1. Gene
  2. RYBP - RING1 and YY1 binding protein Gene

RYBP - RING1 and YY1 binding protein Gene

Homo sapiens

Also known as AAP1; DEDAF; YEAF1; APAP-1

Gene ID: 23429 | Gene type: protein coding

About RYBP

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:72,374,593-72,446,623 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 232 orthologues and 1 paralogue. Ubiquitous expression in placenta (RPKM 20.7), testis (RPKM 18.4) and 25 other tissues.

Summary

Predicted to enable DNA binding activity and transcription coregulator activity. Involved in several processes, including histone H2A monoubiquitination; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and positive regulation of transcription, DNA-templated. Located in nucleoplasm. Colocalizes with PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

RYBP Products(1)

mRNA Protein Name
NM_012234.6 NP_036366.3 RING1 and YY1-binding protein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables nucleic acid binding EXP
EXP: Inferred from Experiment
19170609 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
16943429 GOA
involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
27060496 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27060496 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
27060496 GOA
Cellular Component GO Annotation Evidence Reference Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
16943429 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27060496 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RYBP Protein Structure

zf-RanBP

zf-RanBP: Zn-finger in Ran binding protein and others (111 - 134)

  • 0
  • 100
  • 200
  • 317 a.a.
Protein Preferred Names Protein Names

RING1 and YY1-binding protein

DED-associated factor

RYBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
RYBP Q8N488 NF2 Homo sapiens P35240-4 32814053
Intra
RYBP Q8N488 NF2 Homo sapiens P35240-4 32814053
Intra
RYBP Q8N488 NF2 Homo sapiens P35240-4 32814053
Intra
RYBP Q8N488 COMT Homo sapiens P21964-2 32814053
Intra
RYBP Q8N488 COMT Homo sapiens P21964-2 32814053
Intra
RYBP Q8N488 COMT Homo sapiens P21964-2 32814053
Intra
RYBP Q8N488 MAT2A Homo sapiens P31153 32814053
Intra
RYBP Q8N488 MAT2A Homo sapiens P31153 32814053
Intra
RYBP Q8N488 MAT2A Homo sapiens P31153 32814053
Intra
RYBP Q8N488 GTF3C3 Homo sapiens Q9Y5Q9 32814053
Intra
RYBP Q8N488 GTF3C3 Homo sapiens Q9Y5Q9 32814053
Intra
RYBP Q8N488 GTF3C3 Homo sapiens Q9Y5Q9 32814053
Intra
RYBP Q8N488 KIF1B Homo sapiens O60333-2 32814053
Intra
RYBP Q8N488 KIF1B Homo sapiens O60333-2 32814053
Intra
RYBP Q8N488 KIF1B Homo sapiens O60333-2 32814053
Intra
RYBP Q8N488 DMWD Homo sapiens G5E9A7 32814053
Intra
RYBP Q8N488 DMWD Homo sapiens G5E9A7 32814053
Intra
RYBP Q8N488 DMWD Homo sapiens G5E9A7 32814053
Intra
RYBP Q8N488 PSEN1 Homo sapiens P49768-2 32814053
Intra
RYBP Q8N488 PSEN1 Homo sapiens P49768-2 32814053
Intra
RYBP Q8N488 PSEN1 Homo sapiens P49768-2 32814053
Intra
RYBP Q8N488 BANP Homo sapiens Q8N9N5-2 32296183
Intra
RYBP Q8N488 PSEN2 Homo sapiens P49810 32814053
Intra
RYBP Q8N488 PSEN2 Homo sapiens P49810 32814053
Intra
RYBP Q8N488 PSEN2 Homo sapiens P49810 32814053
Intra
RYBP Q8N488 ELAVL4 Homo sapiens P26378-2 32814053
Intra
RYBP Q8N488 ELAVL4 Homo sapiens P26378-2 32814053
Intra
RYBP Q8N488 ELAVL4 Homo sapiens P26378-2 32814053
Intra
RYBP Q8N488 XAGE1A Homo sapiens Q9HD64 32296183
Cross
RYBP Q8N488 P0C6X7-PRO_0000037319 Human SARS coronavirus P0C6X7-PRO_0000037319 22046132
Cross
RYBP Q8N488 P0C6X7-PRO_0000037319 Human SARS coronavirus P0C6X7-PRO_0000037319 22046132
Intra
RYBP Q8N488 DCTN1 Homo sapiens Q14203-5 32814053
Intra
RYBP Q8N488 DCTN1 Homo sapiens Q14203-5 32814053
Intra
RYBP Q8N488 DCTN1 Homo sapiens Q14203-5 32814053
Intra
RYBP Q8N488 TGM2 Homo sapiens P21980-2 32814053
Intra
RYBP Q8N488 TGM2 Homo sapiens P21980-2 32814053
Intra
RYBP Q8N488 TGM2 Homo sapiens P21980-2 32814053
Intra
RYBP Q8N488 F8 Homo sapiens P00451-2 32814053
Intra
RYBP Q8N488 F8 Homo sapiens P00451-2 32814053
Intra
RYBP Q8N488 F8 Homo sapiens P00451-2 32814053
Intra
RYBP Q8N488 q9p1n4_human Homo sapiens Q9P1N4 32814053
Intra
RYBP Q8N488 q9p1n4_human Homo sapiens Q9P1N4 32814053
Intra
RYBP Q8N488 q9p1n4_human Homo sapiens Q9P1N4 32814053
Intra
RYBP Q8N488 GIPC1 Homo sapiens O14908-2 32814053
Intra
RYBP Q8N488 GIPC1 Homo sapiens O14908-2 32814053
Intra
RYBP Q8N488 GIPC1 Homo sapiens O14908-2 32814053
Intra
RYBP Q8N488 TDP1 Homo sapiens Q9NUW8 32814053
Intra
RYBP Q8N488 TDP1 Homo sapiens Q9NUW8 32814053
Intra
RYBP Q8N488 TDP1 Homo sapiens Q9NUW8 32814053
Intra
RYBP Q8N488 UBC Homo sapiens P0CG48 17070805
Intra
RYBP Q8N488 UBC Homo sapiens P0CG48 17070805
Intra
RYBP Q8N488 SRP9 Homo sapiens P49458 32814053
Intra
RYBP Q8N488 SRP9 Homo sapiens P49458 32814053
Intra
RYBP Q8N488 SRP9 Homo sapiens P49458 32814053
Intra
RYBP Q8N488 PKM Homo sapiens P14618 32814053
Intra
RYBP Q8N488 PKM Homo sapiens P14618 32814053
Intra
RYBP Q8N488 PKM Homo sapiens P14618 32814053
Intra
RYBP Q8N488 TP53 Homo sapiens P04637 34316702
Intra
RYBP Q8N488 TP53 Homo sapiens P04637 19098711
Intra
RYBP Q8N488 TP53 Homo sapiens P04637 19098711
Intra
RYBP Q8N488 MDM2 Homo sapiens Q00987 19098711
Intra
RYBP Q8N488 MDM2 Homo sapiens Q00987 19098711
Intra
RYBP Q8N488 MDM2 Homo sapiens Q00987 19098711
Intra
RYBP Q8N488 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
RYBP Q8N488 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
RYBP Q8N488 RNF11 Homo sapiens Q9Y3C5 32814053
Intra
RYBP Q8N488 FUS Homo sapiens P35637 34316702
Intra
RYBP Q8N488 NEFL Homo sapiens P07196 32814053
Intra
RYBP Q8N488 NEFL Homo sapiens P07196 32814053
Intra
RYBP Q8N488 NEFL Homo sapiens P07196 32814053
Intra
RYBP Q8N488 HTRA2 Homo sapiens O43464 32814053
Intra
RYBP Q8N488 HTRA2 Homo sapiens O43464 32814053
Intra
RYBP Q8N488 HTRA2 Homo sapiens O43464 32814053
Intra
RYBP Q8N488 SPRED1 Homo sapiens Q7Z699 32814053
Intra
RYBP Q8N488 SPRED1 Homo sapiens Q7Z699 32814053
Intra
RYBP Q8N488 SPRED1 Homo sapiens Q7Z699 32814053
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587-2 17070805
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587-2 28514442
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587-2 17070805
Intra
RYBP Q8N488 NDRG1 Homo sapiens Q92597 32814053
Intra
RYBP Q8N488 NDRG1 Homo sapiens Q92597 32814053
Intra
RYBP Q8N488 NDRG1 Homo sapiens Q92597 32814053
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496 34316702
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496
TAP
27705803
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496 28514442
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496 32296183
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496 33961781
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496 32296183
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496 32296183
Intra
RYBP Q8N488 RNF2 Homo sapiens Q99496
TAP
24981860
Intra
RYBP Q8N488 SNCB Homo sapiens Q16143 32814053
Intra
RYBP Q8N488 SNCB Homo sapiens Q16143 32814053
Intra
RYBP Q8N488 SNCB Homo sapiens Q16143 32814053
Intra
RYBP Q8N488 GFAP Homo sapiens P14136 32814053
Intra
RYBP Q8N488 GFAP Homo sapiens P14136 32814053
Intra
RYBP Q8N488 GFAP Homo sapiens P14136 32814053
Intra
RYBP Q8N488 GRN Homo sapiens P28799 32814053
Intra
RYBP Q8N488 GRN Homo sapiens P28799 32814053
Intra
RYBP Q8N488 GRN Homo sapiens P28799 32814053
Intra
RYBP Q8N488 DR1 Homo sapiens Q01658 32814053
Intra
RYBP Q8N488 DR1 Homo sapiens Q01658 32814053
Intra
RYBP Q8N488 DR1 Homo sapiens Q01658 32814053
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 25416956
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 33961781
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 32296183
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587
TAP
27705803
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 16189514
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 34316702
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 16943429
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 25416956
Intra
RYBP Q8N488 RING1 Homo sapiens Q06587 32296183
Intra
RYBP Q8N488 EAF1 Homo sapiens Q96JC9 32296183
Cross
RYBP Q8N488 Trpm7 Mus musculus Q923J1 24855944
Cross
RYBP Q8N488 Trpm7 Mus musculus Q923J1
IF
24855944
Intra
RYBP Q8N488 FLNA Homo sapiens P21333-2 32814053
Intra
RYBP Q8N488 FLNA Homo sapiens P21333-2 32814053
Intra
RYBP Q8N488 FLNA Homo sapiens P21333-2 32814053
Intra
RYBP Q8N488 PEX1 Homo sapiens O43933 32814053
Intra
RYBP Q8N488 PEX1 Homo sapiens O43933 32814053
Intra
RYBP Q8N488 PEX1 Homo sapiens O43933 32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RYBP Proteins

Cat. No. Product Name Accession Purity
HY-P74590 RYBP Protein, Human (sf9, His-GST) Q8N488 (M1-F228) ≥95%

RYBP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82052 RYBP Antibody (YA1797) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 13

PCH13

Pontocerebellar Hypoplasia Type 13

Pontocerebellar Hypoplasia 13

Doid:0112332

Hypoplasia, Pontocerebellar, Type 13

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma

Hodgkin Disease

Hodgkin'S Lymphoma

Hodgkins Lymphoma

Classic Hodgkin Lymphoma

CHL

Hodgkin Lymphoma, Susceptibility To

Hl

Hodgkin'S Sarcoma

Stage I Subdiaphragmatic Hodgkin Lymphoma

Stage Ii Subdiaphragmatic Hodgkin Lymphoma

Lymphoma, Hodgkin'S

Classic Hodgkin Disease

Hodgkin'S Disease

Lymphoma, Hodgkin, Susceptibility To

Hodgkin'S Disease Of Intrapelvic Lymph Nodes

Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb

Malignant Lymphogranuloma

Malignant Lymphogranulomatosis

Malignant Hodgkin Lymphoma

Classical Hodgkin Lymphoma, Type Not Specified

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus RYBP MGD MGI:1929059
Rattus norvegicus RYBP RGD RGD:1307077
Bos taurus RYBP VGNC VGNC:106910
Macaca mulatta RYBP VGNC VGNC:84088
Canis familiaris RYBP VGNC VGNC:58331
Felis catus RYBP VGNC VGNC:102696
Others RYBP NCBI