Hras - HRas proto-oncogene, GTPase Gene

Rattus norvegicus

Also known as HRAS1; c-H-ras

Gene ID: 293621 | Gene type: protein coding

About Hras

Primary_assembly 1: 196,296,263-196,300,615 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 224 orthologues, 41 paralogues and is associated with 104 phenotypes. Biased expression in Muscle (RPKM 343.7), Brain (RPKM 196.6) and 9 other tissues.

Summary

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular senescence; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in intracellular membrane-bounded organelle and plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Hras Products(2)

mRNA	Protein	Name
NM_001130441.1	NP_001123913.1	GTPase HRas
NM_001098241.1	NP_001091711.1	GTPase HRas

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18514235	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	15917294	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	12077341	RGD
involved in cellular senescence	IEP IEP: Inferred from expression pattern	17706954	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	2581126	RGD
involved in positive regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	9487126	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	18163378	RGD
acts upstream of or within positive regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	19029245	RGD
involved in response to isolation stress	IEP IEP: Inferred from expression pattern	19616040	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	19878719	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Hras Protein Structure

H_N_K_Ras_like

0
100
200
290 a.a.

Protein Preferred Names

Protein Names

GTPase HRas

H-Ras-1	Harvey ras1 protein
Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog	Harvey rat sarcoma virus oncogene
p21ras	transforming protein p21

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0660	Eicosapentaenoic Acid	Activator	98.70%	Yes
HY-15136	Lonafarnib		99.87%	Yes
HY-W011269	Eicosapentaenoic Acid sodium	Activator	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16373	CP-609754	Inhibitor	99.21%	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156498	RMC-7977	Inhibitor	99.48%	Unkown
HY-100002	ML162		99.45%	Unkown
HY-122862	RAS inhibitor Abd-7	Inhibitor	99.16%	Unkown
HY-113849	MLS-573151	Inhibitor	99.74%	Unkown
HY-18674	K-Ras-IN-1	Inhibitor	98.00%	Unkown
HY-145962A	MRTX-EX185 formic	Inhibitor	97.32%	Unkown
HY-123242	FTI-2153	Inhibitor	99.11%	Unkown
HY-15879	LB42708		≥99.0%	Unkown
HY-125904	4-Hydroxyretinoic acid	Activator	95.11%	Unkown
HY-115489A	GGTI-286 TFA	Inhibitor	/	Unkown
HY-123242A	FTI-2153 TFA	Inhibitor	99.11%	Unkown
HY-115489	GGTI-286	Inhibitor	/	Unkown
HY-145962	MRTX-EX185	Inhibitor	/	Unkown
HY-117935	GGTI-286 hydrochloride	Inhibitor	/	Unkown
HY-117807	A-176120	Inhibitor	/	Unkown
HY-120763	LB42908	Inhibitor	/	Unkown
HY-120828	Albenatide	Agonist	/	Unkown
HY-151263	G4/HDAC-IN-1		/	Unkown
HY-15136B	(Rac)-Lonafarnib		/	Unkown
HY-RS06354	HRAS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06355	Hras Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06356	Hras Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120271	GGTI-297	Inhibitor	/	Unkown
HY-B0660A	Eicosapentaenoic acid (metformin)	Activator	/	Unkown
HY-B0660S1	Eicosapentaenoic acid 1,2,3,4,5-13C5	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hras	NCBI	NCBI:3265

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