2. Gene
  3. Gc - GC, vitamin D binding protein Gene

Gc - GC, vitamin D binding protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as DBP; VDB; Vdbp; DBP02

Gene ID: 24384 | Gene type: protein coding

About Gc

Summary

Enables vitamin D binding activity. Involved in several processes, including female pregnancy; lactation; and response to estradiol. Located in several cellular components, including axon; extracellular space; and perinuclear region of cytoplasm. Biomarker of brain ischemia and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); chronic obstructive pulmonary disease; hepatocellular carcinoma; human immunodeficiency virus infectious disease; and rheumatic fever. Orthologous to human GC (GC vitamin D binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Gc Products(1)

mRNA Protein Name
NM_012564.3 NP_036696.2 vitamin D-binding protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
8660573 RGD
enables vitamin D binding IDA
IDA: Inferred from direct assay
49052 RGD
Biological Process GO Annotation Evidence Reference Source
involved in female pregnancy IEP
IEP: Inferred from expression pattern
217634 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
217634 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
6321624 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
12144717 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
217634 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
19034485 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
8660573 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
19034485 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vitamin D-binding protein

gc-globulin

group specific component

Related Agents

Approval
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0561 Spironolactone 99.63% Yes
HY-13693 Mometasone furoate Agonist 99.86% Yes
HY-108741 Plecanatide Agonist 99.75% Unkown
HY-17569 Difluprednate Inhibitor 99.64% Yes
HY-108741A Plecanatide acetate Agonist 99.51% Unkown
HY-108741R Plecanatide (Standard) Agonist / Unkown
Clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-109110 Avasopasem manganese 96.02% Phase 3
HY-14823 Sobetirome Agonist 99.91% Phase 2
HY-10498 Lexibulin 99.50% Phase 2
HY-13336 Imisopasem manganese 98.15% Phase 2
HY-14181A Cinaciguat hydrochloride Activator 98.90% Phase 2
HY-132829 Rucosopasem manganese / Phase 2
HY-P0118 Disitertide / Phase 2
HY-P0118A Disitertide TFA / Phase 2
HY-10498A Lexibulin dihydrochloride / Phase 2
HY-114577 Palifosfamide tromethamine Chemical / Phase 2
HY-P3499 Dolcanatide Agonist 99.39% Phase 1
HY-12946 BI 653048 Inhibitor 99.84% Phase 1
HY-12946A BI 653048 phosphate Inhibitor / Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99693 Lenvervimab Inhibitor ≥99% Phase 3
HY-P99013 Codrituzumab Inhibitor 95.70% Phase 2
HY-P99020 Fresolimumab Inhibitor 99.51% Phase 2
Pre-clinical Phase
Bioactive Molecules (54)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108314A GC7 Sulfate Inhibitor ≥98.0% Unkown
HY-D1020 7-Aminoactinomycin D Inhibitor ≥99.0% Unkown
HY-P0118B Disitertide diammonium 99.53% Unkown
HY-136684 BrBzGCp2 Inhibitor 98.68% Unkown
HY-141513 NH-3 Antagonist 99.41% Unkown
HY-111798A Heme Oxygenase-1-IN-1 hydrochloride Inhibitor 99.03% Unkown
HY-N0103 Sophocarpine 98.63% Unkown
HY-111208 CCT129957 Inhibitor 99.71% Unkown
HY-111798 Heme Oxygenase-1-IN-1 Inhibitor 99.11% Unkown
HY-W040129 Chromomycin A3 Inhibitor 99.66% Unkown
HY-19345A Vacquinol-1 dihydrochloride Activator 99.44% Unkown
HY-108628 SU16f Inhibitor 99.36 Unkown
HY-I0450 Anticancer agent 265 99.74% Unkown
HY-152038 SPEN-IN-1 98.47% Unkown
HY-N0103A Sophocarpine monohydrate 99.91% Unkown
HY-100721 GC376 sodium Inhibitor 99.96% Unkown
HY-132184 5,6-Epoxyeicosatrienoic acid Inhibitor 99.00% Unkown
HY-130189 S-Phenylmercapturic acid 99.38% Unkown
HY-149453 MCUF-651 Modulator 99.85% Unkown
HY-151482 SARS-CoV-2 Mpro-IN-2 Inhibitor 98.96% Unkown
HY-114043 NCGC00092410 Inhibitor 99.54% Unkown
HY-131389 Cholesteryl heptadecanoate ≥98.0% Unkown
HY-155789 C17 Globotriaosylceramide (d18:1/17:0) ≥99.0% Unkown
HY-108314 GC-7 Inhibitor / Unkown
HY-160178 Glucocorticoid receptor agonist-3 Ala-Ala-Mal 99.72% Unkown
HY-107547 BPIPP Inhibitor / Unkown
HY-101282 Glutaminyl Cyclase Inhibitor 3 Inhibitor / Unkown
HY-108353S Isoprenaline-d7 acetate / Unkown
HY-111442 GC 14 Antagonist / Unkown
HY-118274 ADDA / Unkown
HY-130229 (±)5,6-DHET lactone / Unkown
HY-145381 11β-HSD1-IN-6 Inhibitor / Unkown
HY-146398 AMPK activator 6 Activator / Unkown
HY-148392 Neu5Gcα(2-6) N-Glycan-Asn / Unkown
HY-149774 GC-78-HCl / Unkown
HY-156020 Glucocerebrosidase-IN-2 Inhibitor / Unkown
HY-157001 7-Deaza-dGTP tetralithium / Unkown
HY-160180 Glucocorticoid receptor agonist-4 Ala-Ala-Mal / Unkown
HY-161177 PROTAC KRAS G12D degrader 2 Inhibitor / Unkown
HY-162293 CDK8-IN-14 Inhibitor / Unkown
HY-166965 Neu5Gc(α2,6)N-Acetylgalactosamine / Unkown
HY-19345 Vacquinol-1 Activator / Unkown
HY-P10090 Apoptin-derived peptide / Unkown
HY-P10786 LinTT1 peptide Inhibitor / Unkown
HY-P1911 CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156) / Unkown
HY-RS05316 GC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W127357 Tripelargonin / Unkown
HY-W127496 Methyl 13-methyltetradecanoate / Unkown
HY-W130478S 1-Phenylhexane-d5 / Unkown
HY-132184S 5,6-Epoxyeicosatrienoic acid-d11 / Unkown
HY-154171 Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one / Unkown
HY-160832 GC373 Inhibitor / Unkown
HY-165420 GC-IN-2 Inhibitor / Unkown
HY-N10626 Neu5Gcα(2-6) N-Glycan / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990844 Anti-GC1q R/C1QBP Antibody (60.11) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gc NCBI NCBI:2638
Canis familiaris Gc NCBI NCBI:475172
Macaca fascicularis Gc NCBI NCBI:102135316
Mus musculus Gc NCBI NCBI:14473
Susscrofa domestica Gc NCBI
Macaca mulatta Gc NCBI NCBI:705708