CFL1 - cofilin 1 Gene

Homo sapiens

Also known as CFL; cofilin; HEL-S-15

Gene ID: 1072 | Gene type: protein coding

About CFL1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,854,673-65,858,180 (from NCBI)

This gene has 15 transcripts (splice variants), 170 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 413.9), colon (RPKM 411.4) and 25 other tissues.

Summary

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin Cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

CFL1 Products(1)

mRNA	Protein	Name
NM_005507.3	NP_005498.1	cofilin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	11812157	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12361576	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament depolymerization	IDA IDA: Inferred from direct assay	11812157	GOA
involved in cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in positive regulation by host of viral process	IMP IMP: Inferred from mutant phenotype	25556234	GOA
involved in regulation of cell morphogenesis	IMP IMP: Inferred from mutant phenotype	21834987	GOA
involved in regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	24464040	GOA
involved in response to virus	IEP IEP: Inferred from expression pattern	16548883	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25556234	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	29162887	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CFL1 Protein Structure

Cofilin_ADF

0
100
166 a.a.

Protein Preferred Names

Protein Names

cofilin-1

18 kDa phosphoprotein

CFL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CFL1	P23528	CFL2	Homo sapiens	Q549N0	Y2H Prey Pooling	25416956
Intra	CFL1	P23528	PLD1	Homo sapiens	Q13393	Pull Down	17853892
Intra	CFL1	P23528	PLD1	Homo sapiens	Q13393	Anti Bait CoIP	17853892
Intra	CFL1	P23528	EGFR	Homo sapiens	P00533	Ub Reconstruction	20029029
Intra	CFL1	P23528	YWHAZ	Homo sapiens	P63104	Pull Down	12361576
Intra	CFL1	P23528	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	CFL1	P23528	CFL2	Homo sapiens	Q9Y281	Anti Tag CoIP	33961781
Intra	CFL1	P23528	CFL2	Homo sapiens	Q9Y281	Y2H	21516116
Intra	CFL1	P23528	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	25416956
Intra	CFL1	P23528	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	32296183
Intra	CFL1	P23528	ACTG1	Homo sapiens	P63261	Validated Y2H	32296183
Intra	CFL1	P23528	ACTG1	Homo sapiens	P63261	Y2H Array	25416956
Intra	CFL1	P23528	ACTG1	Homo sapiens	P63261	Y2H Array	32296183
Intra	CFL1	P23528	ACTC1	Homo sapiens	P68032	Anti Tag CoIP	33961781
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Validated Y2H	25416956
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Y2H Prey Pooling	32296183
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Y2H Prey Pooling	25416956
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Validated Y2H	32296183
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Y2H Array	32296183
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Y2H Array	29892012
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Y2H Pooling	16189514
Intra	CFL1	P23528	ACTB	Homo sapiens	P60709	Y2H Array	31515488
Intra	CFL1	P23528	HUNK	Homo sapiens	P57058	Anti Bait CoIP	20133759
Intra	CFL1	P23528	HUNK	Homo sapiens	P57058	Anti Tag CoIP	20133759
Intra	CFL1	P23528	LIMK1	Homo sapiens	P53667	Anti Bait CoIP	20133759
Intra	CFL1	P23528	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	CFL1	P23528	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	CFL1	P23528	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	CFL1	P23528	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	CFL1	P23528	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	CFL1	P23528	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	CFL1	P23528	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	CFL1	P23528	PS1TP5BP1	Homo sapiens	Q1KLZ0	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CFL1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75682	Cofilin-1 Protein, Human (His)	P23528 (M1-L166)	≥95%

Related Diseases

Diseases

Alias

Smith-Lemli-Opitz Syndrome

SLOS	Rsh Syndrome
7-Dehydrocholesterol Reductase Deficiency	Slo Syndrome
Rutledge Lethal Multiple Congenital Anomaly Syndrome	Lethal Acrodysgenital Syndrome
Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobar Lung	Smith-Opitz-Inborn Syndrome
Polydactyly, Sex Reversal, Renal Hypoplasia, And Unilobular Lung	Smith Lemli Opitz Syndrome
Smith-Lemli-Opitz Syndrome, Type Ii

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Williams-Beuren Syndrome

Williams Syndrome	WBS
Wms	Deletion 7q11.23
Monosomy 7q11.23	Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb
Fanconi Schlesinger Syndrome	Beuren Syndrome
Elfin Facies Syndrome	Elfin Facies With Hypercalcemia
Hypercalcemia-Supravalvar Aortic Stenosis	Ws

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02568	CFL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CFL1	RGD	RGD:69285
Felis catus	CFL1	VGNC	VGNC:102749
Bos taurus	CFL1	VGNC	VGNC:27253
Mus musculus	CFL1	MGD	MGI:101757
Macaca mulatta	CFL1	VGNC	VGNC:100911
Canis familiaris	CFL1	VGNC	VGNC:56088
Others	CFL1	NCBI

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