PDCD10 - programmed cell death 10 Gene

Homo sapiens

Also known as CCM3; TFAR15

Gene ID: 11235 | Gene type: protein coding

About PDCD10

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,683,298-167,734,892 (from NCBI)

This gene has 18 transcripts (splice variants), 279 orthologues and is associated with 3 phenotypes. Ubiquitous expression in colon (RPKM 13.1), lymph node (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes an evolutionarily conserved protein associated with cell Apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

PDCD10 Products(3)

mRNA	Protein	Name
NM_007217.4	NP_009148.2	programmed cell death protein 10
NM_145859.2	NP_665858.1	programmed cell death protein 10
NM_145860.2	NP_665859.1	programmed cell death protein 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	20489202	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi reassembly	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in establishment of Golgi localization	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	22291017	GOA
involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IGI IGI: Inferred from genetic interaction	22652780	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	17360971	GOA
involved in negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in positive regulation of MAP kinase activity	IDA IDA: Inferred from direct assay	17360971	GOA
involved in positive regulation of Notch signaling pathway	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	23541896	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17360971	GOA
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23388056	GOA
involved in positive regulation of intracellular protein transport	IMP IMP: Inferred from mutant phenotype	27807006	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in positive regulation of protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in positive regulation of stress-activated MAPK cascade	IDA IDA: Inferred from direct assay	22652780	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20332113	GOA
NOT involved in regulation of Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	20332113	GOA
NOT involved in stress fiber assembly	IMP IMP: Inferred from mutant phenotype	20332113	GOA
involved in wound healing, spreading of cells	IMP IMP: Inferred from mutant phenotype	20332113	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of FAR/SIN/STRIPAK complex	IDA IDA: Inferred from direct assay	18782753	GOA
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	22652780	GOA
located in Golgi apparatus	IDA IDA: Inferred from direct assay	20332113	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22652780	GOA
located in cytosol	IDA IDA: Inferred from direct assay	17360971	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDCD10 Protein Structure

DUF1241

0
100
200
212 a.a.

Protein Preferred Names

Protein Names

programmed cell death protein 10

TF-1 cell apoptosis-related protein 15

PDCD10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Array	31515488
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	C4orf19	Homo sapiens	Q8IY42	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	q96ba2_human	Homo sapiens	Q96BA2	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	q96ba2_human	Homo sapiens	Q96BA2	Validated Y2H	25416956
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Array	25416956
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0-2	Anti Tag CoIP	28514442
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815	Anti Tag CoIP	28514442
Intra	PDCD10	Q9BUL8	MINAR1	Homo sapiens	Q9UPX6	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	MINAR1	Homo sapiens	Q9UPX6	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	MINAR1	Homo sapiens	Q9UPX6	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	FRYL	Homo sapiens	O94915-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	FRYL	Homo sapiens	O94915-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STRN	Homo sapiens	O43815-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	PROSER2	Homo sapiens	Q86WR7-2	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	PROSER2	Homo sapiens	Q86WR7-2	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	CCM2	Homo sapiens	Q9BSQ5	Anti Tag CoIP	17657516
Intra	PDCD10	Q9BUL8	CCM2	Homo sapiens	Q9BSQ5	Confocal	17657516
Intra	PDCD10	Q9BUL8	CCM2	Homo sapiens	Q9BSQ5	Pull Down	17657516
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	BLI	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	Pull Down	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	GMS	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	X-Ray Diffraction	23665169
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	X-Ray Diffraction	23541896
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	SPR	23665169
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289-1	Anti Tag CoIP	23541896
Intra	PDCD10	Q9BUL8	PLEKHS1	Homo sapiens	Q5SXH7-1	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	PLEKHS1	Homo sapiens	Q5SXH7-1	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	PTPN13	Homo sapiens	Q12923	Pull Down	17657516
Intra	PDCD10	Q9BUL8	PTPN13	Homo sapiens	Q12923	Anti Tag CoIP	17657516
Intra	PDCD10	Q9BUL8	MST4	Homo sapiens	Q499L9	Y2H Array	25416956
Intra	PDCD10	Q9BUL8	MST4	Homo sapiens	Q499L9	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Anti Tag CoIP	33961781
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STK26	Homo sapiens	Q9P289	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H	17657516
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H	21516116
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Pull Down	17657516
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Prey Pooling	25416956
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	SPR	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Solution Sedimentation	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	17657516
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Prey Pooling	32296183
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	X-Ray Diffraction	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Pull Down	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	28514442
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	GMS	23665169
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Array	25416956
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Anti Tag CoIP	33961781
Intra	PDCD10	Q9BUL8	STK25	Homo sapiens	O00506	Y2H Array	32296183
Intra	PDCD10	Q9BUL8	FARSA	Homo sapiens	Q9Y285	Validated Y2H	32296183
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	BLI	23541896
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	18782753
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	Pull Down	23541896
Intra	PDCD10	Q9BUL8	STK24	Homo sapiens	Q9Y6E0	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDCD10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71190	PDCD10 Protein, Human	Q9BUL8 (M1-Al212 )	≥95%

Related Diseases

Diseases

Alias

Cerebral Cavernous Malformations 3

Cerebral Cavernous Malformation 3	CCM3
Cerebral Cavernous Malformations-3	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 3

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Cerebral Cavernous Malformation, Familial

Familial Cerebral Cavernous Malformation	Familial Cavernous Hemangioma
Familial Cerebral Cavernous Angioma	Familial Brain Cavernous Angioma
Familial Cerebral Cavernoma	Hereditary Brain Cavernous Angioma
Hereditary Cerebral Cavernoma	Hereditary Cerebral Cavernous Malformation

Cavernous Hemangioma

Hemangioma, Cavernous	Cavernoma
Cavernous Haemangioma

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation	Intracranial Arteriovenous Malformation
Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To	Intracranial Arteriovenous Malformations
Bavm	Cerebral Arteriovenous Malformations
Intracranial Hemorrhage In Brain Cerebrovascular Malformations	Arteriovenous Malformation Of The Brain, Somatic
Intracranial Avm	Arteriovenous Malformations Cerebral

Klippel-Trenaunay-Weber Syndrome

Klippel-Trenaunay Syndrome	KTS
Ktw Syndrome	Angioosteohypertrophy Syndrome
Angio-Osteohypertrophy Syndrome	Klippel Trenaunay Syndrome
Klippel-Trénaunay-Weber Syndrome	Haemangiectatic Hypertrophy
Weber-Klippel-Trenaunay	Congenital Dysplastic Angiopathy
Klippel-Trenaunay Disease	Weber Klippel Trenaunay

Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome	CCMS
Rib Gap Defects With Micrognathia	Ccm Syndrome

Cerebral Cavernous Malformations 2

Cerebral Cavernous Malformation 2	CCM2
Cerebral Cavernous Malformations-2	Cavernous Angiomatous Malformations
Cavernous Hemangioma Of The Brain	Cerebral Capillary Malformations
Cerebral Cavernoma	Familial Cavernous Angioma
Cerebral Cavernous Malformations, Type 2

Brain Angioma

Brain Hemangioma

Intracranial Cavernous Angioma

Intracranial Cavernoma

Intracranial Cavernous Hemangioma

Intracranial Structure Hemangioma

Angioma Of Intracranial Structure	Hemangioma Of Intracranial Structure
Hemangioma Of Intracranial Structures

Cerebral Angioma

Hemangioma Of Cerebrum

Cerebral Hemangioma

Venous Malformations, Multiple Cutaneous And Mucosal

VMCM	Multiple Cutaneous And Mucosal Venous Malformations
Mucocutaneous Venous Malformations	Vmcm1
Cutaneous And Mucosal Venous Malformation	Dominantly Inherited Venous Malformations

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Vascular Anomaly
Spinal Cord Vascular Diseases	Vascular Tissue Disease

Hemangioma Of Liver

Hepatic Hemangioma	Angioma Of Liver
Hepatic Angioma

Myopathy, Centronuclear, 4

CNM4	Centronuclear Myopathy 4
Congenital Myopathy With Internal Nuclei And Atypical Cores	Centronuclear Myopathy Type 4
Myopathy, Centronuclear, Type 4

Intracranial Abscess

Abscess Of Brain	Brain Empyema
Cranial Abscess	Intracerebral Abscess
Cerebral Abscess	Cerebral Embolic Abscess
Cerebral Pyogenic Abscess	Septic Brain Infection
Temporosphenoidal Abscess	Ventricular Empyema
Intracranial Suppuration	Intracranial Vein Sinus Abscess

3-Methylcrotonyl-Coa Carboxylase 2 Deficiency

MCC2D	Mcc2 Deficiency
3-Methylcrotonyl Coa Carboxylase 2 Deficiency	3-Methylcrotonylglycinuria Ii
Methylcrotonylglycinuria, Type Ii	3-Methylcrotonoyl-Coa Carboxylase 2 Deficiency
3-Methylcrotonylglycinuria Type Ii	Mcgii
Methylcrotonylglycinuria Type Ii

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Hemorrhagic Disease

Hemorrhagic Disorders	Hemorrhagic Diathesis
Hemorrhagic Diseases	Bleeding Tendency
Acquired Coagulation Factor Inhibitor Disorder	Acquired Inhibitor Of Coagulation
Antithrombinaemia	Antithromboplastinogenaemia
Circulating Anticoagulant Disorder	Haemorrhagic Disorder Due To Antithrombinaemia
Haemorrhagic Disorder Due To Excess Administered Heparin	Antithromboplastinaemia
Haemorrhagic Disorder Due To Hyperheparinemia

Arteriovenous Malformation

Arteriovenous Malformations	Arteriovenous Hemangioma
Cirsoid Aneurysm	Racemose Aneurysm
Racemose Angioma	Racemose Hemangioma
Congenital Arteriovenous Malformation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10188	PDCD10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDCD10	RGD	RGD:1359329
Felis catus	PDCD10	VGNC	VGNC:68743
Bos taurus	PDCD10	VGNC	VGNC:32658
Mus musculus	PDCD10	MGD	MGI:1928396
Macaca mulatta	PDCD10	VGNC	VGNC:75793
Canis familiaris	PDCD10	VGNC	VGNC:53465
Others	PDCD10	NCBI

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