Ngf - nerve growth factor Gene

Rattus norvegicus

Also known as Ngfb; beta-NGF

Gene ID: 310738 | Gene type: protein coding

About Ngf

Summary

Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin Trk Receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]

Ngf Products(1)

mRNA	Protein	Name
NM_001277055.1	NP_001263984.1	beta-nerve growth factor precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	19129380	RGD
involved in cell population proliferation	IMP IMP: Inferred from mutant phenotype	23934089	RGD
involved in cell proliferation in forebrain	IMP IMP: Inferred from mutant phenotype	29409115	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	19129380	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	21541365	RGD
involved in negative regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	22926925	RGD
involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	23934089	RGD
involved in neuron projection development	IDA IDA: Inferred from direct assay	3336364	RGD
acts upstream of or within positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	19029245	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	17310240	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	18973572	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18846328	RGD
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	18846328	RGD
acts upstream of or within positive regulation of neurotrophin TRK receptor signaling pathway	IDA IDA: Inferred from direct assay	19029245	RGD
acts upstream of or within positive regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	19029245	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20605787	RGD
involved in positive regulation of stem cell proliferation	IDA IDA: Inferred from direct assay	18846328	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19059440	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	19200610	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19012240	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	18981959	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	19824047	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18818126	RGD
involved in response to ozone	IEP IEP: Inferred from expression pattern	21075861	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18756821	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18836171	RGD
involved in sensory perception of hot stimulus	IDA IDA: Inferred from direct assay	27392124	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	1315318	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19065562	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-nerve growth factor

nerve growth factor (beta polypeptide)

pro-nerve growth factor long

Related Agents

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-I0021	Bepotastine	Antagonist	98.58%	Unkown
HY-A0015	Bepotastine besilate	Antagonist	99.77%	Unkown
HY-B0446	Naphazoline hydrochloride		98.12%	Unkown
HY-111326A	Naphazoline nitrate		≥98.0%	Unkown
HY-111326	Naphazoline		99.74%	Unkown
HY-I0021A	Bepotastine tosylate	Antagonist	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99297	Bedinvetmab	Inhibitor	99.80%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17622	Tavilermide	Agonist	99.57%	Phase 3
HY-109194	Udonitrectag		98.46%	Phase 2
HY-120251A	Leteprinim potassium	Inhibitor	≥99.0%	Phase 2

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99221	Tanezumab	Antagonist	99.52%	Phase 3
HY-P99195	Fasinumab	Inhibitor	98.11%	Phase 3
HY-P99200	Fulranumab	Inhibitor	96.74%	Phase 3

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6732	K-252a	Inhibitor	99.45%	Unkown
HY-108466	Ro 08-2750	Inducer	98.63%	Unkown
HY-18314	GW 441756		99.95%	Unkown
HY-N0380	Nardosinone	Activator	99.89%	Unkown
HY-133968	24-Methylenecholesterol	Activator	99.48%	Unkown
HY-110166	PD 90780		≥99.0%	Unkown
HY-N0857	Deoxyandrographolide	Activator	99.87%	Unkown
HY-P3709A	TRAF6 peptide TFA	Inhibitor	95.99%	Unkown
HY-120553	B-355252	Inhibitor	≥99.0%	Unkown
HY-124637	ALE-0540	Antagonist	98.24%	Unkown
HY-A0015A	(Rac)-Bepotastine besilate	Inhibitor	99.52%	Unkown
HY-P3709	TRAF6 peptide	Inhibitor	/	Unkown
HY-11055	KP 544		/	Unkown
HY-116202	PACA	Activator	/	Unkown
HY-117517	NG-012	Activator	/	Unkown
HY-120251	Leteprinim	Inhibitor	/	Unkown
HY-124152	3,4-Dephostatin	Inhibitor	/	Unkown
HY-130179	RC-33 hydrochloride	Inducer	/	Unkown
HY-146523	TRK-IN-17	Inhibitor	/	Unkown
HY-146524	TRK-IN-18	Inhibitor	/	Unkown
HY-A0015S	Bepotastine-d6 besylate	Antagonist	/	Unkown
HY-D2336	PROTAC Aster-A degrader-1		/	Unkown
HY-N10325	Sarbronine M		/	Unkown
HY-N12170	Kissoone C		/	Unkown
HY-N12566	Erinacin B		/	Unkown
HY-N3928	Garciniaxanthone E		/	Unkown
HY-N3938	Gelsemiol		/	Unkown
HY-NP144	Nerve Growth Factor 7S,murine submaxillary gland		/	Unkown
HY-P10140	JNK-IN-15, Cell-Permeable	Inhibitor	/	Unkown
HY-P10141	JNK-IN-15, Cell-Permeable, Negative Control	Inhibitor	/	Unkown
HY-P5156	BDS-I	Inhibitor	/	Unkown
HY-RS09277	NGF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-171450	TrkA-IN-9	Inhibitor	/	Unkown
HY-N13170	Glycoside H2		/	Unkown
HY-RS16265	NGF Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99627	Frunevetmab		95.00%	Unkown
HY-P990474	Anti-NGF/bNGF Antibody	Inhibitor	/	Unkown
HY-P990749	Luvagrobart	Inhibitor	/	Unkown
HY-P99820	Ranevetmab		/	Unkown
HY-P99825	Relfovetmab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ngf	NCBI	NCBI:4803
Mus musculus	Ngf	NCBI	NCBI:18049
Leporidae	Ngf	NCBI

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