Ngf - nerve growth factor Gene

Mus musculus

Also known as Ngfb; beta-NGF

Gene ID: 18049 | Gene type: protein coding

About Ngf

Summary

Enables transmembrane receptor protein tyrosine kinase activator activity. Involved in positive regulation of DNA binding activity; positive regulation of Ras protein signal transduction; and positive regulation of protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell projection organization; and positive regulation of macromolecule metabolic process. Located in neuron projection terminus. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and neurogenic bladder. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Ngf Products(2)

mRNA	Protein	Name
NM_001112698.2	NP_001106168.1	beta-nerve growth factor isoform B precursor
NM_013609.3	NP_038637.1	beta-nerve growth factor isoform A

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	19036963	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of axon extension	IMP IMP: Inferred from mutant phenotype	8861722	MGI
acts upstream of or within cellular response to acid chemical	IDA IDA: Inferred from direct assay	25542970	MGI
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	23785138	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	14623868	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11731452	MGI
acts upstream of or within nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	7854358	MGI
acts upstream of or within nerve growth factor signaling pathway	IGI IGI: Inferred from genetic interaction	24270184	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	11731452	MGI
acts upstream of or within neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	14623868	MGI
acts upstream of or within neuron projection development	IDA IDA: Inferred from direct assay	27655914	MGI
acts upstream of or within peripheral nervous system development	IMP IMP: Inferred from mutant phenotype	14736860	MGI
involved in positive regulation of DNA binding	IMP IMP: Inferred from mutant phenotype	10362258	MGI
involved in positive regulation of Ras protein signal transduction	IDA IDA: Inferred from direct assay	11877426	MGI
acts upstream of or within positive regulation of axon extension	IDA IDA: Inferred from direct assay	18052984	MGI
acts upstream of or within positive regulation of axon extension	IMP IMP: Inferred from mutant phenotype	8861722	MGI
acts upstream of or within positive regulation of collateral sprouting	IDA IDA: Inferred from direct assay	18052984	MGI
acts upstream of or within positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	24733831	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	10362258	MGI
acts upstream of or within positive regulation of neuron maturation	IDA IDA: Inferred from direct assay	23015435	MGI
acts upstream of or within positive regulation of neuron maturation	IGI IGI: Inferred from genetic interaction	23015435	MGI
acts upstream of or within positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	23015435	MGI
acts upstream of or within positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	23015435	MGI
involved in positive regulation of neuron projection development	IGI IGI: Inferred from genetic interaction	11877426	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	27655914	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19036963	MGI
acts upstream of or within positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	24760869	MGI
acts upstream of protein phosphorylation	IDA IDA: Inferred from direct assay	27655914	MGI
acts upstream of or within regulation of neuron differentiation	IDA IDA: Inferred from direct assay	16516892	MGI
acts upstream of or within regulation of neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	16298082	MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol	IGI IGI: Inferred from genetic interaction	24265601	MGI
acts upstream of or within sensory perception of pain	IMP IMP: Inferred from mutant phenotype	8137419	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-nerve growth factor

nerve growth factor, beta

Recombinant Ngf Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7661	Beta-NGF Protein, Mouse (120a.a)	P01139 (S122-G241)	≥95%
HY-P70530	Beta-NGF Protein, Mouse (110a.a)	P01139 (M130-R239)	≥95%
HY-P73317	Beta-NGF Protein, Mouse (CHO)	P01139 (S122-G241)	≥95%
HY-P700162AF	Animal-Free Beta-NGF Protein, Mouse (His)	P01139 (S122-G241)	≥95%

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-I0021	Bepotastine	Antagonist	98.03%	Unkown
HY-A0015	Bepotastine besilate	Antagonist	99.77%	Unkown
HY-B0446	Naphazoline hydrochloride		98.12%	Unkown
HY-111326A	Naphazoline nitrate		≥98.0%	Unkown
HY-111326	Naphazoline		/	Unkown
HY-I0021A	Bepotastine tosylate	Antagonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99297	Bedinvetmab	Inhibitor	99.80%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17622	Tavilermide	Agonist	98.98%	Phase 3
HY-109194	Udonitrectag		98.46%	Phase 2
HY-120251A	Leteprinim potassium	Inhibitor	≥99.0%	Phase 2

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99221	Tanezumab	Antagonist	99.52%	Phase 3
HY-P99195	Fasinumab	Inhibitor	98.11%	Phase 3
HY-P99200	Fulranumab	Inhibitor	96.74%	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6732	K-252a	Inhibitor	99.45%	Unkown
HY-18314	GW 441756		99.95%	Unkown
HY-108466	Ro 08-2750	Inducer	98.63%	Unkown
HY-N0380	Nardosinone	Activator	99.89%	Unkown
HY-110166	PD 90780	Antagonist	≥99.0%	Unkown
HY-N0857	Deoxyandrographolide	Activator	99.87%	Unkown
HY-P3709A	TRAF6 peptide TFA	Inhibitor	95.99%	Unkown
HY-120553	B-355252	Inhibitor	≥99.0%	Unkown
HY-A0015A	(Rac)-Bepotastine besilate	Inhibitor	99.52%	Unkown
HY-124637	ALE-0540	Antagonist	98.24%	Unkown
HY-P3709	TRAF6 peptide	Inhibitor	/	Unkown
HY-117517	NG-012	Activator	/	Unkown
HY-120251	Leteprinim	Inhibitor	/	Unkown
HY-124152	3,4-Dephostatin	Inhibitor	/	Unkown
HY-130179	RC-33 hydrochloride	Inducer	/	Unkown
HY-146523	TRK-IN-17	Inhibitor	/	Unkown
HY-146524	TRK-IN-18	Inhibitor	/	Unkown
HY-D2336	PROTAC Aster-A degrader-1		/	Unkown
HY-N10325	Sarbronine M		/	Unkown
HY-N12170	Kissoone C		/	Unkown
HY-N12566	Erinacin B		/	Unkown
HY-N3928	Garciniaxanthone E		/	Unkown
HY-N3938	Gelsemiol		/	Unkown
HY-P10140	JNK-IN-15, Cell-Permeable	Inhibitor	/	Unkown
HY-P10141	JNK-IN-15, Cell-Permeable, Negative Control	Inhibitor	/	Unkown
HY-P5156	BDS-I	Inhibitor	/	Unkown
HY-RS09277	NGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-11055	KP 544		/	Unkown
HY-A0015S	Bepotastine-d6(besylate)	Antagonist	/	Unkown
HY-N13170	Glycoside H2		/	Unkown
HY-RS16265	NGF Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990474	Anti-NGF/bNGF Antibody	Inhibitor	/	Unkown
HY-P990749	Luvagrobart	Inhibitor	/	Unkown
HY-P99820	Ranevetmab		/	Unkown
HY-P99825	Relfovetmab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ngf	NCBI	NCBI:4803
Leporidae	Ngf	NCBI
Rattus norvegicus	Ngf	NCBI	NCBI:310738

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