GC - GC vitamin D binding protein Gene

Homo sapiens

Also known as DBP; VDB; GRD3; VDBG; VDBP; GcMAF; DBP/GC; Gc-MAF; DBP-maf; HEL-S-51

Gene ID: 2638 | Gene type: protein coding

About GC

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:71,741,693-71,805,520 (from NCBI)

This gene has 8 transcripts (splice variants), 140 orthologues and 3 paralogues. Restricted expression toward liver (RPKM 1264.0).

Summary

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

GC Products(3)

mRNA	Protein	Name
NM_000583.4	NP_000574.2	vitamin D-binding protein isoform 1 precursor
NM_001204306.1	NP_001191235.1	vitamin D-binding protein isoform 1 precursor
NM_001204307.1	NP_001191236.1	vitamin D-binding protein isoform 3 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IPI IPI: Inferred from physical interaction	12119014	GOA
enables calcidiol binding	IDA IDA: Inferred from direct assay	11799400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GC Protein Structure

Serum_albumin

VitD-bind_III

0
100
200
300
400
474 a.a.

Protein Preferred Names

Protein Names

vitamin D-binding protein

epididymis secretory protein Li 51

Recombinant GC Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71068	Vitamin D-binding protein/GC Protein, Human (HEK293, His)	P02774-1 (L17-L474)	≥95%
HY-P71736	Vitamin D-binding protein/GC Protein, Human (P.pastoris, His-SUMOstar)	P02774-1 (R19-L474)	≥95%
HY-P72202	Vitamin D-binding protein/GC Protein, Human (His)	P02774-1 (R19-L474)	≥95%

Related Diseases

Diseases

Alias

Rickets

Vitamin D Deficiency	Vitamin D
Active Rickets	Hypovitaminosis D
Nutritional Rickets	Vitamin D Deficiency Disease
Vitamin-D Deficiency Rickets	Vitamin D-Dependent Rickets
Avitaminosis D	Infantile Osteomalacia
Juvenile Osteomalacia

Blastomycosis

Gilchrist'S Disease	North American Blastomycosis
Blastomyces Dermatitidis Infection	Blastomycotic Infection
Infection By Blastomyces Dermatitidis	Gilchrist Disease
Chicago Disease	Chicago Disease Or Disorder
Blastomycosis, Unspecified	Blastomyces Infection

Hepatic Encephalopathy

Encephalopathy, Hepatic	Portal-Systemic Encephalopathy
Hepatoencephalopathy	He - [Hepatic Encephalopathy]
Hepatic Encephalopathy Nos	Hepatic Encephalopathy, Stage Unspecified
Hepatic Coma	Hepatocerebral Encephalopathy
Hepatocerebral Intoxication

Osteoporosis, Juvenile

Idiopathic Juvenile Osteoporosis	Idiopathic Osteoporosis
Juvenile Osteoporosis	Ijo

Osteomalacia

Adult Rickets

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Hyperparathyroidism

Hyperparathyroidism And Other Disorders Of Parathyroid Gland	Parathyroid Hyperfunction
Hpth - [Hyperparathyroidism]	Parathyroid Gland Hyperfunction
Parathyroid Glandular Hyperfunction

Cystinosis

Cystine Storage Disease	Cystine Diathesis
Cystine Disease	Cystinoses
Protein Defect Of Cystin Transport	Cystin Transport, Protein Defect Of
Nephropathic Cystinosis	Protein Defect Of Cystine Transport

Pulmonary Tuberculosis

Tuberculosis, Pulmonary	PTB
Tuberculosis Pulmonary

Anteroseptal Myocardial Infarction

Donnai-Barrow Syndrome

Faciooculoacousticorenal Syndrome	Dbs/Foar Syndrome
Foar Syndrome	Diaphragmatic Hernia-Exomphalos-Hypertelorism Syndrome
Facio-Oculo-Acoustico-Renal Syndrome	Diaphragmatic Hernia, Exomphalos, Absent Corpus Callosum, Hypertelorism, Myopia, Sensorineural Deafness, And Proteinuria
Diaphragmatic Hernia-Hypertelorism-Myopia-Deafness Syndrome	Holmes-Schepens Syndrome
Syndrome Of Ocular And Facial Anomalies, Telecanthus And Deafness	DBS
Diaphragmatic Hernia Exomphalos Absent Corpus Callosum Hypertelorism Myopia Sensorineural Deafness And Proteinuria	Diaphragmatic Hernia-Exomphalos-Corpus Callosum Agenesis
Diaphragmatic Hernia-Hypertelorism-Myopia-Hearing Loss Syndrome	Syndrome Of Ocular And Facial Anomalies, Telecanthus And Hearing Loss
Donnai Barrow Syndrome

Hypervitaminosis D

Vitamin D Hyperalimentation

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Parathyroid Gland Disease

Parathyroid Diseases	Disease Of Parathyroid Glands
Parathyroid Disease

Vitamin D-Dependent Rickets

Vddr

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Diabetes Mellitus

Diabetes

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Mineral Metabolism Disease

Mineral Metabolism Disorder

Disorder Of Mineral Metabolism

Osteogenic Sarcoma

Osteosarcoma	OSRC
Osteosarcoma, Somatic	Neoplasms, Bone Tissue
Bone Tissue Neoplasm	Osteoid Sarcoma
Skeletal Sarcoma	Osteosarcoma Of Bone
Bone Sarcoma

Scoliosis

Analbuminemia

ANALBA	Congenital Analbuminemia
Hypoalbuminemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0561	Spironolactone		99.66%	Yes
HY-13693	Mometasone furoate	Agonist	99.86%	Yes
HY-108741	Plecanatide	Agonist	99.75%	Unkown
HY-108741A	Plecanatide acetate	Agonist	99.51%	Unkown

Clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109110	Avasopasem manganese		96.02%	Phase 3
HY-14823	Sobetirome	Agonist	99.92%	Phase 2
HY-10498	Lexibulin		99.50%	Phase 2
HY-13336	Imisopasem manganese		98.15%	Phase 2
HY-14181A	Cinaciguat hydrochloride	Activator	98.90%	Phase 2
HY-P0118	Disitertide		/	Phase 2
HY-132829	Rucosopasem manganese		/	Phase 2
HY-P0118A	Disitertide TFA		/	Phase 2
HY-10498A	Lexibulin dihydrochloride		/	Phase 2
HY-114577	Palifosfamide tromethamine	Chemical	/	Phase 2
HY-P3499	Dolcanatide	Agonist	99.39%	Phase 1
HY-12946	BI 653048	Inhibitor	99.84%	Phase 1
HY-12946A	BI 653048 phosphate	Inhibitor	/	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99693	Lenvervimab	Inhibitor	/	Phase 3
HY-P99020	Fresolimumab	Inhibitor	99.51%	Phase 2

Pre-clinical Phase

Bioactive Molecules (51)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108314A	GC7 Sulfate	Inhibitor	≥98.0%	Unkown
HY-P0118B	Disitertide diammonium		99.53%	Unkown
HY-D1020	7-Aminoactinomycin D	Inhibitor	≥99.0%	Unkown
HY-136684	BrBzGCp2	Inhibitor	98.68%	Unkown
HY-141513	NH-3	Antagonist	99.41%	Unkown
HY-111798A	Heme Oxygenase-1-IN-1 hydrochloride	Inhibitor	99.03%	Unkown
HY-N0103	Sophocarpine		98.63%	Unkown
HY-111208	CCT129957	Inhibitor	99.71%	Unkown
HY-111798	Heme Oxygenase-1-IN-1	Inhibitor	99.11%	Unkown
HY-W040129	Chromomycin A3	Inhibitor	99.66%	Unkown
HY-19345A	Vacquinol-1 dihydrochloride		99.44%	Unkown
HY-152038	SPEN-IN-1	Inhibitor	98.47%	Unkown
HY-N0103A	Sophocarpine monohydrate		99.91%	Unkown
HY-108628	SU16f	Inhibitor	99.09%	Unkown
HY-114043	NCGC00092410	Inhibitor	99.54%	Unkown
HY-130189	S-Phenylmercapturic acid		99.38%	Unkown
HY-131389	Cholesteryl heptadecanoate		≥98.0%	Unkown
HY-132184	5,6-Epoxyeicosatrienoic acid		≥99.0%	Unkown
HY-108314	GC-7	Inhibitor	/	Unkown
HY-151482	SARS-CoV-2 Mpro-IN-2	Inhibitor	98.96%	Unkown
HY-155789	C17 Globotriaosylceramide (d18:1/17:0)		98.00%	Unkown
HY-149453	MCUF-651	Modulator	99.85%	Unkown
HY-160178	Glucocorticoid receptor agonist-3 Ala-Ala-Mal		99.72%	Unkown
HY-101282	Glutaminyl Cyclase Inhibitor 3	Inhibitor	/	Unkown
HY-108353S	Isoprenaline-d7 acetate		/	Unkown
HY-111442	GC 14	Antagonist	/	Unkown
HY-123023	12(S)-HETE D8		/	Unkown
HY-145381	11β-HSD1-IN-6	Inhibitor	/	Unkown
HY-146398	AMPK activator 6	Activator	/	Unkown
HY-148392	Neu5Gcα(2-6) N-Glycan-Asn		/	Unkown
HY-149774	GC-78-HCl		/	Unkown
HY-156020	Glucocerebrosidase-IN-2	Inhibitor	/	Unkown
HY-160180	Glucocorticoid receptor agonist-4 Ala-Ala-Mal		/	Unkown
HY-161177	PROTAC KRAS G12D degrader 2	Inhibitor	/	Unkown
HY-162293	CDK8-IN-14	Inhibitor	/	Unkown
HY-165420	GC-IN-2		/	Unkown
HY-166965	Neu5Gc(α2,6)N-Acetylgalactosamine		/	Unkown
HY-19345	Vacquinol-1		/	Unkown
HY-N10626	Neu5Gcα(2-6) N-Glycan		/	Unkown
HY-N13059	Waldiomycin		/	Unkown
HY-P10090	Apoptin-derived peptide		/	Unkown
HY-P1911	CEF27, Epstein-Barr Virus BRLF-1 lytic (148-156)		/	Unkown
HY-RS05316	GC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W127357	Tripelargonin		/	Unkown
HY-W127496	Methyl 13-methyltetradecanoate		/	Unkown
HY-W130478S	1-Phenylhexane-d5		/	Unkown
HY-107547	BPIPP	Inhibitor	/	Unkown
HY-118274	ADDA		/	Unkown
HY-154171	Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one		/	Unkown
HY-157001	7-Deaza-dGTP tetralithium		/	Unkown
HY-160832	GC373	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GC	MGD	MGI:95669
Felis catus	GC	VGNC	VGNC:62485
Canis familiaris	GC	VGNC	VGNC:41136
Bos taurus	GC	VGNC	VGNC:29277
Macaca mulatta	GC	VGNC	VGNC:72897
Rattus norvegicus	GC	RGD	RGD:2667
Macaca fascicularis	GC	NCBI	NCBI:102135316
Susscrofa domestica	GC	NCBI
Others	GC	NCBI

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