2. Gene
  3. DTNB - dystrobrevin beta Gene

DTNB - dystrobrevin beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 1838 | Gene type: protein coding

About DTNB

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:25,377,243-25,673,577 (from NCBI)

This gene has 30 transcripts (splice variants), 45 orthologues and 36 paralogues. Ubiquitous expression in salivary gland (RPKM 3.0), brain (RPKM 2.3) and 25 other tissues.

Summary

This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. [provided by RefSeq, Mar 2016]

DTNB Products(30)

mRNA Protein Name
NM_001256303.2 NP_001243232.1 dystrobrevin beta isoform 6
NM_001256304.3 NP_001243233.1 dystrobrevin beta isoform 7
NM_001256308.2 NP_001243237.1 dystrobrevin beta isoform 8
NM_001320932.2 NP_001307861.1 dystrobrevin beta isoform 9
NM_001320933.2 NP_001307862.1 dystrobrevin beta isoform 10
NM_001320934.2 NP_001307863.1 dystrobrevin beta isoform 11
NM_001320935.2 NP_001307864.1 dystrobrevin beta isoform 12
NM_001320936.2 NP_001307865.1 dystrobrevin beta isoform 13
NM_001320937.2 NP_001307866.1 dystrobrevin beta isoform 14
NM_001351381.2 NP_001338310.1 dystrobrevin beta isoform 15
NM_001351382.2 NP_001338311.1 dystrobrevin beta isoform 16
NM_001351383.2 NP_001338312.1 dystrobrevin beta isoform 17
NM_001351384.2 NP_001338313.1 dystrobrevin beta isoform 18
NM_001351385.2 NP_001338314.1 dystrobrevin beta isoform 19
NM_001351386.2 NP_001338315.1 dystrobrevin beta isoform 20
NM_001351387.2 NP_001338316.1 dystrobrevin beta isoform 21
NM_001351388.2 NP_001338317.1 dystrobrevin beta isoform 22
NM_001351389.2 NP_001338318.1 dystrobrevin beta isoform 23
NM_001351390.2 NP_001338319.1 dystrobrevin beta isoform 24
NM_001351391.2 NP_001338320.1 dystrobrevin beta isoform 25
NM_001351392.2 NP_001338321.1 dystrobrevin beta isoform 26
NM_001351393.2 NP_001338322.1 dystrobrevin beta isoform 27
NM_001351394.2 NP_001338323.1 dystrobrevin beta isoform 28
NM_001351395.2 NP_001338324.1 dystrobrevin beta isoform 29
NM_001394686.1 NP_001381615.1 dystrobrevin beta isoform 30
NM_021907.5 NP_068707.1 dystrobrevin beta isoform 1
NM_033147.4 NP_149159.2 dystrobrevin beta isoform 2
NM_033148.4 NP_149160.1 dystrobrevin beta isoform 3
NM_183360.3 NP_899204.1 dystrobrevin beta isoform 4
NM_183361.3 NP_899205.1 dystrobrevin beta isoform 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in neuron differentiation IMP
IMP: Inferred from mutant phenotype
27223470 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27223470 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27223470 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTNB Protein Structure

EF-hand_2

EF-hand_2: EF hand (16 - 140)

EF-hand_3

EF-hand_3: EF-hand (144 - 232)

ZZ

ZZ: Zinc finger, ZZ type (240 - 280)

  • 0
  • 100
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  • 400
  • 500
  • 627 a.a.
Protein Preferred Names Protein Names

dystrobrevin beta

DTN-B

DTNB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DTNB O60941 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
DTNB O60941 DMD Homo sapiens P11532
Anti Tag CoIP
33961781
Intra
DTNB O60941 DMD Homo sapiens P11532
Y2H Array
25416956
Intra
DTNB O60941 NUP62 Homo sapiens P37198
Y2H Pooling
16189514
Intra
DTNB O60941 NUP62 Homo sapiens P37198
Y2H Array
31515488
Intra
DTNB O60941 NUP62 Homo sapiens P37198
Y2H Prey Pooling
25416956
Intra
DTNB O60941 VCP Homo sapiens P55072
Y2H Prey Pooling
25416956
Intra
DTNB O60941 VCP Homo sapiens P55072
Y2H Array
25416956
Intra
DTNB O60941 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
25416956
Intra
DTNB O60941 TRAF2 Homo sapiens Q12933
Validated Y2H
25416956
Intra
DTNB O60941 TRAF2 Homo sapiens Q12933
Y2H Pooling
16189514
Intra
DTNB O60941 TXLNA Homo sapiens P40222
Y2H Array
31515488
Intra
DTNB O60941 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra
DTNB O60941 ZBTB9 Homo sapiens Q96C00
Y2H Array
31515488
Intra
DTNB O60941 ZBTB9 Homo sapiens Q96C00
Y2H Prey Pooling
25416956
Intra
DTNB O60941 ZBTB9 Homo sapiens Q96C00
Y2H Array
25416956
Intra
DTNB O60941 GGA1 Homo sapiens Q9UJY5
Validated Y2H
25416956
Intra
DTNB O60941 GGA1 Homo sapiens Q9UJY5
MAPPIT
25416956
Intra
DTNB O60941 GGA1 Homo sapiens Q9UJY5
Y2H Array
25416956
Intra
DTNB O60941 GGA1 Homo sapiens Q9UJY5
Y2H Prey Pooling
25416956
Intra
DTNB O60941 DTNBP1 Homo sapiens Q96EV8
Y2H Prey Pooling
25416956
Intra
DTNB O60941 CTNNAL1 Homo sapiens Q9UBT7
Far-WB
21115837
Intra
DTNB O60941 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
DTNB O60941 HMG20A Homo sapiens Q9NP66
Y2H Pooling
16189514
Intra
DTNB O60941 HMG20A Homo sapiens Q9NP66
Y2H Array
25416956
Intra
DTNB O60941 CEP63 Homo sapiens Q96MT8
Y2H Array
25416956
Intra
DTNB O60941 CEP63 Homo sapiens Q96MT8
Y2H Prey Pooling
25416956
Intra
DTNB O60941 CEP63 Homo sapiens Q96MT8
Validated Y2H
25416956
Intra
DTNB O60941 ABI3 Homo sapiens Q9P2A4
Validated Y2H
25416956
Intra
DTNB O60941 ABI3 Homo sapiens Q9P2A4
Y2H Array
25416956
Intra
DTNB O60941 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
25416956
Intra
DTNB O60941 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra
DTNB O60941 ABI2 Homo sapiens Q9NYB9
Y2H Array
25416956
Intra
DTNB O60941 ABI2 Homo sapiens Q9NYB9
Y2H Array
29892012
Intra
DTNB O60941 ABI2 Homo sapiens Q9NYB9
Y2H Prey Pooling
25416956
Intra
DTNB O60941 ABI2 Homo sapiens Q9NYB9
Validated Y2H
25416956
Intra
DTNB O60941 PPFIA1 Homo sapiens Q13136
Y2H Array
25416956
Intra
DTNB O60941 PPFIA1 Homo sapiens Q13136
Anti Tag CoIP
33961781
Intra
DTNB O60941 PPFIA1 Homo sapiens Q13136
Y2H Array
29892012
Intra
DTNB O60941 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra
DTNB O60941 CEP55 Homo sapiens Q53EZ4
Validated Y2H
25416956
Intra
DTNB O60941 CEP55 Homo sapiens Q53EZ4
Y2H Array
25416956
Intra
DTNB O60941 SPZ1 Homo sapiens Q9BXG8
Y2H Array
31515488
Intra
DTNB O60941 SPZ1 Homo sapiens Q9BXG8
Y2H Array
25416956
Intra
DTNB O60941 SPZ1 Homo sapiens Q9BXG8
Y2H Prey Pooling
25416956
Intra
DTNB O60941 SNTG2 Homo sapiens Q9NY99
MAPPIT
25416956
Intra
DTNB O60941 NDEL1 Homo sapiens Q9GZM8
Y2H Prey Pooling
25416956
Intra
DTNB O60941 NDEL1 Homo sapiens Q9GZM8
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Muscular Dystrophy

Muscular Dystrophies

Congenital Md

Congenital Muscular Dystrophy

Cmd

Mdc

Dystrophy, Muscular

Gower'S Muscular Dystrophy

Progressive Musclular Dystrophy

Pseudohypertrophic Atrophy

Pseudohypertrophic Muscle Paralysis

Pseudohypertrophic Muscular Atrophy

Pseudohypertrophic Muscular Dystrophy

Pseudohypertrophic Paralysis

Pseudomuscular Hypertrophy
Hermansky-Pudlak Syndrome

Hps

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Hermanski-Pudlak Syndrome

Hermansky Pudlak Syndrome

Platelet Storage Pool Deficiency
Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy

Benign Rolandic Epilepsy

Epilepsy, Rolandic

Bcects

Benign Childhood Epilepsy With Centrotemporal Spike

Sylvan Seizures

Becrs

Bects

Bre

Benign Epilepsy Of Childhood With Centrotemporal Spikes

Benign Familial Epilepsy Of Childhood With Rolandic Spikes

Centrotemporal Epilepsy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15915 DTNB 98.67% Unkown
HY-W127380 Arachidonoyl thio-PC ≥98.0% Unkown
HY-125744 Palmitoyl thio-PC / Unkown
HY-RS04036 DTNB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W713925 Diheptanoyl Thio-PC / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DTNB RGD RGD:1309579
Bos taurus DTNB VGNC VGNC:28232
Macaca mulatta DTNB VGNC VGNC:82136
Felis catus DTNB VGNC VGNC:61644
Mus musculus DTNB MGD MGI:1203728