2	NP_001239225.1	CCAAT/enhancer-binding protein gamma
NM_001806.4	NP_001797.1	CCAAT/enhancer-binding protein gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7665092	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	15833715	GOA
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	7665092	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7665092	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	7665092	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA repair	IEP IEP: Inferred from expression pattern	16255782	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15833715	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16255782	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase II transcription regulator complex	IPI IPI: Inferred from physical interaction	20102225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEBPG Protein Structure

bZIP_2

0
100
150 a.a.

Protein Preferred Names

Protein Names

CCAAT/enhancer-binding protein gamma

CCAAT/enhancer binding protein (C/EBP), gamma

CEBPG Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CEBPG	P53567	DDIT3	Homo sapiens	P35638-2	Validated Y2H	25416956
Intra	CEBPG	P53567	DDIT3	Homo sapiens	P35638-2	Y2H Array	25416956
Intra	CEBPG	P53567	BATF3	Homo sapiens	Q9NR55	FRET	23661758
Intra	CEBPG	P53567	ATF2	Homo sapiens	P15336	FRET	23661758
Intra	CEBPG	P53567	ATF2	Homo sapiens	P15336	Anti Tag CoIP	33961781
Intra	CEBPG	P53567	CEBPA	Homo sapiens	P49715	Peptide Array	20102225
Intra	CEBPG	P53567	PFDN6	Homo sapiens	O15212	Y2H Prey Pooling	32296183
Intra	CEBPG	P53567	PFDN6	Homo sapiens	O15212	Y2H Array	32296183
Intra	CEBPG	P53567	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	25416956
Intra	CEBPG	P53567	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	CEBPG	P53567	ATF4	Homo sapiens	P18848	FRET	23661758
Intra	CEBPG	P53567	ATF4	Homo sapiens	P18848	Y2H Array	25416956
Intra	CEBPG	P53567	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	CEBPG	P53567	ATF4	Homo sapiens	P18848	Validated Y2H	25416956
Intra	CEBPG	P53567	ATF5	Homo sapiens	Q9Y2D1	FRET	23661758
Intra	CEBPG	P53567	ATF5	Homo sapiens	Q9Y2D1	Y2H Prey Pooling	32296183
Intra	CEBPG	P53567	ATF5	Homo sapiens	Q9Y2D1	Validated Y2H	32296183
Intra	CEBPG	P53567	ATF5	Homo sapiens	Q9Y2D1	Y2H Array	32296183
Intra	CEBPG	P53567	ATF5	Homo sapiens	Q9Y2D1	Y2H Array	20211142
Intra	CEBPG	P53567	ATF3	Homo sapiens	P18847	Peptide Array	20102225
Intra	CEBPG	P53567	ATF3	Homo sapiens	P18847	FRET	23661758
Intra	CEBPG	P53567	MLLT6	Homo sapiens	P55198	Y2H Pooling	16189514
Intra	CEBPG	P53567	DDIT3	Homo sapiens	P35638	FRET	23661758
Intra	CEBPG	P53567	DDIT3	Homo sapiens	P35638	Y2H Pooling	16189514
Intra	CEBPG	P53567	DDIT3	Homo sapiens	P35638	Peptide Array	20102225
Intra	CEBPG	P53567	DDIT3	Homo sapiens	P35638	Y2H Array	20211142
Intra	CEBPG	P53567	BATF2	Homo sapiens	Q8N1L9	FRET	23661758
Intra	CEBPG	P53567	BATF	Homo sapiens	Q16520	FRET	23661758
Intra	CEBPG	P53567	ATF7	Homo sapiens	P17544	Anti Tag CoIP	33961781
Intra	CEBPG	P53567	CEBPD	Homo sapiens	P49716	Peptide Array	20102225
Intra	CEBPG	P53567	JUN	Homo sapiens	P05412	FRET	23661758
Intra	CEBPG	P53567	JUN	Homo sapiens	P05412	Anti Tag CoIP	33961781
Intra	CEBPG	P53567	FOS	Homo sapiens	P01100	SLC	31467278
Intra	CEBPG	P53567	CEBPB	Homo sapiens	P17676	Peptide Array	20102225
Cross	CEBPG	P53567	HBZ	Human T-cell leukemia virus 1	P0C746	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CEBPG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74254	CEBP gamma/CEBPG Protein, Human (His)	P53567 (P39-N147)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02449	CEBPG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CEBPG	MGD	MGI:104982
Bos taurus	CEBPG	VGNC	VGNC:27163
Macaca mulatta	CEBPG	VGNC	VGNC:71003
Canis familiaris	CEBPG	VGNC	VGNC:39089
Rattus norvegicus	CEBPG	RGD	RGD:2330
Others	CEBPG	NCBI

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