Prmt1 - protein arginine N-methyltransferase 1 Gene

Mus musculus

Also known as Mrmt1; Hrmt1l2; 6720434D09Rik

Gene ID: 15469 | Gene type: protein coding

About Prmt1

Chromosome 7: 44,625,413-44,635,992 reverse strand.GRCm39:CM001000.3

This gene has 14 transcripts (splice variants), 206 orthologues, 7 paralogues and is associated with 13 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 124.9), CNS E18 (RPKM 124.2) and 27 other tissues.

Summary

Enables Histone Methyltransferase activity and protein-arginine omega-N asymmetric methyltransferase activity. Involved in RNA splicing and cardiac muscle tissue development. Acts upstream of or within in utero embryonic development and peptidyl-arginine methylation, to asymmetrical-dimethyl arginine. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and lung. Orthologous to human PRMT1 (protein arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Prmt1 Products(3)

mRNA	Protein	Name
NM_019830.3	NP_062804.1	protein arginine N-methyltransferase 1 isoform 1
NM_001252476.1	NP_001239405.1	protein arginine N-methyltransferase 1 isoform 2
NM_001252477.1	NP_001239406.1	protein arginine N-methyltransferase 1 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GATOR1 complex binding	IDA IDA: Inferred from direct assay	38006878	MGI
enables histone methyltransferase activity	IDA IDA: Inferred from direct assay	16682010	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12529443	MGI
enables protein methyltransferase activity	IMP IMP: Inferred from mutant phenotype	10848611	MGI
enables protein-arginine N-methyltransferase activity	IDA IDA: Inferred from direct assay	21652632	MGI
enables protein-arginine omega-N asymmetric methyltransferase activity	IDA IDA: Inferred from direct assay	38006878	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in RNA splicing	IMP IMP: Inferred from mutant phenotype	30321814	MGI
involved in cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	30321814	MGI
involved in cellular response to methionine	IMP IMP: Inferred from mutant phenotype	38006878	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	10848611	MGI
involved in positive regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	38006878	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	30321814	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Prmt1 Protein Structure

AdoMet_MTases

0
100
200
300
353 a.a.

Protein Preferred Names

Protein Names

protein arginine N-methyltransferase 1

arginine N-methyltransferase 1	heterogeneous nuclear ribonucleoproteins methyltransferase-like 2
histone-arginine N-methyltransferase PRMT1

Related Agents

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19615	MS023	Inhibitor	99.73%	Unkown
HY-18962	AMI-1	Inhibitor	≥98.0%	Unkown
HY-12970A	EPZ020411 hydrochloride	Inhibitor	98.15%	Unkown
HY-12970	EPZ020411	Inhibitor	98.06%	Unkown
HY-107574	TC-E 5003	Inhibitor	98.03%	Unkown
HY-110137	Furamidine dihydrochloride	Inhibitor	≥99.0%	Unkown
HY-19615B	MS023 dihydrochloride	Inhibitor	99.78%	Unkown
HY-122096	DCLX069	Inhibitor	98.03%	Unkown
HY-128717B	GSK3368715 trihydrochloride	Inhibitor	/	Unkown
HY-149005	PRMT5-IN-19	Inhibitor	/	Unkown
HY-146810	PRMT4-IN-1	Inhibitor	/	Unkown
HY-162230	PRMT5-IN-33	Inhibitor	/	Unkown
HY-164456	AMI-408	Inhibitor	/	Unkown
HY-161334	CARM1-IN-4	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prmt1	NCBI	NCBI:3276

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