Sstr2 - somatostatin receptor 2 Gene

Mus musculus

Also known as SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2

Gene ID: 20606 | Gene type: protein coding

About Sstr2

Chromosome 11: 113,510,168-113,516,854 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 264 orthologues, 15 paralogues and is associated with 32 phenotypes. Biased expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.2) and 13 other tissues.

Summary

The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several Hormones and Other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine Phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Sstr2 Products(2)

mRNA	Protein	Name
NM_009217.5	NP_033243.2	somatostatin receptor type 2 isoform B
NM_001042606.3	NP_001036071.1	somatostatin receptor type 2 isoform A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables somatostatin receptor activity	IDA IDA: Inferred from direct assay	1346068	MGI
enables somatostatin receptor activity	IMP IMP: Inferred from mutant phenotype	7929134	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	7929134	MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	9166719	MGI
acts upstream of or within neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	9166719	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	7929134	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	9166719	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr2 Protein Structure

7tmA_SSTR2

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 2

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0036	Octreotide	Agonist	99.64%	Unkown
HY-P0036B	Octreotide pamoate	Agonist	/	Unkown

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5362	NODAGA-LM3	Antagonist	99.33%	Phase 2
HY-P0024	Veldoreotide	Activator	/	Phase 2
HY-P10137	Satoreotide	Antagonist	98.88%	Phase 2
HY-P5362A	NODAGA-LM3 TFA	Antagonist	/	Phase 2
HY-P3294	Onzigolide	Agonist	/	Phase 2
HY-106103	Seglitide	Agonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.21%	Unkown
HY-P1202A	CYN 154806 TFA	Antagonist	99.81%	Unkown
HY-P1202	CYN 154806	Antagonist	99.76%	Unkown
HY-P3124A	BIM-23190 hydrochloride	Agonist	99.64%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.37%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P2545	[Tyr1]-Somatostatin-14		/	Unkown
HY-110161	sst2 Receptor agonist-1	Agonist	/	Unkown
HY-P3124	BIM-23190	Agonist	/	Unkown
HY-P2434	AP102		/	Unkown
HY-P2150	Cortistatin-29		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sstr2	NCBI	NCBI:6752

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