Sstr4 - somatostatin receptor 4 Gene

Mus musculus

Also known as sst4; Smstr4

Gene ID: 20608 | Gene type: protein coding

About Sstr4

Chromosome 2: 148,237,264-148,238,687 forward strand.GRCm39:CM000995.3

This gene has 1 transcript (splice variant), 100 orthologues, 15 paralogues and is associated with 12 phenotypes.

Summary

Predicted to enable neuropeptide binding activity and Somatostatin Receptor activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of arachidonic acid secretion; and regulation of signal transduction. Predicted to act upstream of or within signal transduction. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; gut; and respiratory system. Orthologous to human SSTR4 (Somatostatin Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Sstr4 Products(1)

mRNA	Protein	Name
NM_009219.3	NP_033245.2	somatostatin receptor type 4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17950729	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr4 Protein Structure

7tmA_SSTR4

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

somatostatin receptor type 4

SS-4-R	SS4-R
SS4R

Sstr4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sstr4	P49660	Dlg4	Mus musculus	Q62108	Pull Down	17950729

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105172	TT-232	Agonist	98.27%	Phase 2
HY-P0024	Veldoreotide	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.21%	Unkown
HY-P4452	PRL 2915	Antagonist	99.57%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-P0024A	Veldoreotide TFA	Agonist	98.37%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P2150	Cortistatin-29		/	Unkown
HY-139347	SSTR4 agonist-1	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sstr4	NCBI	NCBI:6754

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