IK - IK cytokine Gene

Homo sapiens

Also known as RED; RER; CSA2

Gene ID: 3550 | Gene type: protein coding

About IK

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:140,647,829-140,662,480 (from NCBI)

This gene has 10 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 59.6), bone marrow (RPKM 39.1) and 25 other tissues.

Summary

The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]

IK Products(1)

mRNA	Protein	Name
NM_006083.4	NP_006074.2	protein Red

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22365833	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22190034	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	24252166	GOA
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	22351768	GOA
involved in protein localization to kinetochore	IMP IMP: Inferred from mutant phenotype	22351768	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of U2-type precatalytic spliceosome	IDA IDA: Inferred from direct assay	28781166	GOA
colocalizes with mitotic spindle pole	IDA IDA: Inferred from direct assay	22351768	GOA
colocalizes with nuclear chromosome	IMP IMP: Inferred from mutant phenotype	24252166	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	24252166	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28781166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IK Protein Structure

RED_N

RED_C

0
100
200
300
400
500
557 a.a.

Protein Preferred Names

Protein Names

protein Red

IK cytokine, down-regulator of HLA II

IK Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	IK	Q13123	MFAP1	Homo sapiens	P55081	Y2H	22365833
Intra	IK	Q13123	MFAP1	Homo sapiens	P55081	Anti Tag CoIP	22365833
Intra	IK	Q13123	DNAJB6	Homo sapiens	O75190	Y2H Array	32814053
Intra	IK	Q13123	DNAJB6	Homo sapiens	O75190	Validated Y2H	32814053
Intra	IK	Q13123	DNAJB6	Homo sapiens	O75190	Y2H Pooling	32814053
Intra	IK	Q13123	EGLN3	Homo sapiens	Q9H6Z9	Validated Y2H	32296183
Intra	IK	Q13123	RNF113A	Homo sapiens	O15541	Y2H	22365833
Intra	IK	Q13123	RNF113A	Homo sapiens	O15541	Anti Tag CoIP	22365833
Intra	IK	Q13123	XAB2	Homo sapiens	Q9HCS7	Anti Tag CoIP	22365833
Intra	IK	Q13123	SMU1	Homo sapiens	Q2TAY7	Y2H Prey Pooling	32296183
Intra	IK	Q13123	SMU1	Homo sapiens	Q2TAY7	Y2H	22365833
Intra	IK	Q13123	SMU1	Homo sapiens	Q2TAY7	Validated Y2H	32296183
Intra	IK	Q13123	SMU1	Homo sapiens	Q2TAY7	Y2H Array	32296183
Intra	IK	Q13123	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	IK	Q13123	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	IK	Q13123	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	IK	Q13123	PRPF6	Homo sapiens	O94906	Y2H	22365833
Intra	IK	Q13123	PRPF6	Homo sapiens	O94906	Anti Tag CoIP	22365833
Intra	IK	Q13123	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	25416956
Intra	IK	Q13123	RBM10	Homo sapiens	P98175	Y2H	22365833
Intra	IK	Q13123	RBM10	Homo sapiens	P98175	Anti Tag CoIP	22365833
Intra	IK	Q13123	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	IK	Q13123	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	IK	Q13123	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	IK	Q13123	SNIP1	Homo sapiens	Q8TAD8	Anti Tag CoIP	22365833
Intra	IK	Q13123	SNIP1	Homo sapiens	Q8TAD8	Y2H	22365833
Intra	IK	Q13123	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	IK	Q13123	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	IK	Q13123	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Cross	IK	Q13123	rev	Human immunodeficiency virus	P04618	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Skin Amelanotic Melanoma

Skin Amelanotic Malignant Melanoma

Amelanotic Skin Melanoma

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Chronic Atrial And Intestinal Dysrhythmia

CAID	Caid Syndrome
Cohesinopathy Affecting Heart And Gut Rhythm	Chronic Atrial Intestinal Dysrhythmia Syndrome
Chronic Atrial And Intestinal Dysrhythmia Syndrome	Chronic Atrial Dysrhythmia-Intestinal Motility Disorder
Dysrhythmia, Atrial And Intestinal, Chronic

Gordon Holmes Syndrome

Cerebellar Ataxia And Hypogonadotropic Hypogonadism	Lhrh Deficiency And Ataxia
Cerebellar Ataxia-Hypogonadism Syndrome	GDHS
Cahh	Luteinizing Hormone-Releasing Hormone Deficiency With Ataxia
Gordon-Holmes Syndrome	Deficiency Of Luteinizing Hormone-Releasing Hormone With Ataxia
Luteinizing Hormone-Releasing Hormone, Deficiency Of, With Ataxia	Cerebellar Ataxia - Hypogonadism
Luteinizing Hormone Releasing Hormone, Deficiency Of With Ataxia	Ataxia, Cerebellar, And Hypogonadotropic Hypogonadism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100795A	Pirmenol hydrochloride	Inhibitor	99.34%	Unkown
HY-100795	Pirmenol	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153585	IK-930	Inhibitor	99.26%	Phase 1
HY-118148	UK-66914	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15416	NS309	Activator	99.09%	Unkown
HY-103137	Zacopride hydrochloride		99.69%	Unkown
HY-101253	AM-92016 hydrochloride		≥98.0%	Unkown
HY-112544	IK1 inhibitor PA-6	Inhibitor	99.62%	Unkown
HY-120685	WAY-125971	Antagonist	/	Unkown
HY-126704	Tedisamil		/	Unkown
HY-136805	Kv1.5-IN-1		/	Unkown
HY-146365	HIV-1 inhibitor-30		/	Unkown
HY-RS06656	IK Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-118317	Zacopride		/	Unkown
HY-118734	IK-862	Inhibitor	/	Unkown
HY-120059	NS4591		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	IK	VGNC	VGNC:30100
Felis catus	IK	VGNC	VGNC:67750
Mus musculus	IK	MGD	MGI:1345142
Canis familiaris	IK	VGNC	VGNC:54958
Rattus norvegicus	IK	RGD	RGD:1359352
Macaca mulatta	IK	VGNC	VGNC:73703
Macaca fascicularis	IK	NCBI	NCBI:102130643
Susscrofa domestica	IK	NCBI
Leporidae	IK	NCBI
Others	IK	NCBI

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