ARFIP1 - ADP ribosylation factor interacting protein 1 Gene

Homo sapiens

Also known as HSU52521

Gene ID: 27236 | Gene type: protein coding

About ARFIP1

Cytogenetic location: 4q31.3 Genomic coordinates (GRCh38): 4:152,779,954-152,912,357 (from NCBI)

This gene has 11 transcripts (splice variants), 259 orthologues and 2 paralogues. Ubiquitous expression in gall bladder (RPKM 8.9), colon (RPKM 8.5) and 25 other tissues.

Summary

Enables phosphatidylinositol-4-phosphate binding activity. Involved in negative regulation of retrograde transport, endosome to Golgi. Acts upstream of or within intracellular protein transport and regulation of protein secretion. Located in Golgi membrane; cytosol; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARFIP1 Products(6)

mRNA	Protein	Name
NM_001025593.3	NP_001020764.1	arfaptin-1 isoform 2
NM_001025595.3	NP_001020766.1	arfaptin-1 isoform 1
NM_001287431.2	NP_001274360.1	arfaptin-1 isoform 1
NM_001287432.2	NP_001274361.1	arfaptin-1 isoform 1
NM_001287433.2	NP_001274362.1	arfaptin-1 isoform 2
NM_014447.4	NP_055262.1	arfaptin-1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-4-phosphate binding	IDA IDA: Inferred from direct assay	23695357	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22981988	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within intracellular protein transport	IDA IDA: Inferred from direct assay	12606037	GOA
involved in negative regulation of retrograde transport, endosome to Golgi	IMP IMP: Inferred from mutant phenotype	25789876	GOA
acts upstream of or within regulation of protein secretion	IDA IDA: Inferred from direct assay	12606037	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	9038142	GOA
located in cytosol	IDA IDA: Inferred from direct assay	9038142	GOA
located in trans-Golgi network membrane	IDA IDA: Inferred from direct assay	23695357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARFIP1 Protein Structure

Arfaptin

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

arfaptin-1

ARFIP1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARFIP1	P53367	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	TNFRSF10D	Homo sapiens	Q9UBN6	Validated Y2H	32296183
Intra	ARFIP1	P53367	TNFRSF10D	Homo sapiens	Q9UBN6	Y2H Array	32296183
Intra	ARFIP1	P53367	MAGEA6	Homo sapiens	P43360	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	MAGEA6	Homo sapiens	P43360	Validated Y2H	32296183
Intra	ARFIP1	P53367	MAGEA6	Homo sapiens	P43360	Y2H Array	32296183
Intra	ARFIP1	P53367	KRT33B	Homo sapiens	Q14525	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	KRT33B	Homo sapiens	Q14525	Y2H Array	32296183
Intra	ARFIP1	P53367	KRT33B	Homo sapiens	Q14525	Validated Y2H	32296183
Intra	ARFIP1	P53367	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	ARFIP1	P53367	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	ARFIP1	P53367	ARL1	Homo sapiens	P40616	Pull Down	22981988
Intra	ARFIP1	P53367	ARL1	Homo sapiens	P40616	Anti Tag CoIP	35271311
Intra	ARFIP1	P53367	ARL1	Homo sapiens	P40616	Anti Tag CoIP	22981988
Intra	ARFIP1	P53367	SYNGR3	Homo sapiens	O43761	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	SYNGR3	Homo sapiens	O43761	Y2H Array	32296183
Intra	ARFIP1	P53367	CMTM5	Homo sapiens	Q96DZ9-2	Validated Y2H	32296183
Intra	ARFIP1	P53367	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Array	32296183
Intra	ARFIP1	P53367	CMTM5	Homo sapiens	Q96DZ9-2	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	PRKD1	Homo sapiens	Q15139	Protein Kinase Assay	22981988
Intra	ARFIP1	P53367	SMIM5	Homo sapiens	Q71RC9	Y2H Array	32296183
Intra	ARFIP1	P53367	SMIM5	Homo sapiens	Q71RC9	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	SMIM5	Homo sapiens	Q71RC9	Validated Y2H	32296183
Intra	ARFIP1	P53367	SMPD2	Homo sapiens	O60906	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	SMPD2	Homo sapiens	O60906	Y2H Array	32296183
Intra	ARFIP1	P53367	DESI2	Homo sapiens	Q9BSY9	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	DESI2	Homo sapiens	Q9BSY9	Validated Y2H	32296183
Intra	ARFIP1	P53367	DESI2	Homo sapiens	Q9BSY9	Y2H Array	32296183
Intra	ARFIP1	P53367	AFF1	Homo sapiens	P51825-3	Y2H Array	32296183
Intra	ARFIP1	P53367	AFF1	Homo sapiens	P51825-3	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	SFT2D1	Homo sapiens	Q8WV19	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	SFT2D1	Homo sapiens	Q8WV19	Validated Y2H	32296183
Intra	ARFIP1	P53367	SFT2D1	Homo sapiens	Q8WV19	Y2H Array	32296183
Intra	ARFIP1	P53367	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	ARFIP1	P53367	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	ARFIP1	P53367	ARF1	Homo sapiens	P84077	Pull Down	22981988
Intra	ARFIP1	P53367	ARF1	Homo sapiens	P84077	Anti Tag CoIP	22981988
Intra	ARFIP1	P53367	ARFIP2	Homo sapiens	P53365	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	ARFIP2	Homo sapiens	P53365	Y2H Array	32296183
Intra	ARFIP1	P53367	ARFIP2	Homo sapiens	P53365	Anti Tag CoIP	35271311
Intra	ARFIP1	P53367	BSND	Homo sapiens	Q8WZ55	Validated Y2H	32296183
Intra	ARFIP1	P53367	BSND	Homo sapiens	Q8WZ55	Y2H Array	32296183
Intra	ARFIP1	P53367	BSND	Homo sapiens	Q8WZ55	Y2H Prey Pooling	32296183
Intra	ARFIP1	P53367	SCAMP1	Homo sapiens	O15126	Y2H Array	32296183
Intra	ARFIP1	P53367	SCAMP1	Homo sapiens	O15126	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00905	ARFIP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARFIP1	VGNC	VGNC:38038
Mus musculus	ARFIP1	MGD	MGI:1277120
Macaca mulatta	ARFIP1	VGNC	VGNC:69878
Felis catus	ARFIP1	VGNC	VGNC:59871
Bos taurus	ARFIP1	VGNC	VGNC:26067
Rattus norvegicus	ARFIP1	RGD	RGD:708401

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