1. Gene
  2. Hmgb1 - high mobility group box 1 Gene

Hmgb1 - high mobility group box 1 Gene

Mus musculus

Also known as p30; Hmg1; HMG-1; SBP-1

Gene ID: 15289 | Gene type: protein coding

About Hmgb1

Summary

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

Hmgb1 Products(2)

mRNA Protein Name
NM_001313894.1 NP_001300823.1 high mobility group protein B1
NM_010439.4 NP_034569.1 high mobility group protein B1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium-dependent protein kinase regulator activity IDA
IDA: Inferred from direct assay
7741753 MGI
enables cytokine activity IDA
IDA: Inferred from direct assay
7635200 MGI
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
enables nucleic acid binding EXP
EXP: Inferred from Experiment
15379539 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11099378 MGI
enables protein kinase activator activity IDA
IDA: Inferred from direct assay
7741753 MGI
enables single-stranded RNA binding IDA
IDA: Inferred from direct assay
19890330 MGI
Biological Process GO Annotation Evidence Reference Source
involved in base-excision repair IMP
IMP: Inferred from mutant phenotype
17803946 MGI
acts upstream of or within cellular response to interleukin-7 IDA
IDA: Inferred from direct assay
29581031 MGI
involved in cellular response to lipopolysaccharide IDA
IDA: Inferred from direct assay
28096568 MGI
involved in chromatin organization IDA
IDA: Inferred from direct assay
18650382 MGI
involved in endothelial cell chemotaxis IDA
IDA: Inferred from direct assay
16365390 MGI
involved in endothelial cell proliferation IDA
IDA: Inferred from direct assay
16365390 MGI
acts upstream of or within eye development IMP
IMP: Inferred from mutant phenotype
10391216 MGI
acts upstream of glycogen catabolic process IMP
IMP: Inferred from mutant phenotype
10391216 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
10391216 MGI
involved in macrophage activation involved in immune response IMP
IMP: Inferred from mutant phenotype
19890330 MGI
acts upstream of myeloid cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
involved in myeloid dendritic cell activation IMP
IMP: Inferred from mutant phenotype
19890330 MGI
acts upstream of myeloid progenitor cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
involved in plasmacytoid dendritic cell activation IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
16365390 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
20819940 MGI
acts upstream of or within positive regulation of glycogen catabolic process IMP
IMP: Inferred from mutant phenotype
10391216 MGI
involved in positive regulation of innate immune response IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interferon-beta production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
19890330 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
19264983 MGI
involved in positive regulation of monocyte chemotactic protein-1 production IMP
IMP: Inferred from mutant phenotype
19264983 MGI
acts upstream of or within positive regulation of myeloid cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
acts upstream of or within positive regulation of myeloid progenitor cell differentiation IDA
IDA: Inferred from direct assay
7635200 MGI
involved in positive regulation of non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16267105 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
7741753 MGI
involved in positive regulation of sprouting angiogenesis IDA
IDA: Inferred from direct assay
16365390 MGI
involved in positive regulation of toll-like receptor 2 signaling pathway IDA
IDA: Inferred from direct assay
16267105 MGI
involved in positive regulation of toll-like receptor 4 signaling pathway IDA
IDA: Inferred from direct assay
16267105 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10391216 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
19264983 MGI
involved in positive regulation of wound healing IDA
IDA: Inferred from direct assay
16365390 MGI
involved in regulation of T cell mediated immune response to tumor cell IDA
IDA: Inferred from direct assay
23108142 MGI
involved in regulation of nucleotide-excision repair IMP
IMP: Inferred from mutant phenotype
18650382 MGI
involved in regulation of tolerance induction IMP
IMP: Inferred from mutant phenotype
18631454 MGI
acts upstream of or within response to glucocorticoid IMP
IMP: Inferred from mutant phenotype
10391216 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
10391216 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9767109 MGI
located in early endosome IDA
IDA: Inferred from direct assay
19890330 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
7635200 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
12609598 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9767109 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high mobility group protein B1

amphoterin

high mobility group protein 1

Recombinant Hmgb1 Proteins

Cat. No. Product Name Accession Purity
HY-P73104 HMGB1/HMG-1 Protein, Mouse (HEK293, Fc, solution) P63158 (M1-E215) ≥95%
HY-P73104A HMGB1/HMG-1 Protein, Mouse (HEK293, Fc) P63158 (M1-E215) ≥95%
HY-P700182AF Animal-Free HMGB1/HMG-1 Protein, Mouse (His) P63158 (M1-E215) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Hmgb1 NCBI NCBI:3146