PARK7 - Parkinsonism associated deglycase Gene

Homo sapiens

Also known as DJ1; DJ-1; GATD2; HEL-S-67p

Gene ID: 11315 | Gene type: protein coding

About PARK7

Cytogenetic location: 1p36.23 Genomic coordinates (GRCh38): 1:7,961,711-7,985,505 (from NCBI)

This gene has 10 transcripts (splice variants), 216 orthologues and is associated with 3 phenotypes. Ubiquitous expression in adrenal (RPKM 125.5), thyroid (RPKM 111.2) and 25 other tissues.

Summary

The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

PARK7 Products(2)

mRNA	Protein	Name
NM_001123377.2	NP_001116849.1	Parkinson disease protein 7
NM_007262.5	NP_009193.2	Parkinson disease protein 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15790595	GOA
enables L-dopa decarboxylase activator activity	IDA IDA: Inferred from direct assay	19703902	GOA
enables copper ion binding	IDA IDA: Inferred from direct assay	23792957	GOA
enables cupric ion binding	IDA IDA: Inferred from direct assay	24567322	GOA
enables cuprous ion binding	IDA IDA: Inferred from direct assay	24144264	GOA
enables cytokine binding	IPI IPI: Inferred from physical interaction	21097510	GOA
NOT enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	22683601	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	23743200	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	19703902	GOA
enables glyoxalase (glycolic acid-forming) activity	IDA IDA: Inferred from direct assay	31653696	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	15502874	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	19229105	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	18626009	GOA
enables mercury ion binding	IDA IDA: Inferred from direct assay	23792957	GOA
enables nuclear androgen receptor binding	IPI IPI: Inferred from physical interaction	17510388	GOA
enables oxidoreductase activity, acting on peroxide as acceptor	IDA IDA: Inferred from direct assay	24567322	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	20304780	GOA
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	21097510	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11477070	GOA
NOT enables protein deglycase activity	IDA IDA: Inferred from direct assay	31653696	GOA
enables protein deglycase activity	IDA IDA: Inferred from direct assay	25416785	GOA
enables protein deglycase activity	IMP IMP: Inferred from mutant phenotype	26995087	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	18711745	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	24144264	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	21785459	GOA
enables signaling receptor activator activity	IDA IDA: Inferred from direct assay	17510388	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21785459	GOA
NOT enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	22683601	GOA
enables small protein activating enzyme binding	IPI IPI: Inferred from physical interaction	15983381	GOA
enables superoxide dismutase copper chaperone activity	IDA IDA: Inferred from direct assay	24567322	GOA
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	15790595	GOA
enables tyrosine 3-monooxygenase activator activity	IDA IDA: Inferred from direct assay	19703902	GOA
enables ubiquitin-like protein conjugating enzyme binding	IPI IPI: Inferred from physical interaction	15983381	GOA
enables ubiquitin-protein transferase inhibitor activity	IDA IDA: Inferred from direct assay	24899725	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	21097510	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA repair	IDA IDA: Inferred from direct assay	28596309	GOA
involved in androgen receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17510388	GOA
involved in cellular detoxification of aldehyde	IDA IDA: Inferred from direct assay	28993701	GOA
involved in cellular detoxification of methylglyoxal	IDA IDA: Inferred from direct assay	28993701	GOA
involved in cellular response to glyoxal	IDA IDA: Inferred from direct assay	22523093	GOA
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	15983381	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	24899725	GOA
involved in detoxification of copper ion	IMP IMP: Inferred from mutant phenotype	23792957	GOA
involved in detoxification of hydrogen peroxide	IDA IDA: Inferred from direct assay	14749723	GOA
involved in glycolate biosynthetic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in glyoxal metabolic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in guanine deglycation	IDA IDA: Inferred from direct assay	28596309	GOA
involved in guanine deglycation, glyoxal removal	IDA IDA: Inferred from direct assay	28596309	GOA
involved in guanine deglycation, methylglyoxal removal	IDA IDA: Inferred from direct assay	28596309	GOA
involved in hydrogen peroxide metabolic process	IDA IDA: Inferred from direct assay	24567322	GOA
involved in lactate biosynthetic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in methylglyoxal catabolic process to lactate	IDA IDA: Inferred from direct assay	28993701	GOA
NOT involved in methylglyoxal metabolic process	IDA IDA: Inferred from direct assay	27903648	GOA
involved in methylglyoxal metabolic process	IDA IDA: Inferred from direct assay	22523093	GOA
involved in negative regulation of TRAIL-activated apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in negative regulation of death-inducing signaling complex assembly	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	14652021	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	22683601	GOA
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	14652021	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	24947010	GOA
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	22511790	GOA
involved in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	14752510	GOA
acts upstream of negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	22523093	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15790595	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23743200	GOA
acts upstream of negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	17015834	GOA
involved in negative regulation of protein K48-linked deubiquitination	IDA IDA: Inferred from direct assay	21097510	GOA
involved in negative regulation of protein acetylation	IDA IDA: Inferred from direct assay	22683601	GOA
involved in negative regulation of protein export from nucleus	IGI IGI: Inferred from genetic interaction	15983381	GOA
involved in negative regulation of protein phosphorylation	IGI IGI: Inferred from genetic interaction	15983381	GOA
involved in negative regulation of protein sumoylation	IDA IDA: Inferred from direct assay	16731528	GOA
acts upstream of negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	17015834	GOA
involved in negative regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24899725	GOA
acts upstream of positive regulation of L-dopa biosynthetic process	IMP IMP: Inferred from mutant phenotype	16731528	GOA
involved in positive regulation of dopamine biosynthetic process	IDA IDA: Inferred from direct assay	19703902	GOA
acts upstream of positive regulation of interleukin-8 production	IDA IDA: Inferred from direct assay	21097510	GOA
involved in positive regulation of mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	19822128	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in positive regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	21097510	GOA
involved in positive regulation of protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in positive regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	24947010	GOA
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	20969476	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21097510	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17015834	GOA
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15790595	GOA
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16731528	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22492997	GOA
involved in protein repair	IDA IDA: Inferred from direct assay	25416785	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	24947010	GOA
acts upstream of protein stabilization	IMP IMP: Inferred from mutant phenotype	17015834	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	17015834	GOA
NOT involved in regulation of TRAIL production	IMP IMP: Inferred from mutant phenotype	21785459	GOA
involved in regulation of androgen receptor signaling pathway	IDA IDA: Inferred from direct assay	11477070	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	23743200	GOA
involved in regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	18711745	GOA
involved in regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15983381	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	24567322	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	22683601	GOA
located in chromatin	IDA IDA: Inferred from direct assay	16731528	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	12446870	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14662519	GOA
located in cytosol	IMP IMP: Inferred from mutant phenotype	21785459	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	31536960	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15790595	GOA
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	21785459	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11477070	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARK7 Protein Structure

DJ-1_PfpI

0
100
189 a.a.

Protein Preferred Names

Protein Names

Parkinson disease protein 7

Parkinson disease (autosomal recessive, early onset) 7

Recombinant PARK7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71625	PARK7/DJ-1 Protein, Human (GST)	Q99497 (1M-188K)	≥95%
HY-P74653	PARK7/DJ-1 Protein, Human (His)	Q99497 (M1-D189)	≥95%

Related Diseases

Diseases

Alias

Parkinson Disease 7, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 7	PARK7
Parkinson'S Disease 7	Autosomal Recessive Early-Onset Parkinson'S Disease 7
Parkinson Disease 7	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Type 2
Autosomal Recessive Early-Onset Parkinson Disease Type 7	Parkinson Disease, Type 7

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1

Guam Disease	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam
Als-Pdc	Lytico-Bodig Disease
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To	Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome	Parkinsonism-Dementia-Als Complex
Pdals	Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam
Parkinson-Dementia Complex Of Guam	G-Pdc
Guam Parkinsonism-Dementia Complex	ALS-PDC1
Als/Pdc Of Guam	Amyotrophic Lateral Sclerosis
Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1	Amyotrophic Lateral Sclerosis, Guam Form
Parkinsonian Disorders

Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6	Parkinson Disease 6
PARK6	Parkinson Disease 6, Early Onset
Parkinson'S Disease 6	Parkinson Disease 6, Early-Onset
Autosomal Recessive Early-Onset Parkinson'S Disease 6	Early-Onset Parkinson Disease 6
Autosomal Recessive Early-Onset Parkinson Disease Type 6	Parkinson Disease 6 Early-Onset
Parkinson Disease 6 Late-Onset Susceptibility To	Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1
Parkinsonism Young Adult Onset	Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1
Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease	PARK2
Pdj	Autosomal Recessive Juvenile Parkinson Disease 2
Epdf	Parkinson Disease, Juvenile, Type 2
Parkinson'S Disease 2	Autosomal Recessive Juvenile Parkinson Disease
Early-Onset Parkinson Disease	Parkinson Disease 2
Parkinson Disease, Juvenile, Autosomal Recessive	Parkinsonism, Early-Onset, With Diurnal Fluctuation
Autosomal Recessive Juvenile Parkinson'S Disease 2	Jp
Juvenile Parkinsonism	Parkinson Disease Autosomal Recessive, Early Onset
Parkinsonism, Early Onset, With Diurnal Fluctuation	Yopd
Autosomal Recessive Early-Onset Parkinson Disease Type 2	Chromosome 6-Linked Autosomal Recessive Parkinsonism
Early-Onset Parkinsonism With Diurnal Fluctuation	Parkinsonism Young Adult Onset
Parkinson Disease, Type 2	Parkinsonism, Juvenile

Parkinsonism

Parkinsonism-Plus	Idiopathic Parkinsonism
Primary Parkinsonism	Paralysis Agitans Syndrome
Parkinsonian Syndrome	Trembling Paralysis
Paralysis Agitans	Shaking Palsy
Shaking Paralysis

Parkinson Disease 3, Autosomal Dominant

PARK3	Parkinson Disease 3
Parkinson Disease 3, Autosomal Dominant Lewy Body	Parkinson'S Disease 3
Autosomal Dominant Lewy Body Parkinson Disease 3	Autosomal Dominant Parkinson Disease 3
Parkinson Disease Type 3	Autosomal Dominant Parkinson Disease
Parkinson Disease, Autosomal Dominant	Parkinson Disease, Familial, Type 1

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Glottis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Glottis

Squamous Cell Carcinoma Of Glottis

Anterior Dislocation Of Lens

Movement Disease

Movement Disorders

Movement Disorder

Early-Onset Parkinson'S Disease

Early-Onset Parkinson Disease

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Progressive Supranuclear Ophthalmoplegia
Psp	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Postencephalitic Parkinson Disease

Postencephalitic Parkinsonism

Parkinson Disease, Postencephalitic

Kufor-Rakeb Syndrome

Park9	Krppd
KRS	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia
Autosomal Recessive Parkinson Disease 9	Parkinson Disease 9
Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset	Autosomal Recessive Juvenile Onset Parkinson Disease 9
Parkinson Disease Type 9	Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia
Park 9	Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cln12 Disease	Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis
Parkinson Disease Autosomal Recessive 9

Parkinson Disease 15, Autosomal Recessive Early-Onset

Parkinsonian-Pyramidal Syndrome	Pallidopyramidal Syndrome
Parkinson Disease 15, Autosomal Recessive	PARK15
Pkps	Pallido-Pyramidal Syndrome
Parkinson'S Disease 15	Autosomal Recessive Early-Onset Parkinson Disease 15
Autosomal Recessive Early-Onset Parkinson'S Disease 15	Pallido-Pyramidal Disease
Parkinson Disease 15	Parkinson Disease 15 Autosomal Recessive
Pps	Parkinson Disease, Type 15

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Polyneuropathy

Polyneuropathies

Vascular Parkinsonism

Dystonia 12

DYT12	Rdp
Generalized Dystonia	Dystonia-12
Rapid-Onset Dystonia-Parkinsonism	Familial Dystonia
Dystonia Musculorum Deformans	Dystonic Disorders
Idiopathic Familial Dystonia	Dystonia-Parkinsonism, Rapid-Onset
Fragments Of Torsion Dystonia	Dyt-Atp1a3
Rapid-Onset Dystonia Parkinsonism	Rodp
Dystonia, Type 12	Dystonia 3, Torsion, X-Linked
Idiopathic Non-Familial Dystonia	Symptomatic Torsion Dystonia
Dystonia Disorders

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder	Rem Sleep Behaviour Disorder
Rapid Eye Movement Sleep Behaviour Disorder	Rem - [Rapid Eye Movement] Behaviour Disorder

Alzheimer Disease 2

AD2	Alzheimer Disease Associated With Apoe4
Alzheimer'S Disease 2	Alzheimer Disease-2
Alzheimer Disease 2, Late-Onset	Alzheimer Disease 2, Late Onset
Late-Onset Alzheimer Disease	Alzheimer Disease, Type 2
Alzheimer Disease, Late Onset

Dystonia

Dystonic Disease	Dystonic Disorder
Dystonia Disorders	Neuroleptic Dyskinesia

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Gaucher Disease, Type I

Glucocerebrosidase Deficiency	Acid Beta-Glucosidase Deficiency
Gba Deficiency	GD1
Gd I	Gaucher Disease, Noncerebral Juvenile
Gaucher Disease Type 1	Gaucher Disease Type I
Gaucher'S Disease Type I	Gaucher Disease
Gd 1	Non-Cerebral Juvenile Gaucher Disease
GD	Gaucher Disease 1
Adult Non-Neuronopathic Gaucher Disease	Noncerebral Juvenile Gaucher Disease
Type 1 Gaucher Disease	Gaucher Disease, Type 1

Meier-Gorlin Syndrome 3

MGORS3

Meier-Gorlin Syndrome, Type 3

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Gaucher'S Disease

Gaucher Disease	Kerasin Thesaurismosis
Glucocerebrosidase Deficiency	Glucosylceramidase Deficiency
Cerebroside Lipidosis Syndrome	Acid Beta-Glucosidase Deficiency
Glucosylceramide Beta-Glucosidase Deficiency	Acute Cerebral Gaucher Disease
Gaucher Splenomegaly	Glucocerebrosidosis
Glucosyl Cerebroside Lipidosis	Kerasin Lipoidosis
Lipoid Histiocytosis	Glocucerebrosidase Deficiency
Sphingolipidosis 1	Gaucher Syndrome
Gauchers Disease	Gd
Glucosylceramide Lipidosis	Kerasin Histiocytosis
Gaucher Disease, Type 1	Gaucher Disease, Type 2

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Choreatic Disease

Chorea

Hereditary Chorea

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency	Nadh:Q(1) Oxidoreductase Deficiency
MC1DN1	Nadh-Coenzyme Q Reductase Deficiency
Isolated Mitochondrial Respiratory Chain Complex I Deficiency	Isolated Nadh-Coenzyme Q Reductase Deficiency
Isolated Nadh-Coq Reductase Deficiency	Isolated Nadh-Ubiquinone Reductase Deficiency
Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of	Nuclear Type Mitochondrial Complex I Deficiency 1
Isolated Complex I Deficiency	Complex 1 Mitochondrial Respiratory Chain Deficiency
Nadh Coenzyme Q Reductase Deficiency	Complex I Mitochondrial Respiratory Chain Deficiency
Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I	Nadh:Ubiquinone Oxidoreductase Deficiency
Complex I, Mitochondrial Respiratory Chain, Deficiency Of

Pick Disease Of Brain

Pick Disease	Pick'S Disease
Pick Disease Of The Brain	Lobar Atrophy Of Brain
Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-163562	JYQ-164	Inhibitor	/	Unkown
HY-163563	JYQ-173		/	Unkown
HY-163564	JYQ-194		/	Unkown
HY-RS10043	PARK7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PARK7	VGNC	VGNC:44266
Rattus norvegicus	PARK7	RGD	RGD:621808
Macaca mulatta	PARK7	VGNC	VGNC:106466
Bos taurus	PARK7	VGNC	VGNC:32586
Mus musculus	PARK7	MGD	MGI:2135637
Felis catus	PARK7	VGNC	VGNC:64042
Others	PARK7	NCBI